EKS-ORC-00267
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00267
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR388.91.6E-116203501299
StatusUnreviewed
Ensembl ProteinENSOCUP00000017190
UniProt AccessionG1SGJ0;
Protein Name
Protein Synonyms/Alias
Gene NameBMPR2
Gene Synonyms/Alias BMPR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000001971ENSOCUP00000017190ENSOCUT00000027713
ENSOCUG00000001971ENSOCUP00000001701ENSOCUT00000001973
OrganismOryctolagus cuniculus
Functional Description
Protein Length1037
Protein Sequence
(FASTA)
KKVVIFRKWV MPLLIYSLLC VKVILASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC 60
SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHFEECV VTTTPPSIQN GTYRFCCCST 120
DLCNVNFTEN FPPPDTTPLS PPHSFNRDET IIIALASVSV LAVLIVALCF GYRMLTGDRK 180
QGLHSMNMME AAASEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF 240
INEKNIYRVP LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS 300
SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS DFGLSMRLTG 360
NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEIFMRC 420
TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI 480
EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRMPKI 540
GPYPDYSSSS YIEDSIHHTD SIVKNISSEH SVSSTPLTTG EKNRNSINYE RQQAQARIPS 600
PETSVTSLST NTTATNTTGL TPSTGMTTIS EVPYPDETSL HAANATQSIG PTPVCLQLTE 660
EDLATNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS STSSSLLYPL IKLAVEVTGQ 720
QDFTQAANGQ ACLIPDVPPT QIYPLPKQQN LPKRPTSLPL NTKNSTKEPR LKFGSKHKSN 780
LKQVETGVAK MNTINAAEPH VVTVTMNGVA GRNHVNSHAA TTQYANGTVP SGQTANIGAH 840
RAQEMLQNQF ISEDTRLNIN SSPDEHEPLL RREQQAGRDE GVLDRLVDRR ERPLEGGRTN 900
SNNNNSNPCS EQDVLTQSVP STVADPGPSK PRRAQRPNSL DLSATNVLDG SSMQIGESTQ 960
DGKSGSGEKI KKRVKTPYSL KRWRPSTWVI STEPLDCEVN SYGNDRAVHS KSSTAVYLAE 1020
GGTATTMVSK DIGMNCL 1037
Nucleotide Sequence
(FASTA)
AAAAAAGTAG TGATTTTCAG GAAATGGGTG ATGCCGCTGC TGATTTATAG TTTATTATGT 60
GTAAAGGTCA TTTTAGCTTC CCAGAATCAA GAACGGCTAT GTGCATTTAA AGATCCATAT 120
CAACAGGACC TTGGGATAGG AGAGAGTCGT ATCTCACATG AAAATGGGAC AATACTATGT 180
TCAAAAGGTA GCACCTGCTA TGGCCTTTGG GAGAAATCAA AAGGGGACAT AAATCTTGTA 240
AAACAAGGAT GCTGGTCTCA CATTGGAGAC CCCCAAGAGT GTCACTTTGA AGAATGTGTA 300
GTAACCACCA CCCCTCCCTC AATTCAGAAT GGAACATACC GTTTCTGCTG CTGTAGCACA 360
GATTTATGTA ATGTCAACTT TACTGAGAAT TTTCCACCTC CTGATACAAC ACCACTCAGT 420
CCACCTCATT CATTTAATCG AGATGAGACG ATAATCATTG CTTTGGCATC AGTCTCTGTA 480
TTAGCTGTTT TGATAGTTGC CTTATGCTTT GGATACAGAA TGTTAACAGG AGATCGAAAA 540
CAAGGTCTTC ACAGTATGAA CATGATGGAG GCAGCAGCAT CAGAGCCTTC TCTTGACCTA 600
GATAATCTAA AACTATTGGA GCTAATTGGC CGGGGTCGAT ATGGAGCAGT TTATAAAGGT 660
TCCTTAGATG AGCGTCCAGT TGCCGTAAAA GTATTTTCCT TTGCAAATCG TCAGAATTTT 720
ATCAATGAGA AGAACATTTA CAGAGTGCCT TTGATGGAAC ATGACAACAT CGCTCGCTTT 780
ATAGTTGGAG ATGAGAGAGT TACTGCAGAT GGACGCATGG AGTATTTGCT TGTGATGGAG 840
TATTATCCCA ATGGATCTCT ATGCAAGTAT TTGAGTCTCC ATACAAGTGA CTGGGTAAGC 900
TCTTGCCGTC TGGCTCATTC TGTGACTAGA GGACTGGCTT ATCTTCACAC AGAATTACCA 960
CGAGGAGATC ATTATAAACC TGCAATTTCT CATCGAGATT TAAACAGCAG AAATGTCCTG 1020
GTAAAAAATG ATGGAACCTG TGTTATTAGT GACTTTGGGT TGTCCATGAG GCTGACTGGA 1080
AACAGACTTG TACGCCCAGG AGAAGAAGAT AATGCAGCCA TAAGTGAGGT TGGCACAATC 1140
AGATATATGG CACCAGAAGT GCTAGAAGGA GCTGTGAACC TGAGGGACTG TGAATCAGCT 1200
TTGAAACAAG TAGACATGTA TGCACTTGGA CTAATCTACT GGGAGATATT TATGAGATGT 1260
ACAGACCTCT TCCCAGGTGA ATCTGTACCA GAGTACCAGA TGGCTTTTCA GACAGAAGTT 1320
GGAAACCATC CCACTTTTGA AGATATGCAG GTTCTTGTGT CTAGGGAAAA ACAGAGACCC 1380
AAGTTCCCGG AAGCCTGGAA AGAAAACAGC CTGGCAGTGA GATCACTCAA GGAGACAATC 1440
GAAGACTGTT GGGACCAGGA TGCAGAGGCT CGGCTTACTG CACAGTGTGC TGAGGAGAGA 1500
ATGGCTGAAC TTATGATGAT ATGGGAAAGG AACAAATCTG TGAGCCCAAC TGTCAATCCA 1560
ATGTCTACTG CTATGCAGAA TGAGCGCAAC CTGTCACATA ATAGGCGTAT GCCAAAAATT 1620
GGCCCTTATC CAGATTACTC TTCTTCCTCA TACATTGAAG ACTCCATCCA TCATACTGAC 1680
AGCATTGTGA AGAACATTTC CTCTGAGCAT TCCGTGTCCA GCACACCTTT GACTACAGGG 1740
GAAAAGAACC GGAACTCAAT TAATTATGAA CGGCAACAAG CACAAGCTCG AATCCCCAGC 1800
CCTGAAACGA GCGTCACCAG CCTGTCCACC AATACAACAG CCACAAACAC CACTGGTCTC 1860
ACTCCTAGTA CTGGCATGAC TACTATATCT GAGGTGCCGT ACCCAGATGA AACCAGTCTT 1920
CATGCTGCAA ATGCTACACA GTCGATTGGG CCAACACCTG TGTGCTTACA GCTAACAGAA 1980
GAAGACTTGG CGACCAACAA GCTAGACCCA AAAGAAGTTG ATAAGAACCT CAAAGAAAGC 2040
TCTGATGAGA ATCTCATGGA ACATTCTCTT AAACAGTTCA GTGGGCCAGA CCCATTGAGC 2100
AGCACCAGTT CTAGCTTGCT TTACCCACTC ATAAAGCTTG CAGTAGAAGT GACTGGACAG 2160
CAGGACTTCA CACAGGCTGC AAATGGCCAA GCATGTTTAA TTCCTGATGT TCCACCTACT 2220
CAGATTTATC CTCTTCCCAA ACAACAGAAC CTTCCTAAGA GACCTACTAG TTTGCCTTTG 2280
AACACCAAAA ATTCAACAAA GGAGCCCCGG CTAAAATTTG GCAGCAAGCA CAAATCAAAC 2340
TTGAAACAAG TAGAAACTGG GGTTGCCAAA ATGAACACAA TCAATGCAGC AGAACCTCAT 2400
GTGGTGACTG TTACCATGAA TGGGGTGGCA GGTAGAAACC ATGTTAACTC CCATGCTGCC 2460
ACAACCCAGT ACGCCAATGG GACAGTACCA TCTGGCCAGA CAGCCAACAT AGGGGCACAT 2520
AGGGCCCAAG AAATGCTGCA GAATCAATTT ATCAGTGAGG ACACCAGGCT GAATATTAAT 2580
TCCAGTCCTG ATGAGCATGA ACCTTTACTG AGACGAGAGC AGCAGGCTGG CCGTGATGAA 2640
GGTGTTCTGG ATCGTCTGGT GGACAGGAGG GAACGGCCAC TAGAAGGTGG CCGAACTAAT 2700
TCCAATAACA ACAACAGCAA TCCATGTTCA GAACAAGATG TTCTTACACA AAGTGTTCCA 2760
AGCACAGTAG CAGATCCTGG GCCATCAAAG CCCAGAAGAG CACAGAGGCC TAATTCTCTG 2820
GATCTTTCAG CCACAAATGT CCTGGATGGC AGCAGCATGC AGATAGGTGA GTCAACACAA 2880
GATGGCAAAT CAGGATCAGG TGAAAAGATC AAGAAACGTG TGAAAACTCC CTATTCTCTT 2940
AAGCGGTGGC GCCCCTCCAC CTGGGTCATC TCCACTGAAC CACTGGACTG TGAGGTCAAC 3000
AGCTATGGCA ACGATAGGGC AGTTCATTCC AAATCCAGCA CCGCTGTTTA CCTTGCAGAA 3060
GGAGGCACTG CCACAACCAT GGTGTCTAAA GATATAGGAA TGAACTGTCT GTGA 3114
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+
Q: 203   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  262
         6899********************************************************
S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119
          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++  
Q: 263   GDErVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  322
         **9999**************************************************9766
S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175
          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R
Q: 323   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  381
         .46***********************************999877787999**********
S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232
         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg
Q: 382   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  441
         *****************99*****************************************
S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291
         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+
Q: 442   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  501
         ***************************9999*************************9987
Domain Sequence
(FASTA)
LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60
GDERVTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120
DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180
MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240
HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00267
EKS-ANC-00273
EKS-BOT-00285
EKS-CAJ-00291
EKS-CAF-00291
EKS-CAP-00320
EKS-DAR-00625
EKS-DRM-00145
EKS-EQC-00277
EKS-FEC-00271
EKS-GAG-00238
EKS-GAA-00349
EKS-GOG-00284
EKS-HOS-00291
EKS-ICT-00269
EKS-LAC-00296
EKS-LOA-00295
EKS-MAM-00287
EKS-MEG-00225
EKS-MOD-00280
EKS-MUM-00316
EKS-MUP-00281
EKS-MYL-00287
EKS-NOL-00263
EKS-ORN-00368
EKS-ORA-00247
EKS-OTG-00290
EKS-PAT-00269
EKS-PES-00254
EKS-PEM-00153
EKS-POA-00276
EKS-PRC-00027
EKS-PTV-00041
EKS-RAN-00301
EKS-SAH-00267
EKS-SUS-00250
EKS-TAG-00297
EKS-TAR-00369
EKS-TAS-00021
EKS-TEN-00366
EKS-VIP-00019
EKS-XET-00358
EKS-XIM-00360
Gene Ontology
GO:0005901; C:caveola
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0009952; P:anterior/posterior pattern specification
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0009267; P:cellular response to starvation
GO:0048286; P:lung alveolus development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0001707; P:mesoderm formation
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0003085; P:negative regulation of systemic arterial blood pressure
GO:0045906; P:negative regulation of vasoconstriction
GO:0030513; P:positive regulation of BMP signaling pathway
GO:0030501; P:positive regulation of bone mineralization
GO:0010595; P:positive regulation of endothelial cell migration
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010634; P:positive regulation of epithelial cell migration
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916; P:regulation of lung blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0006366; P:transcription from RNA polymerase II promoter
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0060841; P:venous blood vessel development
KEGG
InterPros
IPR000472; Activin_rcpt.
IPR015770; BMPRII.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013