EKS-ORC-00368
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00368
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11347.47.5E-104538794257
StatusUnreviewed
Ensembl ProteinENSOCUP00000002062
UniProt AccessionG1SHF8;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K6
Gene Synonyms/Alias MAP3K6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000002379ENSOCUP00000016494ENSOCUT00000030222
ENSOCUG00000002379ENSOCUP00000002062ENSOCUT00000002387
OrganismOryctolagus cuniculus
Functional Description
Protein Length1177
Protein Sequence
(FASTA)
ADVAVLEVSS SLAQPSLFYH LGVRESFSMT NNVLLCSQAD LPDLQALRED VFQKNSDCVG 60
SYTLIPYVVT ATGRVLCGDA GLLRGLADGL VQAGMGTEAL LTPLVGRLAR LLEATPTDSC 120
GYFRETIRQD IRQARERFSG QRLRQELARL QQRLDSVELL SPDIVMNLLL SYRDVQDYSA 180
IIELVETLQA LPTCDVAEQH NVCFHYTFAL NRRNRPGDRE KALAVLLPLV QCEGSVAPDL 240
YCMCGRVYKD MFFSSGFRDA GCLEQAYHWY RKAFDVEPSL HSGINAAVLL MAAGQHFEDS 300
EELQLIGMKL GCLLARKGCV EKMQYYWDVG FYLGAQILAN DSTQVVLAAE QLYKLNAPIW 360
YLVSVMETFL LYQHFRPTPE PPGGPPRRAH FWLHFLLQSC QPLKTAAPPG NQCSVLVVEM 420
SKVLLPARLE VQGKALVKAV ALSLLEPETQ GDPSGWTFPV ASICGVSASK RDERCCFLYA 480
LPPAQDMQLC FPSVGHCQWF CGLIQALVTN ANASTPAEEA EGVGEVLEFD YEYTESGERL 540
VLGKGTYGVV YAGRERHTRV RIAIKEIPER DRRFSQPLHE EIALHKRLRH KNIVRYLGSA 600
SQGGYLKIFM EEVPGGSLSS LLRSVWGPLK DNESTISFYT RQILQGLSYL HDNHIVHRDI 660
KGDNVLINTF SGLLKISDFG TSKRLAGITP CAETFTGTLQ YMAPEIIDQG PRGYGKAADI 720
WSLGCTVIEM ATGRPPFHEL GSPQAAMFQV GMYKVHPPMP ASLSAEAQAF LLRTFEPDPR 780
LRASAQALLG DPFLQPGKRS RSPSSPQPSL PPSGVPAASP TPSADSATQS QTFPSPQAPP 840
QGSASPPKRC LSYGGTSQLR VPEEPGVEEP TPSEESSGLS LLHQESKRRA MLAAVLEQEL 900
PELAESLRGE KEQSQGSRLD RIHVEQLLRC LGAHIHTPNR RQLAQELRAL QGQLRARGLG 960
PTLLHGPLFA FPDAVKEILR RRQIRPHWMF VLDSLLSRAV RAALAVLVPG ARGSGASWPP 1020
ARVWPGEGQQ QETRIRLSPL PGEPAQGPPP LIVQLGLLRA ETDRLRNVLV EKERECQNLV 1080
QRALQRVNEE AGTWALASGP PGALATDESL VQWLQELCVD SGTIQTLLSH SFTLHTLLTC 1140
ATRDDLVYTH IRGGMVCRIW RAILAQRAGS TPVTPGP 1177
Nucleotide Sequence
(FASTA)
GCAGATGTGG CGGTGCTGGA GGTGAGCAGC TCCCTGGCGC AGCCCTCCCT GTTCTACCAC 60
CTCGGCGTGC GGGAGAGCTT CAGCATGACC AACAACGTGC TGCTCTGCTC CCAGGCCGAC 120
CTCCCGGACC TGCAGGCCCT GCGCGAAGAT GTTTTCCAGA AGAATTCGGA TTGCGTTGGC 180
AGCTACACGC TGATCCCCTA TGTGGTGACG GCCACTGGTC GGGTGCTGTG TGGCGATGCA 240
GGCCTCCTGA GGGGCCTGGC CGACGGGCTG GTTCAGGCGG GTATGGGCAC TGAGGCCCTG 300
CTCACTCCCC TGGTGGGCCG GCTCGCCCGC CTGCTGGAGG CCACCCCCAC AGACTCTTGT 360
GGCTACTTCC GGGAGACCAT TCGGCAGGAC ATCCGCCAGG CACGGGAGCG CTTCAGCGGG 420
CAGCGGCTGC GGCAGGAGCT GGCCCGCCTG CAGCAGAGAC TGGACAGCGT GGAGCTGCTG 480
AGCCCGGACA TCGTCATGAA CCTGCTGCTG TCCTACCGAG ACGTGCAGGA CTACTCGGCC 540
ATCATTGAGC TGGTGGAGAC GCTGCAGGCT CTGCCCACCT GTGACGTGGC TGAGCAGCAC 600
AATGTGTGCT TCCACTACAC CTTCGCCCTC AACCGGAGGA ACAGGCCCGG GGACCGGGAG 660
AAGGCGCTGG CTGTGCTGCT GCCCCTAGTG CAGTGCGAGG GCTCCGTGGC GCCCGACCTG 720
TACTGCATGT GCGGCCGCGT CTACAAGGAC ATGTTCTTCA GCTCCGGCTT CCGGGACGCT 780
GGGTGCCTGG AGCAGGCCTA TCACTGGTAC CGCAAGGCTT TCGACGTGGA GCCCAGCCTG 840
CACTCGGGCA TCAACGCAGC TGTGCTGCTC ATGGCTGCCG GCCAGCACTT TGAGGACTCG 900
GAGGAGCTCC AGCTTATAGG CATGAAACTG GGCTGCCTTC TGGCCCGCAA GGGCTGCGTG 960
GAGAAGATGC AGTATTACTG GGATGTAGGT TTCTACCTGG GAGCCCAGAT CCTCGCCAAT 1020
GACTCCACGC AGGTGGTGCT GGCCGCAGAG CAGCTGTACA AGCTCAATGC CCCCATATGG 1080
TACCTGGTGT CGGTGATGGA GACCTTCCTG CTGTATCAGC ACTTCAGACC CACGCCCGAG 1140
CCCCCTGGCG GCCCCCCGCG CCGCGCCCAC TTCTGGCTGC ATTTCTTGCT GCAGTCCTGC 1200
CAGCCTCTCA AGACGGCCGC TCCTCCCGGA AACCAGTGCT CTGTGCTCGT GGTGGAGATG 1260
AGCAAGGTGC TGCTGCCCGC GAGGCTGGAG GTCCAGGGCA AGGCCCTGGT GAAGGCGGTG 1320
GCCCTGAGCC TGCTGGAGCC GGAGACCCAG GGCGATCCTT CCGGCTGGAC CTTCCCAGTC 1380
GCCTCCATCT GTGGGGTCAG CGCCTCCAAG CGGGACGAGC GCTGCTGCTT CCTCTACGCA 1440
CTGCCGCCGG CTCAGGACAT GCAGCTGTGC TTCCCCAGCG TGGGGCACTG CCAGTGGTTC 1500
TGCGGCCTGA TTCAGGCCTT GGTGACCAAT GCGAACGCCT CGACGCCCGC AGAGGAGGCG 1560
GAGGGCGTGG GGGAGGTGCT GGAGTTTGAT TATGAGTACA CGGAGAGTGG CGAGCGGCTC 1620
GTGCTGGGCA AGGGCACGTA CGGGGTGGTG TACGCGGGCC GCGAGCGGCA TACGCGGGTA 1680
CGCATCGCCA TCAAGGAGAT CCCGGAGCGG GACCGCAGGT TCTCTCAGCC CCTGCACGAA 1740
GAGATCGCGC TTCACAAACG CCTGCGCCAC AAGAACATCG TGCGCTACTT GGGCTCCGCC 1800
AGCCAGGGCG GCTATCTCAA GATCTTCATG GAGGAAGTGC CTGGAGGCAG CCTGTCCTCC 1860
TTGCTGCGGT CAGTGTGGGG GCCCCTGAAG GACAACGAGA GCACCATCAG CTTCTACACC 1920
CGCCAGATCC TGCAGGGTCT CAGCTACCTG CATGACAACC ACATTGTGCA CCGCGACATC 1980
AAGGGAGACA ATGTGCTGAT CAACACCTTC AGTGGCCTGC TCAAGATTTC TGACTTTGGC 2040
ACCTCCAAGC GGCTGGCGGG CATCACACCC TGTGCTGAGA CCTTCACAGG GACTCTGCAG 2100
TACATGGCCC CAGAAATCAT TGACCAGGGC CCACGCGGGT ATGGGAAGGC AGCTGACATC 2160
TGGTCGCTGG GCTGCACAGT GATCGAGATG GCCACAGGCC GCCCACCTTT CCACGAGCTA 2220
GGGAGCCCAC AGGCTGCCAT GTTTCAGGTG GGCATGTACA AGGTGCACCC ACCAATGCCT 2280
GCTTCTCTGT CAGCCGAGGC TCAAGCCTTC CTCCTTCGAA CTTTTGAGCC GGACCCCCGG 2340
CTCAGAGCCA GTGCCCAGGC ACTGCTGGGG GACCCCTTCC TGCAGCCTGG GAAGAGGAGT 2400
CGCAGCCCTA GCTCCCCCCA GCCTTCTCTC CCGCCCTCAG GAGTCCCTGC GGCCAGCCCC 2460
ACTCCTTCAG CCGACTCCGC CACCCAGTCC CAGACATTCC CAAGTCCTCA GGCACCCCCT 2520
CAGGGCTCTG CCAGCCCCCC GAAGCGCTGC CTCAGTTATG GCGGCACCAG CCAGCTCCGG 2580
GTGCCCGAGG AGCCAGGGGT GGAGGAGCCC ACGCCCTCGG AGGAGAGCTC GGGGCTCAGC 2640
CTGCTGCACC AGGAGAGCAA GCGCCGGGCC ATGCTGGCGG CGGTGCTGGA GCAGGAGCTG 2700
CCCGAGCTGG CGGAGAGTCT GCGCGGGGAG AAGGAGCAGT CTCAGGGTTC CCGTCTGGAC 2760
CGGATCCATG TGGAACAGCT GCTGCGCTGC CTCGGAGCCC ACATCCACAC TCCCAACCGC 2820
CGGCAGCTGG CCCAGGAGCT GCGGGCGCTG CAAGGGCAGC TGCGGGCCCG GGGCCTGGGG 2880
CCTACACTTC TGCACGGCCC GCTCTTCGCC TTCCCGGATG CGGTGAAGGA GATCCTCCGC 2940
AGGCGCCAGA TCCGCCCGCA CTGGATGTTC GTGCTGGACT CGCTGCTCAG CCGCGCCGTC 3000
CGGGCAGCCC TGGCAGTGCT GGTCCCAGGT GCGCGCGGGA GCGGGGCCAG CTGGCCTCCA 3060
GCGAGGGTGT GGCCGGGCGA AGGGCAGCAG CAGGAGACCA GGATCCGGCT GAGCCCGCTC 3120
CCGGGGGAGC CCGCGCAGGG GCCCCCGCCC CTGATAGTGC AGCTGGGTCT CCTGCGAGCC 3180
GAGACGGACA GGCTTCGAAA TGTCCTTGTG GAGAAGGAGC GCGAGTGCCA GAACCTGGTG 3240
CAGCGGGCTC TGCAGCGGGT GAATGAGGAG GCCGGGACCT GGGCCCTGGC CTCCGGGCCG 3300
CCAGGTGCTC TTGCTACAGA CGAGAGCCTG GTCCAGTGGC TCCAGGAACT GTGCGTGGAT 3360
TCAGGGACCA TCCAAACGCT GCTGAGCCAC AGTTTCACCC TGCACACCCT GCTTACCTGC 3420
GCCACTCGAG ACGACCTCGT CTACACCCAC ATCAGGGGAG GGATGGTGTG CCGGATCTGG 3480
AGAGCCATCT TGGCACAGCG AGCAGGATCC ACGCCAGTTA CCCCTGGGCC C 3531
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya+++ +t+ ++a+Ke+   pe+++  + +++l+eEi+l+k+l+H+n
Q: 538   ERLVLGKGTYGVVYAGRERHTRVRIAIKEI---PERDR--RFSQPLHEEIALHKRLRHKN  592
         5779**************************...78776..499*****************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G++++ ++lkif+E v+gGslssll+  +g+l+  es+i++yt+qil+gl+yLH+
Q: 593   IVRYLGSASQGGYLKIFMEEVPGGSLSSLLRsVWGPLKdnESTISFYTRQILQGLSYLHD  652
         *******************************99****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++
Q: 653   NHIVHRDIKGDNVLINTfSGLLKISDFGTSKRLAGITPC---AETFTGTLQYMAPEIIDQ  709
         *****************9*********************...89****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc+viem+tg++Pf+el++++a+mf+vg+ k++P++p +ls+e+++
Q: 710   GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPASLSAEAQA  769
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         fl +++e dp+ r+sa+ LL ++fl
Q: 770   FLLRTFEPDPRLRASAQALLGDPFL  794
         **********************996
Domain Sequence
(FASTA)
ERLVLGKGTY GVVYAGRERH TRVRIAIKEI PERDRRFSQP LHEEIALHKR LRHKNIVRYL 60
GSASQGGYLK IFMEEVPGGS LSSLLRSVWG PLKDNESTIS FYTRQILQGL SYLHDNHIVH 120
RDIKGDNVLI NTFSGLLKIS DFGTSKRLAG ITPCAETFTG TLQYMAPEII DQGPRGYGKA 180
ADIWSLGCTV IEMATGRPPF HELGSPQAAM FQVGMYKVHP PMPASLSAEA QAFLLRTFEP 240
DPRLRASAQA LLGDPFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00364
EKS-ANC-00380
EKS-BOT-00391
EKS-CAJ-00392
EKS-CAF-00391
EKS-CAP-00420
EKS-EQC-00382
EKS-FEC-00381
EKS-GAA-00477
EKS-HOS-00398
EKS-ICT-00368
EKS-LOA-00400
EKS-MAM-00388
EKS-MAE-00046
EKS-MIM-00057
EKS-MOD-00378
EKS-MUM-00422
EKS-MUP-00384
EKS-MYL-00387
EKS-OTG-00392
EKS-PAT-00368
EKS-POA-00382
EKS-RAN-00404
EKS-SUS-00342
EKS-TUT-00109
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004709; F:MAP kinase kinase kinase activity
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013