EKS-ORC-00434

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00434

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	506.0	3.0E-152	26	310	285

Status

Unreviewed

Ensembl Protein

ENSOCUP00000002161

UniProt Accession

G1SHP8;

Protein Name

Protein Synonyms/Alias

Gene Name

PIK3R4

Gene Synonyms/Alias

PIK3R4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000002495	ENSOCUP00000002161	ENSOCUT00000002498

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1358

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

TLPLTSYKQE LEELKIRLHS AQNCLPFQKA AEKASEKAAM LFRQYVRDNL YDRISTRPFL 120

NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP 180

ADFNYFFDTS RRRTCYIAPE RFVDGGMFAT ELEYMRDPST PLVDLNSNQR TRGELKRAMD 240

IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG HFFPEQVLNK IEDCSIRELV TQMIHREPDK 300

RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIIHNLCGH 360

DLPEKAEGEP RENGLVILVS VITSCLQTLK YCDSKLAALE LILHLAPRLS VEILLDRITP 420

YLLHFSNDSV PRVRAEALRT LTKVLALVKE VPRNDVNIYP EYILPGIAHL AQDDATIVRL 480

AYAENIALLA ETALRFLELV QLKNLNMEND PNSEEIDEVT HPNGNYDTEL QALHEMVQQK 540

VVTLLSDPEN IVKQTLMENG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS 600

IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALNALT CMCQLGLLQK PHVYEFASDI 660

APFLCHPNLW IRYGAVGFIT VVAHQISTAD VYCKLMPYLG PYITQPIIQI ERKLVLLSVL 720

KEPVSRSIFD YALRSKDITS LFRHLHMRQK KRNGSLPDCP PPEDPAIAQL LKKLLSQGMT 780

EEEEDKLLAL KDFMMKSNKA KANLVDQSHL HDSSQKGVID LAALGITGRQ VDLVKAKQEP 840

DDKRARKHVK QDSNVNEEWK SMFGSLEPPT ISQALPKASD QEVIQAGKPP RSESSAGLCV 900

PLSTSPQIAE VTNVQNKKPV IQVLSSTILP STYQIRITTC KTELQQLIQQ KREQCNAERI 960

AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHSLFAT CSNDGTVKIW 1020

NSQKMEGKTT TTRSILTYSR SGGRVKTLTF CQGSHYLAVA SDNGAVQLLG IEASKLPKSP 1080

KIHPLQNRIL DQKEDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK 1140

SGLITSFAVD IHQCWLCIGT SSGTMACWDM RFQLPISSHC HPSRARIRRL SMHPLYQSWV 1200

IAAVQGNNEV SMWDMETGDR RFTLWASSAP PLSELQPSPH SVHGIYCSPA DGNPILLTAG 1260

SDMKIRFWDL AYPERSYVVA GGSSSPSVSY YRKIIEGTEV VQEIQNKQKV GPSDDAPRRG 1320

PESLPVGHHD IITDVATFQT TQGFIVTASR DGIVKVWK 1358

Nucleotide Sequence
(FASTA)

ATGGGAAATC AACTTGCTGG CATTGCTCCC TCCCAGATCC TGTCTGTGGA GAGTTACTTC 60

TCGGACATCC ATGACTTTGA ATATGATAAG AGCCTGGGAA GTACTCGGTT TTTCAAAGTT 120

GCTCGAGCGA AGCATCGAGA AGGCCTGGTG GTCGTGAAGG TCTTTGCGAT TCAGGATCCC 180

ACGTTGCCTC TCACGAGCTA TAAACAAGAG CTGGAGGAGC TGAAGATCCG GCTCCACTCT 240

GCACAGAACT GTCTGCCTTT CCAGAAAGCG GCAGAAAAAG CTTCTGAGAA AGCAGCTATG 300

CTCTTTCGGC AGTATGTCCG AGACAACCTC TACGATCGCA TCAGTACGCG GCCGTTCTTA 360

AATAACATTG AGAAGCGCTG GATCGCCTTC CAGATCCTGA CGGCTGTGGA CCAGGCACAT 420

AAATCCGGGG TCCGTCACGG GGACATCAAG ACTGAAAATG TGATGGTCAC CAGTTGGAAC 480

TGGGTTCTGC TAACTGATTT CGCCAGTTTT AAACCCACTT ACCTTCCAGA GGACAATCCA 540

GCAGATTTCA ATTATTTCTT TGACACTTCA CGGAGAAGAA CTTGCTATAT TGCTCCTGAA 600

CGTTTTGTTG ATGGTGGGAT GTTTGCCACA GAGTTAGAAT ATATGAGAGA TCCTTCAACT 660

CCACTTGTGG ACTTAAATAG CAATCAGAGA ACAAGAGGAG AGTTGAAAAG AGCAATGGAC 720

ATCTTTTCAG CAGGTTGTGT GATTGCTGAA CTTTTTACTG AAGGTGTACC ATTGTTTGAT 780

CTCTCTCAAC TGTTGGCTTA TAGAAATGGA CATTTTTTCC CTGAACAAGT GTTAAATAAA 840

ATTGAAGATT GCAGTATCAG AGAATTGGTA ACTCAGATGA TTCATCGTGA GCCAGATAAA 900

CGATTAGAAG CAGAGGATTA CTTAAAGCAG CAACGTGGCA ATGCTTTTCC TGAAATATTT 960

TACACTTTTC TTCAGCCCTA CATGGCCCAA TTTGCCAAGG AAACATTTCT CTCTGCAGAT 1020

GAGCGTATTC TGGTTATACG GAAGGATTTG GGCAACATTA TTCACAATCT CTGTGGCCAT 1080

GATCTCCCGG AAAAAGCGGA AGGAGAGCCT AGGGAAAATG GGCTGGTTAT CTTGGTGTCA 1140

GTCATAACGT CTTGCCTGCA GACCCTCAAA TACTGTGATT CCAAACTTGC TGCCTTGGAA 1200

CTTATTCTCC ATTTGGCCCC AAGATTAAGT GTGGAAATCC TTTTGGATCG TATTACACCT 1260

TATCTTCTGC ATTTCAGTAA TGACTCTGTT CCTAGGGTGA GGGCTGAAGC CTTGAGAACT 1320

TTGACCAAAG TCCTTGCTCT TGTCAAAGAA GTTCCCCGCA ATGATGTCAA TATCTATCCG 1380

GAATACATTC TGCCAGGCAT AGCCCACTTA GCCCAGGATG ACGCTACTAT TGTTAGACTA 1440

GCCTATGCTG AAAACATAGC TCTACTGGCA GAAACAGCTC TGAGATTCCT GGAATTAGTA 1500

CAGTTAAAAA ACCTCAATAT GGAAAATGAC CCCAATAGTG AAGAAATAGA TGAAGTTACA 1560

CATCCGAATG GAAATTATGA CACAGAGCTC CAAGCCTTAC ATGAAATGGT CCAGCAGAAA 1620

GTTGTTACTT TGTTAAGTGA CCCTGAAAAT ATTGTGAAAC AAACCTTAAT GGAAAACGGA 1680

ATAACACGGC TGTGCGTATT TTTTGGACGT CAGAAAGCCA ATGATGTTTT ATTGTCTCAC 1740

ATGATCACTT TCCTAAATGA TAAGAATGAT TGGCATCTGC GTGGAGCTTT TTTTGATAGT 1800

ATAGTTGGTG TTGCTGCCTA TGTTGGCTGG CAGAGCTCCT CAATTCTCAA GCCCCTGCTG 1860

CAACAAGGTC TTAGTGATGC CGAGGAATTT GTTATTGTGA AGGCTCTTAA TGCCCTTACT 1920

TGTATGTGCC AGTTAGGGCT GTTACAAAAA CCCCATGTCT ATGAATTTGC CAGTGATATT 1980

GCCCCCTTCC TGTGTCATCC TAATCTATGG ATACGCTATG GTGCTGTGGG ATTTATCACA 2040

GTGGTAGCCC ATCAAATAAG CACAGCTGAT GTCTACTGTA AACTGATGCC TTATCTTGGT 2100

CCATACATTA CCCAACCAAT AATACAGATT GAAAGAAAAC TTGTTCTGCT CAGTGTCTTA 2160

AAAGAGCCAG TAAGCCGTTC TATATTTGAT TATGCGTTGA GGTCTAAAGA TATTACTAGC 2220

TTGTTCAGAC ATCTTCACAT GCGTCAGAAG AAACGAAATG GGTCTCTTCC TGACTGCCCT 2280

CCGCCAGAGG ATCCTGCCAT CGCACAGCTT CTAAAGAAAC TTCTATCACA GGGAATGACA 2340

GAAGAAGAGG AAGACAAACT TCTGGCACTG AAGGACTTTA TGATGAAATC TAACAAGGCC 2400

AAGGCCAATC TAGTGGACCA GAGCCATCTT CACGATAGTA GTCAGAAAGG TGTAATTGAC 2460

TTAGCAGCCT TAGGAATAAC TGGGAGACAA GTTGATCTTG TTAAAGCCAA ACAAGAACCA 2520

GATGACAAGC GAGCTAGAAA ACATGTAAAA CAAGACTCAA ATGTAAATGA AGAATGGAAA 2580

AGCATGTTTG GGTCACTGGA ACCACCGACA ATCTCACAGG CACTGCCTAA GGCGAGTGAC 2640

CAGGAGGTGA TTCAGGCTGG GAAGCCTCCA CGTTCTGAGT CCTCTGCTGG CCTTTGTGTC 2700

CCTTTGTCTA CTTCTCCACA GATTGCAGAA GTGACAAATG TCCAGAATAA AAAACCAGTA 2760

ATACAGGTTT TAAGTAGTAC AATTTTGCCA TCTACCTATC AGATTCGGAT CACAACGTGT 2820

AAAACTGAGC TTCAGCAGCT CATACAGCAG AAGCGGGAGC AGTGCAATGC TGAGAGGATA 2880

GCGAAGCAGA TGATGGAAAA TGCCGAGTGG GAGAGCAAAC CCCCCCCACC TGGGTGGCGT 2940

CCTAAAGGGC TACTGGTTGC ACATCTTCAT GAACACAAAT CTGCTGTGAA TCGAATTAGA 3000

GTCTCTGATG AACACTCACT CTTTGCAACA TGTTCAAATG ATGGCACAGT GAAAATCTGG 3060

AATAGTCAGA AGATGGAGGG GAAGACCACC ACTACAAGGT CTATTCTCAC ATACAGCCGA 3120

AGTGGAGGTC GAGTGAAGAC ACTCACATTC TGCCAGGGCT CCCACTACTT AGCTGTGGCG 3180

TCGGATAATG GTGCTGTCCA GCTTCTTGGA ATTGAGGCTT CTAAGCTCCC CAAGTCTCCT 3240

AAGATCCATC CTCTACAAAA CAGAATTCTG GATCAGAAGG AGGACGGCTG TGTTGTGGAC 3300

ATGCATCACT TCAACTCAGG GGCACAGTCC GTTCTCGCCT ACGCCACCGT GAATGGCTCT 3360

CTGGTTGGCT GGGACCTCAG GTCTTCAAGC AACGCCTGGA CGTTAAAGCA TGACTTAAAG 3420

TCAGGCCTCA TCACTTCTTT TGCTGTGGAT ATCCACCAGT GCTGGCTCTG CATTGGTACA 3480

AGCAGTGGAA CCATGGCTTG TTGGGACATG AGGTTCCAGT TGCCCATTTC CAGTCACTGT 3540

CATCCTTCCA GGGCTCGGAT CAGGCGCCTC TCAATGCACC CCCTGTATCA GTCCTGGGTG 3600

ATTGCAGCTG TTCAGGGTAA CAACGAAGTG TCCATGTGGG ACATGGAGAC TGGTGACAGA 3660

AGATTTACTC TCTGGGCCAG CAGTGCACCG CCACTCTCAG AGTTACAGCC TTCTCCTCAC 3720

AGTGTCCATG GGATCTACTG TAGTCCTGCA GATGGAAATC CTATCCTGCT AACAGCTGGC 3780

TCAGACATGA AAATAAGGTT TTGGGACTTG GCTTACCCAG AAAGGTCCTA TGTTGTGGCA 3840

GGAGGCAGTA GTTCCCCATC TGTGTCCTAC TACAGGAAGA TAATTGAAGG GACAGAAGTT 3900

GTTCAGGAAA TCCAGAATAA GCAGAAGGTA GGGCCGAGTG ACGACGCCCC TCGAAGAGGG 3960

CCAGAGTCTC TGCCGGTGGG ACATCACGAC ATCATCACGG ATGTTGCCAC GTTCCAGACA 4020

ACACAGGGCT TCATCGTCAC TGCCTCCAGA GATGGGATTG TGAAGGTGTG GAAATAA 4077

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqncl  60

         +ey+k+lgstrf+kva+ak++eG++vvkvf++qdptl+l+s+kq+leelk++l++aqncl

Q: 26    FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCL  85

         68**********************************************************

S: 61    pfqkvlek..ekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvv  118

         pfqk++ek  ekaa+l+rqyv+dnlydr+strPfln+iek+wiafq+l+a+dq+hksgv+

Q: 86    PFQKAAEKasEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVR  145

         *******999**************************************************

S: 119   hGdiktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsa  178

         hGdiktenv+vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++

Q: 146   HGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDG  205

         ************************************************************

S: 179   lasdekl...rdgstelvdldsiqrlrgelkkamdifsaGcvilelftegrplfelsqll  235

         ++++++l   rd+st+lvdl+s+qr+rgelk+amdifsaGcvi+elfteg+plf+lsqll

Q: 206   GMFATELeymRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLL  265

         ******9999**************************************************

S: 236   ayrsgeflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         ayr+g+f++e+vl+kied ++r+lv+q+i++ep+kr++aed+lk+

Q: 266   AYRNGHFFPEQVLNKIEDCSIRELVTQMIHREPDKRLEAEDYLKQ  310

         *******************************************97

Domain Sequence
(FASTA)

FEYDKSLGST RFFKVARAKH REGLVVVKVF AIQDPTLPLT SYKQELEELK IRLHSAQNCL 60

PFQKAAEKAS EKAAMLFRQY VRDNLYDRIS TRPFLNNIEK RWIAFQILTA VDQAHKSGVR 120

HGDIKTENVM VTSWNWVLLT DFASFKPTYL PEDNPADFNY FFDTSRRRTC YIAPERFVDG 180

GMFATELEYM RDPSTPLVDL NSNQRTRGEL KRAMDIFSAG CVIAELFTEG VPLFDLSQLL 240

AYRNGHFFPE QVLNKIEDCS IRELVTQMIH REPDKRLEAE DYLKQ 285

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005770	; C:late endosome
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 6.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013