EKS-ORA-00241

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00241

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	465.8	5.8E-140	140	427	288

Status

Unreviewed

Ensembl Protein

ENSOANP00000023412

UniProt Accession

F6X0S8;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000014872	ENSOANP00000023412	ENSOANT00000023416

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

438

Protein Sequence
(FASTA)

MCIAEKDLIP RDRPFVCALS AKDGIVTKPY CCDRDHCNKI ELPTTGPPRE KPSPNLGPVE 60

LAAVIAGPVC FVCISLMLIL YICHNRPTIH IRVPNEEDPS LDRPFISEGT TLKDLIYDMT 120

TSGSGSGLPL LVQRTIARTI VLQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE 180

AEIYQTVMLR HENILGFIAA DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMIKL 240

ALSTASGLAH LHMEIVGTQG KPAIAHRDLK SKNILVKKNG TCCIADLGLA VRHDSATDTI 300

DIAPNHRVGT KRYMAPEVLD DSINMKHFES FKRADIYAMG LVFWEIARRC SIGGIHEDYQ 360

LPYYDLVPSD PSVEEMRKIV CEQKLRPNIP NRWQSGEALR VMAKIMRECW YANGAARLTA 420

LRIKKTLSQL SQQEGIKM 438

Nucleotide Sequence
(FASTA)

ATGTGCATCG CAGAAAAGGA TCTGATTCCC CGAGACAGGC CATTTGTGTG CGCACTCTCT 60

GCCAAGGATG GCATAGTGAC CAAACCGTAT TGCTGTGACA GAGATCACTG CAATAAGATA 120

GAGCTGCCCA CCACAGGCCC TCCTCGCGAG AAGCCGTCTC CGAACCTAGG TCCGGTGGAG 180

TTGGCCGCTG TCATCGCTGG ACCCGTCTGC TTCGTCTGCA TTTCCCTCAT GCTGATCTTG 240

TACATCTGTC ACAATCGTCC CACCATTCAC ATCCGGGTTC CCAACGAAGA AGACCCCTCC 300

TTAGATCGCC CTTTTATCTC CGAGGGCACT ACGTTAAAAG ACTTAATTTA CGACATGACA 360

ACATCGGGAT CGGGGTCAGG TTTACCCTTA CTTGTTCAAA GGACAATTGC AAGGACTATC 420

GTGTTGCAAG AAAGTATAGG GAAAGGTCGT TTTGGAGAAG TCTGGCGAGG AAAATGGCGA 480

GGAGAAGAAG TTGCTGTGAA AATATTTTCC TCGAGAGAAG AACGGTCCTG GTTCCGTGAG 540

GCAGAGATTT ATCAGACGGT GATGTTACGT CATGAAAACA TTCTGGGATT CATCGCAGCT 600

GACAATAAAG ACAATGGTAC GTGGACTCAG CTCTGGTTGG TGTCGGATTA TCATGAACAT 660

GGATCCCTTT TTGATTATTT AAACAGATAT ACCGTCACTG TGGAAGGAAT GATCAAGTTA 720

GCTCTGTCCA CCGCCAGTGG ACTGGCACAT CTTCACATGG AGATTGTCGG TACCCAAGGG 780

AAGCCAGCTA TTGCCCATAG AGATTTGAAA TCCAAAAACA TCTTAGTCAA AAAGAATGGG 840

ACGTGCTGCA TTGCCGACTT GGGATTGGCA GTAAGACACG ATTCAGCCAC AGATACAATC 900

GATATTGCCC CGAACCACCG AGTGGGAACT AAAAGGTACA TGGCCCCTGA AGTTCTAGAT 960

GATTCCATAA ATATGAAACA CTTTGAATCA TTCAAACGAG CTGACATCTA TGCAATGGGA 1020

TTAGTGTTCT GGGAAATAGC TCGGCGATGT TCAATTGGTG GAATCCATGA AGACTACCAG 1080

TTGCCTTACT ATGACCTGGT ACCTTCGGAT CCCTCCGTTG AAGAGATGCG GAAGATCGTT 1140

TGTGAACAGA AGCTTCGGCC CAATATCCCC AACCGGTGGC AGAGCGGGGA AGCCTTGCGC 1200

GTGATGGCCA AAATTATGCG GGAGTGTTGG TACGCCAATG GAGCCGCGAG GCTCACGGCT 1260

TTGCGCATCA AGAAGACTCT GTCACAGCTC AGCCAGCAGG AGGGCATAAA AATGTAA 1317

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 140   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  199

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 200   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  259

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 260   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  317

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 318   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  376

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +++v+e+klrP+ip++w++ eal++++k+++ecW+a+++aRltalr+kk+l

Q: 377   RKIVCEQKLRPNIPNRWQSGEALRVMAKIMRECWYANGAARLTALRIKKTL  427

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKI 240

VCEQKLRPNI PNRWQSGEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0044459	; C:plasma membrane part
GO:0043235	; C:receptor complex
GO:0005923	; C:tight junction
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000186	; P:activation of MAPKK activity
GO:0071560	; P:cellular response to transforming growth factor beta stimulus
GO:0030199	; P:collagen fibril organization
GO:0043542	; P:endothelial cell migration
GO:0006917	; P:induction of apoptosis
GO:0043066	; P:negative regulation of apoptotic process
GO:0032331	; P:negative regulation of chondrocyte differentiation
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0030307	; P:positive regulation of cell growth
GO:0008284	; P:positive regulation of cell proliferation
GO:0051272	; P:positive regulation of cellular component movement
GO:0051491	; P:positive regulation of filopodium assembly
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0043393	; P:regulation of protein binding
GO:0031396	; P:regulation of protein ubiquitination
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013