EKS-ORA-00101
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00101
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Met475.06.6E-143679939261
StatusUnreviewed
Ensembl ProteinENSOANP00000023659
UniProt AccessionF6W2E4;
Protein Name
Protein Synonyms/Alias Hepatocyte growth factor receptor;
Gene NameMET
Gene Synonyms/Alias MET;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000015031ENSOANP00000023659ENSOANT00000023663
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length982
Protein Sequence
(FASTA)
QTFQWNSSGC EVRDDEYRME FTTPLQRVDL SMGKFSHVLL TSISTFIKGN LTVANLGTAE 60
GRFMQVVISR SDPPSPHVDF LLDNHPVSPE VIVVNSSMPD GYTLVITGKK ITKIPLNGLG 120
CDHFKSCRQC LSAPSFVQCG WCDDRCTTAE KCDYGLWTQD TCPPTIFEII PSSAPLEGGT 180
MLTVCGWDFG FQKNNKFELR KTKVLVGNQS CTLFFNESST NKLKCTAGPS TQPRLNISIS 240
VSNAQGGRRS KTFSYVDPKI TSISPRYGPI AGGTLLTLTG KYLNCGSSRH ISIGGKTCTL 300
RSVSEHVLEC YTPSQTVPTL YAVKMKIDLA NREAGTFIYK EDPVIHEIHP TKSFLSGGST 360
ITGFGKNLNG SSAPKMIIQV AEVGRNFTVA CQSRSNAEII CCTTPSLQQL NLPPPFKTKA 420
FFVFDGVQSA NFDLIYVHNP VFKLFEKPVM ISMGNKHVLE IKGDHIDSEA VKGEVLKVGN 480
KSCENVLLNL ESVFCTVPRD LLKVNTELNI EWQQAVSSTI LGKVIVLPDQ NFTGLIAGVA 540
SISVLLLLFL GLFLWMKKKK QIKDLGSELV RYDPRVHTPH LDRLVSARSI SPTAEMVSNE 600
SVDYRATFPE DQFPNSSQNG SCRQAHYPLA DLSPILSSGD SNPSSPLLQS NVHIDISALN 660
PDLVQAVQHV VIGPDSLMVH FTEIIGRGHF GCVYHGTLLD NDDKKIHCAV KSLNRITDIE 720
EVSQFLTEGI IMKDFSHPNV LSLLGICLRR EGSPLVVLPY MKHGDLRNFI RNESHNPTVK 780
DLIGFGLQVA KGMKYLASKK FVHRDLAARN CMLDEKFTVK VADFGLARDM YDKEYYSVHN 840
KTGAKLPVKW MALESLQTQK FTSKSDVWSF GVLLWELMTR GAPPYPDVNT FDITVYLLQG 900
RRLLQPEYCP DPLFEVMLKC WHPNAEMRPS FSELVSKIAV IFSTFIGEHY VHVNATYVNV 960
KCVAPYPSLL SSQDAPDRVV DT 982
Nucleotide Sequence
(FASTA)
CAGACTTTCC AGTGGAATTC TTCGGGCTGC GAGGTGCGTG ATGACGAATA CCGCATGGAG 60
TTCACCACCC CTTTACAGCG CGTCGACCTG TCCATGGGGA AGTTCAGTCA TGTCCTCCTG 120
ACGTCGATAT CCACCTTCAT CAAAGGGAAC CTCACCGTGG CCAATCTTGG CACCGCCGAG 180
GGGCGATTCA TGCAGGTTGT GATTTCTCGC TCAGATCCAC CTTCCCCTCA TGTGGATTTT 240
CTTCTGGACA ACCACCCGGT CTCCCCCGAA GTCATCGTGG TCAATTCTTC AATGCCAGAT 300
GGCTACACGC TGGTCATCAC GGGCAAGAAG ATAACGAAGA TCCCACTGAA TGGCCTTGGC 360
TGTGATCACT TCAAGTCCTG CAGGCAGTGT CTGTCGGCTC CCTCTTTCGT GCAGTGCGGT 420
TGGTGTGACG ACCGGTGCAC TACTGCAGAG AAGTGCGATT ATGGGCTGTG GACCCAAGAC 480
ACCTGCCCAC CCACAATTTT TGAGATAATC CCCAGCAGTG CACCCCTGGA AGGAGGAACC 540
ATGCTGACTG TGTGTGGCTG GGACTTCGGA TTCCAAAAGA ATAACAAGTT TGAGCTGAGG 600
AAAACCAAGG TTCTCGTCGG CAACCAGAGC TGCACTCTGT TCTTCAACGA GAGCTCCACA 660
AACAAGCTGA AATGCACTGC CGGGCCTTCC ACCCAGCCCC GCCTCAACAT CTCCATCAGT 720
GTTTCCAATG CCCAAGGCGG AAGACGATCC AAAACGTTCT CGTACGTGGA CCCTAAGATA 780
ACCAGTATTT CTCCCCGCTA TGGTCCCATA GCTGGAGGAA CTTTACTCAC CTTAACTGGG 840
AAGTACCTGA ACTGTGGAAG TTCCAGACAC ATTTCCATCG GCGGAAAAAC ATGCACCTTG 900
AGGAGTGTGT CGGAACACGT TCTAGAATGC TACACGCCTT CCCAGACCGT ACCCACCCTC 960
TATGCGGTTA AGATGAAGAT CGACTTGGCC AATCGCGAAG CCGGCACTTT CATCTACAAG 1020
GAGGACCCCG TCATCCATGA GATTCACCCA ACCAAATCAT TCCTTAGTGG CGGAAGCACA 1080
ATCACCGGAT TTGGGAAAAA CCTCAACGGA TCCAGTGCTC CTAAGATGAT CATCCAAGTC 1140
GCAGAAGTGG GCAGGAACTT CACAGTAGCA TGTCAAAGTC GTTCTAATGC AGAAATAATC 1200
TGTTGTACGA CTCCTTCACT GCAGCAACTA AATCTGCCAC CCCCCTTCAA AACGAAAGCA 1260
TTTTTTGTAT TTGATGGGGT CCAGTCTGCT AACTTTGACC TCATTTATGT GCACAATCCA 1320
GTGTTTAAGC TGTTTGAAAA GCCAGTGATG ATCTCAATGG GCAACAAACA TGTACTGGAA 1380
ATTAAGGGAG ACCATATTGA TTCCGAAGCA GTCAAAGGGG AGGTGCTGAA AGTTGGAAAT 1440
AAAAGCTGCG AGAACGTCCT CTTGAACTTG GAATCTGTAT TCTGCACGGT CCCCAGGGAT 1500
CTGCTGAAAG TGAATACGGA GTTAAATATA GAGTGGCAGC AGGCAGTCTC CTCGACCATC 1560
CTTGGAAAGG TGATTGTTCT CCCTGACCAG AATTTCACAG GACTAATCGC CGGAGTGGCC 1620
TCCATCTCGG TCTTACTCTT GTTATTCCTG GGCCTTTTTC TGTGGATGAA AAAGAAGAAA 1680
CAAATTAAAG ATCTGGGCAG TGAATTAGTT CGCTATGACC CAAGAGTTCA CACGCCTCAC 1740
CTGGACCGCC TTGTAAGCGC CAGGAGTATC AGCCCCACGG CGGAAATGGT TTCCAATGAA 1800
TCTGTGGACT ACCGAGCGAC GTTCCCAGAA GATCAGTTTC CCAATTCCTC TCAGAACGGA 1860
TCATGCAGAC AAGCCCATTA TCCCCTGGCC GACCTGTCGC CCATTCTCTC CAGTGGGGAC 1920
TCCAACCCAT CTAGCCCACT TCTACAGAGC AACGTTCACA TTGACATCAG CGCCCTGAAC 1980
CCAGATCTAG TCCAAGCCGT TCAGCACGTG GTGATCGGAC CAGACAGCCT GATGGTGCAT 2040
TTCACTGAAA TCATAGGAAG AGGTCATTTT GGGTGTGTGT ATCACGGAAC TCTGTTGGAT 2100
AATGATGACA AAAAAATCCA CTGTGCTGTG AAGTCCTTGA ATAGAATCAC TGACATCGAG 2160
GAGGTGTCAC AGTTCCTCAC CGAGGGGATC ATCATGAAGG ATTTCAGCCA CCCCAACGTC 2220
CTCTCGCTGC TGGGGATCTG TCTCCGCAGG GAAGGGTCAC CCCTGGTGGT CTTACCCTAC 2280
ATGAAGCATG GAGACCTACG CAACTTTATA AGGAACGAAT CTCACAATCC CACCGTGAAA 2340
GACCTCATCG GATTTGGCCT CCAAGTGGCC AAAGGTATGA AATACCTTGC CAGCAAAAAG 2400
TTTGTCCACC GAGACTTGGC TGCCCGAAAT TGTATGCTGG ATGAAAAATT CACTGTCAAG 2460
GTGGCTGATT TTGGCCTGGC CCGAGATATG TACGATAAAG AATATTACAG CGTGCACAAT 2520
AAAACGGGAG CCAAGCTGCC AGTGAAATGG ATGGCTCTCG AAAGTCTGCA GACACAGAAG 2580
TTCACCTCCA AGTCAGATGT GTGGTCCTTC GGCGTCCTTC TCTGGGAGCT GATGACACGA 2640
GGCGCTCCCC CGTATCCCGA CGTGAACACT TTCGATATAA CGGTCTACCT GCTGCAAGGA 2700
AGGAGGCTGC TACAGCCAGA ATACTGTCCG GACCCACTAT TTGAAGTCAT GCTAAAATGC 2760
TGGCATCCCA ACGCTGAAAT GCGCCCGTCC TTCTCGGAAC TGGTTTCAAA GATAGCGGTC 2820
ATCTTCTCCA CTTTCATCGG CGAGCATTAC GTCCACGTGA ACGCCACCTA CGTCAACGTC 2880
AAGTGCGTGG CGCCCTACCC ATCCCTCCTG TCCTCGCAGG ACGCCCCAGA CAGGGTTGTG 2940
GACACATGA 2949
Domain Profile
S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60
         v++ e+iG+GhfG+vy+g+l+d+++kki++avksl+ritdie+v++fl+eg++mk+++hp
Q: 679   VHFTEIIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHP  738
         7899********************************************************
S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120
         nvlsllGi+l+ eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas
Q: 739   NVLSLLGICLRREGSPLVVLPYMKHGDLRNFIRNESHNPTVKDLIGFGLQVAKGMKYLAS  798
         ************************************************************
S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180
         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt
Q: 799   KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  858
         ************************************************************
S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240
         +k ft+ksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd l++vm
Q: 859   QK-FTSKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLFEVM  917
         **.*********************************************************
S: 241   lkcwkakpaerpqfsdlvsiis  262
         lkcw++++++rp+fs+lvs+i+
Q: 918   LKCWHPNAEMRPSFSELVSKIA  939
         *******************996
Domain Sequence
(FASTA)
VHFTEIIGRG HFGCVYHGTL LDNDDKKIHC AVKSLNRITD IEEVSQFLTE GIIMKDFSHP 60
NVLSLLGICL RREGSPLVVL PYMKHGDLRN FIRNESHNPT VKDLIGFGLQ VAKGMKYLAS 120
KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180
QKFTSKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLFEVML 240
KCWHPNAEMR PSFSELVSKI A 261
KeywordATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00115
EKS-ANC-00111
EKS-BOT-00123
EKS-CAE-00100
EKS-CAJ-00125
EKS-CAF-00126
EKS-CAP-00120
EKS-CII-00062
EKS-CIS-00142
EKS-DAR-00379
EKS-EQC-00119
EKS-FEC-00114
EKS-GAG-00103
EKS-GAA-00142
EKS-GOG-00122
EKS-HOS-00125
EKS-ICT-00115
EKS-LAC-00128
EKS-LOA-00118
EKS-MAM-00119
EKS-MEG-00093
EKS-MOD-00120
EKS-MUM-00124
EKS-MUP-00126
EKS-MYL-00133
EKS-NOL-00115
EKS-OCP-00079
EKS-ORN-00150
EKS-ORC-00115
EKS-ORL-00139
EKS-OTG-00126
EKS-PAT-00111
EKS-PES-00105
EKS-PEM-00067
EKS-POA-00116
EKS-RAN-00120
EKS-SAH-00115
EKS-SUS-00109
EKS-TAG-00152
EKS-TAR-00154
EKS-TEN-00142
EKS-VIP-00058
EKS-XET-00102
Gene Ontology
GO:0009925; C:basal plasma membrane
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005008; F:hepatocyte growth factor-activated receptor activity
GO:0000187; P:activation of MAPK activity
GO:0042593; P:glucose homeostasis
GO:0007275; P:multicellular organismal development
GO:0014812; P:muscle cell migration
GO:0051450; P:myoblast proliferation
GO:0010828; P:positive regulation of glucose transport
GO:0046777; P:protein autophosphorylation
GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
KEGG
InterPros
IPR013783; Ig-like_fold.
IPR014756; Ig_E-set.
IPR002909; IPT_TIG_rcpt.
IPR011009; Kinase-like_dom.
IPR003659; Plexin-like.
IPR016201; Plexin-like_fold.
IPR002165; Plexin_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001627; Semaphorin/CD100_Ag.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR015943; WD40/YVTN_repeat-like_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF01437; PSI; 1.
PF01403; Sema; 1.
PF01833; TIG; 3.
SMARTs
SM00429; IPT; 4.
SM00423; PSI; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS51004; SEMA; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013