EKS-ORA-00384

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00384

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	496.0	2.9E-149	18	284	267

Status

Unreviewed

Ensembl Protein

ENSOANP00000023063

UniProt Accession

F7E1U8;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000014636	ENSOANP00000023063	ENSOANT00000023067

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1581

Protein Sequence
(FASTA)

AKPFTQLVKE MQLHRDDFEI IKVIGRGAFG EVAVVKMKST ERIYAMKILN KWEMLKRAET 60

ACFREERDVL VNGDCQWITT LHYAFQDENY LYLVMDYYVG GDLLTLLSKF EDKLPEDMAR 120

FYIGEMVLAI HSIHQLHYVH RDIKPDNVLL DMNGHIRLAD FGSCLKMNDD GTVQSSVAVG 180

TPDYISPEIL QAMEDGMGKY GPECDWWSLG VCMYEMLYGE TPFYAESLVE TYGKIMNHEE 240

RFQFPSHVTD VSEEAKDLIQ RLICSRERRL GQNGIEDFKA HAFFEGLNWE NIRNLEAPYI 300

PDVSSPSDTS NFDVDDDVLR NPEMVPPGSH TGFSGLHLPF IGFTFTTESC FSDRGSLKSI 360

TQSNAVTKDA DVQRDLENSL QIEAYERRIR RLEQEKLELS RKLQESTQTV QSLHSSTRAA 420

GNTNRDKEIK KLNEEVERLK NKIADSNRLE RQLEDAVTLR QEHEDSTHRL KGLEKQYRVL 480

RQEKEDFHKL ESQLEDAVAE ASKERKLREH SESFSKQLEN ELEVLKIKQG GRGLSATLEH 540

QQEISKIKSE LEKKVLFYEE ELVRREACHV LEVKNVKKEV HDSESLQLAL QKEIMMLKDK 600

LEKSKRERHS EMEEAVGTIK DKYERERTML FEENKKLTTE TERLCSFVDK LTAQNRQLED 660

ELQDLAAKKE SVAHWEAQIA EIIQWVSDEK DARGYLQALA SKMTEELESL RSCSLGSRTL 720

DPLWKVRRSQ KLDMSARLEL QSALDAEIRA KQLVQEELRK VKDTNLSFES KLRESEAKNR 780

ELLEEMENLK KKMEEKFRTD AVINSGHYFS FLLGLKLPDF QDSIFEYFNT SPLAHDLTFR 840

SSALPGRERG FPSQPKAHQF SIKSFSSPTQ CSHCTSLMVG LVRQGYACEV CSFACHVSCK 900

ESAPQVCPIP PEQAKRPLGV DVQRGIGTAY KGYVKVPKPT GVKKGWQRAY AVVCDCKLFL 960

YDLPEGKSTQ PGVVASQVLD LRDEDFSVSS VLASDVIHAT RRDIPCIFRV TTSLLGSPSK 1020

TSSLLILTEN ENEKRKWVGI LEGLQSILQK NRLKNQVVHI PQEAYDSTLP LIKTIVTAAI 1080

IDRDRIAVGT EEGLYVIEVT RDVIVRAADC KKVYQIELAP REKIIILACG RNHQVHLYPW 1140

SSFDGSEGNF DIKLPETKGC QFIITATPKK SASTCLFVAV KRLVLCYEIH RTKPFHKKFT 1200

EILTPGNVQW MAVFKDKLCV GHPSGFSLLN IQGDGQSLNL VNPNDPSLMF LSQQSFDALC 1260

AVELSNEEYL LCFSHMGLYV DSQGRRSRMQ ELMWPATPVA CSCNSSYVTV YSEYGVDVFD 1320

VNSMEWVQTI GLRRIRPLNV EGTLNLLNCE PTRLIYFKNK FSVGAVLSVP ETSDNSKKQM 1380

LRTRSKRRFV FKVPEEERLQ QRREMLRDPE LRSKMISNPT NFNHVAHMGP GDGMQVLMDL 1440

PLCPSERKLA PVSSHFLSVT TSSSVKGLFA KPKGLSLSCS KGASRKIIRW TPNSLPTQYY 1500

QPSKFSSRPP GPRLNPGSAI SQGCHLSLSQ PENRASGQPD SDSTKHSTPS NSSNPSGPPS 1560

PNSPHRSQLT LDGLDQSSCD A 1581

Nucleotide Sequence
(FASTA)

GCAAAACCAT TTACGCAACT GGTAAAGGAA ATGCAACTTC ATCGAGATGA CTTTGAAATC 60

ATAAAAGTAA TCGGAAGAGG TGCATTTGGC GAGGTTGCAG TTGTTAAAAT GAAGAGCACT 120

GAACGCATTT ATGCAATGAA GATCCTAAAC AAATGGGAAA TGCTTAAAAG AGCGGAGACA 180

GCTTGTTTCC GAGAAGAGAG AGATGTATTG GTGAATGGTG ATTGCCAGTG GATCACTACA 240

TTACACTACG CCTTTCAAGA CGAAAACTAT CTGTATTTAG TAATGGACTA CTATGTGGGT 300

GGTGATTTAC TGACCCTCCT CAGTAAGTTC GAGGACAAAC TTCCCGAAGA TATGGCAAGA 360

TTCTACATTG GCGAAATGGT GCTGGCCATA CATTCCATTC ATCAGTTGCA TTATGTGCAC 420

AGAGATATTA AACCTGACAA CGTACTTTTG GACATGAATG GTCATATTCG CCTTGCAGAC 480

TTCGGATCTT GCTTGAAGAT GAATGATGAT GGCACTGTTC AGTCCTCTGT GGCAGTGGGT 540

ACCCCTGACT ACATCTCCCC TGAGATTCTA CAAGCAATGG AGGATGGCAT GGGGAAATAT 600

GGCCCTGAAT GTGACTGGTG GTCTCTCGGG GTCTGCATGT ATGAAATGCT TTATGGAGAA 660

ACACCATTTT ATGCAGAATC TTTAGTGGAA ACTTATGGAA AGATCATGAA TCATGAAGAG 720

CGATTTCAGT TTCCATCCCA TGTCACAGAT GTATCAGAAG AAGCAAAAGA CCTCATTCAG 780

AGACTGATCT GTAGTAGAGA ACGCCGTCTG GGACAGAATG GAATCGAGGA TTTCAAAGCT 840

CATGCGTTTT TTGAAGGACT CAATTGGGAA AACATACGCA ATTTAGAAGC ACCTTACATT 900

CCAGATGTCA GCAGTCCTTC CGACACATCA AACTTCGACG TGGATGATGA TGTCTTGAGA 960

AATCCTGAAA TGGTACCTCC TGGTTCTCAT ACTGGCTTTT CTGGATTACA TTTACCATTC 1020

ATTGGTTTTA CATTCACAAC TGAAAGCTGT TTTTCTGATC GAGGCTCTCT GAAGAGCATA 1080

ACGCAGTCAA ATGCTGTAAC CAAAGATGCG GATGTGCAGC GTGATTTAGA GAACAGCTTG 1140

CAGATTGAAG CTTATGAAAG AAGAATCCGA AGATTGGAGC AGGAAAAACT AGAATTAAGT 1200

CGAAAATTGC AGGAATCTAC ACAGACTGTG CAGTCCCTTC ATAGTTCAAC TCGTGCAGCA 1260

GGAAACACAA ACCGAGATAA AGAAATCAAA AAATTAAATG AAGAAGTGGA ACGTTTGAAA 1320

AACAAAATAG CAGATTCTAA TAGGTTAGAG CGACAGCTTG AGGATGCTGT AACACTCCGC 1380

CAAGAACATG AAGACTCAAC CCATAGATTG AAAGGACTGG AAAAACAATA TCGAGTACTA 1440

AGACAAGAGA AAGAAGACTT TCATAAGCTG GAATCTCAAC TGGAGGATGC AGTGGCTGAA 1500

GCATCAAAGG AACGCAAGCT TCGAGAACAC AGTGAAAGTT TTTCTAAGCA GCTGGAAAAT 1560

GAACTGGAAG TCCTTAAGAT AAAGCAAGGA GGTCGTGGAC TAAGTGCCAC ATTAGAGCAT 1620

CAGCAGGAAA TTTCCAAAAT CAAATCGGAA CTTGAGAAGA AGGTCTTGTT TTATGAAGAG 1680

GAATTGGTCA GGCGTGAGGC CTGCCATGTC TTGGAAGTGA AGAATGTGAA AAAGGAGGTG 1740

CATGATTCAG AAAGCCTCCA GTTAGCCCTG CAAAAAGAGA TCATGATGTT AAAAGATAAA 1800

TTAGAAAAGT CGAAACGAGA AAGGCACAGT GAAATGGAGG AAGCAGTGGG CACAATAAAA 1860

GACAAATATG AGCGAGAGAG AACTATGCTA TTTGAGGAAA ACAAGAAATT AACCACTGAA 1920

ACTGAAAGGC TTTGCTCCTT TGTGGATAAA CTGACAGCAC AAAACAGGCA ACTGGAAGAC 1980

GAGCTTCAAG ATTTAGCAGC GAAGAAGGAG TCTGTTGCCC ACTGGGAGGC TCAGATTGCA 2040

GAAATTATTC AGTGGGTAAG TGACGAAAAA GACGCTCGTG GATATCTACA AGCTCTAGCT 2100

TCCAAGATGA CAGAAGAACT TGAGTCACTT AGAAGTTGTA GCCTTGGATC AAGAACACTG 2160

GATCCACTGT GGAAAGTGCG ACGAAGTCAG AAGCTGGATA TGTCAGCCAG ACTTGAGTTG 2220

CAGTCTGCTC TTGATGCAGA GATACGCGCC AAACAGCTTG TTCAAGAGGA GCTAAGGAAG 2280

GTCAAAGACA CAAACCTGTC CTTTGAGAGT AAACTAAGGG AATCTGAAGC AAAAAACCGA 2340

GAACTATTAG AAGAGATGGA AAATTTGAAG AAAAAGATGG AAGAAAAATT TAGGACAGAT 2400

GCAGTCATTA ATTCTGGTCA TTATTTTTCT TTCCTCTTAG GTCTCAAACT TCCAGATTTT 2460

CAGGATTCTA TTTTTGAGTA TTTCAACACT TCACCTCTGG CGCATGATCT GACATTTAGA 2520

AGCTCAGCCT TGCCAGGGCG GGAGAGAGGT TTCCCAAGCC AGCCTAAAGC TCACCAATTC 2580

AGTATCAAGT CCTTTTCAAG CCCAACTCAG TGTAGTCACT GCACTTCCCT CATGGTGGGA 2640

TTAGTCCGAC AAGGCTATGC CTGTGAGGTG TGTTCATTTG CATGCCACGT TTCCTGCAAA 2700

GAAAGTGCAC CTCAAGTCTG TCCTATACCT CCTGAACAAG CTAAAAGACC TCTTGGAGTA 2760

GATGTGCAGC GAGGGATAGG AACTGCCTAC AAAGGTTATG TCAAGGTTCC AAAACCTACA 2820

GGGGTGAAGA AAGGATGGCA GAGAGCATAT GCAGTTGTCT GTGACTGTAA ACTCTTCTTA 2880

TATGATTTAC CCGAAGGAAA ATCTACCCAG CCTGGAGTTG TTGCAAGCCA AGTTTTAGAT 2940

CTCAGAGATG AAGATTTTTC TGTAAGCTCT GTCCTAGCAT CAGATGTAAT ACATGCTACC 3000

CGCCGGGACA TCCCTTGTAT ATTCAGGGTG ACAACCTCTC TCTTAGGATC ACCTTCTAAG 3060

ACTAGTTCAC TGCTGATCCT GACAGAAAAC GAGAACGAAA AGAGGAAGTG GGTTGGAATC 3120

CTAGAGGGGC TACAGTCAAT TCTGCAGAAA AACAGACTGA AAAACCAAGT TGTACATATT 3180

CCACAAGAAG CCTATGACAG CACATTGCCT CTGATTAAAA CTATTGTAAC TGCTGCTATA 3240

ATCGATCGGG ATAGGATAGC TGTCGGTACA GAAGAAGGGC TGTATGTGAT AGAAGTGACC 3300

CGTGACGTAA TCGTCCGAGC TGCTGATTGC AAGAAGGTGT ACCAGATAGA GCTTGCTCCC 3360

AGAGAGAAAA TCATCATTCT CGCCTGTGGG CGGAACCATC AAGTTCACCT GTATCCGTGG 3420

TCGTCCTTCG ACGGATCCGA AGGCAACTTT GACATTAAGC TTCCGGAAAC TAAAGGCTGC 3480

CAGTTTATAA TCACCGCAAC CCCGAAGAAG AGCGCCTCAA CGTGTCTGTT CGTGGCAGTA 3540

AAGCGACTGG TTCTTTGCTA TGAAATTCAC AGAACTAAAC CTTTCCACAA AAAGTTCACG 3600

GAGATTCTGA CCCCAGGAAA TGTACAATGG ATGGCAGTGT TCAAGGACAA GCTCTGTGTT 3660

GGCCACCCAT CTGGGTTCTC TCTGTTGAAC ATCCAGGGAG ATGGACAATC TCTGAACCTG 3720

GTAAATCCTA ATGACCCCTC GCTTATGTTC CTCTCACAGC AGTCTTTTGA TGCCCTCTGT 3780

GCTGTGGAGC TCAGTAATGA GGAATACCTG CTTTGCTTCA GCCATATGGG ATTGTACGTG 3840

GATTCACAAG GTCGGAGGTC ACGCATGCAG GAGCTAATGT GGCCTGCAAC TCCTGTTGCC 3900

TGTAGCTGCA ACTCTTCCTA TGTCACAGTG TACAGTGAGT ATGGCGTGGA TGTCTTTGAT 3960

GTTAATTCAA TGGAATGGGT TCAGACTATT GGTCTCCGCA GGATCCGACC ACTAAACGTA 4020

GAAGGCACAC TGAATCTCCT TAACTGTGAG CCTACCCGAC TAATATACTT CAAGAACAAG 4080

TTTTCAGTAG GAGCTGTGCT CAGTGTGCCC GAAACTTCTG ATAATAGCAA GAAGCAAATG 4140

CTTCGAACCA GAAGTAAAAG ACGATTTGTC TTTAAGGTTC CCGAGGAAGA GCGGTTACAG 4200

CAGAGGAGAG AGATGCTGAG AGACCCAGAA CTACGATCAA AAATGATATC GAACCCAACG 4260

AACTTTAATC ACGTGGCTCA TATGGGACCA GGAGATGGGA TGCAAGTTCT GATGGACCTC 4320

CCTCTGTGTC CATCAGAAAG AAAATTAGCA CCTGTTTCTT CCCATTTTTT GTCTGTGACC 4380

ACATCATCAT CAGTCAAGGG GTTGTTTGCA AAGCCGAAAG GCCTCAGCCT CAGCTGCAGC 4440

AAGGGGGCTT CAAGGAAGAT TATACGGTGG ACTCCCAATT CCCTACCGAC CCAATATTAT 4500

CAGCCCTCCA AGTTTTCCTC TCGGCCACCA GGCCCCCGTC TAAACCCCGG GTCAGCCATT 4560

TCTCAGGGTT GCCATCTTTC CTTAAGCCAG CCAGAAAATC GGGCTTCTGG CCAGCCCGAT 4620

TCGGATTCCA CCAAACACTC GACTCCGTCT AACAGCTCCA ACCCGAGTGG TCCCCCCAGC 4680

CCCAACTCCC CCCATAGGAG TCAGCTCACA CTAGACGGGC TGGATCAGTC GAGCTGTGAC 4740

GCATAA 4746

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavv++k+te++yamkil+k+e+lkrae+a+freerdvlv++d++w

Q: 18    FEIIKVIGRGAFGEVAVVKMKSTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW  77

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde+ylylvm+y+vGGdlltllsk+edklpe++arfy+ e+vla++s+h+l+

Q: 78    ITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIHSIHQLH  137

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdn+lld++Ghi+ladfGsclk+n+dgtv+ssvavGtpdyispe+l+a+e+g+

Q: 138   YVHRDIKPDNVLLDMNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGM  197

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vseeakd

Q: 198   GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEEAKD  257

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gied+k+h+ff

Q: 258   LIQRLICSRERRLGQNGIEDFKAHAFF  284

         **************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVKM KSTERIYAMK ILNKWEMLKR AETACFREER DVLVNGDCQW 60

ITTLHYAFQD ENYLYLVMDY YVGGDLLTLL SKFEDKLPED MARFYIGEMV LAIHSIHQLH 120

YVHRDIKPDN VLLDMNGHIR LADFGSCLKM NDDGTVQSSV AVGTPDYISP EILQAMEDGM 180

GKYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HEERFQFPSH VTDVSEEAKD 240

LIQRLICSRE RRLGQNGIED FKAHAFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>

Gene Ontology

GO:0042641	; C:actomyosin
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0031032	; P:actomyosin structure organization
GO:0016477	; P:cell migration
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013