EKS-ORC-00376
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00376
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR612.03.9E-184591948358
StatusUnreviewed
Ensembl ProteinENSOCUP00000000224
UniProt AccessionG1SCX7;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000000258ENSOCUP00000000224ENSOCUT00000000258
OrganismOryctolagus cuniculus
Functional Description
Protein Length1089
Protein Sequence
(FASTA)
MGPSPPAFLV LVLGWLLAGP SLTRCQLPLP SISPGDSERV VPLNSSFTLR CSGESEVSWQ 60
YPVSEDEGPR VDVRSEENNT GYFVAVLEVG SATAAHTGLY TCYYNHTQTE DSDVEGSHVY 120
IYVPDPDVAF VPLGMTDYLV IVEDDDSAII PCRTTDPETP VTLRNSQGLV PASYDSRHGF 180
NGTFTMGPYV CEATVRGKTV QTIPFNIYAL KATSELDLEM EALQTVYKAG ETIVVTCAVF 240
NNEVVDLQWT YPGEMKGKGV TMLEEIKVPT LKLVYTLTVP RATVKDSGDY ECAARQATEV 300
KEMKKVTIAV HEKGFVEIKP TFNQSEAVNL HEVKHFVVEV RAYPPPRISW LKDSRTLIEN 360
LTEITTDVEQ VQETRLSSMC NRSAACGKWN FLTSVEQGWQ IVQCSAWKAP LAVPATILDL 420
VDDHHPPGEK RVRCTAAGTP PDVEWMICKD IKRCNNETSW TLLANNVSNI VTETHPRGGG 480
AVEGRVTFAK VEETLAVRCL ARNPLGTENR ELKLVAPTLR SELTVAAAVL VLLVVVIVSL 540
IILVVVWKQK PRYEIRWRVI ESISPDGHEY IYVDPMQLPY DSRWEFPRDG LVLGRILGSG 600
AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG PHLNIVNLLG 660
ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSRHPEKPK KELDIFGLNP ADESTRSYVI 720
LSFENNGDYM DMKQADGTQY VPMLERKEVS KYSDIQRSLY DRPASYKKKS ALESEVKNLL 780
SDDNAEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV KICDFGLARD 840
IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG GTPYPGMMVD 900
STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WNSEPEKRPS FYHLSEIVES LLPGQYKKSY 960
EKIHLDFLRS DHPAVARMRV DTDSAYLGVT YKNEEDKLKD WEGGLDEQRL SADSGYIIPL 1020
PDIDPVPEED EEDGGKRNRH SSQTSEESAI ETGSSSSTFM KREDETIEDM DMMDDIGMDS 1080
SDLVEDSFL 1089
Nucleotide Sequence
(FASTA)
ATGGGACCCT CCCCTCCGGC CTTCCTGGTC CTGGTCCTCG GCTGGCTCCT GGCAGGGCCG 60
AGCCTCACGC GCTGCCAGCT CCCGCTACCC TCCATCTCCC CCGGCGACAG CGAGAGGGTG 120
GTGCCGCTGA ACTCCTCTTT CACCCTGCGC TGCTCCGGGG AGAGTGAAGT GAGCTGGCAG 180
TACCCCGTGT CCGAGGACGA GGGCCCCAGG GTGGACGTCA GGAGCGAGGA GAACAACACT 240
GGCTATTTTG TGGCCGTGCT GGAGGTGGGC AGTGCCACCG CGGCCCACAC GGGCTTGTAC 300
ACCTGCTACT ACAACCACAC GCAGACGGAG GACAGCGACG TGGAAGGCAG CCACGTGTAC 360
ATCTACGTGC CGGACCCGGA CGTCGCCTTC GTGCCCCTGG GGATGACCGA CTACCTGGTC 420
ATCGTGGAGG ACGACGACTC GGCCATCATC CCGTGTCGCA CCACCGACCC CGAGACCCCC 480
GTCACCCTGC GCAACAGCCA GGGCCTGGTG CCCGCCTCCT ACGACAGCCG GCACGGCTTC 540
AACGGCACCT TCACCATGGG GCCCTACGTG TGTGAGGCCA CCGTGCGCGG GAAGACCGTG 600
CAGACCATCC CCTTCAACAT CTACGCCTTG AAAGCGACGT CGGAGTTGGA TCTGGAAATG 660
GAAGCGCTCC AGACTGTGTA TAAGGCAGGA GAGACGATTG TGGTCACCTG CGCCGTCTTC 720
AACAACGAAG TGGTGGACCT GCAGTGGACT TACCCCGGGG AGATGAAGGG CAAAGGTGTC 780
ACAATGCTGG AAGAAATCAA AGTCCCCACA CTCAAGCTGG TGTACACGCT GACGGTCCCC 840
AGGGCCACAG TGAAGGACAG CGGGGACTAT GAGTGCGCTG CCCGCCAGGC CACCGAGGTC 900
AAAGAGATGA AGAAGGTCAC CATCGCTGTG CATGAGAAGG GGTTTGTGGA GATCAAGCCC 960
ACTTTCAACC AGTCGGAGGC CGTCAACCTG CACGAAGTGA AGCATTTCGT GGTGGAGGTG 1020
CGCGCCTACC CCCCGCCCAG GATATCCTGG CTGAAGGACA GCCGGACTCT GATCGAGAAT 1080
CTCACGGAGA TCACCACGGA CGTGGAGCAG GTGCAGGAGA CGCGACTAAG CTCCATGTGT 1140
AATCGATCAG CAGCATGTGG AAAATGGAAT TTTCTGACCT CTGTGGAGCA GGGATGGCAG 1200
ATAGTGCAGT GCTCAGCCTG GAAGGCCCCC CTTGCGGTGC CCGCAACCAT CCTGGACTTG 1260
GTGGATGACC ACCACCCCCC GGGGGAAAAA CGGGTGAGGT GCACGGCTGC CGGCACCCCC 1320
CCGGATGTCG AATGGATGAT CTGCAAGGAT ATCAAGAGGT GTAACAATGA AACCTCGTGG 1380
ACGCTTTTGG CCAACAACGT GTCCAACATC GTCACGGAGA CCCACCCCCG GGGCGGGGGC 1440
GCCGTGGAGG GCCGGGTGAC CTTCGCCAAG GTGGAGGAGA CCCTTGCCGT CCGCTGCCTG 1500
GCCAGGAATC CTCTGGGCAC GGAGAACCGC GAGCTGAAGC TGGTGGCTCC CACCCTGCGC 1560
TCGGAACTCA CGGTGGCGGC CGCGGTACTG GTGCTGCTGG TGGTTGTGAT TGTCTCGCTC 1620
ATCATCCTGG TTGTCGTCTG GAAGCAGAAA CCCAGGTACG AGATTCGCTG GCGGGTCATC 1680
GAGTCCATCA GCCCCGACGG CCATGAATAC ATTTACGTGG ACCCCATGCA GCTGCCGTAC 1740
GACTCGCGAT GGGAGTTTCC GCGAGATGGC CTCGTGCTGG GTCGCATCTT GGGATCCGGG 1800
GCCTTTGGGA AAGTGGTGGA AGGGACAGCC TACGGACTGA GCCGGTCCCA GCCGGTCATG 1860
AAGGTGGCGG TAAAGATGCT GAAACCCACG GCCAGGTCCA GCGAGAAGCA GGCTCTCATG 1920
TCCGAGCTGA AGATCATGAC CCACCTGGGG CCGCATCTCA ACATTGTCAA CTTGCTGGGA 1980
GCCTGTACCA AGTCAGGCCC CATTTACATC ATCACCGAGT ACTGCTTCTA TGGGGATTTG 2040
GTCAACTATC TGCATAAGAA CAGGGACAGC TTCCTGAGCC GCCACCCGGA GAAGCCCAAG 2100
AAGGAGCTGG ACATCTTTGG GTTGAACCCT GCAGATGAAA GCACACGGAG CTACGTGATT 2160
CTGTCTTTCG AGAACAATGG TGACTACATG GACATGAAGC AGGCCGACGG CACGCAGTAC 2220
GTCCCCATGC TGGAGCGGAA AGAGGTGTCC AAGTACTCGG ACATCCAGCG CTCGCTGTAC 2280
GATCGCCCGG CTTCCTACAA GAAGAAGTCC GCGCTAGAGT CCGAAGTCAA AAACCTCCTT 2340
TCGGATGACA ACGCGGAAGG CCTCACCTTG TTGGATCTGT TGAGCTTTAC CTACCAAGTC 2400
GCTCGAGGGA TGGAATTTTT GGCTTCAAAA AATTGCGTCC ACCGGGACCT GGCCGCGCGC 2460
AACGTGCTCC TGGCGCAAGG GAAGATTGTC AAGATCTGTG ACTTCGGCCT GGCCAGAGAC 2520
ATCATGCACG ACTCCAACTA CGTCTCCAAA GGCAGCACCT TCCTGCCCGT GAAGTGGATG 2580
GCCCCCGAGA GCATCTTCGA CAACCTCTAC ACCACGCTGA GCGACGTGTG GTCCTACGGC 2640
ATCCTGCTCT GGGAGATCTT CTCTCTCGGG GGCACACCCT ACCCTGGCAT GATGGTGGAC 2700
TCCACCTTCT ACAACAAGAT CAAAAGCGGC TACCGGATGG CCAAGCCTGA CCACGCCACC 2760
AGTGAAGTCT ACGAGATCAT GGTGAAGTGC TGGAACAGCG AGCCCGAGAA GCGGCCCTCC 2820
TTTTACCACC TGAGCGAGAT CGTGGAGAGT CTGCTGCCCG GACAGTATAA AAAGAGCTAT 2880
GAGAAGATCC ACCTGGACTT CCTGAGGAGC GACCACCCCG CCGTGGCGCG CATGCGTGTG 2940
GACACCGACA GCGCGTACCT GGGCGTCACC TACAAGAACG AGGAGGACAA GCTGAAGGAC 3000
TGGGAGGGCG GCCTGGACGA GCAGAGGCTG AGTGCCGACA GCGGCTACAT CATCCCCCTG 3060
CCCGACATCG ACCCCGTGCC CGAGGAGGAC GAGGAGGACG GGGGCAAGCG CAACCGGCAC 3120
AGCTCGCAGA CCTCGGAGGA GAGTGCCATC GAGACGGGTT CCAGCAGCTC CACCTTCATG 3180
AAGAGAGAGG ACGAGACCAT CGAGGACATG GACATGATGG ACGACATTGG CATGGACTCC 3240
TCGGACCTGG TGGAGGACAG CTTCCTGTGA 3270
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 591   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  650
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek   +++eld+++
Q: 651   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSRHPEK---PKKELDIFG  707
         *********************************************999...9999*****
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad+s+rs+++ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 708   LnPADESTRSYVILSFENNGDYMDMKQAdgtqyvpmlerkevskYSDIQRSLYDRPASYK  767
         *9*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kksale+evk+ l++++ e+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 768   KKSALESEVKNLLSDDNAEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  827
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 828   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  887
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++epekrpsf++l+e+
Q: 888   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEI  947
         *********************************************************998
S: 344   l  344
         +
Q: 948   V  948
         6
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSRHPEKPK KELDIFGLNP 120
ADESTRSYVI LSFENNGDYM DMKQADGTQY VPMLERKEVS KYSDIQRSLY DRPASYKKKS 180
ALESEVKNLL SDDNAEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0055003; P:cardiac myofibril assembly
GO:0060326; P:cell chemotaxis
GO:0071230; P:cellular response to amino acid stimulus
GO:0007204; P:elevation of cytosolic calcium ion concentration
GO:0048701; P:embryonic cranial skeleton morphogenesis
GO:0048557; P:embryonic digestive tract morphogenesis
GO:0008210; P:estrogen metabolic process
GO:0030198; P:extracellular matrix organization
GO:0060325; P:face morphogenesis
GO:0001701; P:in utero embryonic development
GO:0033327; P:Leydig cell differentiation
GO:0030324; P:lung development
GO:0001553; P:luteinization
GO:0030539; P:male genitalia development
GO:0072277; P:metanephric glomerular capillary formation
GO:0010544; P:negative regulation of platelet activation
GO:0042475; P:odontogenesis of dentin-containing tooth
GO:0060021; P:palate development
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0070527; P:platelet aggregation
GO:0035790; P:platelet-derived growth factor receptor-alpha signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0045740; P:positive regulation of DNA replication
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0050920; P:regulation of chemotaxis
GO:2000739; P:regulation of mesenchymal stem cell differentiation
GO:0061298; P:retina vasculature development in camera-type eye
GO:0023019; P:signal transduction involved in regulation of gene expression
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013