EKS-ORC-00439
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00439
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK413.45.2E-12426321296
StatusUnreviewed
Ensembl ProteinENSOCUP00000018933
UniProt AccessionG1SII5;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK8
Gene Synonyms/Alias MAPK8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000002873ENSOCUP00000018933ENSOCUT00000031352
ENSOCUG00000002873ENSOCUP00000002496ENSOCUT00000002873
OrganismOryctolagus cuniculus
Functional Description
Protein Length427
Protein Sequence
(FASTA)
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180
MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ 240
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FERLFPDVLF PADSEHNKLK ASQARDLLSK 300
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 360
MDLEERTKNG VIRGQPSPLG AAVISGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEAPA 420
GPLGCCR 427
Nucleotide Sequence
(FASTA)
ATGAGCAGAA GCAAGCGTGA CAACAATTTT TATAGTGTAG AGATCGGAGA TTCTACATTC 60
ACAGTCCTGA AGCGATATCA GAATCTAAAA CCTATAGGTT CTGGAGCTCA AGGAATAGTC 120
TGTGCAGCTT ATGATGCCAT TCTTGAAAGA AATGTTGCCA TCAAGAAGCT AAGCCGGCCG 180
TTTCAGAATC AAACGCATGC TAAGAGGGCC TACAGAGAGC TGGTTCTTAT GAAATGTGTT 240
AATCACAAAA ATATAATTGG CCTTTTGAAT GTTTTTACAC CACAGAAATC TCTAGAAGAA 300
TTTCAAGATG TTTACATAGT CATGGAGCTC ATGGATGCGA ATCTTTGCCA AGTGATTCAG 360
ATGGAACTAG ATCATGAAAG AATGTCCTAC CTTCTCTATC AGATGCTGTG TGGAATCAAG 420
CACCTTCACT CCGCTGGAAT TATTCATCGG GACTTAAAGC CCAGTAATAT AGTAGTAAAA 480
TCAGACTGCA CTTTGAAAAT CCTTGACTTT GGACTGGCCA GGACTGCAGG AACAAGCTTT 540
ATGATGACGC CTTATGTGGT GACTCGCTAC TACAGAGCGC CTGAGGTCAT CCTGGGCATG 600
GGCTACAAGG AGAACGTTGA CATTTGGTCA GTTGGGTGCA TCATGGGAGA AATGATCAAA 660
GGTGGTGTTT TGTTCCCAGG TACAGATCAT ATTGATCAGT GGAATAAAGT TATTGAACAG 720
CTGGGAACAC CATGTCCTGA GTTCATGAAG AAACTGCAAC CAACAGTAAG GACTTACGTG 780
GAAAACAGAC CTAAGTATGC CGGATATAGC TTTGAGAGGC TCTTCCCCGA TGTGCTTTTC 840
CCAGCTGACT CGGAACACAA CAAGCTTAAA GCCAGTCAGG CAAGGGATTT GCTCTCTAAA 900
ATGCTGGTGA TAGATGCATC TAAGAGGATC TCTGTAGACG AAGCTCTCCA GCACCCATAC 960
ATCAATGTCT GGTACGATCC CTCTGAAGCA GAAGCCCCAC CACCAAAGAT TCCTGACAAA 1020
CAGTTAGACG AAAGGGAACA CACGATAGAA GAATGGAAAG AATTGATATA CAAGGAAGTG 1080
ATGGATTTGG AAGAAAGAAC CAAGAATGGA GTTATACGAG GGCAGCCCTC TCCTTTAGGT 1140
GCAGCAGTGA TCAGTGGCTC TCAGCATCCA TCGTCATCGT CGTCTGTCAA TGATGTGTCT 1200
TCAATGTCAA CAGACCCGAC TTTGGCCTCG GATACAGACA GCAGTCTGGA AGCCCCAGCT 1260
GGGCCTCTGG GCTGCTGTAG A 1281
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++lkp+g+Ga+g+v++a+d+  e++vaikklsrpfq++t+akr++REl l+k+++h+Ni
Q: 26    YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85
         899*********************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i ll+vftp+++lee++dvY+v+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs
Q: 86    IGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144
         ************************************9.**********************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180
         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  + 
Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201
         **********************************976..*****************9.99
S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240
         y+++vDiWsvGCI++E+++g +lfpg+d+idq++k++e+lgtp  ef+kk++  ++r+y+
Q: 202   YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP-TVRTYV  260
         *****************************************************.5*****
S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288
         +++pk++  +fe+lfp+            + ++a+dLl+k+Lv+d++kRisv+eaL+hpY
Q: 261   ENRPKYAGYSFERLFPDvlfpadsehnklKASQARDLLSKMLVIDASKRISVDEALQHPY  320
         *****************************99*****************************
S: 289   l  289
         +
Q: 321   I  321
         7
Domain Sequence
(FASTA)
YQNLKPIGSG AQGIVCAAYD AILERNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60
IGLLNVFTPQ KSLEEFQDVY IVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120
GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180
VDIWSVGCIM GEMIKGGVLF PGTDHIDQWN KVIEQLGTPC PEFMKKLQPT VRTYVENRPK 240
YAGYSFERLF PDVLFPADSE HNKLKASQAR DLLSKMLVID ASKRISVDEA LQHPYI 296
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>
EKS-AIM-00433
EKS-ANC-00452
EKS-BOT-00465
EKS-CAJ-00470
EKS-CAF-00466
EKS-CAP-00497
EKS-CII-00262
EKS-CIS-00222
EKS-DAR-00873
EKS-DRM-00223
EKS-EQC-00453
EKS-FEC-00443
EKS-GAG-00388
EKS-GOG-00455
EKS-HOS-00474
EKS-ICT-00440
EKS-LAC-00476
EKS-LOA-00470
EKS-MAM-00462
EKS-MEG-00380
EKS-MOD-00457
EKS-MUM-00498
EKS-MUP-00455
EKS-MYL-00456
EKS-NOL-00422
EKS-OTG-00472
EKS-PAT-00438
EKS-PES-00409
EKS-POA-00453
EKS-SAH-00433
EKS-TAG-00527
EKS-TAS-00066
EKS-TUB-00050
EKS-VIP-00088
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0035033; F:histone deacetylase regulator activity
GO:0004705; F:JUN kinase activity
GO:0071260; P:cellular response to mechanical stimulus
GO:0043066; P:negative regulation of apoptotic process
GO:0032091; P:negative regulation of protein binding
GO:0001503; P:ossification
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0090045; P:positive regulation of deacetylase activity
GO:2000017; P:positive regulation of determination of dorsal identity
GO:0010628; P:positive regulation of gene expression
GO:0032880; P:regulation of protein localization
GO:0046686; P:response to cadmium ion
GO:0009411; P:response to UV
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008351; MAPK_JNK.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01772; JNKMAPKINASE.
Created Date20-Feb-2013