EKS-ORA-00214

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00214

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	329.2	1.6E-98	59	309	251

Status

Unreviewed

Ensembl Protein

ENSOANP00000021069

UniProt Accession

F7DYZ4;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK2

Gene Synonyms/Alias

NUAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000013349	ENSOANP00000021069	ENSOANT00000021072

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

654

Protein Sequence
(FASTA)

PDLWVEAPRP RQPPPPTRAL TPRARVLAAG CVWPLSPRPP MKKQAVKRHH HKHNLRHRYE 60

FLETLGKGTY GKVKKAREQS GKLVAIKLIR KDKIKDEQDL MHIRREIEIM SSLNHPHIIS 120

IHEVFENSTK IVIAMEYASR GDLYDYINER QRLSEREARH FFRQIVSAVY YCHRNGVVHR 180

DLKLENILLD SNGNIKIADF GLSNLYERDK CLQTFCGSPL YASPEIVNGK PYTGPEVDSW 240

SLGVLLYILV HGMMPFDGQD YKTLVKQISN GEYREPTKPS DACGLIRWML MVNPTRRATL 300

EDVASHWWVN WGYPTPLGEQ ALGEGNIGGG GSSESPLASV ADWLRRSSRP LLENGAKVRS 360

FFRHGAGAGG PGGGGLERQC SLKKSRKEHD VTHTLLEWPA GEAAPGPGKG ILKLPKGILK 420

KKTSPPADGQ KEETEVPAVP LPELPALPEP PTPLAPKKGI LKKPRQRESG YYSSPEPSES 480

GDLLDADAGD VFSSSPSPQE DPPQPPGLPF HRKGILKHNG KYSQGRALPT SAFGSLDELA 540

RPLAAPSRSS RPSSAISEDS ILSTESFDRL DLPERLPEPA LRGCVSADDL LGLEEEEEVA 600

PAAGSETGSG QRPLRRWAAS RGREPLRDSC FSLTDCQDVT EVYQRALAIG MKLS 654

Nucleotide Sequence
(FASTA)

CCCGATCTCT GGGTGGAAGC CCCCCGGCCC CGCCAACCTC CACCTCCGAC GCGGGCCTTG 60

ACGCCCCGGG CCCGAGTGTT AGCTGCTGGA TGCGTGTGGC CCCTCTCCCC CAGACCCCCG 120

ATGAAGAAGC AGGCGGTGAA GAGGCACCAT CACAAGCACA ACTTGCGCCA CCGCTACGAG 180

TTCCTGGAGA CCCTGGGCAA GGGCACGTAT GGGAAGGTGA AGAAGGCGCG GGAGCAGTCT 240

GGAAAGCTGG TGGCTATCAA GTTAATCCGA AAAGATAAAA TCAAGGATGA GCAGGATTTG 300

ATGCATATCC GGAGGGAAAT CGAGATCATG TCCTCTCTCA ATCACCCACA TATCATCTCC 360

ATCCATGAAG TGTTCGAGAA CAGCACCAAA ATCGTGATCG CCATGGAATA TGCCAGCCGC 420

GGGGACCTGT ACGACTACAT CAACGAGCGC CAGCGGCTCA GCGAACGGGA GGCCCGCCAT 480

TTCTTCCGCC AGATTGTCTC GGCCGTCTAC TACTGCCACA GGAATGGTGT CGTCCACCGG 540

GATCTCAAGC TGGAAAACAT TCTCCTGGAC TCCAATGGCA ACATCAAGAT TGCAGATTTC 600

GGCCTCTCCA ACCTGTACGA GCGAGACAAG TGCCTTCAGA CATTCTGCGG GAGCCCCCTC 660

TACGCCTCGC CTGAAATAGT CAACGGGAAA CCCTACACAG GCCCTGAGGT GGACAGTTGG 720

TCCCTCGGTG TCCTCCTCTA TATCCTAGTG CATGGTATGA TGCCCTTTGA TGGGCAGGAC 780

TACAAGACCT TGGTTAAGCA GATCAGTAAT GGGGAGTACA GAGAGCCCAC CAAGCCCTCA 840

GACGCCTGTG GCTTGATCCG CTGGATGCTG ATGGTGAACC CCACACGCCG GGCCACCCTT 900

GAGGACGTAG CCAGCCACTG GTGGGTCAAC TGGGGCTACC CAACCCCACT AGGGGAGCAG 960

GCCCTGGGCG AGGGCAACAT CGGGGGCGGT GGCAGCAGCG AGTCACCACT GGCCTCTGTG 1020

GCCGACTGGC TGAGGCGTTC TTCCCGTCCC CTCCTGGAGA ACGGCGCCAA AGTCCGCAGC 1080

TTCTTCAGAC ACGGAGCGGG GGCTGGCGGG CCGGGAGGCG GGGGCCTGGA GCGCCAGTGC 1140

TCCCTCAAGA AGTCCCGCAA GGAACACGAC GTGACCCACA CCCTCCTGGA ATGGCCGGCC 1200

GGGGAGGCGG CCCCAGGACC TGGCAAGGGC ATCCTGAAGC TGCCCAAGGG CATTCTCAAA 1260

AAGAAGACTT CACCCCCAGC CGATGGGCAG AAGGAGGAGA CTGAGGTGCC CGCCGTGCCC 1320

CTTCCCGAAC TCCCTGCCCT CCCAGAGCCC CCCACCCCGT TAGCCCCCAA AAAAGGCATC 1380

TTGAAGAAGC CCCGGCAGAG GGAATCGGGC TATTATTCCT CCCCGGAACC CAGCGAGTCC 1440

GGGGACCTCT TAGATGCGGA TGCCGGTGAT GTGTTTTCCA GCAGCCCCTC CCCCCAGGAA 1500

GACCCCCCAC AGCCTCCGGG GCTTCCCTTC CACCGCAAAG GGATTCTGAA GCACAATGGC 1560

AAGTACTCTC AGGGGAGGGC TCTTCCCACC TCGGCCTTTG GTTCTTTGGA CGAGCTGGCC 1620

CGGCCCTTGG CAGCCCCCTC CCGGTCCAGC CGCCCCTCCA GCGCCATCAG CGAGGACAGC 1680

ATCTTGTCCA CCGAGTCCTT CGATCGGCTG GACCTCCCGG AGCGGCTGCC GGAGCCGGCC 1740

CTGCGGGGCT GCGTCTCGGC GGACGACCTG CTGGGACTTG AGGAGGAGGA AGAGGTAGCC 1800

CCGGCTGCGG GGTCGGAGAC GGGGTCAGGA CAGCGGCCCC TTAGGCGCTG GGCCGCGAGC 1860

CGGGGCCGGG AGCCCCTGCG GGACAGCTGC TTCTCCCTGA CGGACTGCCA GGATGTCACC 1920

GAGGTGTACC AGCGGGCCCT GGCCATCGGC ATGAAACTCA GCTGA 1965

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y++l+tlG+g++gkVk+a+++  ++ va+K+i+k+k+ +e+ l +i+rEiei+++l+hp+

Q: 59    YEFLETLGKGTYGKVKKAREQ-SGKLVAIKLIRKDKIkDEQDLMHIRREIEIMSSLNHPH  117

         99***************9976.799**********996778899****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii+++ev+e+++k+++ +eyas+g+L+dyi+e++rl+e+ear++f+q+vsav Y+h++g+

Q: 118   IISIHEVFENSTKIVIAMEYASRGDLYDYINERQRLSEREARHFFRQIVSAVYYCHRNGV  177

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld+++nikiaDFGl+nl++++k l+tfcGsp Ya+Pe+++gk+Y+gp+v

Q: 178   VHRDLKLENILLDSNGNIKIADFGLSNLYERDKCLQTFCGSPLYASPEIVNGKPYTGPEV  237

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D WslGv+Ly+lv g +Pfd++++k+l+++i++g+++ p+k s ++  L+r +L+v+p++

Q: 238   DSWSLGVLLYILVHGMMPFDGQDYKTLVKQISNGEYREPTKPS-DACGLIRWMLMVNPTR  296

         *****************************************66.5668************

S: 240   Ratieeilkhewl  252

         Rat+e++ +h w+

Q: 297   RATLEDVASHWWV  309

         ************6

Domain Sequence
(FASTA)

YEFLETLGKG TYGKVKKARE QSGKLVAIKL IRKDKIKDEQ DLMHIRREIE IMSSLNHPHI 60

ISIHEVFENS TKIVIAMEYA SRGDLYDYIN ERQRLSEREA RHFFRQIVSA VYYCHRNGVV 120

HRDLKLENIL LDSNGNIKIA DFGLSNLYER DKCLQTFCGS PLYASPEIVN GKPYTGPEVD 180

SWSLGVLLYI LVHGMMPFDG QDYKTLVKQI SNGEYREPTK PSDACGLIRW MLMVNPTRRA 240

TLEDVASHWW V 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030036	; P:actin cytoskeleton organization
GO:0042149	; P:cellular response to glucose starvation
GO:0043066	; P:negative regulation of apoptotic process

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013