EKS-ORA-00320
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00320
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src450.51.6E-135189437249
StatusUnreviewed
Ensembl ProteinENSOANP00000019262
UniProt AccessionF7DLX2;
Protein Name
Protein Synonyms/Alias
Gene NameFYN
Gene Synonyms/Alias FYN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000012162ENSOANP00000019262ENSOANT00000019265
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length455
Protein Sequence
(FASTA)
GVTLFVALYD YEARTEDDLS FHKGEKFQIL NSSEGDWWEA RSLTTGDTGY IPSNYVAPVD 60
SIQAEEWYFG KLGRKDAERQ LLSFGNPRGT FLIRESETTK GAYSLSIRDW DDMKGDHVKH 120
YKIRKLDNGG YYITTRAQFE TLQQLVQHYS ERAAGLCCRL VVPCHKGMPR LTDLSVKTKD 180
VWEIPRESLQ LIKRLGNGQF GEVWMGTWNG NTKVAIKTLK PGTMSPESFL EEAQIMKKLK 240
HDKLVQLYAV VSEEPIYIVT EYMNKGSLLD FLKDGEGRAL KLPNLVDMAA QVAAGMAYIE 300
RMNYIHRDLR SANILVGNGL ICKIADFGLA RLIEDNEYTA RQGAKFPIKW TAPEAALYGR 360
FTIKSDVWSF GILLTELVTK GRVPYPGMNN REVLEQVERG YRMPCPQDCP ISLHELMIHC 420
WKKDPEERPT FEYLQGFLED YFTATEPQYQ PGENL 455
Nucleotide Sequence
(FASTA)
GGAGTTACCC TTTTTGTGGC GCTCTATGAC TATGAAGCAA GAACAGAAGA TGACTTAAGT 60
TTTCATAAAG GAGAAAAATT TCAAATACTT AACAGCTCGG AAGGAGACTG GTGGGAGGCT 120
CGTTCCCTGA CAACAGGAGA TACTGGATAC ATCCCCAGCA ACTATGTGGC TCCGGTTGAC 180
TCCATCCAGG CAGAGGAGTG GTATTTTGGC AAACTTGGCC GAAAAGATGC TGAGAGGCAG 240
CTCTTATCCT TTGGAAACCC CAGGGGTACC TTCCTTATAC GAGAAAGTGA AACCACCAAA 300
GGTGCCTATT CTCTTTCTAT CCGCGACTGG GATGATATGA AAGGAGATCA TGTCAAACAT 360
TATAAAATTC GCAAACTTGA CAATGGCGGA TACTATATTA CAACAAGGGC CCAGTTTGAA 420
ACTCTCCAAC AGCTGGTTCA GCATTACTCA GAGAGAGCTG CAGGTCTGTG CTGCCGCTTA 480
GTAGTCCCCT GTCATAAAGG GATGCCAAGG CTTACTGATC TGTCTGTCAA AACCAAAGAT 540
GTCTGGGAAA TTCCACGAGA ATCACTCCAG TTGATCAAGA GACTGGGAAA TGGGCAGTTT 600
GGGGAAGTAT GGATGGGAAC CTGGAATGGG AACACTAAAG TGGCCATTAA GACTCTTAAG 660
CCTGGCACAA TGTCCCCAGA ATCATTCCTA GAGGAAGCAC AGATCATGAA GAAGCTGAAG 720
CATGATAAAT TGGTCCAGCT TTATGCTGTG GTGTCTGAAG AACCAATCTA CATTGTCACG 780
GAATACATGA ATAAAGGAAG TCTGCTAGAT TTCTTGAAAG ATGGAGAAGG AAGAGCCCTT 840
AAACTCCCGA ATCTTGTGGA CATGGCAGCC CAGGTTGCCG CAGGGATGGC TTACATCGAG 900
CGAATGAATT ATATTCACAG AGACCTGCGA TCAGCTAACA TCCTTGTGGG GAATGGTCTG 960
ATTTGCAAGA TTGCTGATTT TGGATTAGCG CGATTGATTG AAGATAATGA ATACACGGCA 1020
AGACAAGGCG CAAAGTTCCC CATCAAATGG ACAGCCCCGG AAGCCGCTCT CTATGGGAGA 1080
TTCACCATCA AGTCCGACGT GTGGTCCTTC GGCATCTTAC TGACCGAGCT GGTCACGAAA 1140
GGAAGAGTGC CCTACCCAGG CATGAATAAC CGGGAAGTCT TGGAGCAAGT GGAACGTGGT 1200
TACAGGATGC CATGTCCTCA GGACTGCCCC ATCTCCTTGC ATGAGCTTAT GATTCACTGC 1260
TGGAAAAAAG ACCCCGAAGA GCGTCCCACT TTTGAGTATT TGCAGGGTTT TCTGGAAGAC 1320
TACTTTACCG CAACAGAACC CCAGTACCAG CCTGGTGAAA ACCTGTAG 1368
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+k+lG+GqfGevw+g+w+g++kva+ktlk+gt+spe+fleeaqi+kkl+h+klv+ly
Q: 189   LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY  248
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihr
Q: 249   AVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR  307
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 308   DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  367
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp +l+el+++cwkkdpee
Q: 368   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE  427
         ************************************************************
S: 241   rPtfetlqev  250
         rPtfe+lq +
Q: 428   RPTFEYLQGF  437
         *******976
Domain Sequence
(FASTA)
LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT LKPGTMSPES FLEEAQIMKK LKHDKLVQLY 60
AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD 120
LRSANILVGN GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI HCWKKDPEER 240
PTFEYLQGF 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00339
EKS-ANC-00354
EKS-BOT-00365
EKS-CAE-00300
EKS-CAJ-00369
EKS-CAF-00366
EKS-CAP-00398
EKS-CHH-00039
EKS-DAR-00744
EKS-DAN-00035
EKS-DRM-00174
EKS-FEC-00353
EKS-GAM-00219
EKS-GAG-00309
EKS-GAA-00446
EKS-GOG-00358
EKS-HOS-00371
EKS-ICT-00346
EKS-LAC-00380
EKS-LOA-00374
EKS-MAM-00365
EKS-MEG-00300
EKS-MOD-00354
EKS-MUM-00397
EKS-MUP-00359
EKS-MYL-00364
EKS-NOL-00335
EKS-ORN-00470
EKS-ORC-00343
EKS-ORL-00432
EKS-OTG-00370
EKS-PAT-00345
EKS-PES-00325
EKS-POA-00355
EKS-PRC-00071
EKS-PTV-00093
EKS-RAN-00379
EKS-SAH-00336
EKS-SUS-00322
EKS-TAG-00440
EKS-TAR-00466
EKS-TEN-00462
EKS-TUB-00053
EKS-TUT-00097
EKS-VIP-00051
EKS-XET-00483
EKS-XIM-00460
Gene Ontology
GO:0005768; C:endosome
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050798; P:activated T cell proliferation
GO:0010629; P:negative regulation of gene expression
GO:0042177; P:negative regulation of protein catabolic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045471; P:response to ethanol
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013