EKS-ORA-00230

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00230

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	329.4	1.8E-98	24	256	233

Status

Unreviewed

Ensembl Protein

ENSOANP00000026061

UniProt Accession

F7FQP9;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000020496	ENSOANP00000026061	ENSOANT00000029864
ENSOANG00000020496	ENSOANP00000026062	ENSOANT00000029865

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

609

Protein Sequence
(FASTA)

FSLGRPLGGG ELSGLGRGES LHRATDKELP LLKIDKKAMH KAKMVQRVQN EVRIHCQLKH 60

PSILELYNYF EDSNYVYLIL ELCHNGEMNR YLKNRMKPFT EKEVRHFMHQ IVRGLLYLHS 120

HGILHRDLTL SNLLLTGTMN VKIADFGLAT QLALPHEKHY TLCGTPNYIS PEVATRSAHG 180

PAADVWALGC LLYTLLVGRP PFDTDSVRAT LGRVVLADYR LPASLSAEAR DLIGRLLRRD 240

PAARPGLAAL LDHPFLAGGP PAGDAGDSLD SGHATLSTTA AAGSSGVSLS GCSLSRRRLL 300

LAGPPLPDRM TLRPAGILLH LHLLIRLAVA YTLLVKELHT EYNNQPHLPP TINKIPHAGP 360

VTLRSRSLIS FISISVCLPR WTVSPRGAGN VPVYCRTVLS QALTTVLCTQ TDRSSGFSSA 420

ASPQGAQRQP HPGPAALPGP DGPDRSETVQ QWFGNLYIVL SSHLVRCSAP RRCSINTIDW 480

LSDRAKRQLT RVSSGRTRGA HSLIFLGARR DLIHLFKWPP LVSKEVVAQG DPRAAGRDRR 540

AGPAAEGRTL RSVAAPLDAH RLKPIRQKTR RAVVSILDTE EVCVELLKEQ VSREHVKEVL 600

RVSSDGRKV 609

Nucleotide Sequence
(FASTA)

TTCAGTCTGG GCAGGCCTCT TGGAGGAGGT GAGCTCTCAG GGCTTGGAAG AGGGGAATCT 60

CTCCACCGAG CCACGGATAA GGAGCTACCG TTACTAAAGA TCGACAAAAA GGCCATGCAC 120

AAAGCGAAAA TGGTCCAGCG CGTGCAGAAC GAGGTGAGGA TCCACTGTCA GCTGAAGCAC 180

CCCTCCATCT TGGAGCTCTA CAACTACTTT GAAGACAGCA ACTACGTGTA CCTGATCCTG 240

GAACTGTGTC ACAACGGAGA GATGAACAGG TACCTGAAGA ACAGAATGAA ACCTTTTACG 300

GAGAAAGAAG TCCGGCACTT CATGCACCAG ATCGTCCGGG GGCTGCTGTA CCTGCACTCC 360

CACGGCATCC TGCACCGCGA CCTCACCCTG TCCAACCTGC TCCTCACCGG CACCATGAAC 420

GTCAAGATCG CCGACTTCGG ACTGGCCACC CAGCTGGCCC TGCCCCACGA GAAGCACTAC 480

ACGCTGTGCG GCACGCCCAA CTACATCTCG CCCGAGGTGG CCACGCGCAG CGCCCACGGG 540

CCGGCGGCGG ACGTGTGGGC CCTGGGCTGC CTGCTGTACA CCCTGCTGGT GGGCCGCCCG 600

CCCTTCGACA CGGACTCGGT GCGCGCCACG CTGGGCCGGG TGGTCCTGGC CGACTACCGG 660

CTGCCCGCCT CCCTGTCGGC CGAGGCGCGG GACCTGATCG GCCGGCTGCT GCGCCGCGAC 720

CCCGCCGCCC GGCCCGGGCT GGCCGCCCTG CTGGACCACC CCTTCCTGGC GGGCGGCCCC 780

CCGGCCGGCG ACGCGGGCGA CTCGCTGGAC AGCGGCCACG CCACCCTCTC CACCACGGCG 840

GCGGCCGGCT CGTCCGGGGT CAGCCTCAGC GGCTGCTCGC TGAGCCGGAG GAGGCTCCTC 900

CTGGCGGGCC CGCCCCTCCC GGACAGGATG ACCCTCCGCC CCGCGGGCAT CCTTCTACAC 960

CTCCACCTCC TCATACGGCT AGCAGTCGCA TATACACTTC TGGTAAAGGA GCTTCACACA 1020

GAATATAACA ATCAACCACA CCTCCCACCA ACCATAAATA AAATCCCCCA CGCCGGTCCC 1080

GTAACACTTC GGTCCAGATC CCTCATTTCA TTTATTTCTA TTAGCGTCTG TCTCCCCCGC 1140

TGGACCGTAA GCCCCCGGGG GGCCGGGAAT GTGCCTGTTT ATTGCCGTAC TGTGCTCTCC 1200

CAAGCGCTTA CGACAGTGCT CTGCACACAA ACGGACCGCT CCAGCGGGTT TTCTTCAGCT 1260

GCGTCGCCCC AGGGTGCGCA AAGACAACCC CACCCCGGGC CGGCGGCCTT GCCCGGCCCG 1320

GACGGGCCGG ACCGCTCGGA GACGGTGCAG CAGTGGTTTG GGAACCTTTA CATTGTCCTC 1380

TCCTCGCACT TAGTACGGTG CTCCGCACCC AGGAGGTGCT CAATAAATAC GATCGACTGG 1440

CTGTCTGACC GAGCCAAGCG CCAGCTAACT AGGGTATCGT CTGGTCGAAC GCGTGGGGCT 1500

CACAGTCTAA TATTTTTAGG GGCCAGACGT GATCTCATTC ATTTATTTAA ATGGCCGCCG 1560

CTGGTATCGA AAGAAGTAGT CGCTCAAGGG GACCCGCGGG CCGCGGGGCG GGACCGCCGG 1620

GCGGGACCGG CCGCGGAGGG CCGCACCCTG CGGAGCGTCG CGGCCCCGCT GGACGCCCAC 1680

CGCCTCAAAC CCATCAGGCA GAAAACGCGC AGGGCCGTGG TGAGCATCCT GGACACGGAA 1740

GAGGTGTGCG TGGAACTCCT CAAGGAGCAG GTCTCCCGAG AACACGTCAA GGAAGTGCTC 1800

CGCGTGTCCA GCGACGGCAG GAAGGTA 1827

Domain Profile

S: 22    etkevfavkvvpksllakekqrekvekeieihrslkhknivklyeffedkenvylvlelc  81

          t++++ +  ++k++++k+k+ ++v++e++ih++lkh++i++ly++fed+++vyl+lelc

Q: 24    ATDKELPLLKIDKKAMHKAKMVQRVQNEVRIHCQLKHPSILELYNYFEDSNYVYLILELC  83

         57777888889*************************************************

S: 82    srrslaellkrr.kaltepevryylrqivsglkylhekrilhrdlklgnlflneelevki  140

         ++++++++lk+r k++te+evr++++qiv+gl+ylh++ ilhrdl+l+nl+l+ +++vki

Q: 84    HNGEMNRYLKNRmKPFTEKEVRHFMHQIVRGLLYLHSHGILHRDLTLSNLLLTGTMNVKI  143

         ***********99***********************************************

S: 141   gdfGlatrlekeeerkktlcGtPnyiaPevlskkghslevdiWslGcilytllvGkPPfe  200

         +dfGlat+l+ ++e+++tlcGtPnyi+Pev+++++h+  +d+W+lGc+lytllvG+PPf+

Q: 144   ADFGLATQLALPHEKHYTLCGTPNYISPEVATRSAHGPAADVWALGCLLYTLLVGRPPFD  203

         ************************************************************

S: 201   tkelketyekikkaeyslPsslskeaksliakllkkePeerpsleevlkdefl  253

         t++++ t+ +++ a+y+lP+sls+ea++li +ll+++P++rp l ++l+++fl

Q: 204   TDSVRATLGRVVLADYRLPASLSAEARDLIGRLLRRDPAARPGLAALLDHPFL  256

         **************************************************996

Domain Sequence
(FASTA)

ATDKELPLLK IDKKAMHKAK MVQRVQNEVR IHCQLKHPSI LELYNYFEDS NYVYLILELC 60

HNGEMNRYLK NRMKPFTEKE VRHFMHQIVR GLLYLHSHGI LHRDLTLSNL LLTGTMNVKI 120

ADFGLATQLA LPHEKHYTLC GTPNYISPEV ATRSAHGPAA DVWALGCLLY TLLVGRPPFD 180

TDSVRATLGR VVLADYRLPA SLSAEARDLI GRLLRRDPAA RPGLAALLDH PFL 233

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007099	; P:centriole replication
GO:0046601	; P:positive regulation of centriole replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013