EKS-ORC-00102

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00102

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	470.9	9.7E-142	363	613	251

Status

Unreviewed

Ensembl Protein

ENSOCUP00000002049

UniProt Accession

G1TFL8;

Protein Name

Protein Synonyms/Alias

Gene Name

ITK

Gene Synonyms/Alias

ITK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000002369	ENSOCUP00000002049	ENSOCUT00000002371
ENSOCUG00000002369	ENSOCUP00000015711	ENSOCUT00000025808

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

620

Protein Sequence
(FASTA)

MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKTSLAY FEDRHGKKRT LKGSIELSRI 60

KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVSKY 120

HPNFWMDGRW RCCSQLEKLA VGCAQYDPTK NASKKPLPPT PEDNRRSLRE AEENLVIALY 180

DYQTDDPQEL TLQRNEEYYL LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLETYEWY 240

NKSISRDKAE KLLLDTGKEG AFMVRDSRTP GTYTVSVFTK AVLSSGNSCC KTSHIKETND 300

NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVSS WRQKAPVTAG LRYGKWVIDP 360

SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIQEGAMSE EDFIEEAEVM MKLSHPKLVQ 420

LYGVCLEQAP ICLVFEFMEH GCLSDYLRTQ RGLFATETLL GMCLDVCEGM AYLEEACVIH 480

RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 540

VWSFGVLMWE VFSEGKIPYE NRSNSEVVED ISTGFRLYKP RLASSNIYQI MNHCWRERPE 600

DRPPFSILLG QLAEIAESGL 620

Nucleotide Sequence
(FASTA)

ATGAACAACT TCATTCTTCT GGAAGAACAG CTAATCAAGA AATCCCAACA AAAGAGGAGA 60

ACTTCTCCTT CAAACTTTAA AGTCCGCTTC TTTGTTTTAA CCAAAACCAG TCTGGCCTAC 120

TTTGAGGATC GTCATGGGAA AAAGCGCACG TTGAAGGGCT CTATCGAACT CTCCCGAATC 180

AAATGTGTCG AGATTGTGAA GAGTGACATT AGCATCCCGT GCCACTACAA ATACCCATTT 240

CAGGTTGTGC ATGACAACTA CCTCCTGTAT GTGTTCGCTC CAGACCGTGA GAGCCGGCAG 300

CGCTGGGTGC TGGCCCTTAA AGAAGAAACA AGAAATAATA ACAGCTTGGT GTCCAAGTAT 360

CACCCTAACT TCTGGATGGA TGGGAGGTGG AGGTGCTGTT CCCAGCTGGA GAAACTTGCG 420

GTGGGCTGTG CCCAGTATGA TCCAACCAAG AATGCTTCAA AGAAGCCTCT TCCTCCTACT 480

CCTGAGGACA ACAGGCGGTC ACTTCGGGAA GCTGAGGAGA ACCTGGTCAT CGCCCTGTAT 540

GACTACCAAA CAGACGATCC TCAGGAACTC ACGCTGCAGC GCAACGAGGA GTACTACCTG 600

CTGGACAGCT CCGAGATTCA CTGGTGGAGA GTTCAGGACA GGAACGGGCA TGAAGGATAT 660

GTACCAAGCA GTTATCTGGT GGAAAAATCT CCAAATAACC TGGAAACCTA TGAATGGTAC 720

AATAAGAGTA TCAGCCGAGA CAAAGCTGAA AAACTTCTTT TGGACACAGG CAAAGAAGGA 780

GCCTTCATGG TCCGTGATTC CAGGACTCCA GGAACCTACA CCGTGTCTGT TTTCACCAAG 840

GCTGTTTTGT CTTCAGGGAA TAGTTGTTGC AAAACAAGTC ACATCAAGGA AACAAACGAC 900

AACCCCAAGC GATACTATGT GGCTGAAAAG TATGTGTTTG ACTCCATCCC ACTCCTCATC 960

AACTACCATC AACACAATGG AGGAGGTCTT GTCACACGAC TCCGATACCC GGTTTCTTCT 1020

TGGAGACAGA AAGCCCCAGT CACAGCAGGG TTGCGATATG GAAAGTGGGT GATCGACCCC 1080

TCAGAGCTCA CTTTTGTGCA GGAGATTGGC AGCGGGCAGT TTGGATTGGT GCATCTCGGT 1140

TACTGGCTCA ACAAGGACAA GGTAGCCATT AAAACCATTC AGGAGGGAGC TATGTCAGAA 1200

GAGGACTTCA TAGAGGAGGC TGAAGTCATG ATGAAACTCT CTCACCCCAA ACTTGTCCAG 1260

CTCTATGGAG TGTGCCTGGA GCAGGCACCC ATCTGTCTGG TGTTCGAGTT CATGGAGCAC 1320

GGCTGCCTAT CAGATTACCT GCGCACTCAG CGGGGGCTCT TTGCCACAGA GACCCTGCTG 1380

GGCATGTGCC TGGACGTGTG CGAGGGCATG GCCTACCTGG AAGAGGCGTG CGTCATCCAC 1440

AGAGACCTGG CTGCCCGAAA CTGTTTGGTG GGAGAAAACC AGGTCATCAA GGTGTCAGAC 1500

TTCGGGATGA CGAGGTTCGT CCTCGATGAT CAGTACACGA GTTCCACAGG CACCAAGTTC 1560

CCAGTGAAGT GGGCCTCTCC AGAAGTCTTC TCCTTCAGTC GCTACAGTAG CAAGTCAGAC 1620

GTGTGGTCCT TTGGTGTGCT GATGTGGGAA GTCTTCAGTG AAGGCAAAAT CCCGTATGAA 1680

AACCGGAGCA ACTCGGAGGT AGTAGAAGAC ATCAGCACTG GATTTCGGTT ATACAAGCCC 1740

CGTCTGGCCT CGTCTAACAT CTACCAGATT ATGAATCATT GCTGGAGAGA GAGACCGGAA 1800

GACCGGCCAC CATTCTCCAT TCTGTTGGGT CAACTGGCTG AAATCGCAGA ATCGGGACTT 1860

TAG 1863

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea+vmmklshpklvqly

Q: 363   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLY  422

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvcl+q+pi++v+e++e+gcl++ylr++++ +++e+ll mc dvcegm+yle++++ihrd

Q: 423   GVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFATETLLGMCLDVCEGMAYLEEACVIHRD  482

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw

Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  542

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwevfsegk+pye++snsevve++s+g+rly+p+las+++y++m++cw+e+pe+r

Q: 543   SFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASSNIYQIMNHCWRERPEDR  602

         ************************************************************

S: 241   ptfkellsale  251

         p f+ ll +l+

Q: 603   PPFSILLGQLA  613

         *******9986

Domain Sequence
(FASTA)

LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLY 60

GVCLEQAPIC LVFEFMEHGC LSDYLRTQRG LFATETLLGM CLDVCEGMAY LEEACVIHRD 120

LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180

SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASSNIYQIMN HCWRERPEDR 240

PPFSILLGQL A 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0007202	; P:activation of phospholipase C activity
GO:0002250	; P:adaptive immune response
GO:0032609	; P:interferon-gamma production
GO:0032633	; P:interleukin-4 production
GO:0035556	; P:intracellular signal transduction
GO:0001865	; P:NK T cell differentiation
GO:0050852	; P:T cell receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013