EKS-ORA-00339

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00339

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	324.2	8.5E-97	1075	1339	265

Status

Unreviewed

Ensembl Protein

ENSOANP00000021511

UniProt Accession

F7E5H2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000013632	ENSOANP00000021511	ENSOANT00000021514

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1344

Protein Sequence
(FASTA)

RDMENKETLR GLQKMDDRPE ERMIREKLKA TCMPAWKHEW LERRSRRGPV VVKPIPVKAD 60

GSEMNKIAPE SQTEGPANTS SPTPKGRRSP SPSGSPSVPS RTVKSESPGV RRKRASPVPF 120

QSGRITPPRR APSPDGFSPY SPEETNRRVN KVMRARLYLL QQIGPNSFLI GGDSPDNKYR 180

VFIGPQTCSC ARGTFCIHLL FVMLRVFQLE PSDPMLWRKS LKNFEVESLF QKYHSRRSSR 240

IKAPSRNTIQ KFVSRMSNSH TLSSSSTSTS SSENSMKDEE EQMCPICLLG MLDEESLTVC 300

EDGCRNKLHH HCMSIWAEEC RRNREPLICP LCRSKWRSHD FYSHELPSPV DSPSVLRTVQ 360

QQTLQQQQQP LAASPRRSQD SNFNLTHYGV QQIPPAYKDL AEPWIQVFGM ELVGCLFSRN 420

WNIREMALRR LSHDVSGALL LANGESTGNS GSSTSAGGAS GSSQSGISGD VVVESCCSVL 480

SMVCADPVYK VYVAALKTLR AMLVYTPCHS LAERIKLQRL LKPVVETILV KCADANSRTS 540

QLSVSTLLEL CKGQTGELAV GREILKSGSI GISGVDYVLS CILGSQTEPS NWQALLGRLC 600

LIDRMLLEFP AEFYPHIVSG EVLQADTVVD RYKKLLSLLN FALQSIDNSH SMVGKLSRRV 660

FLSAARMVAR VPQVFLKLLE MLSGTSSTHY TRMRRRLMAI ADEMEIAEAI QLGTDDSSSC 720

RRDCFMSPCT PDPSPETPEN NSPDYLIQLE KTGKGLCDVK LGAGPEDVSE TLAGLSVGLP 780

GSVVTTEQPK PTLQTKGRPL SQCLNSSPSS SGHSQLLFPG LPSPSSSSPS VPAGPVTDLS 840

KHRPQGFVPC KMPSASPQTQ RKFSLQIQRT CSEMKELEKL SPIFTQARPV PSAHIHRPKP 900

SRPTPGDASR PGEISKNSMT LDLNDASKGG RAGCGAVIPS DETVFTPVDD KCRLDVNSEL 960

NSSIEDLLEA SLPSSDSTVT FKSEVAVLSP EKADNDNTYK DDMSHNQKCK EKMEAEEEEA 1020

LAIAMAMSAS QDALPVVPQL QVENGEDIII IQQDTPETLP GHTKAKQHYR EDAEWLKGQQ 1080

IGLGAFSSCY QAQDVGTGTL MAVKQVTYVR NTSAEQEEVV EALREEIRMM SHLNHPNIIR 1140

MLGATCEKSN YNLFIEWMAG GSVAHLLSKY GAFKESVVIN YTEQLLRGLS YLHENQIIHR 1200

DVKGANLLID STGQRLRIAD FGAAARLASK GTGAGEFQGQ LLGTIAFMAP EVLRGQQYGR 1260

SCDVWSVGCA IIEMACAKPP WNAEKHSNHL ALIFKIASAT TAPSIPSHLS PGLRDVTLRC 1320

LELQPQDRPP SRELLKHPVF RTTW 1344

Nucleotide Sequence
(FASTA)

CGTGACATGG AGAATAAAGA AACCCTCAGG GGGTTGCAGA AAATGGATGA CCGCCCAGAA 60

GAGCGCATGA TCAGGGAGAA GCTCAAGGCA ACGTGTATGC CGGCCTGGAA GCACGAGTGG 120

CTCGAGAGAA GAAGTAGGAG GGGCCCCGTG GTGGTGAAAC CAATCCCAGT GAAAGCTGAT 180

GGGTCTGAAA TGAACAAAAT AGCACCGGAA TCTCAAACTG AAGGGCCTGC CAATACTTCC 240

TCCCCGACCC CGAAAGGAAG GCGCAGCCCT TCTCCCAGTG GCTCGCCTTC GGTTCCGTCC 300

CGAACCGTTA AATCGGAATC TCCAGGAGTC AGAAGAAAAA GAGCCTCTCC CGTCCCTTTT 360

CAGAGCGGGC GAATCACACC TCCTCGAAGA GCTCCCTCTC CAGATGGCTT CTCCCCATAT 420

AGCCCTGAGG AAACAAATCG CAGGGTCAAC AAAGTTATGC GGGCTAGGTT GTACTTGTTG 480

CAGCAGATTG GACCCAACTC TTTTCTGATT GGAGGAGACA GCCCTGACAA TAAATACAGG 540

GTGTTTATCG GACCTCAGAC TTGCAGCTGT GCCCGCGGAA CATTTTGTAT TCACCTACTG 600

TTTGTCATGC TCCGGGTGTT CCAACTCGAA CCTTCAGATC CAATGCTGTG GAGAAAGAGC 660

TTAAAGAACT TCGAGGTTGA GAGTTTGTTC CAGAAATATC ACAGTAGGCG TAGCTCAAGG 720

ATCAAAGCTC CATCTCGTAA CACCATCCAG AAGTTTGTCT CACGCATGTC AAATTCTCAT 780

ACATTGTCAT CATCTAGTAC TTCTACATCT AGTTCAGAAA ACAGTATGAA GGATGAAGAG 840

GAACAGATGT GTCCTATCTG CCTGTTGGGC ATGCTCGATG AAGAGAGCCT TACAGTATGT 900

GAAGATGGCT GTAGGAACAA GTTACACCAC CACTGCATGT CAATTTGGGC CGAAGAATGT 960

AGAAGAAATA GAGAACCTCT GATCTGCCCT CTTTGTCGGT CTAAGTGGAG ATCCCATGAT 1020

TTTTATAGCC ACGAACTACC TAGCCCCGTG GATTCTCCGT CTGTCCTCCG GACTGTTCAG 1080

CAGCAAACAC TGCAACAGCA GCAGCAGCCC CTGGCTGCAT CACCAAGAAG GAGCCAAGAT 1140

AGTAATTTTA ACCTTACTCA TTACGGAGTT CAGCAGATCC CTCCTGCTTA CAAAGATTTA 1200

GCTGAGCCAT GGATTCAGGT ATTTGGGATG GAGCTGGTTG GCTGCTTATT TTCTCGAAAC 1260

TGGAATATCC GCGAGATGGC ACTCAGACGT CTATCCCACG ATGTCAGCGG GGCCCTGTTG 1320

TTGGCTAATG GCGAAAGCAC TGGAAATTCT GGCAGCAGCA CAAGTGCCGG AGGAGCTAGT 1380

GGGTCATCTC AGTCCGGTAT CTCAGGAGAC GTTGTTGTGG AATCGTGCTG CAGTGTTCTG 1440

TCCATGGTCT GTGCCGACCC CGTCTACAAA GTGTACGTTG CTGCTTTGAA AACTTTAAGA 1500

GCCATGCTGG TATATACTCC TTGCCACAGT CTGGCAGAAA GGATAAAACT ACAGAGACTT 1560

CTCAAGCCAG TTGTAGAGAC CATATTAGTG AAATGTGCGG ATGCCAATAG CCGCACAAGT 1620

CAACTTTCAG TTTCAACACT GCTGGAGTTG TGCAAAGGCC AAACTGGAGA GCTAGCAGTC 1680

GGTCGAGAAA TACTTAAATC TGGGTCCATT GGCATCAGTG GTGTGGATTA TGTCTTAAGT 1740

TGCATTCTTG GAAGCCAAAC TGAACCAAGC AACTGGCAAG CACTGTTGGG GCGCCTTTGT 1800

CTAATAGACA GAATGTTATT GGAATTTCCT GCTGAATTTT ATCCCCATAT TGTCAGTGGA 1860

GAGGTTTTAC AGGCTGACAC TGTAGTAGAC AGGTATAAAA AGCTGCTGTC CCTCTTGAAC 1920

TTTGCCTTGC AATCCATTGA TAATTCCCAC TCGATGGTTG GCAAACTCTC CCGAAGGGTG 1980

TTTCTGAGTG CTGCAAGAAT GGTGGCCAGA GTGCCCCAGG TGTTCCTTAA ATTGTTAGAA 2040

ATGTTGAGTG GGACCAGCTC AACTCATTAC ACGAGGATGC GCCGCCGCCT GATGGCTATC 2100

GCCGATGAAA TGGAAATCGC CGAAGCCATC CAGTTGGGTA CGGACGACTC CTCGAGTTGT 2160

CGGCGGGACT GCTTCATGTC ACCCTGCACC CCTGATCCCT CCCCAGAAAC GCCGGAAAAT 2220

AATTCCCCCG ACTACCTGAT CCAGCTCGAA AAAACCGGGA AAGGATTGTG CGACGTGAAA 2280

CTCGGCGCCG GCCCCGAGGA CGTTTCGGAG ACGCTGGCTG GCCTTTCCGT GGGACTCCCG 2340

GGGTCGGTGG TGACCACGGA GCAACCAAAG CCTACACTTC AGACGAAAGG CAGACCCCTC 2400

AGCCAGTGTT TGAACTCCTC GCCTTCTTCA TCAGGTCATT CCCAATTGTT ATTCCCAGGC 2460

CTGCCCTCCC CTTCATCATC TAGCCCGTCC GTCCCAGCCG GCCCCGTAAC AGATCTCTCG 2520

AAACACAGAC CCCAGGGATT CGTTCCCTGC AAAATGCCCT CCGCCTCGCC TCAGACCCAA 2580

CGGAAATTTT CTCTCCAGAT CCAGAGGACC TGTTCTGAAA TGAAAGAACT TGAAAAACTT 2640

TCCCCGATCT TTACCCAGGC GAGGCCCGTG CCTTCCGCTC ACATACACAG GCCAAAGCCA 2700

TCTCGACCTA CCCCGGGTGA TGCGAGCAGA CCGGGAGAGA TCTCAAAAAA CAGCATGACC 2760

CTCGATTTGA ACGACGCCTC GAAGGGTGGC CGGGCTGGCT GCGGCGCCGT CATTCCAAGC 2820

GACGAGACGG TTTTCACACC GGTGGATGAC AAGTGCAGGC TGGATGTCAA TTCGGAACTC 2880

AACTCCAGCA TCGAGGACCT GCTCGAGGCC TCCTTGCCCT CGAGCGACAG CACGGTCACT 2940

TTCAAGTCCG AAGTCGCGGT CCTGTCTCCC GAAAAAGCCG ACAACGACAA CACGTACAAG 3000

GATGACATGA GTCATAATCA GAAATGCAAA GAAAAGATGG AAGCTGAGGA GGAAGAAGCT 3060

CTAGCGATCG CTATGGCCAT GTCAGCATCT CAGGATGCCT TACCGGTAGT TCCCCAGCTC 3120

CAAGTTGAGA ATGGAGAAGA TATCATCATC ATTCAGCAGG ATACCCCAGA GACCCTGCCA 3180

GGACACACCA AAGCAAAACA GCATTATAGA GAAGATGCAG AATGGCTTAA AGGTCAGCAG 3240

ATAGGACTTG GAGCATTTTC TTCTTGTTAT CAAGCTCAAG ACGTGGGAAC GGGAACTTTG 3300

ATGGCTGTTA AGCAGGTGAC TTATGTGAGG AACACATCGG CAGAGCAAGA AGAAGTGGTT 3360

GAAGCCCTGA GAGAAGAGAT ACGGATGATG AGTCACCTGA ATCATCCTAA CATTATTAGA 3420

ATGTTGGGTG CTACTTGTGA AAAGAGCAAT TACAATCTCT TTATAGAGTG GATGGCAGGA 3480

GGATCAGTGG CTCATTTGCT GAGTAAATAT GGAGCCTTCA AGGAATCAGT AGTTATTAAC 3540

TACACGGAAC AACTGCTTCG TGGTCTCTCC TACCTCCACG AGAACCAGAT CATTCATAGA 3600

GATGTCAAAG GTGCCAATTT GCTGATTGAC AGCACGGGTC AGAGATTGAG AATTGCAGAT 3660

TTTGGAGCTG CAGCCAGGTT GGCTTCCAAA GGAACTGGGG CGGGAGAGTT TCAGGGGCAG 3720

TTGCTGGGCA CCATCGCATT TATGGCCCCG GAGGTGCTAA GAGGCCAGCA GTATGGAAGG 3780

AGCTGTGACG TGTGGAGTGT TGGCTGTGCT ATTATAGAAA TGGCTTGTGC CAAACCACCG 3840

TGGAATGCAG AGAAACACTC CAATCATCTG GCTCTGATCT TTAAGATCGC TAGTGCAACT 3900

ACTGCTCCGT CGATCCCGTC ACATCTGTCT CCCGGCTTAC GGGACGTGAC TCTTCGGTGT 3960

TTAGAACTTC AACCTCAGGA CAGACCTCCA TCGAGAGAGC TACTGAAGCA TCCAGTCTTC 4020

CGGACTACTT GGTAG 4035

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ +++++e++ +v+al+eEi+++++l+

Q: 1075  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSAEQEeVVEALREEIRMMSHLN  1134

         899*******************************999988777699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1135  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1194

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1195  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1254

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1255  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1312

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1313  LRDVTLRCLELQPQDRPPSRELLKHPV  1339

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSA EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVTLRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013