EKS-ORC-00150
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00150
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb489.03.3E-147389646258
StatusUnreviewed
Ensembl ProteinENSOCUP00000002377
UniProt AccessionG1SI78;
Protein Name
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000002740ENSOCUP00000002377ENSOCUT00000002742
OrganismOryctolagus cuniculus
Functional Description
Protein Length707
Protein Sequence
(FASTA)
QEEGLVKEID ISHHVKEGFE KADPSQFELL KVLGQGSYGE EVFLVRKVKG SDAGQLYAMK 60
VLKKATLKVR DRVRSKMERD ILAEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDLFTRLS 120
KEVMFTEEDV KFYLAELALA LDHLHGLGII YRDLKPENIL LDEEGHIKIT DFGLSKEAID 180
HDKRAYSFCG TIEYMAPEVV NRRGHAQSAD WWSFGVLMNT PLTPSLPQGN FTPQTLRTLP 240
APCPAPLPQD LSTVVEGRPS LWLRSHALSA LFTTGAGVDG VEEIKRHPFF VTIDWNDSVA 300
RRKEIKPPFK PAVGRPEDTF HFDPEFTART PTDSPGVPPS ANAHHLFRGF SFVASSLAQE 360
SSQQEPHQVP VHPIVQQLHG NNVHFTDGYE IKEDIGVGSY SVCKRCVHKA TDAEYAVKII 420
DKSKRDPSEE IEILLRYGQH PNIITLKDVY DDGKFVYLVT ELMRGGELLD RILRQRCFSE 480
REASGVLCTI TKTMDYLHSQ GVVHRDLKPS NILYVDESGD PESIRICDFG FAKQLRAENG 540
LLMTPCYTAN FVAPEVLKRQ GYDAACDVWS LGILLYTMLA GFTPFANGPE DTPEEILARI 600
GSGKYALSGG NWDSVSEAAK DVVSKMLHVD PQQRLTAVQV LKHPWIVNRE YLSQSQLSRQ 660
DVHLVKGAMA ATYSALNRAP LAPRLEPVLS SSLAQRRGMK RLTSTRL 707
Nucleotide Sequence
(FASTA)
CAGGAGGAGG GGCTCGTGAA GGAGATTGAC ATCAGCCACC ATGTGAAGGA GGGGTTTGAG 60
AAGGCCGACC CGTCCCAGTT TGAGCTGTTG AAGGTGTTGG GACAGGGCTC CTACGGGGAA 120
GAGGTGTTCC TGGTGCGGAA GGTCAAGGGC TCCGACGCCG GGCAGCTGTA CGCCATGAAA 180
GTCCTCAAGA AGGCCACGCT CAAGGTTCGG GACCGCGTGC GGTCGAAGAT GGAGAGAGAC 240
ATCCTGGCCG AAGTGAATCA CCCCTTCATC GTCAAGCTCC ACTACGCCTT CCAGACGGAG 300
GGGAAGCTGT ACCTGATCCT GGACTTCCTG CGCGGCGGGG ACCTCTTCAC CAGGCTGTCC 360
AAGGAGGTGA TGTTCACGGA GGAGGACGTC AAGTTCTACC TGGCCGAGCT GGCCCTGGCC 420
TTAGACCACC TCCACGGCCT GGGCATCATC TACCGAGACC TGAAACCCGA GAACATCCTC 480
CTGGACGAAG AGGGACACAT CAAGATCACA GACTTCGGCC TGAGCAAGGA GGCCATCGAC 540
CACGACAAGA GAGCCTACTC GTTCTGCGGC ACCATCGAGT ACATGGCGCC CGAGGTGGTG 600
AACCGGCGGG GACACGCGCA GAGCGCAGAC TGGTGGTCGT TCGGCGTGCT CATGAACACA 660
CCCCTAACGC CGTCTCTGCC CCAAGGTAAC TTCACACCCC AAACCCTCCG CACCCTGCCA 720
GCCCCATGCC CTGCACCGCT GCCCCAGGAC CTTAGCACTG TGGTAGAAGG GAGACCCTCA 780
CTCTGGCTTC GATCTCACGC ACTCTCTGCT CTGTTTACAA CAGGTGCTGG CGTTGACGGC 840
GTGGAAGAGA TTAAGCGTCA CCCTTTCTTT GTGACCATAG ACTGGAACGA CAGTGTGGCA 900
CGGAGGAAGG AGATCAAGCC GCCGTTCAAA CCCGCCGTGG GCAGGCCCGA GGACACCTTC 960
CACTTTGACC CCGAGTTCAC GGCGCGGACA CCCACAGACT CTCCCGGGGT GCCCCCGAGT 1020
GCCAACGCTC ATCACCTGTT CAGAGGATTC AGCTTCGTGG CCTCAAGCCT GGCCCAGGAG 1080
TCCTCGCAGC AGGAGCCACA CCAAGTCCCG GTGCACCCGA TCGTGCAGCA GCTACACGGG 1140
AACAACGTCC ACTTCACCGA CGGCTACGAG ATCAAGGAGG ACATCGGGGT GGGCTCCTAC 1200
TCGGTGTGCA AGCGCTGCGT GCACAAAGCG ACGGACGCCG AGTACGCGGT GAAGATCATC 1260
GACAAGAGCA AGAGGGACCC TTCGGAGGAG ATCGAGATCC TCCTGAGATA CGGCCAGCAC 1320
CCGAACATCA TCACCCTCAA GGACGTCTAC GACGACGGCA AGTTCGTGTA CCTGGTGACG 1380
GAGCTGATGC GTGGCGGGGA GCTGCTGGAC CGCATCCTGC GGCAGAGGTG CTTCTCGGAG 1440
CGCGAGGCCA GCGGCGTGCT GTGCACCATC ACCAAGACCA TGGACTACCT GCACTCGCAG 1500
GGGGTGGTGC ACCGAGACCT GAAACCCAGC AACATCCTGT ACGTGGACGA ATCCGGGGAC 1560
CCCGAGTCCA TCCGCATCTG CGACTTCGGC TTCGCCAAGC AGCTGCGGGC GGAGAACGGG 1620
CTGCTGATGA CGCCCTGCTA CACCGCCAAC TTCGTGGCCC CGGAGGTCCT GAAGCGGCAA 1680
GGCTATGATG CGGCGTGCGA CGTCTGGAGT CTGGGGATCC TACTCTACAC CATGCTGGCG 1740
GGGTTCACCC CCTTTGCAAA CGGACCGGAG GACACCCCCG AGGAGATCCT GGCTCGCATC 1800
GGCAGCGGGA AGTACGCCCT CTCTGGGGGC AACTGGGACT CCGTGTCTGA GGCGGCCAAG 1860
GACGTCGTGT CCAAGATGCT CCACGTGGAC CCTCAGCAGC GCCTGACGGC CGTGCAAGTG 1920
CTCAAGCACC CCTGGATTGT CAACAGGGAG TACCTGTCCC AGAGCCAGCT CAGCAGACAA 1980
GACGTGCACC TGGTGAAGGG CGCGATGGCC GCCACCTACT CTGCACTGAA CAGAGCTCCG 2040
CTGGCCCCGC GGCTGGAGCC GGTGCTGTCG TCCAGCCTGG CCCAGCGCCG GGGCATGAAG 2100
AGACTCACGT CCACGCGGTT GTAG 2124
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+GvGsysvckrcvhkat+ e+avkiidkskrd+seeieillry+qhpni+tlkd
Q: 389   YEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKD  448
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk+vylv+el++GGelldri+++++fsereas +l+t++k+++ylh+qGvvhrdlk
Q: 449   VYDDGKFVYLVTELMRGGELLDRILRQRCFSEREASGVLCTITKTMDYLHSQGVVHRDLK  508
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nilyvdes+++esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+
Q: 509   PSNILYVDESGDPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDV  568
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG+llytmlaG++pfangpedt+eeila+i++Gk++lsG++wdsvse+akd+vsk+l+
Q: 569   WSLGILLYTMLAGFTPFANGPEDTPEEILARIGSGKYALSGGNWDSVSEAAKDVVSKMLH  628
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl++ q+lkh+w+
Q: 629   VDPQQRLTAVQVLKHPWI  646
         *****************8
Domain Sequence
(FASTA)
YEIKEDIGVG SYSVCKRCVH KATDAEYAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKFVYL VTELMRGGEL LDRILRQRCF SEREASGVLC TITKTMDYLH SQGVVHRDLK 120
PSNILYVDES GDPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDV 180
WSLGILLYTM LAGFTPFANG PEDTPEEILA RIGSGKYALS GGNWDSVSEA AKDVVSKMLH 240
VDPQQRLTAV QVLKHPWI 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00154
EKS-ANC-00156
EKS-BOT-00161
EKS-CAJ-00165
EKS-CAF-00168
EKS-CAP-00161
EKS-EQC-00163
EKS-GAG-00139
EKS-GOG-00162
EKS-HOS-00167
EKS-ICT-00156
EKS-LOA-00159
EKS-MEG-00128
EKS-MOD-00158
EKS-MUM-00167
EKS-MUP-00165
EKS-OTG-00167
EKS-PES-00142
EKS-POA-00158
EKS-RAN-00159
EKS-SAH-00153
EKS-SUS-00139
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004711; F:ribosomal protein S6 kinase activity
GO:0002035; P:brain renin-angiotensin system
GO:0010659; P:cardiac muscle cell apoptotic process
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0060047; P:heart contraction
GO:0007507; P:heart development
GO:0007243; P:intracellular protein kinase cascade
GO:0000089; P:mitotic metaphase
GO:0045786; P:negative regulation of cell cycle
GO:0008285; P:negative regulation of cell proliferation
GO:0001556; P:oocyte maturation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0010628; P:positive regulation of gene expression
GO:0070613; P:regulation of protein processing
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013