EKS-ORA-00169

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00169

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	471.7	6.7E-142	310	579	270

Status

Unreviewed

Ensembl Protein

ENSOANP00000023083

UniProt Accession

F7DST7;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK2

Gene Synonyms/Alias

LIMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000014650	ENSOANP00000023083	ENSOANT00000023087

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

617

Protein Sequence
(FASTA)

MGSYLSVPAY FTSRDPFRCS ECQDPLTNWY YEKDGKLYCH KDYWGKFGEF CHGCSLLMTG 60

PVMVAGEYKY HPECFACMSC KVIIEDGDAY ALVQHATLYC GKCHNEVVLM PMFERLSTES 120

VQDQLPYSVT LISMPVTTDG KRGFSVTVDS ACSNYATTVQ VKEVSRLHIS PSIRNAIHPG 180

DRILEINGVP VRTLQVDEVE EAISTTSRVL QLLIEHDPVS QRLDQLRLDA RLPAHLKNTA 240

SLHPVGTLDA KENLEGTLRR RSLRRSNSIS KSPGPSSPKE PLLLSRDISR SESLRCSSSY 300

SQQIFRPCDL IHGEVLGKGF FGQAIKVTHK ATGKVMVMKE LIRCDEETQK TFLTEVKVMR 360

ALDHPNVLKF IGVLYKDKKL NLLTEYIEGG TLKDFLRSVD PFPWQQKVSF AKGIASGMAY 420

LHSKCIIHRD LNSHNCLIKL DKTVVVADFG LSRLIVEERK KPPVEKASTK KRTLRKSDRK 480

KRYTVVGNPY WMAPEMLNGK SYDETVDVFS FGIVLCEIIG QVYADPDCLP RTLDFGLNVK 540

LFWEKFVPTD CPPAFFPLAA VCCKLEPESR PPFSKLEDSF EALSLYLGEL AIPLPSELEE 600

IDHNVSMDYG LSRDSLP 617

Nucleotide Sequence
(FASTA)

ATGGGGAGTT ACTTGTCCGT TCCGGCTTAC TTCACTTCCA GAGATCCTTT TCGGTGTTCT 60

GAATGTCAGG ATCCCCTCAC CAACTGGTAC TATGAAAAAG ATGGGAAACT TTACTGCCAC 120

AAGGACTACT GGGGGAAGTT TGGGGAGTTC TGCCATGGCT GCTCCCTACT AATGACTGGC 180

CCCGTCATGG TGGCTGGAGA GTATAAATAC CACCCAGAAT GCTTCGCTTG TATGAGTTGC 240

AAGGTAATCA TTGAAGATGG AGACGCATAC GCACTGGTTC AGCATGCTAC CCTGTACTGT 300

GGGAAATGCC ACAATGAGGT TGTGCTGATG CCCATGTTTG AAAGGCTTTC CACGGAGTCT 360

GTGCAAGACC AATTGCCCTA CTCGGTCACC CTCATCTCCA TGCCGGTCAC CACCGACGGC 420

AAGAGAGGCT TCTCTGTGAC AGTGGACAGT GCCTGTTCCA ACTACGCCAC CACTGTGCAG 480

GTGAAAGAAG TCAGCCGGCT ACACATCAGC CCCAGTATAC GAAATGCCAT CCACCCAGGG 540

GACCGCATCC TGGAGATCAA CGGGGTCCCT GTCCGGACGC TGCAGGTGGA CGAGGTGGAA 600

GAGGCGATTA GTACGACGAG CCGGGTGCTT CAGCTATTGA TTGAGCACGA CCCCGTATCC 660

CAGCGCCTGG ACCAGCTGCG ACTAGATGCA CGACTACCAG CTCACCTGAA GAATACCGCC 720

TCCCTTCACC CGGTCGGCAC GCTGGATGCC AAAGAGAACC TTGAAGGGAC GCTCCGGAGA 780

CGCTCACTCA GGCGCAGTAA CAGCATTTCC AAGTCCCCGG GTCCCAGCTC CCCAAAGGAA 840

CCCTTGCTGC TGAGTCGGGA CATCAGTCGC TCAGAATCCC TCCGCTGCTC CAGCAGCTAT 900

TCCCAGCAGA TCTTCCGACC CTGTGACCTG ATCCATGGGG AGGTCCTGGG AAAAGGCTTC 960

TTTGGGCAGG CCATCAAGGT AACACACAAA GCCACAGGCA AGGTCATGGT CATGAAGGAG 1020

TTAATTCGGT GTGATGAGGA GACACAGAAG ACCTTTTTAA CAGAGGTGAA AGTGATGCGG 1080

GCTCTGGATC ACCCCAACGT GCTCAAGTTC ATTGGCGTCT TGTACAAGGA CAAGAAGCTC 1140

AATCTCCTGA CGGAGTATAT CGAAGGGGGC ACGCTGAAAG ACTTTCTCCG GAGTGTGGAC 1200

CCATTTCCCT GGCAGCAGAA GGTCAGCTTT GCCAAAGGAA TTGCCTCAGG AATGGCCTAT 1260

CTGCATTCCA AGTGCATCAT TCACCGAGAC CTGAACTCAC ACAACTGCCT CATCAAACTG 1320

GACAAAACCG TTGTGGTGGC GGATTTTGGG CTGTCACGAC TCATAGTGGA AGAGAGAAAG 1380

AAGCCTCCCG TAGAGAAGGC TTCCACCAAG AAACGCACCC TGCGGAAGAG TGACCGCAAG 1440

AAACGCTATA CAGTTGTGGG GAACCCTTAC TGGATGGCTC CAGAAATGCT AAATGGAAAG 1500

AGCTATGATG AGACTGTGGA CGTCTTCTCC TTTGGGATCG TTCTTTGTGA GATCATCGGC 1560

CAAGTGTATG CTGACCCTGA TTGCCTTCCC CGCACACTGG ACTTTGGACT CAACGTAAAA 1620

CTTTTCTGGG AGAAATTCGT CCCCACGGAC TGTCCTCCAG CCTTCTTCCC TCTGGCGGCT 1680

GTCTGCTGCA AACTGGAACC CGAGAGCAGA CCTCCATTCT CGAAACTGGA GGACTCCTTT 1740

GAGGCACTCT CCCTCTACCT TGGAGAATTG GCGATCCCGC TCCCCTCTGA GCTGGAGGAG 1800

ATAGACCATA ATGTGAGCAT GGATTACGGA CTGAGCCGGG ACTCACTCCC CTAG 1854

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkGff++++kvth+a+G+vmv+kelir+dee++k++l+evk++r l+hpnvlk

Q: 310   LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRALDHPNVLK  369

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         fiGvl+kdkkl+llteyiegGtlk++l+s +++pw+q+v++ak+iasG++ylhsk+iihr

Q: 370   FIGVLYKDKKLNLLTEYIEGGTLKDFLRSVDPFPWQQKVSFAKGIASGMAYLHSKCIIHR  429

         ************************************************************

S: 121   dlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvGsP  174

         dlns+ncl++ dk+vvvadfGl+rl+veerkk+      +k+r+l+k+drkkr+tvvG+P

Q: 430   DLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPpvekasTKKRTLRKSDRKKRYTVVGNP  489

         *******************************999999999********************

S: 175   ywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvae  234

         ywmaPe+l+gksyde+vdvfsfGivlceii++v+adPd+lPrt dfgl+vk f+ek+v++

Q: 490   YWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPT  549

         ************************************************************

S: 235   dcPeaflklavvccdldpesrpsfeelekk  264

         dcP+af++la+vcc+l+pesrp+f++le++

Q: 550   DCPPAFFPLAAVCCKLEPESRPPFSKLEDS  579

         ***************************986

Domain Sequence
(FASTA)

LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RALDHPNVLK 60

FIGVLYKDKK LNLLTEYIEG GTLKDFLRSV DPFPWQQKVS FAKGIASGMA YLHSKCIIHR 120

DLNSHNCLIK LDKTVVVADF GLSRLIVEER KKPPVEKAST KKRTLRKSDR KKRYTVVGNP 180

YWMAPEMLNG KSYDETVDVF SFGIVLCEII GQVYADPDCL PRTLDFGLNV KLFWEKFVPT 240

DCPPAFFPLA AVCCKLEPES RPPFSKLEDS 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005801	; C:cis-Golgi network
GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 1.
PS50023	; LIM_DOMAIN_2; 1.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013