EKS-ORC-00312

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00312

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	303.3	1.6E-90	1	229	229

Status

Unreviewed

Ensembl Protein

ENSOCUP00000002273

UniProt Accession

G1SHY9;

Protein Name

Protein Synonyms/Alias

Gene Name

NRK

Gene Synonyms/Alias

NRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000002624	ENSOCUP00000002273	ENSOCUT00000002632

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1260

Protein Sequence
(FASTA)

DEEEDLRTEL NLLRKYSFHK NIVSFYGAFF KLSPPGQRHQ LWMVMELCAA GSVTDVVRMT 60

RNQSLKEDWI AYICREILQG LAHLHAHRVI HRDIKGQNVL LTHTAEVKLV DFGVSAQVSR 120

TNGRRNSFIG TPYWMAPEVI NCDEDPRRSY DYRSDVWSVG ITAIEMAEGA PPLCNLQPLE 180

ALFVILRESA PTVKSSGWSR KFHNFMGKCM IKNFLFRPTS ANMLHHPFVH NIKNERHVVE 240

SLTKHLTAII KKRQKKGSVA YSTFSLGDHS KVEGKNGVKE RELNKITNIL PSAAITQPVL 300

KWMKENHTST NLLTPRVLLN AWQQNDPEGY FKHYSHELLR LPTSSRCRPL RVLHGEPSQP 360

RWLPDQEDSQ VQALQQLQGA AKMHMPLQAQ ENAPRPLQRQ AQAPQRLQGA AQVFMPLQAQ 420

GKARVPKREQ QIQGQAQISE QPQDLDQVPE EFQGQEQVPE PQQRQGQAPE QQQIQNQVPE 480

EQLEQNEAPE EAEVQEQAVE PTQAEPDAEE PETIRVHAQV FLPLLSQNHH VLLPLHLDTQ 540

VLIPVQKQTE GVPQAQALIE GLSRDLLRAP HSYNSKPLGP LQTLMENLSA NIFYSQPEQA 600

RKKKSKVSSL RQALAKRLSP KRFRAKSSSQ LAKNSLGRQG RLDKYVKKSN SCLSQNDSFF 660

KQLKSVIKNN YEHRIFPGIF EDRAHRVKFS SRYPSKIISS PTPAHSIEDS ACISEVKKEG 720

KKSAVLGKPH RIRSRRSLDL AVTPEQKYYI VTNKSESTES SSEEESPVTG RRSQSSPPYS 780

TIDQKLLIDV HEIDGDNIGN FTFNTDRTLG HFSCLYCTNS VPVENEQELG AGDEASYAMA 840

SGAAPSELDD GDDNKDISES STLSGFSASH SSASRGSEGS VDTDFASAIS GNRQGNKQYL 900

FELPKRPSDV NVNPLYVSSA SKKPLIHVYE KEFTSEICCG SLWGTGVNLL LGTRSNLYLM 960

DRSGKADITK LIKRRPFRQI QVVEPLNLLI TISGRKNRLR VYHLTWLRNK ILNNDPESKR 1020

RQEEMLKTEE ACKAIDKLTG CEHFSVLQHE ETTYIAIALK SSIHLYAWAP KSFDESTAIK 1080

VFPTLGHKPV TVDLAVGSEK RLKVFFSSAN GYHIIDAESE VMSDVTLPNN PLEIIIPQNI 1140

IILPDCLGIG VMLTFNAEAL SVEANEQLFK KILEVWKDIP SSVAFECTQR TTGWGQKAIE 1200

ARSLQAKVLE SELKRRSIKK LRFLCTRGDK KLFFTSTLRN RHSRVYFMTL GKLEELQSNY 1260

Nucleotide Sequence
(FASTA)

GATGAGGAAG AGGATCTTCG TACTGAACTC AACCTTCTGA GAAAGTACTC TTTTCACAAA 60

AACATTGTGT CCTTCTATGG TGCGTTTTTC AAGCTGAGTC CCCCTGGCCA GAGACACCAA 120

CTTTGGATGG TGATGGAGTT ATGTGCAGCA GGCTCAGTCA CTGACGTAGT GAGGATGACC 180

AGAAATCAGA GTTTAAAAGA AGACTGGATT GCTTATATCT GCCGAGAAAT CCTTCAGGGT 240

CTAGCTCACC TTCATGCACA CCGAGTAATC CACCGGGACA TCAAGGGTCA GAATGTACTC 300

CTGACTCATA CAGCTGAAGT AAAACTCGTG GATTTTGGAG TGAGTGCCCA GGTAAGCAGA 360

ACTAATGGAA GGAGAAATAG CTTCATTGGG ACACCATACT GGATGGCACC TGAGGTGATT 420

AACTGTGACG AGGACCCGAG ACGCTCCTAT GATTACCGAA GTGATGTGTG GTCTGTGGGA 480

ATCACTGCAA TTGAAATGGC TGAAGGGGCT CCTCCTCTGT GTAACCTTCA GCCCTTGGAA 540

GCTCTTTTTG TCATTTTGCG GGAATCTGCA CCTACAGTCA AATCCAGTGG ATGGTCCCGC 600

AAGTTCCACA ATTTCATGGG AAAATGCATG ATAAAAAACT TCCTATTCCG TCCTACTTCT 660

GCAAACATGC TTCATCACCC ATTTGTTCAC AATATCAAAA ATGAGCGACA TGTTGTTGAG 720

TCATTGACGA AGCATCTTAC AGCAATCATC AAAAAAAGAC AGAAAAAAGG CTCTGTGGCA 780

TATTCCACAT TTAGTTTGGG GGATCACAGC AAGGTTGAGG GTAAAAATGG AGTGAAGGAG 840

AGGGAGCTGA ACAAGATCAC AAACATCCTT CCATCAGCTG CCATAACCCA GCCAGTTCTC 900

AAATGGATGA AGGAAAACCA CACATCTACT AATTTGCTAA CTCCCAGAGT ACTACTTAAT 960

GCCTGGCAAC AGAATGATCC AGAGGGATAT TTCAAGCACT ACAGTCATGA GCTTCTGAGA 1020

TTGCCAACCA GCAGCCGATG CAGGCCACTT AGAGTCCTGC ATGGAGAACC CTCTCAGCCG 1080

AGATGGTTAC CTGATCAAGA AGACTCACAG GTCCAGGCAC TTCAGCAACT CCAGGGGGCA 1140

GCCAAGATGC ACATGCCACT ACAGGCTCAG GAGAACGCAC CTAGGCCTCT ACAGAGGCAA 1200

GCGCAGGCAC CTCAACGACT ACAAGGGGCA GCTCAGGTGT TCATGCCACT ACAGGCTCAG 1260

GGTAAGGCCA GAGTACCCAA AAGAGAGCAG CAGATTCAAG GCCAGGCCCA AATATCAGAA 1320

CAGCCACAAG ATCTGGACCA GGTGCCAGAG GAATTTCAGG GGCAAGAACA GGTGCCTGAA 1380

CCACAGCAAC GGCAGGGCCA GGCCCCTGAA CAACAGCAGA TACAGAACCA GGTACCTGAA 1440

GAGCAGCTGG AGCAGAATGA GGCACCAGAA GAGGCAGAGG TACAAGAACA GGCTGTGGAG 1500

CCCACACAGG CAGAGCCTGA CGCAGAGGAA CCTGAGACAA TACGCGTGCA TGCCCAGGTG 1560

TTTCTGCCCC TGCTTTCACA AAACCACCAT GTGCTGCTGC CCCTGCATCT GGACACTCAG 1620

GTGCTCATTC CAGTGCAGAA GCAAACAGAG GGGGTACCTC AGGCACAGGC ACTGATAGAG 1680

GGGTTATCCA GAGACTTGCT TCGAGCACCA CACTCATACA ACTCCAAGCC ACTTGGTCCA 1740

CTGCAAACCC TGATGGAAAA CCTGTCGGCA AACATATTTT ACTCTCAACC AGAACAGGCA 1800

CGGAAGAAAA AATCTAAAGT TTCCAGTCTA AGACAGGCCC TAGCCAAACG ACTGTCACCA 1860

AAGAGGTTCA GGGCGAAGTC ATCAAGTCAA CTGGCTAAAA ATTCTCTTGG TCGCCAAGGG 1920

AGATTAGATA AGTATGTGAA GAAGTCAAAT TCCTGCCTTA GTCAGAATGA TTCTTTTTTT 1980

AAGCAGCTAA AGTCAGTTAT AAAAAATAAT TATGAACATA GGATATTTCC AGGAATTTTT 2040

GAGGATCGTG CACACCGTGT CAAGTTCTCT TCAAGATATC CTTCAAAAAT CATCTCCTCT 2100

CCAACTCCAG CTCACAGTAT AGAGGACTCA GCTTGTATTT CAGAAGTCAA GAAAGAAGGA 2160

AAAAAATCAG CAGTGTTAGG GAAGCCACAC AGGATTAGAA GCAGAAGGTC CCTGGATTTG 2220

GCAGTGACTC CTGAGCAGAA ATACTATATT GTGACAAATA AGAGTGAGTC CACAGAATCT 2280

TCTTCTGAGG AAGAGAGTCC TGTGACTGGG AGGAGATCCC AGTCCTCGCC GCCTTATTCT 2340

ACTATTGATC AAAAGTTGCT GATTGATGTC CATGAAATTG ATGGTGACAA TATTGGTAAT 2400

TTCACATTTA ACACTGACAG GACATTGGGC CATTTTTCTT GTCTATATTG TACCAATAGT 2460

GTTCCTGTAG AAAATGAACA GGAATTAGGT GCTGGAGATG AGGCCTCCTA TGCCATGGCC 2520

TCAGGTGCTG CACCCTCAGA GCTTGATGAT GGAGATGACA ATAAAGACAT ATCAGAATCA 2580

TCAACACTAT CGGGATTTTC TGCCAGCCAC TCATCTGCTT CCAGAGGTTC TGAGGGCTCT 2640

GTTGATACTG ACTTTGCCAG TGCCATTTCA GGAAATAGGC AAGGGAATAA ACAATATTTA 2700

TTTGAATTAC CTAAGCGACC CTCTGATGTC AATGTTAACC CACTCTATGT CTCGTCTGCA 2760

AGTAAAAAAC CACTAATCCA CGTGTATGAA AAGGAATTCA CTTCTGAGAT CTGCTGTGGT 2820

TCTTTGTGGG GAACAGGAGT CAATTTGCTG CTGGGAACCA GGTCTAATTT GTATCTGATG 2880

GACAGAAGTG GAAAGGCAGA CATTACAAAA CTTATAAAGC GAAGACCTTT CCGCCAGATT 2940

CAAGTCGTGG AGCCACTCAA TTTGCTGATT ACCATCTCTG GTCGTAAGAA CAGACTTCGA 3000

GTGTATCATT TGACCTGGTT GAGAAACAAG ATTTTGAATA ATGATCCAGA AAGTAAAAGA 3060

AGACAGGAGG AAATGCTGAA GACGGAGGAA GCCTGCAAAG CCATTGATAA GTTGACAGGC 3120

TGTGAACACT TCAGTGTCCT CCAACATGAA GAAACAACCT ATATTGCAAT TGCTTTGAAA 3180

TCATCAATTC ACCTTTATGC GTGGGCACCA AAGTCCTTTG ATGAAAGCAC TGCTATTAAA 3240

GTATTTCCAA CACTTGGTCA CAAGCCAGTG ACAGTTGACT TGGCTGTTGG CTCTGAAAAA 3300

AGACTAAAGG TTTTCTTCAG CTCAGCAAAT GGCTATCACA TCATCGATGC AGAATCTGAG 3360

GTTATGTCTG ATGTGACCCT GCCAAATAAT CCCCTGGAAA TCATTATACC ACAGAATATC 3420

ATCATTTTAC CTGACTGCTT GGGGATTGGC GTGATGCTCA CCTTCAACGC TGAAGCCCTG 3480

TCCGTGGAAG CCAACGAGCA GCTCTTCAAG AAGATCCTGG AAGTGTGGAA AGACATCCCA 3540

TCCTCTGTAG CTTTCGAGTG TACACAGCGA ACCACAGGAT GGGGTCAAAA GGCCATTGAA 3600

GCGCGCTCTT TGCAAGCAAA GGTTCTGGAA AGTGAGCTGA AGCGTAGGTC GATTAAGAAG 3660

CTGAGATTTC TGTGTACCCG GGGTGACAAG AAGCTGTTCT TTACCTCTAC CCTGCGGAAT 3720

CGCCACAGCC GGGTTTACTT TATGACCCTT GGAAAACTTG AAGAACTTCA AAGCAATTAT 3780

Domain Profile

S: 38    ekleelqkeisvlkklkh.pniveylesflk......eeelwlvmeylagGslsdlvkee  90

         +++e+l++e+++l+k++  +niv+++++f+k      +++lw+vme++a+Gs++d+v+++

Q: 1     DEEEDLRTELNLLRKYSFhKNIVSFYGAFFKlsppgqRHQLWMVMELCAAGSVTDVVRMT  60

         57899***********966*****************99**********************

S: 91    lkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlek  150

         ++++lkE++iayi+re+l++L++lH+++viHrdik++n+Llt+ +eVkL+dfgv+aq+++

Q: 61    RNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHTAEVKLVDFGVSAQVSR  120

         ************************************************************

S: 151   trkkrktvvgtpywmAPEviaqe...ekgYdekaDiwslGItaielaegepPfkdleplk  207

         t+ +r++++gtpywmAPEvi+++   +++Yd+++D+ws+GItaie+aeg+pP+++l+pl+

Q: 121   TNGRRNSFIGTPYWMAPEVINCDedpRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLE  180

         ***********************99999********************************

S: 208   allkilkneppklkskkkfskefkefvekclqknpekRpsasellkhkFl  257

         al+ il++++p++ks+  +s++f++f+ kc+ kn+ +Rp+++++l+h+F+

Q: 181   ALFVILRESAPTVKSS-GWSRKFHNFMGKCMIKNFLFRPTSANMLHHPFV  229

         *************888.********************************7

Domain Sequence
(FASTA)

DEEEDLRTEL NLLRKYSFHK NIVSFYGAFF KLSPPGQRHQ LWMVMELCAA GSVTDVVRMT 60

RNQSLKEDWI AYICREILQG LAHLHAHRVI HRDIKGQNVL LTHTAEVKLV DFGVSAQVSR 120

TNGRRNSFIG TPYWMAPEVI NCDEDPRRSY DYRSDVWSVG ITAIEMAEGA PPLCNLQPLE 180

ALFVILRESA PTVKSSGWSR KFHNFMGKCM IKNFLFRPTS ANMLHHPFV 229

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tarsius syrichta"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007256	; P:activation of JNKK activity
GO:0008285	; P:negative regulation of cell proliferation
GO:0007567	; P:parturition
GO:0060721	; P:regulation of spongiotrophoblast cell proliferation

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036

; CNH; 1.

Prosites

PS50219	; CNH; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013