EPS-ORA-00019

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORA-00019

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	284.3	1.3E-84	23	289	267

Status

Unreviewed

Ensembl Protein

ENSOANP00000018791

UniProt Accession

F6ZZ09;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000011857	ENSOANP00000018791	ENSOANT00000018794

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL DGWSFFAVYD 60

GHAGSQVAKY CCEHLLDHIT SNQDFRGADG PPSVESVKNG IRTGFLQIDE HMRVISEKKH 120

GADRSGSTAV GVMISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG 180

SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VCEIERSEDD DQFIILACDG 240

IWDVMGNEEL CDFVRSRLEV TDDLERVCNE IVDTCLYKGS RDNMSVILIC FPNAPKVLPE 300

AVKREAELDK YLESRVEEII KKQGEGVPDL VHVMRTLATE SIPNLPPGGE LASKRSVIEA 360

VYNRLNPYRN DDTDSASTDD MW 382

Nucleotide Sequence
(FASTA)

ATGGGAGCAT TTTTAGACAA GCCAAAGATG GAGAAACATA ATGCCCAGGG CCAGGGCAAC 60

GGGCTGCGGT ATGGGCTGAG CAGCATGCAG GGGTGGCGAG TGGAGATGGA GGACGCGCAC 120

ACGGCCGTGA TCGGTTTGCC CAGCGGACTG GACGGGTGGT CTTTCTTTGC CGTCTACGAC 180

GGGCACGCCG GCTCCCAGGT AGCCAAGTAC TGCTGCGAGC ACTTGTTAGA CCACATCACC 240

AGTAACCAGG ATTTTCGAGG AGCCGACGGG CCGCCGTCCG TGGAGAGCGT CAAGAACGGG 300

ATCCGGACGG GCTTCCTGCA GATTGACGAA CACATGCGCG TGATCTCGGA GAAGAAGCAC 360

GGTGCCGACC GGAGCGGCTC GACCGCGGTG GGGGTCATGA TTTCTCCCCA GCATACTTAT 420

TTCATCAACT GTGGAGACTC CCGCGGGTTG CTTTGTAGGA ACAGGAAGGT TCATTTCTTC 480

ACCCAAGACC ACAAACCCAG CAACCCCCTG GAGAAGGAGC GCATCCAGAA CGCGGGTGGC 540

TCGGTCATGA TCCAGCGTGT GAACGGCTCT CTCGCCGTGT CGCGGGCACT GGGGGACTTT 600

GATTACAAAT GCGTCCACGG GAAAGGGCCG ACGGAGCAGC TGGTCTCCCC GGAACCCGAA 660

GTGTGCGAGA TCGAGCGGTC GGAAGACGAC GACCAGTTCA TCATCCTCGC TTGTGACGGG 720

ATCTGGGACG TCATGGGCAA CGAGGAGCTC TGCGACTTCG TGCGGTCCCG GCTCGAGGTG 780

ACCGACGACC TGGAGAGAGT TTGCAACGAA ATCGTCGACA CCTGCCTGTA CAAGGGAAGC 840

CGAGACAACA TGAGCGTGAT ACTGATCTGT TTTCCGAATG CACCGAAGGT ATTGCCAGAG 900

GCCGTGAAGA GGGAGGCAGA GTTGGACAAG TACCTGGAAA GCAGAGTAGA AGAAATCATA 960

AAGAAGCAGG GGGAAGGCGT TCCAGACTTA GTCCACGTGA TGCGGACGCT AGCCACGGAG 1020

AGCATCCCAA ACCTCCCGCC GGGGGGGGAA CTGGCCAGCA AGCGCAGTGT GATTGAAGCC 1080

GTTTACAATC GATTGAATCC CTACCGAAAC GATGACACTG ACTCTGCATC AACTGATGAC 1140

ATGTGGTAA 1149

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t+   ++  p+  d ++ff+vyDGh+gs+vak+c e+l +++

Q: 23    RYGLSSMQGWRVEMEDAHTA---VIGLPSGLDGWSFFAVYDGHAGSQVAKYCCEHLLDHI  79

         69****************97...4555555566***************************

S: 62    aeele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskl  117

         + + +    ++ ++ + vk+ ++++Fl++de+++v++ek++  d+sGstav ++i++++

Q: 80    TSNQDfrgaDGPPSVESVKNGIRTGFLQIDEHMRVISEKKHGADRSGSTAVGVMISPQHT  139

         ***999999889999*********************************************

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRa  177

         y++n+GdSr +Lcrn+k++  ++dHkps++ E+eRi++aggsv+ +   Rv+G+LavsRa

Q: 140   YFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSRA  196

         **********************************************...***********

S: 178   lGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrd  227

         lGd+++k         ++v+pePev +++++++d+ f+iLa+DG+wdv+ nee++++vr+

Q: 197   LGDFDYKcvhgkgpteQLVSPEPEVCEIERSEDDDqFIILACDGIWDVMGNEELCDFVRS  256

         ******************************999999************************

S: 228   vlekkeaeqeaakkLvklalargskdnvsaivv  260

         +le +++++ +++++v+++l +gs+dn+s+i++

Q: 257   RLEVTDDLERVCNEIVDTCLYKGSRDNMSVILI  289

         ****************************99976

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPSGLDG WSFFAVYDGH AGSQVAKYCC EHLLDHITSN 60

QDFRGADGPP SVESVKNGIR TGFLQIDEHM RVISEKKHGA DRSGSTAVGV MISPQHTYFI 120

NCGDSRGLLC RNRKVHFFTQ DHKPSNPLEK ERIQNAGGSV MIQRVNGSLA VSRALGDFDY 180

KCVHGKGPTE QLVSPEPEVC EIERSEDDDQ FIILACDGIW DVMGNEELCD FVRSRLEVTD 240

DLERVCNEIV DTCLYKGSRD NMSVILI 267

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004871	; F:signal transducer activity
GO:0010991	; P:negative regulation of SMAD protein complex assembly
GO:0030512	; P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0030177	; P:positive regulation of Wnt receptor signaling pathway
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

oaa:100086309

;

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013