EKS-ORC-00365

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00365

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	363.9	6.6E-109	371	631	261

Status

Unreviewed

Ensembl Protein

ENSOCUP00000001949

UniProt Accession

G1SH57;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K2

Gene Synonyms/Alias

MAP3K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000002258	ENSOCUP00000001949	ENSOCUT00000002259
ENSOCUG00000002258	ENSOCUP00000025076	ENSOCUT00000026895

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

634

Protein Sequence
(FASTA)

KNHFPNFQIV EPVAMMDDQQ ALNSIMQDLA VLHKASRPAL SLQETRKAKS SSPKKQNDVR 60

VKFEHRGEKR ILQFPRPVKL EDLRSKAKIA FGQSMDLHYT NNELVIPLTT QDDLDKAVEL 120

LDRSIHMKSL KILLVINGNA QATTVEPLTS LEDLDNTVFG AERKKRLSVI GSTSRDRSSP 180

PPGYIPDELH QVARNGSFTS INSEGEFIPE SMDQMLDPLS LSSPENSGSG SCPSLDSPLD 240

GESYPKSRMP RAQSYPDNHQ EFSDYDNPIF EKFGKGGTYP RRYHISYHHQ EYNDGRKTFP 300

RARRTQGTSF RSPVSFSPTD HSLSTSSGSS IFTPEYDDSR IRRRGSDIEN PTLTVMDISP 360

PSRSPRAPTN WRLGKLLGQG AFGRVYLCYD VDTGRELAVK QVQFDPESPE TSKEVNALEC 420

EIQLLKNLLH ERIVQYYGCL RDPQEKTLSI FMEYMPGGSI KDQLKAYGAL TENVTRKYTR 480

QILEGVHYLH SNMIVHRDIK GANILRDSTG NVKLGDFGAS KRLQTICLSG TGMKSVTGTP 540

YWMSPEVISG EGYGRKADIW SVACTVVEML TEKPPWAEFE AMAAIFKIAT QPTNPKLPPH 600

VSDYTRDFLK RIFVEVKLRP SADELLRHMF VHYH 634

Nucleotide Sequence
(FASTA)

AAGAACCATT TTCCTAATTT TCAAATTGTT GAACCAGTTG CCATGATGGA TGATCAGCAG 60

GCTTTGAACT CAATCATGCA AGATCTGGCT GTCCTTCACA AGGCAAGTCG GCCAGCACTA 120

TCCTTACAGG AAACCAGAAA GGCAAAATCT TCATCACCAA AAAAACAGAA TGATGTCCGG 180

GTCAAATTTG AACACAGAGG AGAAAAAAGA ATCCTTCAGT TCCCCAGACC AGTTAAACTG 240

GAAGATCTGA GGTCTAAAGC TAAAATTGCC TTTGGACAGT CTATGGATCT ACATTATACC 300

AATAACGAGT TGGTAATTCC ACTAACTACC CAAGATGACT TGGATAAAGC TGTGGAACTG 360

TTGGATCGTA GTATTCATAT GAAGAGCCTC AAAATATTGC TTGTAATAAA TGGTAATGCA 420

CAGGCTACTA CTGTAGAACC ATTAACATCA CTAGAAGATT TGGATAACAC AGTATTTGGA 480

GCAGAAAGGA AAAAACGACT GTCTGTGATA GGTTCCACTA GTAGAGACAG AAGCTCCCCT 540

CCCCCAGGAT ACATTCCAGA TGAATTACAC CAGGTTGCCC GGAACGGGTC ATTCACTAGC 600

ATCAACAGTG AAGGAGAGTT CATTCCAGAG AGCATGGACC AAATGCTGGA TCCATTATCT 660

TTAAGCAGTC CTGAAAATTC TGGCTCAGGA AGTTGTCCAT CACTTGATAG TCCTTTGGAT 720

GGAGAGAGCT ATCCAAAGTC ACGAATGCCT AGGGCACAGA GCTATCCAGA TAATCATCAG 780

GAATTTTCAG ATTATGATAA CCCTATCTTT GAGAAATTTG GAAAAGGAGG AACATATCCA 840

AGAAGGTATC ATATTTCATA TCACCACCAA GAGTATAATG ATGGTCGTAA AACTTTTCCA 900

AGAGCCAGAA GGACCCAGGG GACCAGCTTT CGGTCTCCTG TGAGTTTCAG TCCTACTGAT 960

CACTCCTTAA GTACCAGTAG TGGAAGCAGT ATCTTTACCC CGGAGTATGA TGATAGTCGA 1020

ATAAGAAGAA GGGGAAGTGA TATAGAGAAT CCTACCTTGA CTGTGATGGA CATCAGCCCA 1080

CCCAGCCGTT CACCTCGAGC TCCAACTAAC TGGAGATTGG GCAAACTGCT TGGCCAAGGA 1140

GCCTTTGGCA GGGTCTACCT CTGTTATGAT GTTGATACCG GAAGAGAATT GGCTGTTAAG 1200

CAAGTTCAAT TTGACCCCGA GAGCCCTGAG ACCAGCAAGG AAGTAAATGC ACTTGAATGT 1260

GAAATTCAGC TGTTGAAAAA CCTGCTGCAT GAGCGAATTG TTCAGTATTA TGGCTGTTTG 1320

AGGGATCCCC AGGAAAAAAC ACTTTCCATA TTTATGGAAT ATATGCCAGG GGGTTCAATT 1380

AAGGACCAAT TGAAAGCGTA TGGAGCTCTT ACTGAGAATG TGACAAGGAA ATATACCCGT 1440

CAAATTTTAG AGGGTGTCCA CTATTTGCAC AGTAATATGA TTGTCCATAG AGACATCAAA 1500

GGTGCAAATA TCCTGCGAGA TTCAACAGGC AATGTCAAAC TGGGAGATTT TGGGGCCAGC 1560

AAACGGCTTC AAACCATCTG TCTGTCGGGG ACAGGAATGA AGTCTGTCAC AGGCACACCA 1620

TACTGGATGA GCCCTGAAGT AATCAGTGGA GAAGGCTATG GTAGAAAAGC AGATATCTGG 1680

AGTGTAGCAT GTACTGTGGT AGAGATGTTA ACTGAAAAGC CACCGTGGGC TGAATTTGAA 1740

GCGATGGCCG CCATCTTTAA AATCGCCACT CAGCCAACAA ACCCAAAGCT GCCACCTCAT 1800

GTCTCAGACT ATACTCGAGA TTTCCTCAAA CGGATTTTTG TAGAGGTCAA ACTGAGACCT 1860

TCAGCTGATG AACTTTTAAG GCACATGTTT GTGCATTATC AC 1902

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         w+ ++++g+G+fg+vy+++dvdtg+ lavK+v+++pe+ +++kev+al++Ei+llk+l H

Q: 371   WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPESPETSKEVNALECEIQLLKNLLH  430

         78899*******************************************************

S: 61    enivkyyGv..eveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLH  118

         e+iv+yyG+  + +e++l+if+Ey++gGs++++l++yg+l+e+v++kyt+qileg++yLH

Q: 431   ERIVQYYGClrDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLH  490

         *********777899*********************************************

S: 119   ekkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         +++ivHRDiKgaNil ds+g+vkl+DFGaskrl++++ + + ++s+tGt+++m+PEvi++

Q: 491   SNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISG  550

         **********************************************************99

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         +  gygrkaDiWs++c+v+emlt+k+P+ae+ e++a++fk++++ t+P++p ++s+ ++d

Q: 551   E--GYGRKADIWSVACTVVEMLTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRD  607

         8..****************************.9***************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++++ ++ k rpsa+eLL+h+f+

Q: 608   FLKRIF-VEVKLRPSADELLRHMFV  631

         ******.89**************96

Domain Sequence
(FASTA)

WRLGKLLGQG AFGRVYLCYD VDTGRELAVK QVQFDPESPE TSKEVNALEC EIQLLKNLLH 60

ERIVQYYGCL RDPQEKTLSI FMEYMPGGSI KDQLKAYGAL TENVTRKYTR QILEGVHYLH 120

SNMIVHRDIK GANILRDSTG NVKLGDFGAS KRLQTICLSG TGMKSVTGTP YWMSPEVISG 180

EGYGRKADIW SVACTVVEML TEKPPWAEFE AMAAIFKIAT QPTNPKLPPH VSDYTRDFLK 240

RIFVEVKLRP SADELLRHMF V 261

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0071260	; P:cellular response to mechanical stimulus
GO:0045893	; P:positive regulation of transcription, DNA-dependent

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666	; PB1; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013