EPS-ORC-00059

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORC-00059

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	134.0	8.5E-39	364	519	156

Status

Unreviewed

Ensembl Protein

ENSOCUP00000002563

UniProt Accession

G1SIP7;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000002939	ENSOCUP00000002563	ENSOCUT00000002949

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1235

Protein Sequence
(FASTA)

RALCLPGGFA FVYEAQDLGS GREYALKRLL SDEEEKNRAI IQEVCFMKKL SGHPNIVQFC 60

SAASIGKEES DTGQAEFLLL TELCKGQLVE FLKKVESKGP VSCDTVLKIF YQTCRAVQHM 120

HKQKPPIIHR DLKVENLLLS NQGTIKLCDF GSATTISHYP DYSWSAQKRA LVEEEITRNT 180

TPMYRTPEIV DLYSNFPIGE KQDIWALGCI LYLLCFRQHP FEDGAKLRIV NGKYSIPADD 240

TRYTVFHGLI RAMLRVNPEE RLSIAEVVHR LQEIAAARNV NPKSPITELL EQNGGYGNVA 300

LSRAPPHPGG PVSSGYGGGL ALAEYDQSYG GFLDILRGGT ERLFSNLKDT SSRVIQSVAN 360

YAKGDLDISY VTSRIAVMSF PAEGVESAIK NNIEDVRLFL DAKHAGHYAV YNLSPRTYRA 420

SKFHSRVSEC GWAARRAPLL HNLYSICRDM HGWLRRDPKN VCVVHCTDGR AVFAVLVRFM 480

CLCRLFSTAE AAVYMFSMKR CPPGIWPSHK RYIEYVCDMV AEEPVTPHGK PVLVRAVVMT 540

PVPLFNKQRS GCRPFCEVHV GDERVATTSQ EYDRLREFRI EDGKAVIPLG ITVQGDVLLV 600

IYHTRSTLGG RLQAKMRAAC VLQREEQHTG VGPGEASRVS HCRYDLDACD IQEKYPDLFQ 660

VSLDVEVEPR DRPSREALPW ESARTRGLTP KVFFSSREEQ QTLTMFGKPE LPRQPGSTAR 720

YEAGVESPEA EPPESDSPRS SSTDASHFLH TLDWQEEGEP ALGVAEATPG TDEDDSEAST 780

EEEPPCPGAS GDPGSPEEDA VTAGDPQGPP REDSVDLLGL HSERGPGPAA PSQACGVPSS 840

NAELLSGLLG LPETTAEGPP GDLLGSEAPL LLASPAPPLS ARSTPQGGPP TAADPFDPLL 900

PASDACSQPR SKPDLFGEFL ASDPVATSPL FPSTHSAPPP SCSTDFLHLG DLPAEPGKMT 960

SSSSHPDLLG GWDAWAEASV PGPAPTPAAE GPLFSAGGQP GPQATRTKPQ NLDPFADLGD 1020

LSSGLQGAPA GLPPGGFIPR AAPSPRGAWQ TSRPPAPGPS QHAQAKPRPP YTASVIGGRE 1080

ERGIRAPGFA QKPKVSESDF EDLLSDQGFA SRADRKGPKT MAEMRRQGLA RDADPLKLKL 1140

LDWVEGKERN IRALLSTLHT VLWDGESRWT PLSMCACMPC PCNVHVPWRP LVTAALPCLR 1200

PQAAGQPYEQ LAKMIFMELN DAWSEFESQG SRPLF 1235

Nucleotide Sequence
(FASTA)

CGAGCGCTCT GTCTTCCAGG AGGGTTTGCG TTTGTGTATG AAGCTCAGGA CCTGGGAAGT 60

GGCAGAGAAT ATGCCTTGAA GAGGCTGCTG TCCGACGAGG AGGAGAAGAA CAGGGCCATC 120

ATCCAAGAGG TCTGCTTCAT GAAGAAGCTC TCCGGCCATC CCAACATTGT CCAGTTTTGT 180

TCTGCAGCAT CAATAGGGAA AGAAGAGTCG GACACCGGGC AGGCCGAGTT CCTCCTGCTC 240

ACAGAGCTCT GCAAAGGGCA GCTGGTGGAG TTTCTAAAGA AAGTTGAGTC GAAGGGTCCT 300

GTGTCGTGCG ACACGGTTCT GAAGATTTTC TACCAGACGT GCAGAGCGGT GCAGCACATG 360

CACAAGCAGA AGCCGCCCAT CATCCACAGG GACCTCAAGG TTGAAAACTT GCTGCTGAGT 420

AACCAGGGGA CCATTAAGCT GTGTGACTTC GGCAGCGCCA CGACCATCTC GCATTACCCC 480

GACTACAGCT GGAGTGCCCA GAAGCGCGCC CTGGTGGAGG AGGAGATCAC GAGGAACACA 540

ACGCCCATGT ACAGGACGCC AGAGATCGTG GACTTGTACT CCAACTTCCC CATCGGCGAG 600

AAGCAGGACA TCTGGGCTCT GGGCTGCATC CTGTACCTGC TGTGTTTCCG GCAGCACCCT 660

TTTGAAGATG GAGCAAAGCT TCGAATTGTG AACGGGAAGT ACTCCATCCC CGCAGACGAC 720

ACGCGGTACA CGGTGTTCCA CGGCCTCATC CGTGCCATGC TGAGGGTGAA CCCCGAGGAG 780

CGACTGTCCA TCGCCGAGGT GGTGCACCGG CTGCAGGAGA TCGCGGCTGC CAGGAACGTG 840

AACCCCAAGT CGCCCATCAC GGAGCTCCTG GAGCAGAATG GAGGCTACGG GAACGTGGCG 900

CTGTCCCGGG CTCCACCCCA TCCCGGGGGC CCCGTGAGCA GCGGCTACGG TGGAGGTCTG 960

GCGCTGGCCG AGTACGACCA GTCCTATGGA GGGTTCCTGG ACATCCTGCG GGGTGGTACC 1020

GAGCGCCTCT TCAGCAACCT CAAGGACACC TCCTCCAGGG TCATCCAGTC TGTGGCCAAC 1080

TATGCCAAGG GCGACCTGGA CATCTCCTAC GTCACCTCCC GCATAGCCGT GATGTCATTC 1140

CCGGCGGAGG GCGTGGAGTC GGCCATCAAA AACAACATAG AGGATGTGCG GCTGTTCCTG 1200

GACGCCAAGC ACGCGGGCCA CTACGCCGTC TACAACCTGT CCCCCAGGAC GTACCGGGCC 1260

TCCAAGTTCC ACAGCCGCGT CTCTGAGTGT GGCTGGGCTG CCAGGCGGGC GCCCCTCCTG 1320

CACAACCTGT ACAGCATCTG CAGGGACATG CATGGCTGGC TCCGGCGGGA CCCCAAGAAC 1380

GTCTGTGTGG TGCACTGCAC GGATGGGAGA GCTGTGTTCG CCGTGCTAGT CCGCTTTATG 1440

TGTCTCTGCC GCCTCTTCAG CACCGCGGAG GCCGCCGTGT ACATGTTCAG CATGAAGCGC 1500

TGCCCGCCGG GCATCTGGCC ATCCCACAAA AGGTACATCG AGTACGTGTG CGACATGGTG 1560

GCCGAGGAGC CCGTCACGCC GCACGGCAAG CCCGTGCTGG TGCGGGCCGT GGTCATGACG 1620

CCCGTGCCAC TCTTCAACAA GCAGAGGAGC GGCTGCAGGC CCTTCTGCGA GGTGCACGTG 1680

GGGGACGAGC GCGTGGCCAC CACGTCCCAG GAGTACGACA GGCTGAGGGA GTTCAGAATC 1740

GAGGATGGGA AAGCGGTCAT TCCCCTGGGC ATCACTGTGC AGGGCGACGT GCTCCTCGTC 1800

ATCTACCACA CCAGGTCCAC GCTGGGAGGG CGGCTGCAGG CCAAGATGAG GGCAGCTTGC 1860

GTGCTGCAGC GTGAGGAGCA GCACACGGGA GTCGGCCCTG GGGAGGCCTC GCGAGTGAGT 1920

CACTGCAGGT ATGACTTGGA TGCGTGCGAC ATTCAGGAGA AATACCCAGA CTTATTCCAA 1980

GTGAGTCTGG ACGTGGAGGT GGAGCCCAGA GACCGGCCGA GCCGGGAGGC CCTGCCCTGG 2040

GAGAGTGCGC GCACCAGGGG GCTGACGCCC AAGGTCTTCT TCTCCAGCCG GGAGGAGCAG 2100

CAGACACTGA CCATGTTTGG GAAGCCCGAG CTCCCCCGGC AGCCCGGCTC CACGGCTCGG 2160

TACGAGGCTG GCGTGGAGTC TCCGGAAGCT GAGCCCCCGG AGTCGGACTC ACCTCGGAGC 2220

AGCAGCACGG ACGCCAGTCA CTTCCTCCAC ACGCTGGATT GGCAGGAGGA GGGGGAGCCA 2280

GCGCTGGGCG TGGCGGAAGC CACCCCAGGC ACCGATGAGG ACGACAGCGA GGCGTCCACC 2340

GAGGAGGAGC CGCCCTGCCC CGGCGCCAGC GGGGACCCTG GGTCCCCCGA AGAGGATGCA 2400

GTCACTGCGG GCGACCCGCA GGGGCCCCCG CGAGAGGACT CTGTGGACCT GCTGGGGCTG 2460

CACTCTGAGA GGGGCCCGGG GCCGGCTGCC CCCTCACAGG CCTGTGGGGT CCCCTCCAGC 2520

AACGCCGAGC TGCTCAGTGG CCTCCTTGGG CTCCCAGAGA CCACCGCAGA AGGGCCCCCT 2580

GGCGACCTGC TTGGCAGCGA GGCACCCCTG CTCCTGGCCA GCCCGGCCCC TCCCCTCAGC 2640

GCACGGAGCA CCCCGCAGGG GGGTCCCCCC ACCGCTGCCG ACCCCTTCGA CCCGTTGCTG 2700

CCGGCGTCTG ACGCCTGCTC CCAGCCCCGC TCCAAGCCCG ACCTTTTTGG CGAGTTCCTG 2760

GCTTCAGACC CCGTGGCCAC GTCGCCCCTT TTCCCCTCCA CCCACAGCGC CCCGCCCCCA 2820

TCCTGCAGCA CCGACTTCCT GCACCTGGGG GATCTGCCAG CAGAGCCCGG CAAGATGACC 2880

AGCTCCTCCA GCCACCCGGA CCTGCTGGGG GGCTGGGATG CCTGGGCCGA GGCCTCCGTG 2940

CCTGGGCCAG CCCCCACACC AGCTGCAGAA GGCCCCCTCT TCTCTGCAGG GGGTCAGCCT 3000

GGCCCCCAGG CCACCCGGAC CAAACCTCAG AACCTGGACC CATTTGCTGA CCTGGGCGAC 3060

CTCAGCTCCG GCCTCCAAGG TGCACCTGCT GGACTCCCCC CCGGGGGCTT CATCCCCAGA 3120

GCAGCCCCCT CTCCCAGAGG TGCCTGGCAG ACAAGCCGGC CGCCGGCCCC AGGCCCCTCC 3180

CAGCACGCCC AGGCCAAGCC CAGGCCTCCC TATACCGCCA GCGTCATCGG GGGGCGGGAG 3240

GAGCGGGGCA TCCGAGCCCC CGGTTTCGCC CAGAAGCCGA AAGTCTCAGA GAGCGACTTT 3300

GAAGACCTGC TGTCCGACCA AGGCTTTGCC TCCAGGGCCG ACAGGAAGGG GCCCAAGACC 3360

ATGGCAGAGA TGAGGAGGCA GGGCCTGGCC AGAGACGCAG ACCCCCTGAA GCTGAAGCTC 3420

CTGGACTGGG TGGAAGGCAA GGAGAGGAAC ATCCGGGCCC TGCTGTCCAC GCTGCACACG 3480

GTGCTGTGGG ACGGCGAGAG CCGCTGGACA CCCCTGAGCA TGTGTGCCTG CATGCCATGT 3540

CCATGCAACG TCCATGTGCC GTGGCGCCCT CTGGTGACAG CAGCTCTGCC CTGTCTCCGC 3600

CCGCAGGCCG CGGGGCAGCC GTACGAGCAG CTGGCCAAGA TGATCTTCAT GGAGCTGAAC 3660

GACGCCTGGT CCGAGTTCGA GAGCCAGGGC TCCCGGCCCC TCTTCTGA 3708

Domain Profile

S: 8     fdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcserrydltk  67

          dld+ yvt ri  +sfPae+ e+  +nn+++v  +ld kh ++y +ynl s r y  +k

Q: 364   GDLDISYVTSRIAVMSFPAEGVESAIKNNIEDVRLFLDAKHAGHYAVYNL-SPRTYRASK  422

         59************************************************.*********

S: 68    lnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvivcayll  127

         ++++v+e g+   +aP l++l sic++++ Wl +d++nv v+hc  g+    v+v  ++

Q: 423   FHSRVSECGWAARRAPLLHNLYSICRDMHGWLRRDPKNVCVVHCTDGRAVFAVLV-RFMC  481

         ************************************************9998887.6999

S: 128   aseisakadealdtfgerrtredkvagvkqPsqrryvsyfsql  170

           + +++a+ a+++f+++r           Ps +ry++y + +

Q: 482   LCRLFSTAEAAVYMFSMKRCPPG-----IWPSHKRYIEYVCDM  519

         9*****************97654.....59*********8876

Domain Sequence
(FASTA)

GDLDISYVTS RIAVMSFPAE GVESAIKNNI EDVRLFLDAK HAGHYAVYNL SPRTYRASKF 60

HSRVSECGWA ARRAPLLHNL YSICRDMHGW LRRDPKNVCV VHCTDGRAVF AVLVRFMCLC 120

RLFSTAEAAV YMFSMKRCPP GIWPSHKRYI EYVCDM 156

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013