EKS-ORA-00220

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00220

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	250.6	1.7E-74	977	1229	253

Status

Unreviewed

Ensembl Protein

ENSOANP00000024597

UniProt Accession

F7DR68;

Protein Name

Protein Synonyms/Alias

Gene Name

PASK

Gene Synonyms/Alias

PASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000015612	ENSOANP00000024597	ENSOANT00000024601

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1305

Protein Sequence
(FASTA)

MLLRFLPGDM EEPVKRSSAS EMNRSFPCIN KCHGRKNGLS KLCRSKTTLS EERWSSYCLS 60

SLTAQNICRG KLSGCRTRLE HSSLSGSAYS TPCCSFLNGL ATGSSGLSLP TPVCNPNKAI 120

FTVDGQTTEI LVVNDKACKL LGCSSHDLIG QKLSTLFSKT DDDVAEALSE ERMESDGRAA 180

VTFGIVVDIV GRNNEKIPVS VWMKRIKNEC GHCCVVVLEP VERISAWVTF QSDGKITSCD 240

LFFAQLYGYT SSEEVAGLQI ADLIPSVQIP PPGKKIPKNL EVQRTVGRAK EGTTFPLSLK 300

LKPRIPEGEP EETKTEPPSD YCFFSASIWV FTTISGLITL LPDGTIYGIN NSFALMLFGY 360

ERSELIGKSI TVLIPGFYNY MDPVDDSSLP LVHLVDCLEM ENMSSAEERK KSHAGDWHLA 420

SSAEVPEVNI FPAGDEVRSQ SEKLKLAGCE RGELSVRAHA QPRNGGGLPS NPSTPPGTSA 480

AGVDGLTAKN LPTHGEQPLS ENQQSRTYKE ESNTHPSLPD GHFPGKTDTR PSILDSSFKF 540

SVDPNGGSPP IKTQPEDRNV RVGGLLPVAR RESVDSGETS GHHLGEISKI EDLEDPQGYS 600

EKAFTPDGKE RGIESGTKDS IGPHSNASNI SFGTPTQDEP WQGMMSDSRP ERQTSAITEQ 660

LVKPNLVWTV GRSRFESGAD PPSMCGVRDG GIYGGHARLP IDCKTSGAAS NSEEANGPDI 720

KVHAICGDLK DLELNVIEGA VSGSWATSVD LRASSSFVGD ADTSEENIPS PIFDAPRRPG 780

SLKLTDASSI ESQIGQVGDG CLGDDDEDPS EVCKNFEESE GEGLLRNSDG LSARPKPVQQ 840

RLKTQATSTP VKTSSEPTAK IPDVKSEILE GSYTGSCYHR DGARLSMQFE VKRVELKDPA 900

ALFCCWVGKD FFQSHKEATA RTQLFLSSVP SSSQSIVEVS GFSLGEIMRT KRWFDDPPRV 960

MEMEILKACE GEYSEHYNTL TPIGSGAFGF VWTAKNKEEN KEVVVKFIWK NKILEDCWVE 1020

DPELGKVTRE ILILSEIQHP NIIKVLGVFE NEGFFQLVME KHGSGLDLFT FIDHHPSLDE 1080

PLASYMFRQL VSAVAYLRSK NILHRDIKDE NIIIAEDFTI KLIDFGSAAY MERGKLFYTF 1140

CGTIEYCSPE VLMGNPYRGP ELEMWSLGVT LYTLIFEENP FCELEEAMEA VLNPPYYVSE 1200

ELMNLVSGLL QPIPEQRTTL EKLFQDPWVI QPVNLANYTW EEVCPFAKPG SSHLKGQVLR 1260

TATGLGLEQR QDGKMDQSST PLDQDLGNCF TCQGDTAQEQ VLPRD 1305

Nucleotide Sequence
(FASTA)

ATGCTTCTTC GCTTTCTTCC AGGAGATATG GAAGAACCCG TTAAACGGAG TAGTGCCTCC 60

GAGATGAATA GATCCTTCCC GTGCATCAAC AAATGTCACG GCCGGAAGAA TGGACTCTCC 120

AAACTCTGCA GGAGTAAAAC GACCCTCTCG GAAGAGAGAT GGAGCTCCTA CTGCTTGTCT 180

TCACTGACGG CCCAAAATAT TTGTCGCGGC AAACTGAGCG GCTGTCGGAC CCGCCTGGAA 240

CATTCCTCTC TGTCCGGTTC GGCGTATAGT ACGCCCTGTT GCTCTTTTCT GAATGGGCTG 300

GCCACGGGAT CGTCCGGCCT TTCTCTACCC ACACCCGTGT GCAATCCAAA TAAAGCCATC 360

TTCACCGTTG ACGGACAGAC GACAGAGATC CTCGTCGTCA ACGATAAAGC CTGCAAGCTC 420

CTCGGCTGTA GCAGCCACGA TCTGATCGGC CAGAAACTGT CCACGCTGTT TTCCAAGACC 480

GACGACGACG TAGCGGAAGC TTTAAGTGAG GAGCGAATGG AGTCGGACGG ACGTGCCGCG 540

GTGACTTTTG GCATAGTGGT GGACATCGTT GGGCGCAACA ATGAGAAGAT TCCTGTGTCC 600

GTGTGGATGA AGAGGATAAA AAATGAGTGC GGTCACTGTT GTGTGGTTGT GCTGGAACCC 660

GTGGAAAGAA TCTCTGCTTG GGTCACCTTT CAAAGTGATG GAAAGATAAC ATCCTGTGAC 720

CTCTTCTTTG CTCAACTCTA TGGTTATACA TCTTCGGAGG AAGTCGCTGG GTTACAGATC 780

GCCGACCTGA TTCCTTCCGT GCAGATTCCT CCTCCTGGCA AGAAAATCCC AAAGAATCTC 840

GAAGTTCAAA GAACCGTTGG GAGAGCCAAG GAGGGCACTA CCTTTCCTCT GAGTTTAAAA 900

CTGAAACCCA GGATCCCAGA AGGGGAACCG GAAGAGACGA AAACAGAACC CCCTTCAGAC 960

TACTGTTTTT TCTCCGCTTC TATCTGGGTT TTCACCACCA TCAGTGGCCT CATCACTCTT 1020

CTACCGGATG GAACCATCTA TGGCATCAAC AACAGTTTTG CCTTAATGTT GTTTGGTTAT 1080

GAAAGGTCGG AGCTGATAGG GAAGAGCATC ACGGTCCTGA TTCCTGGGTT CTACAACTAT 1140

ATGGACCCAG TGGATGACAG TTCCTTGCCT TTGGTCCATC TTGTTGATTG CCTAGAGATG 1200

GAAAACATGA GTAGTGCTGA GGAGAGGAAG AAGAGCCATG CAGGAGACTG GCATCTAGCT 1260

AGCAGCGCTG AAGTTCCGGA GGTCAACATT TTCCCTGCTG GAGATGAGGT CCGATCACAG 1320

AGTGAGAAGC TGAAGCTTGC CGGATGCGAA AGAGGAGAGC TGTCGGTTAG GGCTCACGCC 1380

CAACCTAGGA ATGGGGGCGG CCTTCCTTCA AACCCTTCGA CCCCTCCAGG AACATCTGCG 1440

GCAGGTGTGG ACGGCCTCAC TGCGAAGAAT CTACCAACCC ATGGTGAACA GCCTCTGTCT 1500

GAGAACCAGC AGAGTAGAAC GTACAAGGAG GAGAGTAACA CACATCCGAG CCTTCCCGAT 1560

GGACATTTTC CCGGAAAAAC CGATACGAGA CCATCGATTT TAGATTCAAG TTTTAAATTC 1620

TCCGTAGACC CAAACGGAGG TTCACCGCCC ATCAAAACTC AGCCTGAGGA CAGAAACGTC 1680

CGTGTTGGCG GCCTGCTTCC GGTAGCTCGG CGGGAATCGG TCGACAGTGG AGAGACCTCA 1740

GGCCATCACC TAGGTGAAAT ATCGAAAATA GAAGACCTAG AAGACCCTCA AGGATATTCC 1800

GAAAAAGCTT TTACTCCCGA CGGAAAAGAA CGGGGCATAG AAAGCGGGAC AAAGGACTCG 1860

ATTGGTCCTC ATTCTAATGC TTCTAATATC TCATTTGGAA CCCCCACTCA AGATGAACCG 1920

TGGCAGGGGA TGATGAGCGA TTCCAGACCA GAGCGGCAGA CTTCGGCCAT CACGGAGCAG 1980

TTGGTGAAAC CAAACTTGGT TTGGACCGTT GGACGCTCTC GCTTTGAGTC TGGAGCAGAT 2040

CCACCGTCTA TGTGTGGCGT GAGAGACGGT GGCATTTATG GTGGTCACGC AAGACTCCCT 2100

ATAGATTGTA AAACGTCGGG TGCTGCCAGT AATTCTGAAG AGGCGAATGG ACCGGACATT 2160

AAGGTGCATG CTATCTGTGG CGACCTCAAG GATTTGGAGC TGAACGTCAT CGAAGGAGCG 2220

GTTTCAGGCT CATGGGCCAC TTCAGTCGAC CTAAGGGCAA GCTCTTCCTT CGTGGGGGAC 2280

GCCGATACAA GCGAGGAGAA TATTCCTAGT CCGATATTTG ACGCCCCTCG AAGGCCCGGA 2340

TCCTTAAAAC TGACCGACGC CTCTTCAATT GAGAGTCAAA TCGGACAGGT CGGTGACGGT 2400

TGCTTGGGAG ATGATGATGA GGATCCCTCG GAGGTTTGTA AGAACTTTGA AGAGAGTGAA 2460

GGTGAGGGCC TTCTACGGAA CAGTGACGGT CTCTCAGCTC GTCCAAAGCC TGTGCAGCAG 2520

AGACTGAAAA CTCAGGCGAC GTCCACCCCG GTGAAGACTT CCAGTGAGCC GACTGCCAAA 2580

ATACCTGATG TGAAGTCTGA GATTTTGGAA GGCAGTTATA CGGGAAGCTG CTATCACAGA 2640

GATGGCGCTA GACTCAGCAT GCAGTTTGAA GTGAAACGGG TGGAGTTGAA AGACCCCGCG 2700

GCCTTGTTTT GCTGTTGGGT GGGGAAAGAC TTCTTTCAGA GTCATAAGGA AGCAACAGCG 2760

AGGACTCAGC TTTTCCTCTC CAGTGTGCCT AGTTCGTCCC AGTCCATAGT GGAGGTTTCT 2820

GGATTCAGCC TAGGAGAAAT AATGAGAACA AAACGATGGT TTGATGATCC CCCCAGAGTT 2880

ATGGAGATGG AAATATTGAA GGCTTGTGAG GGAGAATATT CAGAGCACTA CAATACCCTC 2940

ACTCCCATTG GCAGCGGTGC CTTTGGCTTC GTTTGGACTG CCAAGAATAA AGAAGAAAAC 3000

AAAGAGGTTG TGGTGAAGTT TATTTGGAAG AACAAGATAC TAGAAGACTG CTGGGTAGAA 3060

GATCCCGAAT TAGGAAAAGT TACTCGAGAG ATTCTAATTC TTTCAGAGAT TCAGCATCCC 3120

AATATAATTA AGGTTCTGGG CGTATTTGAA AATGAAGGCT TTTTCCAGCT AGTGATGGAG 3180

AAACACGGAT CAGGCCTTGA CCTCTTTACG TTCATCGATC ACCATCCTAG TCTCGATGAA 3240

CCGTTGGCAA GCTATATGTT CAGACAGCTG GTGTCAGCAG TTGCCTACCT TCGGTCCAAG 3300

AACATCCTCC ACAGAGACAT TAAAGATGAG AATATCATCA TTGCTGAGGA TTTCACCATC 3360

AAGCTGATCG ACTTCGGCTC GGCAGCCTAC ATGGAACGTG GGAAATTATT TTATACCTTC 3420

TGCGGAACCA TAGAATATTG CTCACCAGAA GTCCTCATGG GAAATCCATA CCGGGGGCCC 3480

GAGCTGGAGA TGTGGTCACT TGGCGTTACA CTGTACACTT TAATATTCGA AGAGAATCCT 3540

TTCTGTGAGT TAGAAGAGGC CATGGAGGCC GTATTAAATC CTCCTTACTA TGTTTCAGAA 3600

GAGTTAATGA ATCTAGTATC CGGGCTTCTG CAGCCTATTC CAGAACAACG CACAACCCTG 3660

GAAAAGTTGT TCCAAGATCC TTGGGTGATT CAGCCGGTGA ACCTGGCTAA CTACACTTGG 3720

GAAGAGGTTT GCCCTTTCGC TAAGCCAGGA AGTAGCCATC TCAAAGGACA AGTCCTTCGT 3780

ACAGCAACAG GCCTCGGTCT AGAGCAGAGG CAAGACGGCA AAATGGATCA GTCTTCCACT 3840

CCTCTGGATC AAGACTTGGG GAACTGCTTC ACGTGTCAGG GCGACACCGC TCAGGAGCAA 3900

GTTCTGCCCA GGGATTGA 3918

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl......seeslekikrEieilkk  54

         y++l+ +G+g+fg V +ak+ke++++v+vK+i k+k+      ++ +l k++rEi il++

Q: 977   YNTLTPIGSGAFGFVWTAKNKEENKEVVVKFIWKNKIledcwvEDPELGKVTREILILSE  1036

         88999*******************************99999998888*************

S: 55    lkhpniikllevietkkklylvle.yasggeLfdyieekgrlkekearklfkqlvsavkY  113

         ++hpniik+l v+e++ +++lv+e + sg +Lf  i ++ +l+e  a+ +f+qlvsav Y

Q: 1037  IQHPNIIKVLGVFENEGFFQLVMEkHGSGLDLFTFIDHHPSLDEPLASYMFRQLVSAVAY  1096

         ************************888899******************************

S: 114   lhskgivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkk  173

         l+sk+i HrD+K eN+++ ++ +ik++DFG a+++++gkl+ tfcG+++Y++Pe+l+g++

Q: 1097  LRSKNILHRDIKDENIIIAEDFTIKLIDFGSAAYMERGKLFYTFCGTIEYCSPEVLMGNP  1156

         ************************************************************

S: 174   YegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklL  233

         Y+gp++++WslGv+Ly+l++++ Pf e       e+ ++  l+ p+++s+el++L++ lL

Q: 1157  YRGPELEMWSLGVTLYTLIFEENPFCEL------EEAMEAVLNPPYYVSEELMNLVSGLL  1210

         *************************998......677788888999**************

S: 234   vvdpekRatieeilkhewl  252

         +  pe+R+t+e++ +++w+

Q: 1211  QPIPEQRTTLEKLFQDPWV  1229

         ******************7

Domain Sequence
(FASTA)

YNTLTPIGSG AFGFVWTAKN KEENKEVVVK FIWKNKILED CWVEDPELGK VTREILILSE 60

IQHPNIIKVL GVFENEGFFQ LVMEKHGSGL DLFTFIDHHP SLDEPLASYM FRQLVSAVAY 120

LRSKNILHRD IKDENIIIAE DFTIKLIDFG SAAYMERGKL FYTFCGTIEY CSPEVLMGNP 180

YRGPELEMWS LGVTLYTLIF EENPFCELEE AMEAVLNPPY YVSEELMNLV SGLLQPIPEQ 240

RTTLEKLFQD PWV 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000014	; PAS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00091	; PAS; 2.
SM00220	; S_TKc; 1.

Prosites

PS50112	; PAS; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013