EPS-ORC-00129

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORC-00129

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PDP	374.1	2.5E-112	227	440	214

Status

Unreviewed

Ensembl Protein

ENSOCUP00000000499

UniProt Accession

G1SDK9;

Protein Name

Protein Synonyms/Alias

Gene Name

PDP2

Gene Synonyms/Alias

PDP2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000000578	ENSOCUP00000000499	ENSOCUT00000000576

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

529

Protein Sequence
(FASTA)

MSGTVSSRIL SSARKSVATW QGGRRLYSRY VLQRSLRGRF FSQAPPTLQS KFPAGGFALQ 60

KACRHTSTEE EDFHLQLGPE QVNEVLRASE LTHKILNLNS GAPNSVLRFE SNQLAANSPV 120

EDRRGVASCL QTDGLMFGVF DGHGGPACAQ AVSERLFYYV AVSLMSYQTL EQMEGAMENM 180

KPVLPILQWL KHPGDSIYKN VTSVHLDHLR VYWQELLDLH MEMGPSIEEA LIHSFQRLDS 240

DISLEIQAPL EDEMAKNLSL QVAFSGATAC MAHINGLHLH VANAGDCRAI LGVQEDNGRW 300

SCLPLTRDHN AWNEAELSRL KREHPESEGR TIVVDDRLLG ILLPCRAFGD VQLKWSPELQ 360

RSVLGRGFDT EALNIYQFTP PHYHTPPYLT AKPEVTYHKL RPQDKFLVLA SDGLWDVLSN 420

EDVVRLVVGH LADVGRHKPD LAQGRTNLGL MQSLLLQRKA SGLPAADRNA ATHLIRHALG 480

SNEYGEMEPE RLTAMLTLPE DLARMYRDDI TVTVVYFNSD SIDAYYRGG 529

Nucleotide Sequence
(FASTA)

ATGTCGGGTA CGGTGTCCTC CCGGATCTTA AGTTCCGCCA GGAAGAGCGT TGCCACGTGG 60

CAAGGGGGCA GACGTTTGTA TTCAAGATAT GTCCTGCAGA GGAGTCTGAG AGGGAGGTTC 120

TTTTCCCAGG CGCCACCCAC CTTACAAAGC AAATTCCCGG CTGGTGGCTT TGCCCTGCAG 180

AAAGCCTGCA GACACACGTC GACGGAGGAA GAGGATTTCC ACTTGCAGCT CGGCCCCGAG 240

CAGGTAAATG AAGTGCTTCG GGCCAGCGAG TTGACCCACA AGATTCTCAA CCTCAACAGC 300

GGAGCCCCGA ATTCAGTGTT GCGATTTGAA AGCAACCAGC TGGCTGCCAA TTCCCCCGTG 360

GAGGACCGGC GAGGCGTGGC CTCCTGCCTG CAGACCGACG GACTGATGTT CGGGGTCTTC 420

GATGGACATG GTGGTCCCGC ATGCGCACAA GCCGTGAGCG AGAGACTCTT CTACTATGTG 480

GCGGTGTCCC TGATGTCCTA TCAGACCCTG GAGCAGATGG AGGGAGCCAT GGAAAACATG 540

AAGCCCGTGC TACCCATCCT GCAGTGGCTG AAGCACCCAG GGGACAGCAT CTACAAGAAT 600

GTCACCTCGG TGCACCTCGA CCACCTCCGC GTCTACTGGC AGGAACTGCT TGACCTGCAC 660

ATGGAAATGG GACCGAGTAT CGAAGAGGCA TTGATACACT CCTTCCAAAG ACTGGATTCT 720

GACATCTCGC TGGAAATCCA GGCCCCCCTG GAGGACGAGA TGGCCAAGAA CTTGTCGCTC 780

CAGGTCGCCT TCTCTGGGGC AACAGCCTGC ATGGCCCACA TCAACGGCCT GCACTTGCAT 840

GTGGCAAACG CCGGTGACTG CCGGGCCATC CTGGGTGTGC AGGAGGACAA CGGCAGGTGG 900

TCTTGTCTGC CCCTTACCCG TGACCACAAT GCCTGGAACG AGGCCGAGCT GTCCCGGCTG 960

AAGAGGGAGC ACCCCGAGTC AGAGGGCAGG ACGATCGTCG TAGATGACAG GCTGCTAGGC 1020

ATCCTGCTGC CCTGCAGGGC CTTCGGGGAC GTTCAGCTCA AGTGGAGCCC GGAGCTGCAG 1080

CGCAGCGTCC TGGGGAGGGG CTTCGACACA GAGGCCCTCA ACATTTACCA GTTCACGCCC 1140

CCCCACTACC ACACGCCGCC CTACCTGACT GCCAAGCCCG AGGTCACGTA CCACAAGCTG 1200

AGGCCCCAGG ACAAGTTCCT CGTGCTGGCC TCCGATGGCC TGTGGGACGT GCTGAGCAAC 1260

GAGGACGTGG TGAGGCTGGT GGTGGGGCAC CTGGCCGACG TGGGTCGGCA CAAGCCAGAC 1320

CTGGCCCAGG GACGCACCAA CCTGGGGCTC ATGCAGAGTC TGCTGCTGCA GAGGAAAGCC 1380

AGCGGGCTCC CTGCGGCCGA CCGAAATGCT GCCACGCATC TGATCAGACA CGCCCTGGGC 1440

AGTAATGAAT ACGGCGAGAT GGAGCCGGAG CGGCTGACGG CCATGCTGAC GCTGCCGGAG 1500

GACCTGGCGC GGATGTACCG GGATGACATC ACTGTCACTG TGGTCTATTT TAACTCAGAC 1560

TCCATTGATG CTTATTACCG GGGCGGTTAA 1590

Domain Profile

S: 5     vkealvnafkrldedisleaqvsdedevlrylvlrvalsGataclahvdGvdlhvantGd  64

         ++eal+++f+rld+disle+q++ ede+ ++l+l+va+sGatac+ah++G++lhvan+Gd

Q: 227   IEEALIHSFQRLDSDISLEIQAPLEDEMAKNLSLQVAFSGATACMAHINGLHLHVANAGD  286

         89**********************************************************

S: 65    sravlGvqeedgswsavklsrdhnaqneselerlkaehpkseaktvikedrllglliplr  124

         +ra+lGvqe++g+ws+++l+rdhna+ne+el+rlk+ehp+se +t++ +drllg+l+p+r

Q: 287   CRAILGVQEDNGRWSCLPLTRDHNAWNEAELSRLKREHPESEGRTIVVDDRLLGILLPCR  346

         ************************************************************

S: 125   afGdvkfkwskelqkrvvesgfdvladneykfiapnyytppyltaepevtyhrlrpqdkf  184

         afGdv++kws elq++v+ +gfd++a+n+y+f++p+y+tppylta+pevtyh+lrpqdkf

Q: 347   AFGDVQLKWSPELQRSVLGRGFDTEALNIYQFTPPHYHTPPYLTAKPEVTYHKLRPQDKF  406

         ************************************************************

S: 185   lvlasdGlwdllsredvvrlvgeylaeadttlte  218

         lvlasdGlwd+ls+edvvrlv+++la+   ++ +

Q: 407   LVLASDGLWDVLSNEDVVRLVVGHLADVGRHKPD  440

         **************************99888765

Domain Sequence
(FASTA)

IEEALIHSFQ RLDSDISLEI QAPLEDEMAK NLSLQVAFSG ATACMAHING LHLHVANAGD 60

CRAILGVQED NGRWSCLPLT RDHNAWNEAE LSRLKREHPE SEGRTIVVDD RLLGILLPCR 120

AFGDVQLKWS PELQRSVLGR GFDTEALNIY QFTPPHYHTP PYLTAKPEVT YHKLRPQDKF 180

LVLASDGLWD VLSNEDVVRL VVGHLADVGR HKPD 214

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013