EKS-ORC-00377
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00377
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR598.55.2E-180598956359
StatusUnreviewed
Ensembl ProteinENSOCUP00000025166
UniProt AccessionG1SG06;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000001725ENSOCUP00000001483ENSOCUT00000001727
ENSOCUG00000001725ENSOCUP00000025166ENSOCUT00000021050
OrganismOryctolagus cuniculus
Functional Description
Protein Length1081
Protein Sequence
(FASTA)
LPGILPALSL RWSLLLSLLL LLGPEASQGL VITPPGPELV LNISSTFVLT CSGSAPVVWE 60
RLSQEPWQEV AVNQDGTFSS VLTLSNVTGT DTGEYFCSYN GSQGLDPSER KRLYIFVPDP 120
TMSFLPTEPE ELFIFLTEIT ETTIPCRVTD PRLVVTLHEK KEDVPLPIPY DHQRGFSGTF 180
EDKTYVCKTT IGDREVDSDA YYVYSLQVSS INVSVNAVQT VVRQGENITI MCIVTGNEVV 240
NFEWRYPRQE SGRLVEPVTD FLFDVPSHIR SILHIPNAET GDSGTYICNV SESVNDHRDE 300
KAINVTVVES GYVRLLGELG ALQFADLHRS RTLQVVFEAY PPPTVLWFKD NRTLGDSSAG 360
EIALSTRNVS ETRYVSELTL VRVKVAEAGR YTMRAFHEDA EAQLSFQLQV NVPVRVLELS 420
ESHLASGEQI VRCRGRGMPQ PNVTWFTCRD LKSRCPSELP PTPLGNRSED ESQLETNVTY 480
WAEEQEFEVV STLRLRHVDQ PLSVRCVLRN LRDYDTKEVT VVPHSLPFKV VVISAILALV 540
VLTIISLIIL IMIWQKKPRY EIRWKVIESV SSDGHEYIYV DPMQLPYDST WELPRDQLVL 600
GRTLGSGAFG QVVEATAHGL SHSQATMKVA VKMLKSTARS SEKQALMSEL KIMSHLGPHL 660
NVVNLLGACT KGGPIYIITE YCRYGDLVDY LHRNKHTFLQ QHSDKRRSPS AELYSNALAV 720
GLRLPSHMSL TGESDGGYMD MSKDESVDYV PMLDMKGDVK YADIDSSNYM APYDNYVPSA 780
PERPYRTTLI NESPLLSYTD LVGFSYQVAN GMEFLASKNC VHRDLAARNV LICEGKLVKI 840
CDFGLARDIM RDSNYISKGS TFLPLKWMAP ESIFNSLYTT LSDVWSFGIL LWEIFTLGGT 900
PYPELPMNEQ FYNAIKRGYR MAQPAHASDE IYEIMQKCWE EKFEIRPPFS QLVLLLERLL 960
GEGYKKKYQQ VDEEFLRSDH PAILRSQARF PGFHGLRSPL DTGSVLYTAV QPNEGDNDYI 1020
IPLPDPKPEV ADEGPLEGSP SLASSTLNEA NTSSTISCDS PLEPQEEAEL EAQVEAPEEP 1080
P 1081
Nucleotide Sequence
(FASTA)
CTTCCAGGGA TCCTCCCTGC TCTGTCTCTT CGCTGGTCGC TGCTGCTGTC CCTGCTCTTG 60
CTGCTGGGAC CGGAAGCCTC CCAGGGCCTG GTCATCACTC CTCCAGGGCC AGAACTGGTC 120
CTCAACATCT CCAGCACCTT CGTGCTGACC TGCTCGGGTT CGGCTCCGGT GGTGTGGGAG 180
CGGCTGTCCC AGGAGCCCTG GCAGGAAGTG GCCGTGAACC AGGACGGCAC CTTCTCCAGC 240
GTGCTCACCC TGAGCAATGT CACTGGGACA GACACCGGCG AGTACTTCTG CAGCTACAAC 300
GGCTCGCAGG GGCTGGACCC CAGCGAGCGG AAGCGGCTCT ACATCTTTGT GCCAGATCCC 360
ACCATGAGCT TCCTCCCCAC GGAACCTGAG GAACTCTTCA TCTTCCTCAC GGAGATAACT 420
GAGACCACAA TTCCGTGCCG AGTGACAGAC CCTCGGCTGG TGGTAACACT GCACGAGAAG 480
AAGGAGGACG TCCCGCTGCC CATTCCCTAT GACCACCAGC GTGGCTTCTC GGGGACCTTT 540
GAGGACAAGA CCTACGTGTG CAAGACCACC ATCGGGGACA GGGAGGTGGA CTCCGATGCC 600
TACTACGTCT ACAGCCTCCA GGTGTCATCC ATCAACGTCT CTGTGAACGC GGTGCAGACC 660
GTGGTCCGCC AGGGCGAGAA CATCACCATC ATGTGCATCG TGACCGGCAA CGAGGTGGTC 720
AACTTCGAGT GGCGGTACCC CCGCCAGGAG AGTGGGCGGC TGGTGGAGCC GGTGACCGAC 780
TTCCTGTTTG ATGTGCCCTC CCACATCCGC TCCATCCTGC ACATCCCCAA TGCTGAGACA 840
GGCGACTCTG GGACCTACAT CTGCAACGTG TCGGAGAGCG TGAATGACCA TCGCGATGAA 900
AAGGCCATCA ATGTCACTGT GGTTGAGAGC GGCTACGTGC GGCTGCTGGG AGAGCTGGGC 960
GCGCTGCAGT TCGCCGACCT GCACCGGAGC CGTACGCTGC AGGTGGTGTT CGAGGCCTAC 1020
CCTCCGCCCA CCGTCCTGTG GTTCAAGGAC AACCGCACCC TGGGTGACTC CAGCGCCGGC 1080
GAGATCGCCC TGTCCACACG CAATGTGTCT GAGACCCGGT ACGTGTCAGA ACTGACGCTG 1140
GTGCGGGTGA AGGTGGCGGA GGCGGGCAGG TACACCATGC GGGCTTTCCA CGAGGACGCC 1200
GAGGCACAGC TCTCCTTCCA GCTGCAGGTC AACGTCCCTG TCCGTGTGCT GGAGCTGAGC 1260
GAGAGCCACC TCGCCAGTGG GGAGCAGATA GTTCGCTGTC GTGGCCGGGG CATGCCTCAG 1320
CCGAATGTCA CCTGGTTTAC CTGCAGAGAC CTGAAAAGCA GGTGCCCGTC CGAGCTGCCG 1380
CCCACGCCGC TGGGGAACCG CTCCGAGGAC GAGAGCCAGC TAGAGACCAA CGTGACGTAC 1440
TGGGCGGAGG AGCAGGAGTT TGAGGTGGTG AGCACACTGC GCCTGCGCCA CGTGGATCAG 1500
CCGCTGTCGG TGCGCTGTGT GCTGCGCAAC CTGCGTGACT ACGACACCAA GGAGGTCACC 1560
GTGGTGCCGC ATTCGCTGCC CTTCAAAGTG GTGGTGATCT CGGCCATCCT GGCCTTGGTG 1620
GTGCTCACGA TCATCTCCCT CATCATCCTC ATCATGATCT GGCAGAAGAA GCCACGCTAC 1680
GAGATCCGGT GGAAGGTGAT CGAGTCCGTG AGCTCTGATG GCCACGAGTA CATCTACGTG 1740
GACCCCATGC AGCTGCCCTA CGACTCCACA TGGGAGCTGC CGCGGGACCA GCTCGTGCTC 1800
GGTCGCACCC TCGGCTCCGG CGCCTTCGGG CAGGTGGTGG AGGCCACGGC CCATGGCCTC 1860
AGTCACTCGC AGGCCACCAT GAAGGTGGCT GTGAAGATGT TGAAATCCAC AGCCCGGAGC 1920
AGTGAGAAGC AAGCCCTCAT GTCCGAGCTG AAGATTATGA GTCACCTTGG GCCACACCTG 1980
AACGTGGTCA ACCTGCTGGG GGCCTGCACC AAGGGAGGCC CCATCTACAT CATCACCGAG 2040
TACTGCCGCT ACGGCGACCT GGTGGACTAC CTGCACCGCA ACAAGCACAC CTTCCTGCAG 2100
CAGCACTCCG ACAAGCGCCG CTCGCCCAGC GCTGAGCTCT ACAGCAACGC CCTGGCCGTC 2160
GGCCTGCGGC TGCCCAGCCA CATGTCCCTG ACCGGCGAGA GTGACGGCGG CTACATGGAC 2220
ATGAGCAAGG ACGAGTCGGT GGACTACGTG CCCATGCTGG ACATGAAAGG AGATGTCAAA 2280
TACGCAGACA TTGACTCCTC CAACTACATG GCCCCTTACG ATAACTACGT CCCCTCCGCC 2340
CCCGAGAGGC CCTACCGGAC CACTCTGATC AACGAGTCCC CGCTACTCAG CTACACGGAC 2400
CTCGTGGGCT TCAGCTACCA GGTGGCCAAC GGCATGGAGT TCCTGGCCTC CAAGAACTGC 2460
GTTCACCGAG ACCTGGCAGC CAGGAACGTG CTCATCTGCG AGGGCAAGCT GGTCAAGATC 2520
TGTGACTTCG GCCTGGCCCG AGACATCATG CGCGACTCCA ACTACATCTC CAAAGGCAGC 2580
ACCTTCCTGC CCCTGAAGTG GATGGCCCCG GAGAGCATCT TCAACAGCCT CTACACCACC 2640
CTGAGCGACG TGTGGTCCTT TGGGATCCTC CTCTGGGAGA TCTTCACCCT GGGCGGCACG 2700
CCGTACCCGG AGCTGCCCAT GAACGAGCAA TTCTACAATG CCATCAAGCG GGGCTACCGC 2760
ATGGCCCAGC CTGCACATGC CTCCGACGAG ATCTACGAGA TTATGCAGAA GTGCTGGGAA 2820
GAGAAGTTTG AGATTCGGCC CCCTTTCTCC CAACTCGTGC TGCTTCTCGA GAGGCTGCTG 2880
GGCGAGGGTT ACAAAAAGAA GTACCAGCAG GTGGATGAGG AGTTTCTCAG GAGTGACCAC 2940
CCGGCCATCC TCCGGTCCCA AGCCCGCTTC CCTGGGTTCC ACGGCCTCCG ATCTCCCCTG 3000
GACACCGGCT CTGTCCTCTA CACGGCCGTG CAGCCCAACG AGGGCGACAA CGACTACATC 3060
ATCCCCCTGC CTGACCCCAA GCCCGAGGTT GCTGATGAGG GCCCCCTGGA GGGCTCCCCC 3120
AGCCTTGCCA GCTCCACCCT GAATGAGGCC AACACGTCTT CCACCATCTC CTGTGACAGC 3180
CCCCTGGAGC CCCAAGAAGA AGCAGAGCTC GAGGCACAGG TGGAGGCCCC GGAGGAGCCC 3240
CCG 3243
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG
Q: 598   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  657
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl+++++k++ +++el+s+a
Q: 658   PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQQHSDKRRSPSAELYSNA  717
         ************************************************************
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164
         l ++  l s++sl+ es++ y+d++kd                ++d++ss++++++++++
Q: 718   LAVGLRLPSHMSLTGESDGGYMDMSKDesvdyvpmldmkgdvkYADIDSSNYMAPYDNYV  777
         ************************************************************
S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224
          sa er ++++l++e s  l+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk
Q: 778   PSAPERPYRTTLINE-SPLLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  836
         *************99.99******************************************
S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284
         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+
Q: 837   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  896
         ************************************************************
S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+qlv ll
Q: 897   LGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL  956
         ********************************************************9986
Domain Sequence
(FASTA)
LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQQHSDKRR SPSAELYSNA 120
LAVGLRLPSH MSLTGESDGG YMDMSKDESV DYVPMLDMKG DVKYADIDSS NYMAPYDNYV 180
PSAPERPYRT TLINESPLLS YTDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240
VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 300
GGTPYPELPM NEQFYNAIKR GYRMAQPAHA SDEIYEIMQK CWEEKFEIRP PFSQLVLLL 359
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005019; F:platelet-derived growth factor beta-receptor activity
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0060326; P:cell chemotaxis
GO:0001701; P:in utero embryonic development
GO:0001822; P:kidney development
GO:0006807; P:nitrogen compound metabolic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777; P:protein autophosphorylation
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048705; P:skeletal system morphogenesis
GO:0048745; P:smooth muscle tissue development
GO:0001894; P:tissue homeostasis
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013