EKS-ORC-00019
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00019
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/Trio399.76.4E-12010271281255
StatusUnreviewed
Ensembl ProteinENSOCUP00000023689
UniProt AccessionG1SD86;
Protein Name
Protein Synonyms/Alias
Gene NameKALRN
Gene Synonyms/Alias KALRN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000000397ENSOCUP00000000356ENSOCUT00000000406
ENSOCUG00000000397ENSOCUP00000019467ENSOCUT00000028091
ENSOCUG00000000397ENSOCUP00000023689ENSOCUT00000031880
OrganismOryctolagus cuniculus
Functional Description
Protein Length1329
Protein Sequence
(FASTA)
SSENGGKSES VANLQAQPSL NSIHSSPGPK RSTNTLKKWL TSPVRRLNSG KADGNIKKQK 60
KVRDGRKSFD LGSPKPGEET TPQGDSADED LGGRRLGLMG GSLQSSLSLK SKKGWGEDEP 120
DEESHTPLPP PMKIFDNDPT QDEMSSSLLA ARQAATEVPT AADLVSAIEK LVKSKLLFSL 180
EENMERLLID GGSSVDSSEN STKKKSVVAQ SPRNLEEEQK AKALRGRMFV LNELVQTEKD 240
YVKDLGIVVE GFMKRIEEKG VPEDMRGKDK IVFGNIHQIY DWHKDFFLAE LEKCIQEQDR 300
LAQLFIKHER KLHIYVWYCQ NKPRSEYIVA EYDAYFEEVK QEISQRLTLS DFLIKPIQRI 360
TKYQLLLKDF LRYSEKAGLE CSDIEKAVEL MCLVPKRCND MMNLGRLQGF EGTLTAQGKL 420
LQQDTFYVIE LDAGMQSRTK ERRVFLFEQI VIFSELLRKG SLTPGYMFKR SIKMNYLVLE 480
EDVDNDPCKF ALINRETSER VILQAANADI QQAWVQDINQ VLETQRDFLN VSSMELKVQG 540
KAEGGMPAGG AEQMSTSPAL RGGYFDTLQG QGGVEGPGPG SYLQRRMQAA PSQCSPPETS 600
GNLTASCPPQ ARRTCFLPGP TSSPAVLSPP LKLFLSTPTT THTRSPTQPH PAAPSLPRLQ 660
ILVGFPELRV TICSHPAALQ SPIEYQRKER STAVMRSQPA RAPQASPRPY SSVPVGSEKP 720
PKGSSYNPSL PPLKISTSNG SPGFDYHQPG DKFEGSKKCS STVKPSAPCE QAEQADVGSC 780
NGSSSMAVIK DYYALKENEI CVSQGEVVQV LTVNQQNMCL VYQPASDQSP AAEGWVPGSI 840
LAPLTKASAA AAENSDGSIK KSCSWHTLRM RKRAEVENTG KNEATGPRKP KDILGNKVSV 900
KILNPNFIQE VAPEFLVPLV DVTCLLGDTV LLQCKVCGRP KPTVTWKGPD QNILDTDSST 960
ATYTISSCDS GEITLKICNL MPQDSGIYTC IATNDHGTAS TSATVKVQDA AADGATISWK 1020
ENFDAAYTEL NEIGRGRFSI VKKCVHKATR RDVAVKFVSK KLKKKEQAAH EAALLQHLQH 1080
PQYITLHDTY ESPTSYILIL ELMDDGRLLD YLMNHDELME EKVAFYIRDI MEALQYLHNC 1140
RVAHLDIKPE NLLIDLRIPV PRVKLIDLED AVQISGHFHI HQLLGNPEFA APEVIQGIPV 1200
SLGTDIWSIG VLTYVMLSGV SPFLDESKEE TCINVCRVDF SFPQEYFCGV SSAARDFIKV 1260
ILQEDFRRRP TAATCLQHPW LQPHNGSYSK IPLDTSRLAC FIERRKHQHD VRPVPDVKSY 1320
IISRASQGT 1329
Nucleotide Sequence
(FASTA)
TCCAGTGAAA ACGGAGGCAA GTCTGAGTCC GTGGCCAACC TGCAGGCTCA GCCCTCCCTG 60
AACTCCATCC ACAGCTCCCC CGGTCCCAAG CGCTCCACCA ACACCCTGAA GAAGTGGCTG 120
ACCAGTCCCG TGCGCCGGCT CAACAGCGGG AAGGCGGATG GCAACATCAA GAAGCAGAAG 180
AAAGTGCGGG ATGGTCGGAA GAGCTTCGAC CTGGGGTCTC CGAAGCCTGG GGAGGAGACG 240
ACCCCACAGG GAGACAGCGC CGATGAGGAT TTGGGAGGCA GACGTCTGGG CCTGATGGGA 300
GGCAGTCTGC AGTCCTCCCT TTCTCTGAAG AGCAAGAAAG GTTGGGGAGA AGATGAGCCA 360
GATGAAGAGT CCCACACCCC ACTCCCTCCG CCTATGAAGA TCTTTGACAA CGACCCCACG 420
CAGGACGAGA TGTCCTCCTC TTTGCTAGCA GCTCGGCAGG CTGCCACTGA AGTTCCTACT 480
GCTGCAGACC TTGTCAGTGC AATAGAAAAG TTGGTCAAAA GCAAGCTGCT CTTTAGCTTA 540
GAAGAAAATA TGGAGCGCCT ACTGATAGAT GGCGGTTCAA GTGTTGACTC TTCTGAAAAC 600
TCCACAAAAA AAAAGAGTGT TGTGGCTCAG AGTCCCAGGA ACCTGGAAGA AGAACAGAAA 660
GCCAAGGCCC TGAGAGGCAG GATGTTTGTC CTGAATGAGC TGGTGCAGAC AGAGAAGGAC 720
TATGTCAAGG ACCTGGGAAT CGTGGTGGAG GGCTTCATGA AGAGAATAGA AGAAAAGGGT 780
GTCCCCGAGG ATATGCGAGG GAAGGATAAA ATCGTGTTTG GGAATATTCA CCAGATCTAT 840
GACTGGCATA AGGATTTTTT CCTGGCTGAA CTGGAAAAAT GTATCCAAGA GCAGGACAGA 900
CTGGCCCAGC TCTTTATTAA ACACGAGCGG AAGCTGCACA TCTACGTGTG GTACTGCCAG 960
AATAAGCCAC GCTCCGAGTA CATCGTTGCA GAGTACGACG CCTACTTTGA GGAGGTGAAA 1020
CAGGAGATCA GTCAAAGGCT GACGCTCAGT GACTTCCTCA TCAAGCCCAT TCAGAGAATA 1080
ACGAAATACC AGTTGCTGCT GAAGGACTTC CTGAGATACA GCGAGAAGGC TGGCTTGGAG 1140
TGTTCTGATA TCGAGAAAGC AGTGGAGTTA ATGTGCCTTG TTCCCAAACG CTGCAATGAC 1200
ATGATGAACC TGGGACGCCT GCAAGGCTTC GAGGGCACCC TGACCGCGCA AGGGAAGCTG 1260
CTACAACAGG ACACCTTCTA CGTGATCGAG CTGGACGCAG GCATGCAGTC CCGGACCAAG 1320
GAGAGACGTG TGTTCCTCTT CGAACAGATC GTCATCTTCA GTGAGCTGCT CAGGAAGGGC 1380
TCCCTGACCC CAGGCTACAT GTTCAAAAGG AGCATCAAGA TGAATTACTT GGTCCTGGAG 1440
GAGGATGTGG ACAATGACCC CTGCAAGTTT GCACTCATCA ACAGGGAGAC TTCCGAGAGG 1500
GTCATTCTGC AAGCCGCCAA CGCAGACATC CAGCAGGCCT GGGTGCAGGA CATCAACCAA 1560
GTCCTGGAAA CACAGCGCGA CTTCTTAAAT GTATCCAGCA TGGAACTAAA AGTCCAGGGA 1620
AAGGCAGAAG GTGGCATGCC GGCTGGGGGT GCTGAGCAGA TGAGCACCAG CCCAGCTTTG 1680
AGGGGTGGTT ATTTTGACAC ACTCCAGGGA CAAGGAGGTG TTGAGGGACC AGGGCCAGGC 1740
TCTTACTTAC AAAGACGCAT GCAGGCAGCT CCAAGCCAGT GCTCCCCTCC TGAGACCTCA 1800
GGTAATCTGA CTGCATCCTG CCCCCCACAG GCGCGCCGCA CTTGCTTCCT TCCTGGGCCC 1860
ACCTCCAGTC CGGCTGTCCT CAGCCCGCCT CTGAAGCTCT TTCTCAGCAC CCCCACGACC 1920
ACCCACACCC GCTCACCTAC ACAGCCCCAT CCTGCAGCGC CTTCTCTCCC TCGTCTCCAA 1980
ATCCTTGTGG GATTCCCGGA GCTTAGAGTG ACCATCTGCT CTCACCCTGC AGCGCTCCAG 2040
TCGCCCATTG AGTATCAGCG GAAGGAGAGG AGCACAGCCG TGATGAGGTC CCAGCCTGCG 2100
AGGGCGCCCC AAGCCAGCCC CAGGCCCTAC TCCTCTGTCC CTGTGGGCTC TGAGAAGCCC 2160
CCAAAGGGCT CCAGCTATAA CCCATCTCTG CCACCCCTGA AGATATCTAC CTCCAATGGC 2220
AGTCCAGGGT TCGACTACCA CCAGCCTGGG GACAAGTTCG AGGGCAGCAA GAAATGCTCT 2280
TCCACTGTGA AACCCTCTGC CCCCTGTGAA CAAGCTGAAC AGGCTGACGT GGGAAGCTGC 2340
AACGGGAGCT CATCCATGGC TGTGATCAAA GATTACTATG CACTGAAGGA GAATGAAATT 2400
TGTGTGAGCC AAGGTGAGGT GGTCCAGGTC CTCACCGTCA ACCAGCAGAA CATGTGCCTG 2460
GTGTACCAGC CCGCCAGCGA CCAATCCCCT GCGGCCGAGG GCTGGGTCCC GGGCAGCATC 2520
CTGGCGCCCC TCACCAAAGC CTCAGCAGCC GCAGCAGAAA ATAGTGACGG GAGCATCAAG 2580
AAGTCATGTT CATGGCATAC TCTACGCATG AGAAAGCGGG CGGAAGTGGA GAACACGGGT 2640
AAAAATGAAG CCACAGGGCC TCGTAAACCC AAGGATATTC TGGGCAACAA AGTCTCTGTT 2700
AAAATCTTAA ATCCAAATTT CATCCAAGAA GTGGCCCCAG AATTCCTTGT GCCCTTAGTG 2760
GACGTGACCT GCTTGCTTGG GGACACAGTG CTACTGCAGT GCAAAGTGTG CGGGCGGCCG 2820
AAGCCCACCG TCACCTGGAA GGGGCCCGAC CAGAACATCC TCGACACGGA CAGCAGCACG 2880
GCCACCTACA CCATCTCCTC CTGTGATTCT GGGGAGATCA CCCTGAAGAT CTGCAACCTC 2940
ATGCCCCAGG ACAGCGGGAT TTATACCTGC ATAGCCACCA ACGACCACGG GACCGCGTCC 3000
ACGTCGGCCA CAGTTAAGGT GCAAGATGCG GCTGCTGACG GTGCCACCAT TTCTTGGAAG 3060
GAAAATTTTG ATGCTGCGTA TACCGAGCTG AATGAAATCG GCAGAGGCCG TTTCTCCATC 3120
GTGAAGAAGT GCGTCCACAA GGCCACGCGC AGAGACGTTG CTGTGAAGTT CGTGAGCAAG 3180
AAGCTGAAGA AGAAGGAGCA GGCAGCGCAC GAGGCGGCCC TGTTGCAACA CCTGCAGCAC 3240
CCTCAGTACA TCACTCTCCA CGACACCTAC GAGTCCCCCA CCTCCTACAT CCTGATCCTG 3300
GAGCTGATGG ATGACGGCCG GCTCTTAGAC TACCTTATGA ACCACGACGA GCTGATGGAG 3360
GAAAAAGTCG CCTTCTACAT CCGGGACATC ATGGAGGCCC TGCAGTACCT TCACAACTGC 3420
AGGGTGGCCC ACCTGGACAT AAAGCCTGAA AACCTGCTCA TTGACCTGCG GATTCCAGTG 3480
CCTCGAGTCA AGCTCATTGA CCTGGAGGAC GCTGTCCAGA TCTCGGGTCA CTTCCACATC 3540
CACCAGCTGC TGGGGAACCC CGAGTTTGCT GCCCCGGAAG TGATCCAAGG CATCCCCGTC 3600
TCCCTGGGCA CGGACATCTG GAGCATCGGG GTTCTGACGT ACGTCATGCT GAGCGGGGTC 3660
TCCCCCTTCT TGGACGAGAG CAAAGAGGAG ACCTGCATCA ACGTGTGCAG GGTGGACTTC 3720
AGCTTCCCCC AGGAGTACTT CTGCGGCGTG AGCAGCGCAG CCCGAGACTT CATCAAAGTG 3780
ATCTTACAGG AAGACTTTCG GAGGCGGCCC ACGGCCGCCA CCTGCCTGCA GCACCCGTGG 3840
CTGCAGCCCC ACAACGGCAG CTACTCCAAG ATCCCCCTGG ACACCTCCCG CCTGGCATGC 3900
TTCATAGAAC GTCGCAAGCA CCAGCACGAC GTGCGGCCCG TCCCCGACGT CAAGAGCTAC 3960
ATCATCAGCC GGGCGAGCCA GGGCACGTAG 3990
Domain Profile
S: 1     yevleeigRGrFsvvkkvrekatkravaakfvpkkakkkaqvlrEaeiLkrLqHpllvsl  60
         y++l+eigRGrFs+vkk+++kat+r+va+kfv+kk kkk+q+++Ea++L++LqHp++++l
Q: 1027  YTELNEIGRGRFSIVKKCVHKATRRDVAVKFVSKKLKKKEQAAHEAALLQHLQHPQYITL  1086
         899*********************************************************
S: 61    hdayetprslvlilElcsdeeLLdrlaekeslsEsevkaylrqllealqYLHnsrvlHLD  120
         hd+ye+p+s++lilEl++d++LLd+l+++++l+E++v++y+r+++ealqYLHn+rv+HLD
Q: 1087  HDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLD  1146
         ************************************************************
S: 121   ikpenllv.laaaeeavkivDlgnAqeltpeepqekllgtpEfvaPEiiegepvseatDi  179
         ikpenll+ l+++ ++vk++Dl++A++++ ++++++llg+pEf+aPE+i+g pvs +tDi
Q: 1147  IKPENLLIdLRIPVPRVKLIDLEDAVQISGHFHIHQLLGNPEFAAPEVIQGIPVSLGTDI  1206
         ********99**************************************************
S: 180   WavGvlayvlLsgvsPfldeskretllnilkgrvsfseelfaglseeAkeFlkkvLqedp  239
         W++Gvl+yv+LsgvsPfldesk+et++n++++++sf++e+f+g+s++A++F+k++Lqed+
Q: 1207  WSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPQEYFCGVSSAARDFIKVILQEDF  1266
         ************************************************************
S: 240   rkRPsaaecLqhpWl  254
         r+RP+aa+cLqhpWl
Q: 1267  RRRPTAATCLQHPWL  1281
         **************8
Domain Sequence
(FASTA)
YTELNEIGRG RFSIVKKCVH KATRRDVAVK FVSKKLKKKE QAAHEAALLQ HLQHPQYITL 60
HDTYESPTSY ILILELMDDG RLLDYLMNHD ELMEEKVAFY IRDIMEALQY LHNCRVAHLD 120
IKPENLLIDL RIPVPRVKLI DLEDAVQISG HFHIHQLLGN PEFAAPEVIQ GIPVSLGTDI 180
WSIGVLTYVM LSGVSPFLDE SKEETCINVC RVDFSFPQEY FCGVSSAARD FIKVILQEDF 240
RRRPTAATCL QHPWL 255
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; SH3 domain; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00018
EKS-ANC-00015
EKS-BOT-00019
EKS-CAJ-00019
EKS-CAF-00019
EKS-CAP-00020
EKS-GAG-00018
EKS-GOG-00021
EKS-HOS-00020
EKS-LAC-00020
EKS-LOA-00019
EKS-MAM-00019
EKS-MOD-00019
EKS-MUM-00019
EKS-MUP-00020
EKS-MYL-00020
EKS-NOL-00019
EKS-ORN-00029
EKS-ORL-00027
EKS-OTG-00020
EKS-PES-00019
EKS-POA-00018
EKS-RAN-00019
EKS-SAH-00018
EKS-SUS-00019
EKS-TAG-00018
EKS-TAR-00028
EKS-TEN-00030
EKS-XET-00018
EKS-XIM-00027
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005089; F:Rho guanyl-nucleotide exchange factor activity
GO:0035023; P:regulation of Rho protein signal transduction
KEGG
InterPros
IPR001251; CRAL-TRIO_dom.
IPR000219; DH-domain.
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
IPR018159; Spectrin/alpha-actinin.
IPR002017; Spectrin_repeat.
Pfam
PF00041; fn3; 1.
PF07679; I-set; 1.
PF00069; Pkinase; 1.
PF00621; RhoGEF; 2.
PF00018; SH3_1; 1.
PF00435; Spectrin; 4.
SMARTs
SM00060; FN3; 1.
SM00408; IGc2; 1.
SM00233; PH; 2.
SM00325; RhoGEF; 2.
SM00220; S_TKc; 1.
SM00516; SEC14; 1.
SM00326; SH3; 2.
SM00150; SPEC; 7.
Prosites
PS50191; CRAL_TRIO; 1.
PS50010; DH_2; 2.
PS50853; FN3; 1.
PS50835; IG_LIKE; 1.
PS50003; PH_DOMAIN; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
Created Date20-Feb-2013