EKS-ORA-00007

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00007

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	496.8	1.1E-149	522	781	260

Status

Unreviewed

Ensembl Protein

ENSOANP00000022947

UniProt Accession

F7C3F7;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHB4

Gene Synonyms/Alias

EPHB4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000014567	ENSOANP00000022947	ENSOANT00000022951

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

895

Protein Sequence
(FASTA)

MLECLSLARA GRACKETFTV FYYESDADTA TALSPSWMEN PYVKVDTVAA EHLTRKRPGA 60

EATGKVNVKT LRLGPLSKAG FYLAFQDQGA CMALLSLHLF YKKCPELTVN LTRFPETVPR 120

ELVVPVAGSC VAGTAPAPGP GPSLYCREDG QWAEQPVTGC VCAPGYEAAE EHTRCRACAS 180

GFFKPLAGEG SCQQCPQNSA PNAPGSVLCP CRVGYFRAPT DSPGSPCTTP PSAPRSVVAR 240

LNGSSLRLEW SAPLETGGRE DLTYGLRCRE CRPGGSCVPC SGGIAFDPGP RGLAEPWVGV 300

QGLRPDVTYA FEVTASNGVS AQAPGPPPAE AVNVTTDREV PPAVSDVAVT GRSPSSLRLS 360

WSVPHTSSGA VLDYEVKYHE KGVEGPSGVR FLKTSENRVE LRGLKLGATY LVQVRARSEA 420

GYGPFGREHH TQTQLDANET WREQLALIAG TAVVGVILVL VVVVVAVLCL RKQSSSRDPE 480

YSDKPGQYLI GHGTKVYIDP FTYEDPNEAV REFAKEIDVS YVKIEEVIGA GEFGEVCRGR 540

LKAPGKKESY VAIKTLKGGY TERQRREFLS EASIMGQFEH PNIIRLEGVV TNSVPVMILT 600

EFMENGALDS FLRLNDGQFT PIQLVGVLRG IASGMRYLAE MSYVHRDLAA RNILVNSNLV 660

CKVSDFGLSR FLEENSSDPT YTSSLGGKIP IRWTAPEAIA FRKFTSASDA WSYGIVMWEV 720

MSFGERPYWD MSNQDVINAI EQDYRLPPPP ECPTSLHQLM LDCWQKDRNA RPRFPQVVSA 780

LDKLIRNPAS LKIVARDNGG ASHPLLDQRL PHFSAFGSVG EWLRAIKMGR YEDSFTAAGF 840

NSFELVSQIS AEDLLRIGVT LAGHQKKILT SVQHMKTQAK PGASTSGPGT PAPQY 895

Nucleotide Sequence
(FASTA)

ATGCTCGAGT GCCTGTCCCT GGCCCGCGCC GGCCGGGCCT GCAAGGAGAC CTTCACCGTC 60

TTCTACTACG AAAGCGACGC CGACACCGCC ACTGCCCTCA GTCCCTCCTG GATGGAGAAC 120

CCCTACGTCA AGGTGGACAC AGTGGCGGCG GAACATCTGA CGCGGAAACG CCCTGGGGCG 180

GAGGCGACGG GGAAGGTGAA CGTGAAGACG CTGAGGTTGG GCCCCCTGTC CAAGGCCGGC 240

TTCTATCTGG CCTTCCAGGA CCAGGGGGCC TGCATGGCTC TCCTCTCCCT CCACCTCTTC 300

TACAAGAAGT GCCCCGAGCT GACCGTCAAC CTCACCCGCT TCCCCGAGAC CGTGCCCCGG 360

GAGCTGGTGG TGCCCGTGGC CGGGAGCTGC GTGGCGGGCA CCGCCCCGGC CCCCGGGCCC 420

GGCCCCAGCC TCTACTGCCG GGAGGACGGT CAGTGGGCCG AACAGCCGGT CACCGGCTGC 480

GTCTGCGCCC CGGGTTACGA GGCCGCCGAG GAGCACACCC GCTGCCGAGC CTGTGCCTCT 540

GGGTTCTTCA AACCGCTGGC GGGAGAGGGG TCTTGTCAGC AGTGCCCCCA GAACAGCGCT 600

CCCAACGCCC CCGGCTCTGT CCTCTGTCCG TGTCGCGTCG GCTACTTCCG GGCCCCGACG 660

GATTCTCCCG GCTCTCCCTG CACCACACCC CCGTCGGCCC CCCGGAGCGT GGTGGCCCGC 720

CTCAACGGGT CGTCCCTGCG GCTGGAGTGG AGCGCCCCGC TGGAGACCGG GGGCCGCGAG 780

GACCTGACCT ACGGGCTGCG CTGCCGGGAG TGCCGCCCGG GGGGCTCGTG CGTCCCCTGC 840

AGCGGGGGCA TCGCCTTCGA CCCCGGCCCC CGCGGCCTGG CCGAACCCTG GGTCGGGGTG 900

CAGGGCCTGC GCCCCGACGT CACCTACGCC TTCGAGGTCA CCGCCTCCAA CGGGGTGTCC 960

GCCCAGGCCC CCGGGCCGCC CCCGGCCGAA GCAGTCAACG TCACCACTGA CCGTGAAGTG 1020

CCTCCCGCTG TATCCGACGT CGCGGTGACA GGGAGGTCCC CGAGCAGCTT GAGGCTGAGC 1080

TGGAGTGTCC CCCACACGTC CAGCGGGGCC GTGCTCGACT ACGAGGTCAA GTACCATGAA 1140

AAGGGCGTGG AGGGCCCCAG CGGGGTTCGT TTCCTGAAGA CTTCGGAGAA CCGGGTGGAG 1200

CTGAGGGGGC TGAAGCTGGG GGCCACCTAC CTGGTCCAGG TCCGGGCCCG CTCCGAGGCC 1260

GGCTATGGAC CCTTCGGCCG CGAGCACCAC ACCCAGACCC AGCTGGATGC GAACGAGACG 1320

TGGAGGGAGC AGCTGGCACT GATTGCGGGC ACAGCGGTCG TGGGTGTCAT CCTGGTCCTC 1380

GTGGTCGTTG TGGTGGCCGT CCTCTGCCTC AGGAAGCAGA GCAGCAGTCG GGATCCCGAA 1440

TACTCGGACA AACCCGGGCA GTACCTCATC GGGCACGGCA CTAAGGTCTA CATCGACCCC 1500

TTCACTTACG AAGACCCCAA TGAGGCGGTG AGGGAATTTG CCAAGGAGAT TGACGTCTCC 1560

TACGTCAAGA TCGAGGAGGT GATCGGAGCA GGGGAGTTCG GAGAGGTGTG CCGGGGCCGG 1620

CTGAAGGCGC CGGGGAAGAA GGAGAGTTAC GTGGCCATCA AGACACTCAA GGGAGGCTAC 1680

ACGGAGCGTC AAAGGCGTGA GTTCCTGAGC GAGGCCTCCA TCATGGGCCA GTTCGAGCAC 1740

CCCAACATCA TCCGGCTGGA GGGGGTCGTG ACCAACAGCG TACCGGTTAT GATCCTCACC 1800

GAGTTCATGG AGAACGGGGC CCTCGATTCC TTCCTGCGGC TGAATGACGG CCAGTTCACG 1860

CCCATCCAGC TGGTGGGCGT GCTGAGGGGC ATCGCCTCGG GCATGCGCTA CCTGGCCGAG 1920

ATGAGCTACG TCCACCGCGA CCTGGCCGCC CGGAACATCC TGGTCAACAG CAACCTGGTC 1980

TGCAAGGTGT CCGACTTCGG CCTCTCCCGC TTCCTGGAGG AGAACTCGTC CGACCCCACC 2040

TACACCAGCT CTCTGGGCGG GAAAATCCCC ATCCGCTGGA CGGCCCCCGA GGCCATCGCC 2100

TTCCGGAAGT TCACGTCGGC CAGCGACGCC TGGAGCTACG GGATCGTCAT GTGGGAGGTC 2160

ATGTCATTCG GAGAGCGGCC CTACTGGGAC ATGAGCAACC AGGATGTGAT CAACGCCATC 2220

GAGCAGGACT ACCGACTGCC CCCGCCGCCG GAGTGCCCGA CGTCCCTGCA CCAGCTCATG 2280

TTGGACTGCT GGCAGAAGGA CCGGAACGCC CGGCCTCGGT TTCCGCAGGT GGTCAGCGCC 2340

CTGGACAAGC TCATCCGGAA CCCGGCCAGC CTCAAGATTG TGGCTCGAGA CAATGGCGGT 2400

GCCTCCCACC CGCTCCTGGA CCAGCGGCTC CCCCACTTCT CGGCCTTCGG CTCGGTGGGA 2460

GAGTGGCTGC GGGCCATCAA GATGGGCAGA TACGAGGACA GCTTCACGGC GGCCGGCTTC 2520

AACTCCTTCG AGCTCGTCAG CCAGATCTCG GCCGAGGACC TGCTCCGGAT CGGGGTGACC 2580

CTGGCCGGAC ACCAGAAGAA GATCCTGACC AGCGTCCAGC ACATGAAGAC GCAGGCCAAA 2640

CCCGGAGCGT CGACGTCCGG GCCGGGGACC CCGGCTCCCC AGTACTGA 2688

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         vkie+viGaGefGevc+Grlk+pgk+e++vaiktlk+g+te+qrr+flseasi+Gqf+hp

Q: 522   VKIEEVIGAGEFGEVCRGRLKAPGKKESYVAIKTLKGGYTERQRREFLSEASIMGQFEHP  581

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         niirleGvvt+s pvmi+te+mengaldsflr +dgqft iqlvg+lrGiasgm+yl++m

Q: 582   NIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTPIQLVGVLRGIASGMRYLAEM  641

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178

         +yvhrdlaarnilvnsnlvckvsdfGlsr+le++s +++yt+s ggkipirwtapeaia+

Q: 642   SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSsDPTYTSSlGGKIPIRWTAPEAIAF  701

         *******************************99988*****999****************

S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238

         rkftsasd+wsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlppp +cp++l+qlml

Q: 702   RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPECPTSLHQLML  761

         ************************************************************

S: 239   dcwqkdraerpkfeqivsil  258

         dcwqkdr++rp+f q+vs+l

Q: 762   DCWQKDRNARPRFPQVVSAL  781

         *****************975

Domain Sequence
(FASTA)

VKIEEVIGAG EFGEVCRGRL KAPGKKESYV AIKTLKGGYT ERQRREFLSE ASIMGQFEHP 60

NIIRLEGVVT NSVPVMILTE FMENGALDSF LRLNDGQFTP IQLVGVLRGI ASGMRYLAEM 120

SYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEENSSDPTY TSSLGGKIPI RWTAPEAIAF 180

RKFTSASDAW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPPE CPTSLHQLML 240

DCWQKDRNAR PRFPQVVSAL 260

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013