EKS-ORA-00381

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00381

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	357.9	4.1E-107	54	310	257

Status

Unreviewed

Ensembl Protein

ENSOANP00000020106

UniProt Accession

F6VZQ2;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK2

Gene Synonyms/Alias

ULK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000012707	ENSOANP00000032891	ENSOANT00000042138
ENSOANG00000012707	ENSOANP00000020106	ENSOANT00000020109

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1074

Protein Sequence
(FASTA)

ASPFPSAASL PPLHLPSAKL PFPPFLLLLP LSLPLPSALC SSAHLMEVVG DFEYSKKDLI 60

GHGAFAVVFK GRHRKKTDWE VAIKSINKKN LSKSQILLGK EIKILKELQH ENIVALYDVQ 120

ELPNSVFLVM EYCNGGDLAD YLQGTFCLFS KEHQIAAAMR ILHGKGIIHR DLKPQNILLS 180

YASRRKSTIS GIRVKIADFG FARYLHSNMM AATLCGSPMY MAPEVIMSQH YDAKADLWSI 240

GTVIYQCLVG KPPFQANSPQ DLRMFYEKNR SLIPSIPRET SPYLTDLLLN LLQRNQKDRM 300

DFEAFFCHPF FEQVPVKKSC PVPVPIYAGS VSGSSCGSPS CRFASPPSLP DMQHIQEDNL 360

SSPPLGPPNF LQVSKDSAST SSKNSSCDTD DFVLVPHNIS SDHSYDMPMG TAGRRASSEF 420

LVCGGQCQPS LSPRSETAPI PVPTQLRNYQ RIEQNLTSTG SPGSNPHGSP RSAVVRRSNT 480

SPMGFLKMGS CSPVPADTVQ TIGRRLSTGS SRPYSPSPLV GTIPEQLGHC CCGQPQGHES 540

RSRNSSGSPV PPSQSPQSLL LGARLLTDIY QNKQKLRKQH SDPVCPSYAG YGYSHTPQPS 600

RPVSLGTSPT KHTGSSPRSS DWLFKTPLPT IIGSPTKATA PFKIPKTQGT SNLLALVTRQ 660

GPTDAPLPSK GGADPREFSN FLTVQGSERP AAEQQSKTTF GRSVSTGRLS DQQMKTPLGG 720

QLYQGSTESL NAERPMDIAP AGPCGVILAQ PAATGASSRA VMFTVGSPPS SATPPTCTHM 780

VLRTRTTSVG SNSSGGSLCS TSGRVFMGSP PGLYMGSSPP GAEAAPSLKY TPYGNSPPSL 840

EGFITFEAPE LPEETLMERE HTDTLRHLNM MLTFTECVLD LTAIRGGNPE LCTSAVSLYQ 900

IQESVVVDQI SQLSKDWGQV EQLVLYMKAA QLLASSLHLA KAQIKSGKLN PSTAVKQVVK 960

NLNERYKFCI AMCKKLTEKL NHFFSDKQRF IDEINSVTAE KLIYNCAVEM VQSAALDEMF 1020

QQTEDIVYRY HKAALLLEGL AKILQDPGDI ENVHKYKSSI ERRLSALCYS TVTV 1074

Nucleotide Sequence
(FASTA)

GCTTCCCCTT TTCCCTCTGC TGCCTCTCTG CCCCCCCTTC ACCTCCCCTC AGCTAAACTC 60

CCTTTCCCTC CTTTCCTTCT GCTCCTCCCC CTCTCCCTTC CCCTCCCCTC AGCACTGTGC 120

TCATCTGCTC ATTTGATGGA GGTGGTGGGA GACTTCGAGT ACAGCAAGAA GGACCTCATA 180

GGACACGGAG CCTTCGCCGT GGTCTTCAAA GGCCGGCATC GCAAGAAAAC GGATTGGGAA 240

GTTGCTATAA AAAGCATTAA TAAGAAAAAC CTATCAAAAT CACAAATACT GCTTGGAAAG 300

GAAATTAAGA TCTTAAAGGA ACTTCAGCAT GAAAACATTG TGGCCCTTTA TGACGTCCAG 360

GAATTGCCCA ACTCTGTCTT CTTGGTGATG GAGTATTGCA ATGGAGGAGA TTTGGCAGAT 420

TACTTACAAG GTACATTTTG TCTGTTCAGT AAGGAGCACC AGATTGCAGC TGCCATGCGA 480

ATTCTGCACG GCAAAGGAAT AATCCATAGA GATCTTAAAC CACAGAACAT CTTGTTGTCT 540

TATGCAAGTC GTAGGAAGTC GACCATCAGT GGCATTCGTG TAAAAATAGC GGACTTTGGT 600

TTTGCCCGTT ACCTTCATAG TAACATGATG GCAGCCACCC TCTGTGGATC ACCTATGTAT 660

ATGGCTCCTG AAGTTATTAT GTCTCAACAT TATGATGCTA AGGCAGATCT ATGGAGCATA 720

GGGACTGTGA TATACCAGTG CCTGGTTGGA AAACCACCTT TTCAGGCCAA TAGTCCACAA 780

GATTTAAGAA TGTTCTATGA AAAGAACAGG AGTTTGATTC CTAGTATCCC CAGAGAAACA 840

TCACCTTATC TGACTGACCT TCTGTTGAAT TTGCTTCAGC GAAACCAAAA AGATAGAATG 900

GACTTTGAAG CATTTTTCTG TCACCCTTTT TTTGAACAAG TTCCCGTCAA AAAATCCTGC 960

CCAGTTCCAG TCCCTATTTA TGCTGGTTCA GTTTCTGGAA GCTCTTGTGG CTCTCCATCT 1020

TGTCGCTTTG CCTCTCCACC ATCCCTACCA GATATGCAGC ATATTCAGGA AGACAACTTA 1080

TCTTCCCCGC CATTGGGACC TCCAAATTTT CTTCAAGTGT CCAAAGATTC TGCCAGCACA 1140

AGTAGCAAGA ACTCTTCTTG TGACACAGAT GACTTTGTCT TGGTCCCACA TAACATCTCA 1200

TCAGATCATT CATATGATAT GCCAATGGGA ACTGCTGGGA GACGGGCTTC AAGCGAGTTC 1260

TTGGTGTGTG GAGGGCAGTG CCAGCCGTCC CTTTCACCCC GCAGTGAAAC GGCACCCATT 1320

CCAGTTCCCA CTCAGTTACG GAATTACCAA CGCATAGAGC AAAACCTCAC CTCCACCGGT 1380

AGCCCCGGAT CCAACCCACA TGGCTCTCCA AGGTCTGCTG TGGTGCGGAG ATCTAACACC 1440

AGCCCTATGG GTTTTCTCAA GATGGGCTCC TGTTCTCCAG TGCCCGCAGA CACTGTACAG 1500

ACCATCGGTC GCCGACTGTC CACTGGATCC TCCAGGCCAT ACTCCCCTTC CCCCTTAGTT 1560

GGCACCATTC CTGAGCAACT TGGCCATTGT TGCTGCGGGC AGCCCCAGGG CCACGAGTCC 1620

AGGAGTAGAA ACTCTTCAGG ATCACCAGTG CCACCATCTC AGTCACCACA GTCGCTCTTG 1680

CTAGGTGCCA GGCTGCTCAC AGACATCTAC CAGAACAAGC AGAAGCTCCG AAAACAGCAT 1740

TCCGACCCTG TGTGCCCATC CTACGCAGGG TATGGATACA GCCACACGCC ACAGCCCAGC 1800

CGGCCGGTCA GCCTCGGCAC CTCCCCCACC AAGCACACGG GCTCATCCCC TAGAAGCTCA 1860

GACTGGCTCT TTAAAACCCC GTTACCCACA ATCATTGGCT CTCCCACTAA GGCTACAGCA 1920

CCTTTCAAAA TCCCTAAAAC CCAAGGAACC TCCAACTTGC TGGCCTTGGT CACTCGGCAG 1980

GGACCCACAG ACGCGCCCTT GCCCTCCAAA GGTGGGGCCG ACCCAAGGGA GTTCTCGAAT 2040

TTTCTCACAG TCCAAGGAAG CGAAAGACCT GCAGCAGAGC AACAGAGTAA GACCACCTTT 2100

GGCAGATCTG TAAGTACTGG AAGGCTGTCA GATCAACAAA TGAAAACACC CCTGGGTGGA 2160

CAGTTGTACC AAGGCAGCAC AGAGAGTCTG AATGCCGAAC GGCCAATGGA TATAGCGCCT 2220

GCAGGACCCT GTGGAGTAAT TTTAGCCCAA CCTGCTGCAA CAGGAGCGAG TTCTAGGGCT 2280

GTAATGTTTA CTGTAGGATC CCCTCCAAGT AGCGCTACAC CTCCCACCTG TACTCATATG 2340

GTCCTTCGAA CCAGAACAAC TTCAGTTGGA TCCAACAGTT CTGGAGGGTC TCTGTGCTCA 2400

ACTAGTGGCC GGGTGTTTAT GGGGTCCCCT CCTGGTCTTT ACATGGGATC GTCTCCACCT 2460

GGGGCAGAAG CTGCTCCAAG CTTGAAATAC ACACCTTATG GTAATTCACC TCCCAGCCTA 2520

GAGGGGTTCA TCACTTTTGA AGCTCCTGAG CTGCCCGAAG AAACCTTAAT GGAGAGAGAA 2580

CACACTGACA CGCTGCGACA CCTCAATATG ATGCTGACAT TCACCGAGTG CGTATTGGAC 2640

CTGACAGCGA TCCGGGGAGG AAATCCAGAG CTGTGCACTT CCGCGGTGTC TCTCTACCAG 2700

ATTCAGGAGA GTGTAGTTGT GGATCAGATA AGCCAGCTCA GCAAAGACTG GGGGCAAGTA 2760

GAGCAGCTGG TGCTGTACAT GAAAGCGGCC CAGCTGCTGG CTTCATCTCT ACATCTTGCT 2820

AAAGCCCAGA TCAAGTCAGG GAAATTAAAC CCATCCACTG CTGTGAAACA AGTTGTCAAA 2880

AACTTGAACG AGCGATATAA ATTCTGCATC GCCATGTGCA AGAAGCTGAC GGAAAAGCTG 2940

AATCATTTCT TCTCCGACAA ACAAAGATTC ATCGATGAGA TTAACAGTGT GACGGCAGAG 3000

AAGCTCATCT ACAACTGTGC TGTGGAGATG GTTCAGTCAG CAGCCCTGGA TGAGATGTTT 3060

CAGCAGACAG AAGACATCGT GTACCGATAC CACAAGGCAG CCCTCCTTTT GGAAGGCCTG 3120

GCTAAGATCC TCCAAGACCC TGGGGATATT GAAAATGTAC ACAAATATAA ATCTAGTATT 3180

GAAAGGCGAT TGTCTGCACT CTGCTATAGC ACAGTGACCG TT 3222

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         ys+++ iG+G+favv+kgr+rkkt+++vAik+++kk+l+ks+  l keikilkel+heni

Q: 54    YSKKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI  113

         899*********************************************************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         val+dv+e  ++v+lvmeyc+ggdLa++l+ +  L  ++     +q+a+a+++Lh k+i+

Q: 114   VALYDVQELPNSVFLVMEYCNGGDLADYLQGTFCLFSKE-----HQIAAAMRILHGKGII  168

         ******************************999998765.....89**************

S: 121   hrDlkPqniLlsyadakk.elkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         hrDlkPqniLlsya+++k +++ +++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++

Q: 169   HRDLKPQNILLSYASRRKsTISGIRVKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMS  228

         **************9999899***************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdll  239

         q+ydakaDlWSiGt++y++lvGkpPf+a+s+++L++++ekn++l p+ip+e+s+ l+dll

Q: 229   QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLIPSIPRETSPYLTDLL  288

         ************************************************************

S: 240   qsLLqrdpkkRisfeelfahpf  261

          +LLqr++k+R++fe +f+hpf

Q: 289   LNLLQRNQKDRMDFEAFFCHPF  310

         *********************9

Domain Sequence
(FASTA)

YSKKDLIGHG AFAVVFKGRH RKKTDWEVAI KSINKKNLSK SQILLGKEIK ILKELQHENI 60

VALYDVQELP NSVFLVMEYC NGGDLADYLQ GTFCLFSKEH QIAAAMRILH GKGIIHRDLK 120

PQNILLSYAS RRKSTISGIR VKIADFGFAR YLHSNMMAAT LCGSPMYMAP EVIMSQHYDA 180

KADLWSIGTV IYQCLVGKPP FQANSPQDLR MFYEKNRSLI PSIPRETSPY LTDLLLNLLQ 240

RNQKDRMDFE AFFCHPF 257

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0034045	; C:pre-autophagosomal structure membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0010506	; P:regulation of autophagy
GO:0042594	; P:response to starvation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013