EKS-ORA-00229

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00229

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	375.9	1.2E-112	27	279	253

Status

Unreviewed

Ensembl Protein

ENSOANP00000023058

UniProt Accession

F7E2A6;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK5

Gene Synonyms/Alias

PLK5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000014634	ENSOANP00000023058	ENSOANT00000023062

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

598

Protein Sequence
(FASTA)

MDLRGSRRRE RDTLGRFIRD PGTGRIYKRG KLLGKGAFGR CYKLTDMSTN RVFALKVVPR 60

THTGHLEQRG KVEREIELHS CLRHRNVVGF HRHFADHDHI YMVLEYCSRK SLAHILKARK 120

TLTEPEARYY LRGIVGGLRY LHQQGIIHRD LKLSNFFVNK NMEVKIGDLG LATRAEPGGR 180

CRGVLCGTPN YLAPEVISRK GHSVQSDVWA LGCIMYTVLT GSSPFKVSHL REMYQSIREA 240

RYPVPAHLSP HARHLVACLL APNPANRPSL DQILAHDFFT QGFTPDRLPT RSCYAAPIFA 300

VTQPLGKLFQ KATQRFLGGT ALPLPAQQAP NHCLRPAPQG PKSQNIECGG EESGLCPAPI 360

IMNAEVGTVN GGLSRPEGSS GLGVHPATRI LQCCLDSGPP GKASLPPPQQ QRPVLCVTKW 420

VDYSNKYGFG YQLSDGGFAV LLRDGTHMAL RPPLGCVCYS TGQGEPMTFS RTEVPRFLAG 480

KLAVLQFFTR YMQQQLLEGG NPPTPPLADI AVPGVSLQHF LKSDQALLML FSDGTLQVNF 540

YRDRTKLVLS WMGEGPLLTY IDQERRATSY QPGTLQREGC ASPLRQRLSY ALRLLQKL 598

Nucleotide Sequence
(FASTA)

ATGGACCTGA GGGGCTCGAG GCGAAGGGAG AGAGACACCC TGGGCCGCTT CATCCGGGAC 60

CCAGGCACCG GGCGCATCTA CAAGAGGGGA AAGCTCCTGG GAAAGGGTGC TTTCGGCCGC 120

TGTTACAAGC TGACCGACAT GTCCACCAAC AGAGTGTTCG CCCTCAAGGT TGTGCCTCGA 180

ACCCATACCG GCCATCTGGA GCAGCGGGGC AAGGTGGAGC GGGAGATCGA GCTGCACAGC 240

TGCCTGCGGC ACCGCAATGT CGTTGGCTTC CACCGGCACT TTGCTGACCA CGACCACATC 300

TACATGGTGC TGGAGTACTG CAGCCGCAAG TCGCTAGCCC ACATCCTGAA GGCCCGGAAG 360

ACTCTGACTG AACCCGAGGC CCGCTATTAC CTGCGGGGCA TCGTTGGCGG CCTGCGCTAC 420

CTGCACCAGC AGGGAATCAT CCACCGAGAC CTCAAGCTCA GTAATTTCTT CGTCAATAAG 480

AATATGGAAG TGAAGATCGG AGACCTGGGA CTAGCCACCA GAGCAGAGCC AGGGGGCCGC 540

TGCCGAGGGG TGCTGTGCGG GACGCCCAAC TACCTGGCCC CTGAGGTCAT CTCCCGGAAG 600

GGTCACTCGG TCCAGTCGGA CGTCTGGGCT CTGGGCTGTA TCATGTACAC GGTGCTGACC 660

GGCAGCTCCC CGTTCAAGGT GAGCCACCTG CGGGAGATGT ATCAGAGCAT CAGGGAGGCA 720

CGCTACCCCG TGCCCGCCCA CCTCTCCCCC CATGCCCGTC ACCTCGTTGC CTGCTTGCTG 780

GCCCCCAACC CTGCCAACCG GCCCAGCCTG GACCAGATTC TGGCGCATGA CTTCTTCACC 840

CAGGGCTTCA CCCCCGATAG GCTCCCCACC AGGTCCTGCT ATGCGGCTCC CATCTTTGCG 900

GTCACCCAGC CGCTCGGCAA GCTTTTCCAG AAGGCCACAC AGAGGTTCCT GGGGGGTACT 960

GCCCTGCCCT TGCCCGCACA GCAGGCCCCA AACCACTGTC TGCGGCCGGC CCCACAGGGT 1020

CCCAAGAGCC AGAACATTGA GTGTGGGGGA GAGGAGAGTG GTCTTTGTCC TGCACCCATC 1080

ATTATGAATG CGGAAGTCGG GACTGTTAAT GGGGGGCTGT CAAGGCCCGA GGGGAGTTCA 1140

GGATTGGGGG TGCACCCGGC CACCCGGATC CTGCAGTGCT GCTTGGACTC TGGACCTCCA 1200

GGTAAGGCCT CCCTCCCCCC CCCCCAACAA CAGCGTCCCG TGCTCTGCGT CACTAAGTGG 1260

GTGGATTACT CCAATAAGTA CGGTTTCGGC TATCAGCTCT CGGACGGTGG CTTTGCCGTC 1320

CTGCTCCGCG ACGGCACCCA CATGGCTCTG CGTCCACCCC TGGGGTGCGT CTGCTACTCA 1380

ACGGGGCAGG GGGAGCCCAT GACCTTCTCC CGGACGGAGG TGCCCCGGTT CCTGGCGGGC 1440

AAACTGGCCG TGCTGCAGTT TTTCACCCGC TACATGCAGC AGCAGCTGCT GGAGGGAGGG 1500

AACCCGCCAA CACCTCCGCT GGCTGACATA GCAGTCCCTG GCGTCTCCCT GCAGCATTTC 1560

CTCAAGTCGG ATCAGGCCCT GCTTATGCTC TTCAGTGATG GGACACTGCA GGTCAATTTC 1620

TACCGAGACC GCACCAAGCT GGTGCTGAGT TGGATGGGCG AGGGGCCCCT GCTGACCTAC 1680

ATTGACCAGG AGCGCCGAGC CACCTCCTAC CAGCCGGGCA CCCTGCAGCG AGAGGGCTGT 1740

GCCTCACCCC TCCGCCAACG CCTAAGTTAT GCCCTCCGCC TGCTCCAGAA GCTCTAA 1797

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgkllGkG+f +cy+l+d++t++vfa+kvvp+++  + +qr kve+eie+h+ l+h+n

Q: 27    YKRGKLLGKGAFGRCYKLTDMSTNRVFALKVVPRTHTGHLEQRGKVEREIELHSCLRHRN  86

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v ++ +f+d++++y+vle+csr+sla++lk+rk+ltepe+ryylr iv gl+ylh++ i

Q: 87    VVGFHRHFADHDHIYMVLEYCSRKSLAHILKARKTLTEPEARYYLRGIVGGLRYLHQQGI  146

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlkl+n+f+n+++evkigd+Glatr e+ ++++ +lcGtPny+aPev+s+kghs+++

Q: 147   IHRDLKLSNFFVNKNMEVKIGDLGLATRAEPGGRCRGVLCGTPNYLAPEVISRKGHSVQS  206

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+W+lGci+yt+l+G+ Pf+ ++l+e+y+ i++a+y +P++ls++a++l+a ll+++P++

Q: 207   DVWALGCIMYTVLTGSSPFKVSHLREMYQSIREARYPVPAHLSPHARHLVACLLAPNPAN  266

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl+++l ++f+

Q: 267   RPSLDQILAHDFF  279

         ************8

Domain Sequence
(FASTA)

YKRGKLLGKG AFGRCYKLTD MSTNRVFALK VVPRTHTGHL EQRGKVEREI ELHSCLRHRN 60

VVGFHRHFAD HDHIYMVLEY CSRKSLAHIL KARKTLTEPE ARYYLRGIVG GLRYLHQQGI 120

IHRDLKLSNF FVNKNMEVKI GDLGLATRAE PGGRCRGVLC GTPNYLAPEV ISRKGHSVQS 180

DVWALGCIMY TVLTGSSPFK VSHLREMYQS IREARYPVPA HLSPHARHLV ACLLAPNPAN 240

RPSLDQILAH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071363	; P:cellular response to growth factor stimulus
GO:0002357	; P:defense response to tumor cell
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:2000045	; P:regulation of G1/S transition of mitotic cell cycle
GO:0006927	; P:transformed cell apoptotic process

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013