EKS-ORA-00121

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00121

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/CDC7	454.2	2.6E-136	24	409	386

Status

Unreviewed

Ensembl Protein

ENSOANP00000023290

UniProt Accession

F7E9B3;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC7

Gene Synonyms/Alias

CDC7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000014786	ENSOANP00000023290	ENSOANT00000023294

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

410

Protein Sequence
(FASTA)

FLSSGVKKDI EKLYEAVPQL GNVFKIEDKI GEGTFSSVYL ATAQLQIGPE EKIALKHLIP 60

TSHPVRIAAE LQCLTVAGGQ DNVMGVKYCF RKDDHVVIAM PYLEHESFLD ILNSVCFDEV 120

REYMFNLFKA LRRIHQFGIV HRDVKPSNFL YNRRLKEYAL VDFGLAQGTR DTKIELLKVV 180

QPEAQRESRP QIKPHRVTGT KVSLALPEPK EGAPHSALKT SVKRPYSHSQ IQIKQGKDGK 240

EGSVGLSAQR SVFGERNFNI HSSISHESPA VKIVKQSKTM DLASRKMTKK KVVSTKGLNS 300

GVMRKAGSAC PTNLTCECYA TDKVCSVCLS RKQQVAPRAG TPGFRAPEVL TKCPNQTTAI 360

DMWSAGVIFL SLLSGRYPFY KASDDLTALA QIMTIRGSRE TIQAAKTFGE 410

Nucleotide Sequence
(FASTA)

TTTCTTTCCT CAGGAGTTAA AAAAGATATT GAAAAACTTT ACGAAGCCGT GCCACAGCTT 60

GGTAATGTAT TTAAAATTGA GGATAAAATC GGAGAAGGCA CATTCAGTTC TGTTTACTTG 120

GCCACAGCGC AGTTACAAAT AGGACCTGAA GAGAAAATTG CTCTGAAACA TTTAATTCCA 180

ACCAGCCATC CAGTAAGAAT TGCAGCTGAA CTTCAGTGCC TTACCGTAGC TGGGGGCCAG 240

GACAACGTCA TGGGAGTTAA ATACTGCTTT AGAAAAGATG ATCATGTGGT TATTGCTATG 300

CCGTATTTAG AGCATGAATC CTTTCTGGAT ATCTTGAACT CTGTTTGCTT TGATGAAGTA 360

CGGGAATATA TGTTTAATCT ATTTAAAGCA TTAAGGCGTA TCCATCAGTT TGGCATTGTA 420

CACCGTGATG TCAAACCTAG CAATTTCCTG TATAATAGAC GCCTGAAAGA GTATGCCTTA 480

GTAGACTTTG GCTTGGCCCA GGGAACCCGT GACACGAAGA TAGAGCTTCT CAAAGTCGTC 540

CAGCCCGAAG CCCAGCGAGA GAGCCGTCCA CAAATCAAGC CTCACAGAGT CACCGGAACC 600

AAGGTTTCTT TGGCTCTACC AGAACCTAAG GAAGGAGCTC CACACTCAGC TCTGAAAACG 660

TCCGTTAAAA GGCCCTACTC CCACTCACAA ATTCAGATTA AACAAGGAAA AGACGGAAAG 720

GAAGGATCTG TAGGCCTTTC TGCCCAGCGC TCTGTTTTTG GAGAAAGAAA TTTCAATATA 780

CACAGCTCCA TTTCACATGA GAGCCCTGCA GTGAAAATTG TAAAACAGTC AAAGACTATG 840

GATCTCGCTT CCCGAAAGAT GACAAAGAAG AAGGTTGTTT CTACTAAAGG TCTGAATAGT 900

GGTGTGATGA GGAAAGCTGG CAGTGCTTGC CCAACTAATT TGACCTGTGA ATGTTATGCA 960

ACAGATAAAG TTTGCAGTGT TTGCCTGTCG AGGAAGCAGC AAGTTGCCCC TAGGGCAGGA 1020

ACACCAGGAT TCAGAGCACC AGAGGTCCTG ACTAAGTGTC CTAACCAAAC TACAGCAATT 1080

GACATGTGGT CGGCAGGTGT CATATTCCTT TCTCTGCTAA GTGGACGTTA TCCATTTTAC 1140

AAAGCGAGTG ATGATTTAAC GGCTTTGGCA CAGATTATGA CAATTCGTGG ATCCAGGGAA 1200

ACGATCCAGG CTGCTAAAAC TTTTGGTGAG 1230

Domain Profile

S: 1     fkikdkiGeGtfssvylataqleegleekialkhliptshPeriaaeLelltvlgGqenv  60

         fki+dkiGeGtfssvylataql+ g+eekialkhliptshP riaaeL++ltv+gGq+nv

Q: 24    FKIEDKIGEGTFSSVYLATAQLQIGPEEKIALKHLIPTSHPVRIAAELQCLTVAGGQDNV  83

         9***********************************************************

S: 61    vglkecfrkndsvvivlpylehesfldllrslsfqevreYlrnLlvalkrvhkfgivhrD  120

         +g+k+cfrk+d+vvi++pylehesfld+l+s+ f+evreY++nL++al+r+h+fgivhrD

Q: 84    MGVKYCFRKDDHVVIAMPYLEHESFLDILNSVCFDEVREYMFNLFKALRRIHQFGIVHRD  143

         ************************************************************

S: 121   vkpsnfLynrrlkkfaLvDfGLaq.........seaqkeecsrnllsaavekevd.....  166

         vkpsnfLynrrlk++aLvDfGLaq                   + ++ ++++e+

Q: 144   VKPSNFLYNRRLKEYALVDFGLAQgtrdtkielL---------KVVQPEAQRESRpqikp  194

         ************************4444444440.........33444444444455666

S: 167   ............................................................  166

Q: 195   hrvtgtkvslalpepkegaphsalktsvkrpyshsqiqikqgkdgkegsvglsaqrsvfg  254

         6666777778889999999*****************************************

S: 167   ............................................................  166

Q: 255   ernfnihssishespavkivkqsktmdlasrkmtkkkvvstkglnsgvmrkagsacptnl  314

         ************************************************************

S: 167   tcdcygtdkvcsvclsrrqqvanraGtpGfraPevLlkipdqttaiDiwsaGvilLslls  226

         tc+cy+tdkvcsvclsr+qqva+raGtpGfraPevL+k+p+qttaiD+wsaGvi+Lslls

Q: 315   TCECYATDKVCSVCLSRKQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLS  374

         ************************************************************

S: 227   gryPffkasddlealaeivtilGsreiikaakafg  261

         gryPf+kasddl+ala+i+ti+Gsre+i+aak+fg

Q: 375   GRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFG  409

         **********************************9

Domain Sequence
(FASTA)

FKIEDKIGEG TFSSVYLATA QLQIGPEEKI ALKHLIPTSH PVRIAAELQC LTVAGGQDNV 60

MGVKYCFRKD DHVVIAMPYL EHESFLDILN SVCFDEVREY MFNLFKALRR IHQFGIVHRD 120

VKPSNFLYNR RLKEYALVDF GLAQGTRDTK IELLKVVQPE AQRESRPQIK PHRVTGTKVS 180

LALPEPKEGA PHSALKTSVK RPYSHSQIQI KQGKDGKEGS VGLSAQRSVF GERNFNIHSS 240

ISHESPAVKI VKQSKTMDLA SRKMTKKKVV STKGLNSGVM RKAGSACPTN LTCECYATDK 300

VCSVCLSRKQ QVAPRAGTPG FRAPEVLTKC PNQTTAIDMW SAGVIFLSLL SGRYPFYKAS 360

DDLTALAQIM TIRGSRETIQ AAKTFG 386

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008284	; P:positive regulation of cell proliferation
GO:0033261	; P:regulation of S phase

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013