EKS-ORC-00261

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00261

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	453.3	3.8E-136	204	491	288

Status

Unreviewed

Ensembl Protein

ENSOCUP00000025473

UniProt Accession

G1SHK1;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000002439	ENSOCUP00000002109	ENSOCUT00000002439
ENSOCUG00000002439	ENSOCUP00000025473	ENSOCUT00000025532

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

LLIPIMISIK TSMLPLLKNE KPKVNHKLYM CVCEGLSCGS EDHCEGQQCF SSLSINDGFH 60

VYQKGCFQVY EQGKMTCKTP PSPGQAVECC QGDWCNRNIT AQLPTKGKSF SGTQNFHLEV 120

GLIILSVVFA VCLLACLLGV ALRKFKRRNQ ERLNPRDVEY GTIEGLITTN VGDSTLADLL 180

DHSCTSGSGS GLPFLVQRTV ARQITLLECV GKGRYGEVWR GSWQGENVAV KIFSSRDEKS 240

WFRETELYNT VMLRHENILG FIASDMTSRH SSTQLWLITH YHEMGSLYDY LQLTTLDTVS 300

CLRIVLSIAS GLAHLHIEIF GTQGKPAIAH RDLKSKNILV KKNGQCCIAD LGLAVMHSQS 360

TNQLDVGNNP RVGTKRYMAP EVLDETIQVD CFDSYKRVDI WAFGLVLWEV ARRMVSNGIV 420

EDYKPPFYDV VPNDPSFEDM RKVVCVDQQR PNIPNRWFSD PTLTSLAKLM KECWYQNPSA 480

RLTALRIKKT LTKIDNSLDK LKTDC 505

Nucleotide Sequence
(FASTA)

CTGTTAATTC CCATTATGAT CAGCATAAAA ACCTCAATGT TACCACTGTT GAAAAATGAG 60

AAGCCCAAGG TCAACCACAA ACTTTACATG TGTGTATGTG AAGGTCTCTC CTGTGGGAGT 120

GAGGACCACT GTGAAGGCCA GCAGTGCTTC TCCTCATTAA GTATCAATGA TGGCTTCCAT 180

GTCTACCAGA AAGGCTGCTT CCAGGTCTAC GAGCAGGGCA AGATGACCTG CAAGACGCCG 240

CCATCACCGG GCCAGGCTGT GGAGTGCTGC CAAGGGGACT GGTGTAACAG GAACATCACG 300

GCCCAGCTGC CCACTAAAGG GAAGTCATTT TCTGGAACAC AGAATTTCCA CCTGGAGGTT 360

GGCCTCATCA TTCTCTCAGT CGTGTTTGCA GTATGCCTTC TAGCTTGTCT CCTGGGAGTT 420

GCTCTCCGAA AATTTAAAAG GCGCAACCAA GAACGCCTCA ATCCTAGAGA TGTGGAGTAT 480

GGCACCATTG AAGGACTCAT CACCACCAAT GTTGGCGACA GCACTTTAGC AGATTTACTG 540

GATCATTCAT GTACGTCAGG AAGTGGTTCT GGTCTTCCTT TTCTGGTACA AAGAACAGTG 600

GCTCGCCAGA TTACACTATT GGAGTGTGTT GGGAAAGGCA GGTACGGCGA AGTATGGAGG 660

GGCAGTTGGC AAGGGGAAAA TGTAGCCGTG AAGATCTTCT CCTCTCGGGA CGAGAAATCT 720

TGGTTCAGGG AGACTGAATT GTATAACACT GTGATGCTGA GGCATGAAAA TATTTTAGGT 780

TTCATTGCTT CAGACATGAC ATCAAGACAC TCCAGTACTC AGTTGTGGTT AATTACACAT 840

TATCATGAGA TGGGATCCTT GTATGACTAT CTTCAGCTCA CTACTCTGGA TACAGTTAGC 900

TGCCTTCGAA TAGTGCTGTC CATAGCCAGT GGTCTTGCAC ATCTGCATAT AGAGATATTT 960

GGGACCCAAG GGAAACCAGC CATTGCCCAT CGGGATTTAA AAAGCAAAAA CATCCTGGTG 1020

AAGAAGAATG GACAGTGCTG CATAGCAGAT TTGGGCTTGG CTGTCATGCA TTCCCAGAGC 1080

ACCAATCAGC TTGATGTGGG AAACAACCCG CGGGTAGGCA CCAAGCGCTA CATGGCTCCC 1140

GAAGTTCTAG ATGAAACCAT CCAAGTGGAT TGCTTTGATT CTTACAAGCG GGTTGATATT 1200

TGGGCCTTTG GACTTGTTCT GTGGGAAGTG GCCAGGCGTA TGGTAAGCAA TGGTATAGTG 1260

GAGGATTATA AGCCACCATT CTATGATGTG GTTCCCAATG ACCCAAGTTT TGAAGATATG 1320

AGGAAAGTAG TCTGTGTTGA TCAACAGAGG CCAAACATAC CCAACAGATG GTTCTCAGAC 1380

CCGACACTAA CCTCTCTGGC CAAGCTGATG AAAGAATGCT GGTATCAGAA TCCATCTGCA 1440

AGACTCACAG CTCTGCGTAT CAAAAAGACT TTGACCAAAA TTGATAATTC CCTAGACAAA 1500

TTGAAAACTG ACTGTTGA 1518

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tv+lrhenil+fia

Q: 204   ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA  263

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 264   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 324   G--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 382   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  440

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 441   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

ITLLECVGKG RYGEVWRGSW QGENVAVKIF SSRDEKSWFR ETELYNTVML RHENILGFIA 60

SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAIAHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0045177	; C:apical part of cell
GO:0005887	; C:integral to plasma membrane
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0002526	; P:acute inflammatory response
GO:0003289	; P:atrial septum primum morphogenesis
GO:0030509	; P:BMP signaling pathway
GO:0060923	; P:cardiac muscle cell fate commitment
GO:0007368	; P:determination of left/right symmetry
GO:0003143	; P:embryonic heart tube morphogenesis
GO:0003197	; P:endocardial cushion development
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0001702	; P:gastrulation with mouth forming second
GO:0007281	; P:germ cell development
GO:0001701	; P:in utero embryonic development
GO:0001707	; P:mesoderm formation
GO:0003183	; P:mitral valve morphogenesis
GO:0032926	; P:negative regulation of activin receptor signaling pathway
GO:0043066	; P:negative regulation of apoptotic process
GO:0001755	; P:neural crest cell migration
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0001569	; P:patterning of blood vessels
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0060037	; P:pharyngeal system development
GO:0030501	; P:positive regulation of bone mineralization
GO:2000017	; P:positive regulation of determination of dorsal identity
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0023014	; P:signal transduction by phosphorylation
GO:0051145	; P:smooth muscle cell differentiation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013