EKS-ORA-00199

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00199

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	330.8	7.1E-99	90	339	250

Status

Unreviewed

Ensembl Protein

ENSOANP00000021378

UniProt Accession

F7DMW8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K5

Gene Synonyms/Alias

MAP2K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000013555	ENSOANP00000021378	ENSOANT00000021381

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

368

Protein Sequence
(FASTA)

MKAMLSYYYS TVMEQQVNGQ LIEPLQIFPR ACKPPGKRNI HGLKVNTRAG PSHHSSPTIS 60

ESLPGNSLKK SSAELKKILA NGQMNEQDIE NREPLGHGNG GTVYKAFHVP SGKILAVKVI 120

PLDITVELQK QIMSELEILY KCDSSFIIGF YGAFFVENRI SICTEFMDGG SLDVYRKIPE 180

HVLGRIAVAV VKGLTYLWSL KILHRDVKPS NMLVNTRGQV KLCDFGVSTQ LVNSIAKTYV 240

GTNAYMAPER ISGEQYGIHS DVWSLGISFM ELALGRFPYP QIQKNQGSLM LLQCIVDEVS 300

PVLPVGEFSE PFVHFITQCM RKQPKERPAP EDLMGHPFVL QYNDGNAEVV SMWVCRMLEE 360

RRAQQGPQ 368

Nucleotide Sequence
(FASTA)

ATGAAGGCCA TGCTGTCCTA TTATTATTCC ACAGTAATGG AACAGCAAGT AAATGGACAG 60

TTAATAGAGC CTTTGCAGAT ATTTCCAAGA GCCTGCAAGC CTCCTGGGAA ACGGAACATA 120

CATGGCCTGA AGGTGAACAC ACGGGCTGGG CCCTCTCATC ATAGCAGCCC AACAATCTCA 180

GAGTCGCTTC CGGGCAATAG CTTAAAGAAG TCATCCGCCG AACTGAAGAA AATATTAGCC 240

AATGGCCAGA TGAATGAACA AGACATAGAA AATCGAGAGC CCCTCGGTCA CGGCAACGGA 300

GGTACAGTCT ACAAAGCATT TCATGTCCCC AGTGGGAAGA TATTAGCTGT AAAGGTCATA 360

CCACTAGATA TTACAGTGGA ACTTCAGAAG CAAATTATGT CCGAATTAGA AATTCTCTAT 420

AAGTGTGATT CATCATTTAT CATAGGATTT TACGGTGCAT TTTTTGTAGA AAACAGGATC 480

TCGATATGTA CAGAATTCAT GGATGGAGGA TCGCTGGATG TGTACAGAAA AATTCCAGAA 540

CATGTACTGG GACGGATAGC TGTCGCAGTA GTTAAAGGCC TGACCTATTT ATGGAGCTTA 600

AAGATTTTGC ACAGAGACGT CAAGCCCTCA AACATGTTGG TGAACACAAG AGGACAGGTC 660

AAGTTGTGTG ATTTCGGAGT TAGCACTCAG CTGGTGAATT CCATAGCCAA GACGTACGTC 720

GGGACGAACG CTTATATGGC GCCTGAAAGA ATTTCAGGGG AACAGTATGG AATCCATTCC 780

GATGTTTGGA GCTTAGGAAT CTCTTTCATG GAGCTTGCTC TTGGGAGGTT TCCATATCCT 840

CAGATTCAGA AAAACCAGGG ATCTTTAATG TTATTGCAGT GCATTGTTGA TGAGGTTTCG 900

CCGGTCCTTC CGGTTGGAGA GTTCTCCGAG CCATTTGTAC ACTTCATCAC TCAGTGCATG 960

AGGAAGCAGC CAAAAGAAAG ACCAGCCCCT GAGGATTTGA TGGGCCATCC ATTTGTCCTG 1020

CAGTACAACG ACGGGAACGC CGAAGTGGTC TCCATGTGGG TGTGCAGGAT GCTGGAAGAG 1080

CGGCGGGCCC AGCAGGGGCC TCAGTGA 1107

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         e+ e lG+Gngg+V+k+ h +sgkilavK i l+i+ e qkqi++ele+l k+ +s++i+

Q: 90    ENREPLGHGNGGTVYKAFHVPSGKILAVKVIPLDITVELQKQIMSELEILYKC-DSSFII  148

         67889************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+ e+++sic+e+mdg+sld v++k       ipe+vlg+iavavvk+l+yl+ +

Q: 149   GFYGAFFVENRISICTEFMDGGSLD-VYRK-------IPEHVLGRIAVAVVKGLTYLW-S  199

         *************************.6876.......9********************.7

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         lki+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y +

Q: 200   LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGI  258

         8*****************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke...ilellkaivneeppklpeeefseefqefvsk  238

         +sdvWslG++++ela gr+py++ ++    l ll++iv+e +p+lp  efse f++f+++

Q: 259   HSDVWSLGISFMELALGRFPYPQIQKnqgSLMLLQCIVDEVSPVLPVGEFSEPFVHFITQ  318

         **********************998877899*****************************

S: 239   ClkkdekeRpklkellkhafi  259

         C++k++keRp  ++l+ h+f+

Q: 319   CMRKQPKERPAPEDLMGHPFV  339

         *******************96

Domain Sequence
(FASTA)

ENREPLGHGN GGTVYKAFHV PSGKILAVKV IPLDITVELQ KQIMSELEIL YKCDSSFIIG 60

FYGAFFVENR ISICTEFMDG GSLDVYRKIP EHVLGRIAVA VVKGLTYLWS LKILHRDVKP 120

SNMLVNTRGQ VKLCDFGVST QLVNSIAKTY VGTNAYMAPE RISGEQYGIH SDVWSLGISF 180

MELALGRFPY PQIQKNQGSL MLLQCIVDEV SPVLPVGEFS EPFVHFITQC MRKQPKERPA 240

PEDLMGHPFV 250

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013