EKS-ORC-00284
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00284
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk517.29.8E-156432705274
StatusUnreviewed
Ensembl ProteinENSOCUP00000024172
UniProt AccessionG1SEQ3;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameALK
Gene Synonyms/Alias ALK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000001085ENSOCUP00000000943ENSOCUT00000001088
ENSOCUG00000001085ENSOCUP00000024172ENSOCUT00000026059
OrganismOryctolagus cuniculus
Functional Description
Protein Length819
Protein Sequence
(FASTA)
WLFTTCGASG PHGPTQAQCN NAYQNSNQSV VVGSEGPLKG IQIWTVPATD TYSISGYGAA 60
GGKGGKNTMM RSHGVSVLGI FNLEKDDMLY ILVGQQGEDA CPSTNQLIQK VCIGENNVIE 120
EEIRVNRSVH EWAGGGGGGG GATYVFKMKD GVPVPLIIAA GGGGRAYGAK TDTFHPERLE 180
NNSSVLGLNG NSGAAGGGGG WNDNTSLLWA GKSLLEGATG GHSCPQAMKK WGWETRGGFG 240
GGGGGCSSGG GGGGYIGGNA ASNNDPEMDG EDGISFISPL GILYTPALKV MEGHGEVNIK 300
HYLNCSHCEV DECHMDPETH KVICFCDHGT VLAQDGVSCV VSPTAEPHLP LSLILSVVTS 360
ALVAALVLAF SGIMVGECPR APWDFRMELQ SPEYKLSKLR TATIMTDYNP NYCFAGKTSS 420
ISDLKEVPRK NITLIRGLGH GAFGEVYEGQ VSGMPNDPSP LQVAVKTLPE VCSEQDELDF 480
LMEALIISKF NHQNIVRCIG VSLQALPRFI LLELMAGGDL KSFPRGDPAL RPHPKNQPSS 540
LAMLDLLHVA RDIACGCQYL EENHFIHRDI AARNCLLTCP GTGRVAKIGD FGMARDIYRA 600
SYYRKGGCAM LPVKWMPPEA FMEGIFTSKT DTWSFGVLLW EIFSLGYMPY PSKSNQEVLE 660
FVTSGGRMDP PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL ERIEYCTQDP DVINTALPIE 720
YGPLVEEEEK VPMRPKDPEG VPPLLVAPAQ AKREEAPVAA APAALPAASS GKAVKKPETS 780
RPALWNPTYG SWITENPARK NMFICHCLND SSKSPPGTQ 819
Nucleotide Sequence
(FASTA)
TGGCTGTTCA CGACGTGCGG GGCCAGCGGG CCCCATGGCC CCACGCAGGC CCAGTGCAAC 60
AACGCCTACC AGAACTCCAA CCAGAGCGTG GTGGTGGGGA GCGAAGGCCC CCTGAAGGGC 120
ATCCAGATCT GGACAGTGCC AGCCACCGAC ACCTACAGCA TCTCGGGCTA TGGAGCCGCT 180
GGCGGGAAAG GCGGGAAGAA CACCATGATG CGGTCCCATG GCGTGTCTGT GCTAGGCATC 240
TTCAACCTGG AGAAGGACGA CATGCTCTAC ATCCTGGTTG GGCAGCAGGG CGAGGACGCC 300
TGCCCCAGCA CAAACCAGTT AATTCAGAAA GTCTGCATTG GCGAGAATAA CGTGATAGAG 360
GAAGAGATCC GTGTGAACAG AAGCGTGCAC GAGTGGGCAG GAGGAGGAGG AGGGGGCGGT 420
GGAGCCACCT ACGTGTTTAA GATGAAGGAT GGCGTGCCCG TGCCCCTGAT CATTGCGGCC 480
GGCGGTGGCG GCAGGGCCTA TGGGGCCAAG ACAGACACCT TCCACCCAGA GAGACTGGAA 540
AATAACTCCT CGGTCCTGGG GCTGAACGGC AACTCCGGAG CCGCAGGCGG CGGAGGTGGC 600
TGGAATGATA ACACTTCCTT GCTCTGGGCT GGAAAGTCTT TGCTGGAGGG AGCCACCGGA 660
GGACATTCCT GCCCCCAGGC CATGAAGAAG TGGGGGTGGG AGACAAGAGG GGGTTTCGGA 720
GGGGGTGGAG GGGGGTGCTC CTCCGGTGGA GGAGGCGGAG GATACATAGG CGGCAACGCA 780
GCCTCAAACA ATGACCCTGA GATGGATGGG GAAGATGGGA TTTCATTTAT CAGTCCACTG 840
GGCATCCTGT ACACCCCAGC TTTGAAAGTG ATGGAGGGCC ATGGGGAAGT GAATATTAAA 900
CATTACCTAA ACTGCAGTCA CTGTGAGGTA GACGAATGTC ACATGGACCC GGAGACCCAC 960
AAGGTCATCT GCTTCTGTGA CCACGGAACG GTGCTGGCCC AGGACGGCGT CTCCTGTGTT 1020
GTGTCACCCA CTGCGGAGCC CCACCTGCCG CTGTCGCTGA TCCTCTCTGT GGTCACCTCT 1080
GCCCTAGTGG CCGCCCTGGT CCTGGCTTTC TCAGGCATCA TGGTCGGTGA GTGCCCCAGA 1140
GCCCCCTGGG ATTTCCGGAT GGAACTGCAG AGCCCCGAGT ACAAGCTGAG CAAGCTCCGA 1200
ACCGCGACCA TCATGACCGA CTACAACCCC AACTACTGCT TCGCCGGCAA GACCTCCTCC 1260
ATCAGCGACC TGAAGGAGGT GCCCCGGAAG AACATCACCC TCATTCGGGG CCTGGGCCAC 1320
GGCGCGTTTG GGGAGGTGTA CGAAGGCCAG GTGTCCGGAA TGCCCAACGA CCCGAGCCCC 1380
CTGCAGGTGG CTGTGAAGAC CCTGCCTGAG GTGTGTTCAG AACAGGACGA GCTGGATTTC 1440
CTCATGGAGG CCCTGATCAT CAGCAAATTC AACCACCAGA ACATCGTGCG CTGCATCGGC 1500
GTCAGTCTTC AGGCCCTGCC CCGGTTCATC CTGCTGGAGC TCATGGCGGG AGGAGACCTC 1560
AAGTCCTTCC CGCGGGGAGA CCCCGCCCTC CGCCCGCACC CTAAAAATCA GCCCTCCTCC 1620
CTGGCCATGC TGGACCTGCT GCACGTGGCT CGGGACATTG CCTGCGGCTG TCAGTATCTA 1680
GAGGAAAACC ATTTCATCCA CCGGGACATT GCTGCCAGGA ACTGCCTCTT GACCTGTCCA 1740
GGCACGGGAA GAGTGGCCAA GATCGGAGAC TTTGGAATGG CCCGAGACAT CTACAGAGCG 1800
AGCTACTACA GGAAGGGAGG CTGTGCAATG CTGCCAGTTA AGTGGATGCC CCCGGAGGCC 1860
TTCATGGAGG GAATATTTAC CTCCAAAACA GACACGTGGT CCTTCGGAGT GCTGCTCTGG 1920
GAAATATTCT CTCTCGGATA CATGCCGTAC CCCAGCAAAA GCAACCAGGA GGTCCTGGAG 1980
TTCGTCACCA GCGGAGGCCG GATGGACCCG CCCAAGAACT GCCCGGGGCC TGTATACCGG 2040
ATAATGACTC AGTGCTGGCA ACATCAACCA GAAGACAGGC CCAACTTCGC CATAATATTG 2100
GAGAGGATTG AATATTGCAC CCAGGACCCA GACGTCATCA ACACTGCCCT GCCCATAGAA 2160
TATGGGCCCC TGGTGGAAGA GGAGGAAAAG GTGCCCATGC GGCCCAAGGA CCCCGAGGGG 2220
GTCCCTCCGC TGCTGGTGGC TCCAGCGCAG GCCAAGCGGG AGGAGGCGCC CGTCGCAGCC 2280
GCGCCCGCCG CCCTGCCCGC CGCTTCGTCT GGCAAAGCCG TGAAGAAGCC CGAAACAAGC 2340
CGACCAGCCT TATGGAACCC GACGTACGGC TCGTGGATCA CGGAGAATCC CGCCAGAAAG 2400
AACATGTTCA TCTGTCACTG CCTTAATGAC AGTAGCAAAA GTCCTCCTGG GACCCAG 2457
Domain Profile
S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60
         i+l+r+lG+GafGevyeg+vsg+p+d+s+l+vavktlpe++seqdeldfl+ealiiskfn
Q: 432   ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  491
         799*********************************************************
S: 61    henivrliGvsleklprlillellaGGdlksflr...esrpkp.eqlsslamkdllkval  116
         h+nivr+iGvsl++lpr+illel+aGGdlksf r     rp+p +q+sslam dll+va+
Q: 492   HQNIVRCIGVSLQALPRFILLELMAGGDLKSFPRgdpALRPHPkNQPSSLAMLDLLHVAR  551
         *********************************943346999736899************
S: 117   dvakGckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrall  176
         d+a+Gc+yleen+fihrdiaarn+ll+++G++rvaki+dfGmardiyra+yyrkgg+a+l
Q: 552   DIACGCQYLEENHFIHRDIAARNCLLTCPGTGRVAKIGDFGMARDIYRASYYRKGGCAML  611
         ************************************************************
S: 177   pvkwmppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldsp  236
         pvkwmppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+p
Q: 612   PVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPP  671
         ************************************************************
S: 237   keipgsvyrimtdcwkhepedrpkfvsilerlqa  270
         k++pg+vyrimt+cw+h+pedrp+f++iler+++
Q: 672   KNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEY  705
         *******************************986
Domain Sequence
(FASTA)
ITLIRGLGHG AFGEVYEGQV SGMPNDPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60
HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFPRGDPALR PHPKNQPSSL AMLDLLHVAR 120
DIACGCQYLE ENHFIHRDIA ARNCLLTCPG TGRVAKIGDF GMARDIYRAS YYRKGGCAML 180
PVKWMPPEAF MEGIFTSKTD TWSFGVLLWE IFSLGYMPYP SKSNQEVLEF VTSGGRMDPP 240
KNCPGPVYRI MTQCWQHQPE DRPNFAIILE RIEY 274
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00292
EKS-BOT-00308
EKS-CAJ-00312
EKS-CAF-00313
EKS-CAP-00341
EKS-DAR-00653
EKS-EQC-00292
EKS-FEC-00287
EKS-GAG-00253
EKS-GAA-00374
EKS-GOG-00304
EKS-HOS-00307
EKS-ICT-00290
EKS-LAC-00314
EKS-LOA-00317
EKS-MAM-00304
EKS-MEG-00248
EKS-MOD-00295
EKS-MUM-00338
EKS-MUP-00298
EKS-MYL-00306
EKS-NOL-00278
EKS-ORN-00392
EKS-ORA-00265
EKS-ORL-00363
EKS-OTG-00308
EKS-PES-00268
EKS-PEM-00167
EKS-POA-00292
EKS-RAN-00317
EKS-SAH-00287
EKS-SUS-00272
EKS-TAG-00316
EKS-TAR-00396
EKS-TEN-00398
EKS-XET-00375
EKS-XIM-00391
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0048666; P:neuron development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR026830; ALK.
IPR008985; ConA-like_lec_gl_sf.
IPR011009; Kinase-like_dom.
IPR002172; LDrepeatLR_classA_rpt.
IPR000998; MAM_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00629; MAM; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00192; LDLa; 1.
SM00219; TyrKc; 1.
Prosites
PS50060; MAM_2; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013