EKS-ORA-00265

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00265

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	527.3	8.4E-159	751	1018	268

Status

Unreviewed

Ensembl Protein

ENSOANP00000022813

UniProt Accession

F6X759;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

ALK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000014473	ENSOANP00000022813	ENSOANT00000022817

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1256

Protein Sequence
(FASTA)

MLLASTAEGS GWVVLRGRIG RPEKPFRISL DYISSENRSL SAVDSFALKN CSEGMSPGSK 60

MALQSFFTCW NGTVIALGQA CDLRRDCVHG EDEGELCRKL PTGFYCSFEE GGCGWTQDPP 120

APHAPQWQIG KLDGAQFSAQ QGTVPQQTTD CISGSPGMTP SSAPPFPGPP QENSATKVQM 180

SWLIHGFLGG NVSLLLVENK TGKEQSRMVW HFANGEGLST WQRMVLPLAE VSDRFWLQIV 240

TWWEEGSDAV IAFDNVTLSL DCYLTIRGED TTPLDSTPNS SNLFNERNMY KKAVTETKTW 300

ETAHGEVPIS DPTAHWLFTT CGASGPRGPT QTQCNNAYRN SNLTVEVGAE GSLKGVQIWR 360

VPVTDTYRIS GYGAAGGKGG KNTMMRSYGV SVLGIFDLQK GDTLYILVGQ QGEDACPHTN 420

HVIQKVCIGE SNVIEEEIQV NRSVNEWAGG GGGGGGATYI FKILDGEPVP LIVAAGGGGR 480

AYRAKTNPLH PERLENDSSV PGLNGHSGAA GGGGGWNDKT SLLWSGKSLL EGATGGKSCP 540

QAMKKWGWET RGGFGGGGGG CSSGGGGGGY IGGDAAMDND PEVDGEDGVS YISPLGILYT 600

PALKVMEGHG EVNIMQHLNC SHCEVDECHL DPETHKIICY CDHGTVLAED GVSCVASPTT 660

SPHLPLSLIL SVVTSALVAA LVLAFSGIMI GFIQQHNQVL TGIRSCPSPQ GRINESWLLT 720

CLSVYIPLYH GKPLILPISQ LRDASSSNSI LFRGLGHGAF GEVYEGQVSG IPNDPSPLQV 780

AVKTLPEVCS EQDELDFLME ALIISKFNHQ NIVRCIGVSL QALPRFILLE LMAGGDLKSF 840

LRETRPRPSQ PSSLGMLDLL NVARDIACGC QYLEENHFIH RDIAARNCLL TCPGPGRVAK 900

IGDFGMARDI YRASYYRKGG CAMLPVKWMP PEAFMEGIFT SKTDTWSFGV LLWEIFSLGY 960

MPYPSKSNQE VLEFVTSGGR MDPPKSCPGP VYRIMTQCWQ HQPEDRPNFA IILERIEYCT 1020

QDPDVINTAL PVEYGPLIEE EEKVPMRPED PEGIPPLLVS PQQEKKEEGR APPAPPPLPT 1080

SAASRKAMTR AAVAEPPPRV RKGPALEGGH VNMAYSQSNP PSELHKGRGS RNKPTSLWNP 1140

TYGSWFTEKP ATKHNPPAEK EQPPERGSAG HEGNCPVPPN VVTGRLPGSS LLLEPSSLTA 1200

SLKDVPLFRL RHFPCGNVNY GYQQQGLPLE ATSGSGTGNY EDSLLRNKSS GSQPGP 1256

Nucleotide Sequence
(FASTA)

ATGCTGCTGG CATCGACTGC AGAAGGATCC GGCTGGGTGG TGCTTCGGGG ACGAATTGGA 60

CGTCCAGAGA AACCTTTCCG CATCTCCTTA GACTACATCT CAAGTGAAAA TAGAAGCCTG 120

TCTGCAGTGG ACTCTTTTGC ACTGAAGAAC TGTAGTGAAG GGATGTCACC TGGCTCCAAG 180

ATGGCCCTGC AGAGCTTCTT CACCTGCTGG AATGGAACCG TGATAGCCCT GGGGCAGGCG 240

TGTGACCTGC GCAGAGACTG CGTCCATGGA GAGGATGAAG GGGAGCTATG TAGAAAACTC 300

CCCACTGGCT TTTACTGCTC CTTTGAAGAA GGAGGTTGCG GCTGGACCCA GGACCCGCCC 360

GCTCCTCATG CTCCCCAGTG GCAGATCGGG AAGCTGGATG GAGCGCAATT CTCGGCTCAG 420

CAAGGTACTG TCCCTCAACA GACGACTGAT TGTATCTCTG GCTCTCCCGG CATGACCCCT 480

TCCTCTGCCC CCCCTTTTCC CGGGCCCCCC CAGGAGAATA GTGCCACAAA GGTCCAGATG 540

TCCTGGCTCA TCCATGGGTT CTTGGGGGGA AATGTTTCCC TGCTGCTGGT GGAGAACAAA 600

ACAGGAAAGG AGCAGAGCAG GATGGTCTGG CATTTTGCAA ACGGTGAAGG TTTGAGTACC 660

TGGCAAAGGA TGGTCTTGCC TCTCGCTGAG GTGTCAGACA GGTTTTGGCT CCAGATTGTC 720

ACTTGGTGGG AAGAAGGTTC AGATGCTGTC ATTGCTTTTG ACAACGTGAC CCTCAGCCTG 780

GACTGCTACC TGACAATCAG AGGAGAGGAC ACCACCCCGC TAGACTCAAC TCCCAACTCA 840

AGCAACCTGT TCAACGAGAG AAACATGTAC AAGAAGGCAG TGACGGAGAC CAAGACCTGG 900

GAGACTGCAC ATGGAGAAGT CCCCATCTCT GACCCTACAG CACACTGGTT GTTCACTACA 960

TGTGGGGCCA GCGGGCCCCG GGGCCCGACC CAGACACAAT GCAACAACGC CTACAGGAAC 1020

TCGAACCTGA CCGTGGAAGT CGGGGCCGAG GGGTCTCTGA AGGGCGTGCA GATCTGGAGA 1080

GTTCCGGTCA CCGACACATA CAGGATTTCG GGATACGGGG CAGCTGGAGG CAAAGGCGGG 1140

AAGAACACCA TGATGAGATC GTACGGGGTG TCGGTGCTTG GGATTTTTGA CCTTCAGAAG 1200

GGTGACACCT TGTACATCTT GGTGGGACAG CAAGGAGAAG ATGCCTGCCC TCATACAAAC 1260

CATGTGATCC AGAAGGTCTG CATCGGAGAG AGTAATGTGA TTGAAGAGGA AATCCAAGTG 1320

AACCGAAGTG TCAATGAGTG GGCAGGAGGA GGAGGTGGTG GGGGAGGAGC CACGTACATA 1380

TTTAAGATTC TGGACGGGGA GCCGGTCCCT TTGATTGTTG CGGCAGGAGG TGGTGGCCGA 1440

GCGTACAGGG CCAAAACAAA CCCGCTGCAC CCAGAGAGAC TGGAAAATGA CTCCTCCGTT 1500

CCAGGGCTGA ACGGCCATTC AGGAGCCGCA GGTGGCGGAG GTGGCTGGAA CGATAAAACC 1560

TCCCTGCTCT GGTCGGGAAA GTCCTTGCTG GAAGGTGCAA CAGGAGGAAA ATCCTGCCCC 1620

CAGGCCATGA AGAAGTGGGG GTGGGAGACA AGAGGGGGTT TCGGAGGGGG TGGAGGGGGG 1680

TGCTCCTCAG GTGGAGGAGG CGGAGGATAT ATAGGGGGCG ACGCGGCCAT GGACAATGAC 1740

CCCGAGGTGG ACGGGGAGGA TGGGGTGTCT TACATCAGTC CACTGGGCAT CCTGTACACC 1800

CCGGCTCTGA AAGTGATGGA GGGCCATGGG GAGGTGAACA TTATGCAGCA CCTAAACTGC 1860

AGCCACTGCG AGGTGGACGA GTGCCACTTG GACCCCGAGA CCCACAAGAT TATCTGCTAC 1920

TGTGATCACG GCACAGTGCT CGCTGAGGAC GGGGTCTCCT GTGTAGCATC TCCAACAACG 1980

TCCCCGCACC TGCCCCTCTC TCTAATCCTG TCGGTCGTGA CTTCCGCCCT CGTGGCTGCC 2040

CTGGTCCTGG CCTTCTCGGG GATCATGATT GGATTCATCC AGCAGCATAA TCAAGTTTTG 2100

ACTGGGATAA GGTCCTGTCC CTCCCCACAA GGCAGAATAA ATGAGAGTTG GCTTTTAACT 2160

TGTCTGTCTG TGTATATCCC TTTGTACCAT GGAAAACCTT TGATCTTACC CATCTCTCAA 2220

CTCAGAGATG CTAGCAGTTC AAACAGTATC CTGTTCAGGG GGCTGGGCCA CGGTGCCTTT 2280

GGGGAGGTAT ATGAAGGGCA GGTTTCTGGC ATCCCCAATG ACCCCAGCCC GCTGCAGGTG 2340

GCTGTAAAGA CACTGCCCGA GGTATGTTCA GAACAGGATG AGCTGGATTT CCTCATGGAA 2400

GCACTTATCA TCAGCAAGTT CAACCACCAA AACATTGTGC GCTGCATCGG GGTGAGCCTG 2460

CAGGCCCTGC CTCGCTTCAT CCTCCTGGAA CTCATGGCCG GCGGGGACCT GAAGTCCTTC 2520

CTCCGTGAGA CCCGCCCGCG CCCGAGCCAG CCGTCCTCTC TGGGCATGCT GGACCTGCTC 2580

AATGTGGCGC GGGACATCGC CTGTGGCTGC CAGTATTTGG AAGAAAACCA CTTCATCCAC 2640

CGAGATATCG CTGCCAGGAA TTGTCTCTTG ACTTGTCCAG GTCCTGGAAG AGTGGCCAAG 2700

ATTGGAGACT TCGGGATGGC CAGAGACATC TACAGAGCAA GCTATTACAG GAAGGGAGGC 2760

TGTGCGATGC TTCCAGTTAA GTGGATGCCC CCCGAAGCCT TCATGGAGGG GATCTTCACT 2820

TCCAAAACAG ACACATGGTC CTTTGGAGTG CTGCTGTGGG AAATATTCTC CCTTGGATAC 2880

ATGCCCTACC CCAGTAAAAG CAACCAGGAA GTTCTGGAGT TCGTCACCAG TGGAGGTCGG 2940

ATGGATCCAC CAAAAAGCTG CCCTGGGCCA GTGTACCGGA TAATGACCCA GTGCTGGCAG 3000

CATCAGCCCG AAGACAGACC CAACTTTGCC ATCATCTTGG AAAGGATTGA GTACTGCACC 3060

CAGGACCCAG ATGTAATCAA TACTGCTTTG CCAGTAGAAT ATGGCCCATT GATTGAAGAG 3120

GAAGAGAAGG TGCCCATGAG ACCCGAAGAT CCCGAGGGAA TCCCTCCCCT CTTAGTATCC 3180

CCTCAGCAAG AGAAAAAGGA GGAGGGGCGG GCTCCCCCAG CTCCCCCGCC CCTGCCCACT 3240

TCCGCTGCCT CTCGCAAAGC GATGACCAGG GCAGCCGTGG CCGAACCCCC GCCCCGCGTC 3300

CGCAAGGGGC CGGCTTTGGA AGGAGGACAT GTCAACATGG CGTATTCCCA ATCCAATCCA 3360

CCGTCGGAGC TACATAAAGG CCGGGGGTCG AGAAACAAAC CAACCAGCCT GTGGAACCCA 3420

ACGTATGGCT CCTGGTTTAC AGAGAAACCT GCCACCAAAC ACAATCCCCC GGCAGAGAAG 3480

GAACAGCCGC CTGAGAGGGG AAGCGCGGGA CATGAAGGAA ACTGTCCTGT CCCACCCAAC 3540

GTGGTGACTG GCAGGCTGCC AGGCTCCTCC CTGCTTTTAG AACCATCGTC CCTGACTGCC 3600

AGCCTGAAGG ACGTGCCTCT GTTTAGGCTC CGCCACTTCC CGTGTGGGAA CGTCAACTAC 3660

GGCTACCAGC AGCAAGGCTT ACCTTTGGAG GCCACCAGCG GCTCGGGCAC TGGCAATTAC 3720

GAGGACTCCC TCCTAAGAAA CAAGAGTAGC GGCTCCCAGC CCGGCCCCTG A 3771

Domain Profile

S: 3     lvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfnhe  62

         l r+lG+GafGevyeg+vsg+p+d+s+l+vavktlpe++seqdeldfl+ealiiskfnh+

Q: 751   LFRGLGHGAFGEVYEGQVSGIPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQ  810

         579*********************************************************

S: 63    nivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvakGc  122

         nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+q+ssl m dll+va+d+a+Gc

Q: 811   NIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPSQPSSLGMLDLLNVARDIACGC  870

         ************************************************************

S: 123   kyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkwmp  182

         +yleen+fihrdiaarn+ll+++Gp+rvaki+dfGmardiyra+yyrkgg+a+lpvkwmp

Q: 871   QYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMP  930

         ************************************************************

S: 183   peafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeipgs  242

         peaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk +pg+

Q: 931   PEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKSCPGP  990

         ************************************************************

S: 243   vyrimtdcwkhepedrpkfvsilerlqa  270

         vyrimt+cw+h+pedrp+f++iler+++

Q: 991   VYRIMTQCWQHQPEDRPNFAIILERIEY  1018

         *************************986

Domain Sequence
(FASTA)

LFRGLGHGAF GEVYEGQVSG IPNDPSPLQV AVKTLPEVCS EQDELDFLME ALIISKFNHQ 60

NIVRCIGVSL QALPRFILLE LMAGGDLKSF LRETRPRPSQ PSSLGMLDLL NVARDIACGC 120

QYLEENHFIH RDIAARNCLL TCPGPGRVAK IGDFGMARDI YRASYYRKGG CAMLPVKWMP 180

PEAFMEGIFT SKTDTWSFGV LLWEIFSLGY MPYPSKSNQE VLEFVTSGGR MDPPKSCPGP 240

VYRIMTQCWQ HQPEDRPNFA IILERIEY 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013