EKS-ORA-00142
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00142
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb344.34.7E-103395658264
StatusUnreviewed
Ensembl ProteinENSOANP00000023739
UniProt AccessionF6PQK5;
Protein Name
Protein Synonyms/Alias
Gene NameRPS6KA1
Gene Synonyms/Alias RPS6KA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000015078ENSOANP00000023739ENSOANT00000023743
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length718
Protein Sequence
(FASTA)
AKSDYVWLER SAVDSARKDE GVVKEIHITH HVKEGSEKAD PSQFELLKVL GQGSFGKVFL 60
VRKVTQPDSG HLYAMKVLKK ATLKARSSHT TTQPAHFAPL MPTFSLCLHL IYPTSDLSPT 120
SCLWPRTASL FIPRQPQVMF TKEDVKFYLA ELALGLDHLH NLGIIYRDLK PENILLDQEG 180
HIKLTDFGLS KEAIDHEKKA YSFCGTVEYM APEVVNRQGH THSADWWSYG VLMFEMLTGS 240
LPFQGKDRKE TMTLILKAKL GMPQFLSNEA QSLLRALFKR NPANRLGSGT DGAEEIKRHV 300
FYSTIDWNKL YRREIKPPFK PAVAQPDDTF YFDTEFTSRT PKASTGTPPS FFPRFQLRGH 360
GLLEEDGQGK TTQGPPCISV VQQLHGKSLV FSDGYLVKET IGVGSFSVCK RCIHKATNME 420
YAVKVIDKDK RDPSEEIEIL LRYGQHPNII TLKDVYDDGK QVYLVTELMR GGELLDRILR 480
QKFFSEREAS SVLHTVCKTV EYLHSQGVVH RDLKPSNILY VDESGNPECI RICDFGFAKQ 540
LRAENGLLMT PCYTANFVAP EVGRGTGQGE RLQGVPHQSA GCLAGTVGKD MGLPGAARGE 600
LGQPGSEVTD VDISALELKE GRTSNAQRSQ IQDLVSKMLH VDPHQRLTAL QVLQHPWITQ 660
KDKLPQSQLR HQDVQLVKGA MEATYFALNS SKPTPKLKPI ESSILAQRRV KKLPSTTL 718
Nucleotide Sequence
(FASTA)
GCCAAGAGCG ACTACGTTTG GCTGGAGAGA TCCGCCGTGG ACTCCGCCCG GAAGGACGAA 60
GGCGTGGTCA AGGAGATCCA CATCACACAC CACGTGAAGG AAGGGTCGGA GAAGGCCGAC 120
CCGTCCCAGT TTGAGCTCTT GAAGGTCCTG GGCCAGGGCT CCTTCGGCAA AGTGTTCTTG 180
GTGAGGAAGG TCACCCAGCC AGACAGTGGG CACCTCTACG CCATGAAGGT GCTGAAGAAA 240
GCCACGCTGA AGGCTCGCTC CTCTCATACT ACAACACAGC CCGCACACTT CGCTCCCCTA 300
ATGCCAACCT TCTCACTGTG CCTCCATCTC ATCTATCCCA CCTCCGACCT CTCGCCCACG 360
TCCTGCCTCT GGCCTAGAAC TGCTTCCCTC TTCATCCCCC GTCAACCCCA GGTGATGTTC 420
ACGAAAGAAG ATGTGAAGTT TTACCTGGCG GAGCTGGCAC TAGGGCTGGA CCATCTTCAC 480
AACCTGGGCA TCATCTACCG GGACCTCAAG CCAGAGAACA TCCTCCTGGA CCAAGAGGGT 540
CACATCAAGC TCACAGATTT CGGCCTGAGC AAGGAGGCCA TCGACCACGA GAAGAAAGCT 600
TACTCCTTCT GCGGAACGGT CGAATACATG GCTCCCGAGG TGGTCAACCG CCAGGGCCAC 660
ACGCACAGTG CGGACTGGTG GTCCTACGGG GTGTTGATGT TTGAGATGCT CACCGGCTCG 720
CTGCCCTTCC AGGGGAAAGA CAGGAAGGAG ACGATGACGC TGATCCTCAA GGCGAAGTTG 780
GGAATGCCCC AGTTCCTGAG CAATGAAGCC CAGAGCCTTC TGCGTGCCCT GTTCAAGAGG 840
AATCCTGCCA ACCGTCTAGG GTCTGGCACC GACGGGGCCG AAGAGATCAA GCGCCACGTT 900
TTCTACTCCA CCATCGACTG GAACAAACTC TACCGTCGTG AGATCAAGCC CCCGTTCAAG 960
CCTGCCGTGG CCCAACCCGA CGACACCTTC TACTTTGACA CCGAGTTCAC GTCCCGCACG 1020
CCCAAGGCAT CGACTGGAAC CCCACCCAGC TTCTTTCCGC GGTTTCAGCT TCGTGGCCAC 1080
GGGCTGTTGG AGGAGGACGG TCAGGGGAAG ACCACTCAGG GCCCCCCGTG CATTTCGGTG 1140
GTGCAGCAGC TACACGGGAA GAGCCTGGTG TTCAGCGACG GCTACTTGGT CAAGGAGACC 1200
ATCGGCGTGG GCTCCTTCTC AGTGTGCAAG CGCTGCATCC ACAAGGCCAC CAACATGGAG 1260
TACGCCGTCA AGGTGATTGA CAAGGACAAG AGAGACCCCT CGGAGGAGAT CGAGATCCTG 1320
CTGCGCTACG GTCAGCACCC CAACATCATC ACGCTGAAGG ACGTGTACGA TGACGGGAAG 1380
CAGGTGTACT TGGTGACAGA ACTGATGCGG GGCGGCGAGC TACTGGATAG GATCCTGCGG 1440
CAGAAGTTCT TCTCAGAGCG GGAAGCCAGC TCGGTCCTGC ACACCGTCTG TAAAACCGTG 1500
GAGTACCTGC ACTCACAGGG GGTGGTGCAC AGGGACCTGA AGCCCAGCAA CATCCTCTAC 1560
GTGGATGAGT CCGGGAACCC CGAGTGTATC CGCATCTGCG ACTTCGGCTT CGCCAAGCAG 1620
CTGCGTGCCG AGAACGGGCT CCTCATGACG CCCTGCTACA CTGCCAACTT CGTAGCTCCG 1680
GAGGTGGGGC GGGGCACGGG GCAGGGGGAA AGGCTCCAGG GCGTACCACA CCAATCGGCG 1740
GGTTGCCTCG CTGGGACCGT GGGGAAGGAC ATGGGCCTCC CAGGGGCCGC TCGCGGGGAG 1800
CTCGGACAGC CCGGATCTGA AGTTACGGAT GTGGACATAA GTGCACTGGA GCTAAAGGAA 1860
GGGCGAACAT CAAATGCCCA AAGGTCACAG ATCCAAGATC TGGTTTCCAA GATGCTCCAT 1920
GTGGACCCGC ACCAGCGACT CACGGCGCTC CAGGTTCTGC AACACCCGTG GATCACGCAG 1980
AAGGACAAAC TCCCACAGAG CCAGCTGAGG CACCAAGACG TGCAGCTGGT GAAGGGCGCC 2040
ATGGAGGCCA CCTACTTCGC CCTCAACAGC TCCAAGCCGA CCCCCAAGCT GAAGCCCATC 2100
GAGTCGTCCA TTCTGGCACA GCGGAGGGTC AAAAAGCTGC CGTCCACCAC ACTGTGA 2157
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         y+vke++GvGs+svckrc+hkatn+e+avk+idk krd+seeieillry+qhpni+tlkd
Q: 395   YLVKETIGVGSFSVCKRCIHKATNMEYAVKVIDKDKRDPSEEIEILLRYGQHPNIITLKD  454
         689*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk vylv+el++GGelldri+++kffsereas++l+t++k+veylh+qGvvhrdlk
Q: 455   VYDDGKQVYLVTELMRGGELLDRILRQKFFSEREASSVLHTVCKTVEYLHSQGVVHRDLK  514
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGyde...a  177
         p+nilyvdes+n+e+i+i+dfGfak++raengll+tpcyt+nfvapev +  G  e   +
Q: 515   PSNILYVDESGNPECIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVGRGTGQGErlqG  574
         ************************************************999988772224
S: 178   cdlwslGvllytmla..GyvpfangpedtaeeilakikeGkfsls.Geawdsvseeakdl  234
             s G l  t+    G    a+g   ++   ++ +      l+ G + ++   + +dl
Q: 575   VPHQSAGCLAGTVGKdmGLPGAARGELGQPGSEVTDVDISALELKeGRTSNAQRSQIQDL  634
         556789988888754114444588999999999999999999996255666677899***
S: 235   vsklltvdpakrlkleqllkhswl  258
         vsk+l+vdp++rl++ q+l+h+w+
Q: 635   VSKMLHVDPHQRLTALQVLQHPWI  658
         ***********************8
Domain Sequence
(FASTA)
YLVKETIGVG SFSVCKRCIH KATNMEYAVK VIDKDKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKQVYL VTELMRGGEL LDRILRQKFF SEREASSVLH TVCKTVEYLH SQGVVHRDLK 120
PSNILYVDES GNPECIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVGR GTGQGERLQG 180
VPHQSAGCLA GTVGKDMGLP GAARGELGQP GSEVTDVDIS ALELKEGRTS NAQRSQIQDL 240
VSKMLHVDPH QRLTALQVLQ HPWI 264
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0004674; F:protein serine/threonine kinase activity
GO:0043066; P:negative regulation of apoptotic process
GO:2000491; P:positive regulation of hepatic stellate cell activation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013