EKS-ORC-00360

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00360

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	295.9	3.0E-88	463	719	257

Status

Unreviewed

Ensembl Protein

ENSOCUP00000024621

UniProt Accession

G1SIU1;

Protein Name

Protein Synonyms/Alias

Gene Name

100349336

Gene Synonyms/Alias

100349336;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000003001	ENSOCUP00000018426	ENSOCUT00000031654
ENSOCUG00000003001	ENSOCUP00000024621	ENSOCUT00000025149
ENSOCUG00000003001	ENSOCUP00000002612	ENSOCUT00000003004
ENSOCUG00000003001	ENSOCUP00000024692	ENSOCUT00000029079

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

835

Protein Sequence
(FASTA)

MGNYKSRPTQ TCTDEWKKKV SESYVTIIER LEDDLQIKDK ELTELSHIFS SDEAFSEVNL 60

NYRTENGLSL LHLCCICGGN KSHIRTLMLK GLRPSRLTKN GFTALHLAVY KDSAELITSL 120

LHSGADIQQV GYGGLTALHI ATITGHLEAA DVLLQHGANV NVQDAVFFTP LHIAAYYGHE 180

QITRLLLKFG ADVNVSGEVG DRPLHLASAK GFFNIAKLLM EEGSKADVNA QDNEDHVPLH 240

FCSRFGHHDI VKYLLQSDLA VQPHVVNIYG DTPLHLACYN GKFDVAKEII QISGTESLTK 300

ENIFSETAFH SACTYGKSID LVKFLLDQNV ININHQGRDG HTGLHSACYH GHIRLVQFLL 360

DNGADMNLVA CDPSRSSGEK DEQTCLMWAY ERGHDAIVTL LKHYKRPQEE LPCNEYSQPG 420

GDGSYVSVPS PLGKIKNMTK EKADVLLLRA GLPSHFHLQL SEIEFHEIIG SGSFGKVYKG 480

RCRNKIVAIK RYRANTYCSK SDVDMFCREV SILCQLNHPC VIQFVGACLN DPSQFAIVTQ 540

YISGGSLFSL LHEQKRILDL QSKLIIAVDV AKGMEYLHNL TQPIIHRDLN SHNILLYEDG 600

HAVVADFGES RFLQSLDEDN MTKQPGNLRW MAPEVFTQCT RYTIKADVFS YALCLWELLT 660

GEIPFAHLKP AAAAADMAYH HIRPPIGYSI PKPISSLLMR GWNACPEGRP EFSEVVTKLE 720

ECLCNIELMS PASSNSSGSL SPSSSSDCLV SRGGPGRSHV AALRSRFELE YALNARSYSA 780

WSQSARQCSS QGLSLEEMKR SLQYSPIDKY GYVSDPMSPM HFHSCRNSGS FEDSS 835

Nucleotide Sequence
(FASTA)

ATGGGAAATT ATAAATCTAG ACCAACTCAA ACTTGTACTG ATGAATGGAA GAAGAAAGTC 60

AGTGAATCTT ATGTGACTAT AATAGAAAGA TTAGAAGATG ACCTGCAGAT CAAGGATAAA 120

GAGCTTACAG AACTAAGCCA TATATTTAGC TCTGATGAAG CCTTCAGTGA AGTCAATTTA 180

AATTACCGCA CTGAAAACGG GCTCTCTCTA CTTCATTTAT GTTGCATTTG TGGAGGCAAC 240

AAGTCACATA TCCGAACACT TATGTTAAAA GGGCTCCGTC CATCTCGACT GACAAAAAAT 300

GGATTTACAG CCTTGCACTT GGCAGTTTAT AAGGATAGTG CAGAATTGAT CACTTCGCTG 360

CTTCACAGTG GAGCTGATAT ACAGCAAGTT GGGTATGGTG GCCTCACTGC CCTTCACATT 420

GCTACTATAA CTGGTCACCT GGAGGCTGCT GATGTGTTGC TGCAGCATGG AGCTAATGTC 480

AATGTTCAAG ATGCAGTCTT CTTCACTCCA TTGCACATTG CAGCATACTA TGGGCATGAA 540

CAGATTACCC GCCTCCTTTT GAAATTTGGT GCTGATGTAA ATGTAAGTGG TGAAGTTGGA 600

GATAGGCCTC TCCACCTAGC GTCTGCAAAA GGATTCTTCA ATATTGCAAA ACTCTTAATG 660

GAGGAAGGCA GCAAGGCAGA TGTGAATGCT CAGGATAATG AAGACCATGT CCCACTCCAC 720

TTCTGTTCTC GCTTTGGACA CCATGATATA GTGAAGTACC TGCTCCAAAG TGACTTGGCA 780

GTTCAACCCC ATGTTGTTAA TATCTACGGA GACACCCCTT TGCACTTGGC ATGCTACAAT 840

GGCAAATTTG ACGTTGCTAA GGAAATCATT CAAATATCAG GAACAGAAAG TCTGACTAAG 900

GAAAATATCT TCAGTGAAAC AGCTTTTCAC AGTGCTTGTA CCTATGGCAA AAGCATTGAC 960

CTGGTTAAAT TCCTTCTTGA TCAGAATGTC ATAAACATCA ACCACCAAGG AAGGGATGGC 1020

CACACTGGAC TACATTCTGC TTGCTACCAT GGTCACATCC GCCTGGTTCA GTTCTTACTG 1080

GATAATGGAG CTGATATGAA TCTAGTAGCC TGTGATCCCA GCAGGTCTAG TGGTGAAAAA 1140

GATGAGCAGA CATGTTTGAT GTGGGCTTAT GAAAGAGGAC ATGATGCCAT TGTCACACTC 1200

TTGAAGCATT ATAAGAGACC CCAGGAGGAA CTGCCCTGCA ATGAATATTC TCAGCCCGGA 1260

GGAGATGGCT CCTATGTGTC TGTTCCTTCC CCCTTGGGGA AGATCAAAAA CATGACAAAA 1320

GAGAAGGCAG ACGTTCTCCT CCTAAGGGCT GGATTGCCTT CACACTTCCA CCTTCAGCTC 1380

TCAGAAATTG AGTTCCACGA GATTATCGGC TCAGGATCTT TTGGGAAAGT ATATAAAGGA 1440

CGATGCAGAA ATAAAATAGT GGCCATCAAA CGTTACCGAG CCAACACCTA CTGCTCCAAG 1500

TCAGATGTGG ATATGTTTTG CCGGGAGGTG TCCATTCTCT GCCAGCTGAA TCATCCCTGT 1560

GTAATTCAGT TTGTGGGCGC TTGCTTGAAC GATCCCAGCC AGTTTGCCAT TGTCACCCAG 1620

TACATATCAG GAGGTTCCCT GTTCTCCCTC CTTCATGAAC AGAAGAGGAT TCTTGATTTG 1680

CAGTCCAAGT TGATTATTGC AGTAGATGTG GCCAAAGGTA TGGAGTACCT TCACAACCTG 1740

ACACAGCCAA TTATACACCG TGACTTGAAC AGTCACAATA TTCTTCTCTA TGAGGATGGA 1800

CATGCTGTGG TGGCTGATTT TGGAGAATCA AGATTTCTAC AGTCTCTGGA TGAAGACAAC 1860

ATGACAAAAC AACCTGGGAA CCTCCGTTGG ATGGCTCCAG AGGTGTTCAC ACAGTGCACG 1920

CGGTACACCA TCAAAGCTGA CGTCTTCAGC TATGCTCTGT GTCTGTGGGA ACTTCTCACT 1980

GGTGAAATTC CATTCGCCCA TCTCAAGCCA GCAGCTGCAG CAGCAGACAT GGCCTACCAC 2040

CACATTAGAC CTCCCATTGG CTATTCCATT CCCAAGCCCA TATCTTCTCT GCTGATGCGA 2100

GGGTGGAATG CATGTCCTGA AGGAAGACCT GAGTTTTCTG AAGTTGTCAC GAAGTTAGAG 2160

GAATGTCTCT GCAATATTGA GCTGATGTCT CCCGCATCAA GTAACAGCAG TGGGTCTCTC 2220

TCACCATCCT CTTCCTCTGA TTGCCTGGTG AGCCGGGGAG GGCCTGGCCG GAGCCACGTG 2280

GCAGCTTTAC GGAGTCGTTT TGAGTTGGAA TATGCTCTAA ATGCAAGATC CTATTCTGCC 2340

TGGTCCCAAA GTGCTAGACA ATGTTCCTCT CAAGGCCTGT CATTGGAGGA GATGAAAAGA 2400

AGTCTTCAAT ACTCACCCAT TGACAAATAT GGCTACGTGT CTGATCCCAT GAGCCCGATG 2460

CATTTTCATT CTTGCCGGAA TAGTGGCAGC TTTGAGGACA GCAGC 2505

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaee.kekleklereakllsklshpnii  59

         ie++e+igsg+fgkvyk+++r+k va+K++r+++++ k+++++++re+++l++l+hp++i

Q: 463   IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCsKSDVDMFCREVSILCQLNHPCVI  522

         5899****************************99998999********************

S: 60    ellGvcleepn.lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhsea  118

         +++G+cl++p+ +++v++y++ggsL+++lhe +kr +dl+  + +a+++A+Gm+YLh+ +

Q: 523   QFVGACLNDPSqFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHNLT  581

         ***********99******************.99*************************6

S: 119   pkkiihrdLksknvLlseekktlkicdFGtarelsk..stkmsaa.gtlawmaPEvl.ke  174

         + +iihrdL+s+n+Ll  e+ ++ ++dFG++r+l++  +++m+++ g+l+wmaPEv+ ++

Q: 582   Q-PIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSldEDNMTKQpGNLRWMAPEVFtQC  639

         6.9*************.9*****************99877777777**************

S: 175   ekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmk  234

         ++++ k+Dv+Sy+++LWellt+e+P+++l+++a+a+++a++++r+pi+ s+p+++++L+

Q: 640   TRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLM  699

         ************************************************************

S: 235   ecwnedpekRpsfseivksl  254

         + wn++pe Rp+fse+v++l

Q: 700   RGWNACPEGRPEFSEVVTKL  719

         ****************9875

Domain Sequence
(FASTA)

IEFHEIIGSG SFGKVYKGRC RNKIVAIKRY RANTYCSKSD VDMFCREVSI LCQLNHPCVI 60

QFVGACLNDP SQFAIVTQYI SGGSLFSLLH EQKRILDLQS KLIIAVDVAK GMEYLHNLTQ 120

PIIHRDLNSH NILLYEDGHA VVADFGESRF LQSLDEDNMT KQPGNLRWMA PEVFTQCTRY 180

TIKADVFSYA LCLWELLTGE IPFAHLKPAA AAADMAYHHI RPPIGYSIPK PISSLLMRGW 240

NACPEGRPEF SEVVTKL 257

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 1.
PF12796	; Ank_2; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 6.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013