EKS-ORC-00369

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00369

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	340.0	1.3E-101	1060	1323	264

Status

Unreviewed

Ensembl Protein

ENSOCUP00000000580

UniProt Accession

G1SDT3;

Protein Name

Protein Synonyms/Alias

Gene Name

YSK4

Gene Synonyms/Alias

YSK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000000666	ENSOCUP00000000580	ENSOCUT00000000667

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1327

Protein Sequence
(FASTA)

LLFLPSETHA ESLLDICHDT NSSPTDVMTV TKTQNIILQS ISDSEGSDLD ENRSHSTFVS 60

EEGDPGGELQ GWQPRTEGVE IFVTFPREVI HPQERSQDFE ENKNKINSRL SVPTANTRAF 120

FSLPREVDST DPRTGTLAMP PLLLKEEQGS HELSRANLGF LLPRPCSEPN ISTSVIPEEA 180

PHLLKGQQRK SEEFSTSDPK YSSCRIEFPL PPLSLLPMRS GVLTIPPNYK FPKERQRNIP 240

SQTSFIRKLS EPVSQSDAFS PSNKQQEAPV KVLVDQTLRS SDHSIWSRNM CSFRKASHHR 300

QDLERETSWQ SKEVDGWDNA GISDFEKGHS LVAFENCKED NIPTDTEGNI DHGSEKTKAE 360

ENCKYLSSGK EESSGVRNCE QNSEIVCTIP RKLPEAQHSG ITPNQGEEIR NGKSDSKSTS 420

LCEGEAMESN DSLEELTVLK GLTNVASDDP TGRVPEGHDG VQTNIKISTA GETKLEVNGM 480

VPVIPITFPG GRTPKEPAIA KPRLQKRKGP IHSNNFNMLA HPENDKHKVN MHRNKLESKT 540

KTSNRTPHNF MISIEDSIKT TTHKASIKPH VFPALRLVDP RPQQLPRFQR ITPQIEKKES 600

IHWTQKPTKQ SFPCICKNPR IKKSQVPLSV QPTEPRLNYL DLKYSDMFKE INSAADGPGI 660

YEMFGTPVYC HIREAERHEN KYYREICSAP SGRSTTSKCR SSHNERSSNS RTRLAQRRPH 720

TQPPKASLGI KPKHKVLISK EKGCRAVGSN LRDTEDGAAT SEPDRQTKSS GNDFLSAQDE 780

VQPTNLAQTP ENSTEQNEFL PGSDLSPVEE VSVEESTNGD FSSNQILTMS LRDLQELEGL 840

HQQTAFVPSE NSWAVPSEKG SNKHILQEKQ TTATLGKINA SQMLADDLEF DSISDDSKMF 900

MSFSFQEKQE KSSSPTYQHW THPADHDSFA NKSITYQTFG ETLGVANSIS PESLDSVKNE 960

ELTDELLGCL AAELLALDEK DNSSCQMMAN ETDAENLSLD LGGRGHSHSI KELGTDTTNV 1020

KTQTYSNGFR IHGREEQFLN ANEKKTYPET SSKNEDSILW TKGEILGKGA YGTVYCGLTS 1080

QGQLIAVKQV ALDTSDKSAT EKEYRKLQEE VELLKALKHV NIVAYLGTRL EENTVSIFME 1140

FVPGGSISSI INRFGPLPEM VFCKYTKQIL QGVAYLHENC VVHRDIKGNN VMLMPTGIIK 1200

LIDFGCAKRL AWAGLNGTHS DMLKSMHGTP YWMAPEVISE SGYGRKSDIW SIGCTVFEMA 1260

TGKPPLASMD RMAALFYIGA HRGLMPSLPD HFSENAADFV RMCLTRDQHE RPSALQLLSH 1320

PFLKRSH 1327

Nucleotide Sequence
(FASTA)

CTTCTGTTTC TTCCATCAGA AACACATGCT GAATCATTGC TTGACATTTG TCATGATACA 60

AACTCTTCTC CAACGGATGT AATGACAGTC ACCAAAACTC AAAACATAAT CTTGCAAAGC 120

ATCAGTGACA GTGAGGGCTC TGACCTAGAT GAGAACCGCA GTCATTCCAC GTTTGTTAGT 180

GAAGAAGGAG ACCCTGGTGG TGAGCTACAA GGCTGGCAGC CCAGAACAGA AGGTGTTGAG 240

ATTTTTGTGA CTTTTCCAAG AGAGGTCATT CATCCCCAAG AAAGGAGCCA AGATTTCGAA 300

GAAAACAAAA ATAAAATAAA TAGCCGCCTC AGCGTGCCCA CAGCAAACAC GCGCGCGTTC 360

TTTTCTCTTC CAAGGGAAGT GGACAGCACA GACCCGAGGA CAGGCACGCT GGCCATGCCG 420

CCTCTGCTTC TGAAGGAAGA GCAAGGCTCC CATGAGCTCA GCCGTGCAAA CTTGGGCTTC 480

CTATTGCCAA GACCTTGCTC AGAACCAAAC ATCTCCACGT CCGTCATCCC AGAAGAGGCC 540

CCTCATCTTC TGAAAGGGCA GCAGAGAAAA TCTGAAGAAT TTTCTACATC TGATCCAAAG 600

TACAGTAGCT GCAGAATTGA GTTCCCTCTG CCACCATTGT CACTGTTGCC CATGAGATCG 660

GGTGTCTTGA CCATTCCCCC AAATTACAAA TTTCCAAAGG AGAGACAAAG AAATATTCCA 720

AGTCAAACAT CCTTCATTCG TAAGCTCTCA GAGCCCGTTA GTCAATCTGA TGCGTTTAGT 780

CCATCAAACA AGCAGCAGGA AGCCCCAGTG AAGGTGTTGG TGGATCAGAC TCTCAGGTCT 840

TCTGATCACT CCATTTGGTC AAGAAATATG TGCTCTTTCC GCAAGGCTAG CCATCACAGA 900

CAAGACCTGG AGAGGGAGAC GAGCTGGCAA TCCAAGGAAG TAGACGGATG GGACAACGCT 960

GGAATCTCTG ACTTTGAGAA AGGGCATTCT TTGGTGGCCT TTGAGAATTG TAAGGAAGAT 1020

AATATTCCTA CAGATACAGA AGGGAATATT GACCATGGTA GTGAAAAGAC AAAAGCAGAA 1080

GAGAATTGTA AATATCTTTC GTCAGGAAAG GAAGAGAGCT CAGGAGTCAG AAACTGTGAA 1140

CAAAATTCAG AAATTGTATG TACCATTCCA AGGAAGCTCC CAGAAGCCCA GCACTCAGGA 1200

ATAACTCCTA ACCAGGGTGA AGAGATTAGA AATGGAAAAT CTGATTCAAA AAGCACTTCA 1260

TTATGTGAAG GTGAAGCAAT GGAATCCAAT GACAGTTTAG AAGAACTTAC TGTACTTAAA 1320

GGCTTGACCA ATGTAGCCTC TGATGACCCC ACTGGGAGAG TCCCAGAAGG TCATGATGGT 1380

GTGCAGACAA ACATAAAAAT ATCAACAGCA GGAGAAACCA AACTAGAAGT GAATGGTATG 1440

GTGCCTGTTA TCCCAATCAC TTTCCCAGGA GGTAGAACCC CCAAGGAACC AGCTATAGCC 1500

AAACCAAGGC TCCAAAAAAG AAAGGGCCCC ATTCATAGCA ACAACTTTAA CATGCTTGCA 1560

CACCCAGAAA ATGACAAGCA TAAGGTGAAT ATGCATAGGA ATAAATTGGA GTCAAAGACC 1620

AAAACAAGTA ACAGGACACC TCACAATTTC ATGATTTCCA TTGAAGATTC GATTAAGACC 1680

ACCACTCATA AAGCCAGCAT AAAACCTCAC GTTTTCCCTG CTTTGAGACT TGTTGACCCT 1740

AGGCCTCAGC AACTGCCTAG ATTTCAAAGG ATTACGCCAC AGATAGAAAA GAAAGAATCA 1800

ATTCACTGGA CCCAGAAACC TACAAAGCAG TCATTTCCTT GCATCTGTAA AAATCCAAGG 1860

ATAAAAAAAT CACAAGTTCC TCTCTCTGTT CAACCAACAG AACCGAGACT GAATTACCTA 1920

GATCTTAAGT ACAGCGACAT GTTCAAAGAA ATCAACTCAG CTGCTGATGG ACCAGGAATC 1980

TATGAGATGT TTGGGACCCC TGTTTACTGT CACATCAGAG AAGCTGAACG GCATGAAAAC 2040

AAGTATTACC GTGAGATATG CTCAGCTCCA TCTGGCAGAT CTACCACCAG TAAATGCCGG 2100

TCTTCACACA ATGAGAGGAG CAGCAATAGC AGAACAAGAC TTGCCCAGAG AAGACCACAT 2160

ACCCAACCCC CAAAGGCTTC CCTTGGCATT AAACCAAAGC ACAAAGTTTT AATTTCTAAA 2220

GAAAAGGGCT GCAGGGCTGT AGGTAGCAAC CTCCGAGACA CTGAAGATGG TGCTGCTACT 2280

TCAGAACCAG ATCGGCAGAC AAAATCATCA GGAAATGACT TTCTATCTGC CCAAGATGAA 2340

GTTCAGCCCA CGAACTTGGC TCAGACTCCT GAGAATTCCA CTGAGCAGAA TGAATTCCTT 2400

CCTGGCTCAG ATTTATCCCC TGTTGAAGAA GTCTCCGTAG AAGAGTCTAC TAATGGAGAT 2460

TTTTCTAGCA ATCAAATACT CACCATGAGC CTTAGAGATC TGCAAGAGCT TGAAGGGCTG 2520

CACCAGCAGA CCGCGTTTGT CCCCTCAGAA AACAGCTGGG CAGTGCCCAG TGAGAAGGGT 2580

TCTAACAAAC ACATATTGCA AGAAAAGCAG ACTACGGCAA CTCTTGGTAA AATAAATGCC 2640

AGCCAAATGT TAGCTGATGA TCTGGAGTTT GACAGCATTT CAGATGACTC TAAAATGTTT 2700

ATGAGTTTCT CTTTCCAAGA GAAACAGGAA AAGTCCTCTT CCCCAACATA CCAACATTGG 2760

ACACATCCAG CGGATCATGA TAGTTTTGCA AATAAGTCAA TCACATATCA GACATTTGGA 2820

GAAACTTTAG GCGTTGCAAA TTCAATTTCC CCAGAAAGTC TGGACTCAGT AAAGAATGAA 2880

GAATTGACAG ATGAGCTTTT GGGTTGCCTA GCTGCAGAAC TGTTAGCTCT TGATGAGAAA 2940

GACAACAGCT CTTGTCAAAT GATGGCAAAT GAAACAGATG CTGAGAACCT CAGTCTTGAC 3000

CTTGGTGGGA GAGGACACAG CCACAGCATC AAAGAACTGG GCACAGACAC AACAAATGTC 3060

AAAACACAGA CATACAGCAA TGGGTTCAGG ATACATGGCA GAGAGGAGCA ATTTCTCAAT 3120

GCAAATGAAA AGAAGACATA TCCTGAGACT AGTTCAAAGA ATGAAGACTC TATCCTGTGG 3180

ACCAAGGGTG AGATCCTTGG GAAGGGAGCC TACGGCACAG TATACTGTGG TCTCACTAGC 3240

CAAGGGCAGC TAATAGCTGT AAAACAGGTG GCTCTGGATA CCTCTGATAA ATCAGCTACT 3300

GAAAAAGAGT ACCGGAAACT TCAGGAAGAA GTAGAGCTTC TGAAAGCACT GAAACATGTC 3360

AACATTGTGG CCTATCTGGG GACGCGCTTG GAAGAGAACA CTGTAAGCAT TTTCATGGAG 3420

TTTGTCCCTG GTGGCTCAAT CTCGAGTATT ATAAACCGCT TCGGGCCATT GCCGGAGATG 3480

GTGTTCTGTA AGTATACAAA ACAAATTCTG CAAGGCGTTG CTTATCTCCA TGAGAACTGT 3540

GTGGTGCATC GCGACATCAA AGGGAATAAT GTTATGCTCA TGCCAACGGG AATCATAAAG 3600

CTGATTGATT TTGGCTGTGC CAAGCGTTTG GCCTGGGCAG GCCTAAACGG CACCCACAGT 3660

GACATGCTTA AGTCCATGCA CGGGACTCCA TACTGGATGG CCCCAGAAGT CATCAGTGAG 3720

TCTGGCTACG GAAGGAAATC GGATATCTGG AGCATTGGGT GCACTGTGTT TGAGATGGCC 3780

ACGGGAAAGC CCCCGCTGGC TTCCATGGAC AGGATGGCAG CCCTGTTTTA CATAGGAGCT 3840

CATAGAGGGC TGATGCCTTC CCTGCCAGAC CACTTCTCAG AAAACGCAGC TGACTTCGTG 3900

CGCATGTGCC TAACCAGGGA CCAGCATGAG CGACCCTCAG CTCTCCAGCT CCTGAGCCAC 3960

CCCTTCCTGA AGAGAAGCCA CTGA 3984

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpek.ksekkevkalkeEikllkelk  59

         w+k+e++gkG++g+vy++l+ ++g+l+avK+v++++ + ++++ke+++l+eE++llk+lk

Q: 1060  WTKGEILGKGAYGTVYCGLT-SQGQLIAVKQVALDTSDkSATEKEYRKLQEEVELLKALK  1118

         89*****************8.89***********8655055667****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G+  ee++++if+E+v+gGs+ss+++++g+l e+v++kytkqil+g+ayLHe

Q: 1119  HVNIVAYLGTRLEENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHE  1178

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG++krla++  + ++   l+s++Gt+++maPEvi

Q: 1179  NCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHsdmLKSMHGTPYWMAPEVI  1238

         **********************************999988877899**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a++f +ga++  +P++p+++se+

Q: 1239  SES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAALFYIGAHRgLMPSLPDHFSEN  1295

         988..****************************.9*********99979***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa +LL+h+fl

Q: 1296  AADFVRMCLTRDQHERPSALQLLSHPFL  1323

         **************************96

Domain Sequence
(FASTA)

WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSDKSA TEKEYRKLQE EVELLKALKH 60

VNIVAYLGTR LEENTVSIFM EFVPGGSISS IINRFGPLPE MVFCKYTKQI LQGVAYLHEN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCAKR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIS 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAALFYIG AHRGLMPSLP DHFSENAADF 240

VRMCLTRDQH ERPSALQLLS HPFL 264

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013