EKS-ORC-00187

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00187

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	527.2	8.4E-159	5	288	284

Status

Unreviewed

Ensembl Protein

ENSOCUP00000023719

UniProt Accession

G1U2W5;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL4

Gene Synonyms/Alias

CDKL4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000001117	ENSOCUP00000023719	ENSOCUT00000023969
ENSOCUG00000001117	ENSOCUP00000000970	ENSOCUT00000001117

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

358

Protein Sequence
(FASTA)

IMEKYEKLAK IGEGSYGVVF KCRNKSSGQI VAIKKFVESE DDPVVKKIAL REIRMLKQLK 60

HPNLVNLIEV FRRKRKMHLV FEYCDHTLLN ELERNPNGVT DGVIKSVLWQ TLQALNFCHK 120

HNCIHRDVKP ENILITKQGI IKICDFGFAR ILRVPGDTYT DYVATRWYRA PELLVGDTQY 180

GSSVDVWAIG CVFAELLTGQ PLWPGKSDVD QLYLIIRTLG KLIPRHQSIF RSNQFFHGIS 240

IPEPEDMETL EEKFSNAHPV ALNFMKGCLK MNPNDRLTCA QLLESSYFDS FREEQIKRKA 300

RNEHPDPQHW KRDSFHHLFT HVRRLNQLLP LIPGSHISPT PDGRKQVLQL KLDHLPNI 358

Nucleotide Sequence
(FASTA)

ATAATGGAAA AGTACGAAAA ATTAGCTAAG ATTGGAGAAG GATCCTACGG GGTTGTATTC 60

AAATGTAGAA ATAAATCTTC TGGACAGATA GTTGCAATTA AAAAATTTGT GGAATCTGAA 120

GATGATCCTG TTGTGAAGAA AATCGCGCTA AGAGAAATTC GTATGTTGAA ACAATTAAAA 180

CACCCAAACC TTGTGAACCT CATTGAGGTG TTCAGGAGGA AAAGGAAAAT GCATTTAGTT 240

TTTGAATACT GTGATCATAC ACTTTTAAAT GAGCTGGAAA GAAACCCAAA TGGCGTTACC 300

GATGGAGTGA TCAAAAGTGT GCTGTGGCAG ACACTTCAGG CTCTTAATTT CTGCCATAAA 360

CATAACTGTA TTCACAGAGA TGTAAAACCT GAAAATATCC TAATCACTAA GCAAGGAATA 420

ATCAAGATCT GTGACTTCGG GTTTGCACGA ATTCTGAGAG TTCCAGGAGA TACCTACACA 480

GATTATGTTG CAACCAGATG GTACCGAGCC CCTGAGCTGC TCGTGGGTGA TACTCAGTAT 540

GGTTCTTCAG TGGACGTCTG GGCAATCGGT TGTGTTTTTG CAGAGCTCCT GACAGGCCAG 600

CCACTCTGGC CTGGGAAATC AGATGTGGAC CAACTTTATC TGATCATCAG AACACTGGGA 660

AAGCTAATAC CAAGACATCA GTCTATCTTT AGAAGTAACC AGTTTTTCCA TGGCATCAGT 720

ATACCTGAGC CAGAAGACAT GGAAACTCTT GAGGAAAAGT TCTCAAATGC TCATCCTGTG 780

GCTTTGAATT TCATGAAGGG GTGTCTGAAG ATGAATCCAA ATGACAGATT AACCTGTGCC 840

CAACTCCTGG AGAGCTCCTA CTTTGACTCT TTCCGAGAGG AACAAATTAA AAGAAAAGCA 900

CGTAATGAGC ATCCAGACCC CCAGCATTGG AAACGTGACT CTTTTCACCA TCTCTTCACC 960

CATGTTAGAA GACTTAATCA ACTGTTGCCT CTCATACCAG GAAGCCACAT CTCCCCCACA 1020

CCTGATGGAA GAAAACAAGT CCTCCAGTTA AAATTGGATC ATCTTCCAAA CATTTAG 1077

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         yekl+k+GeGsyGvv+kcrnk++gqivaikkf+esedd++vkkialrei++lkqlkh+nl

Q: 5     YEKLAKIGEGSYGVVFKCRNKSSGQIVAIKKFVESEDDPVVKKIALREIRMLKQLKHPNL  64

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnl+evfrrk+k++lvfey+d+t+l+eler+pnGv + ++k++l+q+l+a++fchk+n+i

Q: 65    VNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVTDGVIKSVLWQTLQALNFCHKHNCI  124

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrd+kpenili+k+g++k+cdfGfar+l  pgd+ytdyvatrwyrapellvgdt+yG+sv

Q: 125   HRDVKPENILITKQGIIKICDFGFARILRVPGDTYTDYVATRWYRAPELLVGDTQYGSSV  184

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGc++aelltG+pl+pgksdvdqly+i++tlG+liprhq+if++n++f+G+++pe+

Q: 185   DVWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQFFHGISIPEP  244

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         ed+e+le+k++++++v+l+++k+clk++p++rl+c++ll+++yf

Q: 245   EDMETLEEKFSNAHPVALNFMKGCLKMNPNDRLTCAQLLESSYF  288

         ******************************************98

Domain Sequence
(FASTA)

YEKLAKIGEG SYGVVFKCRN KSSGQIVAIK KFVESEDDPV VKKIALREIR MLKQLKHPNL 60

VNLIEVFRRK RKMHLVFEYC DHTLLNELER NPNGVTDGVI KSVLWQTLQA LNFCHKHNCI 120

HRDVKPENIL ITKQGIIKIC DFGFARILRV PGDTYTDYVA TRWYRAPELL VGDTQYGSSV 180

DVWAIGCVFA ELLTGQPLWP GKSDVDQLYL IIRTLGKLIP RHQSIFRSNQ FFHGISIPEP 240

EDMETLEEKF SNAHPVALNF MKGCLKMNPN DRLTCAQLLE SSYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013