EKS-ORC-00301

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00301

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	333.4	1.1E-99	34	292	259

Status

Unreviewed

Ensembl Protein

ENSOCUP00000002644

UniProt Accession

G1SIX1;

Protein Name

Protein Synonyms/Alias

Gene Name

SLK

Gene Synonyms/Alias

SLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000003035	ENSOCUP00000002644	ENSOCUT00000003039
ENSOCUG00000003035	ENSOCUP00000017589	ENSOCUT00000030822

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1241

Protein Sequence
(FASTA)

MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVYK AQNKETNVLA 60

AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 120

LELERPLTES QIQVVCKQTL EALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN 180

TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP 240

MRVLLKIAKS EPPTLAQPSR WSSDFKDFLK KCLEKNVDAR WNTSQLLQHP FVTVDSNKPI 300

RELIAEAKAE VTEEVEDGKE DDDDEETENS LPIPASKRAS SDLSIASSEE DKLSQNACIL 360

ESVSEKTEHK ISEDKFSSKI VNENSTTTEP EKAMESVNEH VNAHLEALTD LHDRTAILKE 420

NGREEKRPKL ENLREAEDQE TVDINSVAEG KENNIMITLG TNTEYNPEEG KDHQDKQQIF 480

ESKLVKSEEI QDTTIQTVDL VSQETGEKEM DDQSVDKEIG LMKEDTQEKL AKDDNTQNSV 540

ISDISNVVGT TEAVDVAQKA AENSAEQAQS HGLEEVVEVG QKLINKLTEG SEAGGAEEIP 600

VKDTVEINEL DQKSKEGKNE EQLSKSSENT SETNEEPGTN ELEELTGSSS AEEIEVTSAA 660

TDADQKALGS ETQDAPIATT QIDTEKKEIP CEMPSKTEPQ VTTVASQPSE PVSVPIPSIN 720

INSEEAETKG EIGALPKPEG MLPPESENQK ENDTDSGTGS TADNSSIDLN LSISSFLSKT 780

KDSGSISLQE TRRQKKTLKK TRKFIVDGVE VSVTTSKIVT DSDSKTEELR FLRRQELREL 840

RFLQKEEQRA QQQLNGKLQQ QREQIFRRFE QEMMSKKRQY DQEIENLEKQ QKQTIERLEQ 900

EHTNRLRDEA KRIKGEQEKE LSKFQNILKN RKKEVINEVE KAPKELRKEL MKRRREELAQ 960

SQHAQEQEFV QKQQQELDGS LKKIIQQQKA ELANIERECL NNKQQLMRAR EAAIWELEER 1020

HLQEKHQLLK QQLKDQYFMQ RHQLLKRHEK ETEQMQRYNQ RLIEELKNRQ TQERARLPKI 1080

QRSEAKTRMA MFKKSLRINS TATPDQDRDK IKQFAAQEEK RQKNERMAQH QKHENQMRDL 1140

QLQCEANVRE LHQLQNEKCH LLVEHETQKL KELDEEHSQE LKEWREKLRP RKKTLEEEFA 1200

RKLQEQEVFF KMTGESECLN PSTQSRISKF YPIPSLHSTG S 1241

Nucleotide Sequence
(FASTA)

ATGTCCTTCT TCAATTTCCG TAAGATCTTC AAGTTGGGGA GCGAGAAGAA GAAGAAGCAG 60

TACGAGCACG TGAAGAGGGA CCTGAACCCC GAGGAGTTTT GGGAAATCAT AGGCGAGCTG 120

GGCGACGGAG CCTTCGGGAA AGTGTACAAG GCCCAGAATA AAGAGACTAA TGTTTTAGCT 180

GCTGCAAAGG TGATTGACAC CAAGTCTGAA GAAGAACTTG AAGATTATAT GGTTGAGATT 240

GATATACTAG CATCTTGTGA CCACCCAAAT ATAGTCAAAC TTCTGGATGC ATTCTATTAT 300

GAAAACAATC TTTGGATCCT CATTGAATTT TGTGCAGGTG GAGCAGTAGA TGCTGTGATG 360

CTTGAACTTG AGAGACCATT AACTGAGTCC CAAATACAAG TTGTTTGCAA ACAAACTTTG 420

GAGGCATTGA ACTACTTACA CGATAATAAA ATCATCCACA GAGATCTAAA AGCTGGCAAC 480

ATACTTTTTA CTTTAGATGG GGATATTAAA TTAGCGGATT TTGGAGTATC AGCTAAAAAC 540

ACAAGGACAA TTCAAAGAAG AGACTCTTTT ATTGGCACAC CATATTGGAT GGCTCCTGAA 600

GTAGTCATGT GTGAAACATC TAAGGACAGA CCCTATGACT ACAAAGCTGA TGTCTGGTCC 660

CTGGGCATCA CTTTAATAGA AATGGCTGAG ATAGAACCAC CTCATCATGA ATTAAATCCA 720

ATGAGAGTGC TGCTAAAAAT TGCAAAATCG GAGCCTCCTA CATTGGCACA GCCATCGAGA 780

TGGTCTTCAG ATTTTAAGGA CTTTCTTAAA AAATGCTTGG AAAAGAATGT GGATGCTAGG 840

TGGAATACAT CTCAGCTTCT ACAGCATCCA TTTGTTACTG TTGATTCCAA CAAACCCATC 900

CGAGAATTGA TTGCAGAGGC CAAGGCTGAA GTAACAGAAG AAGTTGAAGA TGGCAAAGAG 960

GATGATGATG ATGAGGAAAC AGAAAATTCT CTGCCAATAC CTGCAAGTAA GCGTGCCTCC 1020

TCTGACCTTA GTATTGCCAG CTCTGAAGAA GATAAACTTT CACAAAATGC TTGTATTTTG 1080

GAATCTGTCT CAGAGAAAAC AGAACACAAA ATTTCTGAAG ATAAATTCAG CAGCAAAATT 1140

GTTAATGAAA ACTCCACAAC CACTGAACCT GAAAAGGCTA TGGAGAGTGT TAATGAACAT 1200

GTTAATGCTC ATTTAGAAGC TCTCACTGAC CTCCATGATA GAACAGCGAT TCTCAAGGAG 1260

AATGGGAGAG AGGAGAAGAG ACCAAAACTT GAAAATTTAC GTGAGGCAGA AGACCAAGAA 1320

ACTGTGGATA TTAATTCAGT CGCTGAAGGA AAAGAGAATA ATATAATGAT AACTTTAGGA 1380

ACAAACACTG AATACAATCC TGAGGAAGGA AAGGATCATC AGGACAAGCA ACAGATATTT 1440

GAAAGTAAAC TTGTAAAATC TGAAGAAATT CAAGATACTA CTATTCAAAC AGTGGATTTA 1500

GTTTCTCAAG AAACTGGAGA AAAAGAGATG GATGATCAGT CAGTTGATAA GGAAATTGGG 1560

CTTATGAAGG AAGATACTCA GGAGAAATTG GCAAAAGATG ACAACACTCA AAACAGTGTA 1620

ATCAGTGACA TAAGCAATGT CGTAGGAACA ACTGAGGCAG TAGATGTTGC TCAGAAGGCA 1680

GCTGAAAACA GCGCTGAGCA AGCTCAGAGT CATGGTCTGG AAGAAGTGGT TGAAGTTGGT 1740

CAGAAATTAA TTAATAAGCT CACGGAGGGC TCTGAGGCTG GAGGTGCTGA GGAAATTCCT 1800

GTTAAAGATA CAGTTGAAAT TAATGAGCTA GATCAAAAAT CTAAAGAAGG CAAAAATGAG 1860

GAACAATTAA GCAAAAGTTC AGAAAACACA TCGGAGACCA ATGAGGAACC AGGAACAAAT 1920

GAATTAGAGG AACTTACTGG ATCAAGTAGT GCTGAAGAAA TAGAGGTCAC AAGTGCAGCG 1980

ACTGATGCCG ACCAAAAGGC TTTGGGAAGT GAAACTCAGG ATGCTCCCAT AGCCACTACT 2040

CAGATAGACA CAGAAAAAAA GGAAATCCCA TGTGAAATGC CAAGTAAAAC AGAACCTCAG 2100

GTTACTACTG TAGCTTCTCA ACCCAGTGAA CCTGTGTCTG TTCCAATACC CAGTATTAAC 2160

ATCAACTCTG AAGAAGCAGA AACTAAAGGA GAAATAGGTG CTTTACCAAA ACCTGAAGGC 2220

ATGCTGCCAC CAGAATCAGA GAATCAAAAG GAAAATGATA CTGATTCAGG CACTGGGTCC 2280

ACTGCTGATA ATAGCAGCAT TGACTTGAAT TTATCCATCT CTAGCTTCCT AAGTAAAACT 2340

AAAGACAGTG GATCAATATC TTTACAAGAA ACAAGAAGAC AAAAGAAAAC ATTGAAGAAA 2400

ACACGCAAAT TTATTGTTGA TGGTGTAGAA GTGAGTGTAA CAACGTCAAA GATAGTTACA 2460

GATAGTGATT CCAAAACTGA AGAATTGAGA TTTCTTAGAC GTCAGGAACT TCGGGAATTA 2520

AGATTTCTTC AAAAAGAAGA GCAAAGAGCC CAACAACAGC TTAATGGCAA ATTGCAGCAA 2580

CAACGGGAAC AAATTTTCCG GCGCTTTGAG CAAGAAATGA TGAGTAAAAA GCGACAGTAT 2640

GATCAGGAAA TAGAGAATCT AGAAAAACAG CAGAAACAGA CCATTGAACG TCTGGAACAA 2700

GAACATACAA ATCGCTTGCG AGATGAAGCC AAGCGCATTA AAGGAGAACA AGAGAAAGAG 2760

CTGTCCAAAT TTCAGAATAT ACTAAAGAAC CGAAAGAAGG AGGTTATAAA TGAAGTGGAG 2820

AAAGCACCCA AAGAGCTGAG GAAAGAGCTC ATGAAACGCA GGAGAGAGGA GCTTGCACAA 2880

AGCCAGCATG CTCAGGAACA AGAATTTGTT CAGAAGCAAC AACAAGAATT AGATGGCTCT 2940

TTGAAAAAGA TCATCCAACA ACAGAAGGCA GAGTTAGCCA ATATTGAAAG AGAGTGCCTG 3000

AATAACAAAC AACAACTCAT GAGAGCTCGA GAAGCTGCAA TTTGGGAGCT TGAAGAACGA 3060

CACTTACAAG AAAAACACCA GCTGCTCAAA CAGCAACTTA AAGATCAGTA TTTCATGCAA 3120

AGACATCAGC TACTTAAGCG ACATGAAAAG GAAACAGAAC AAATGCAGCG TTACAATCAA 3180

CGACTTATTG AGGAGCTGAA AAACCGACAG ACCCAAGAAA GAGCAAGACT GCCCAAGATT 3240

CAACGCAGTG AAGCCAAGAC TCGAATGGCC ATGTTTAAGA AAAGTTTGAG AATTAACTCA 3300

ACAGCCACAC CAGATCAGGA CCGGGACAAA ATTAAACAAT TTGCAGCCCA AGAAGAAAAG 3360

AGGCAGAAAA ATGAGAGAAT GGCTCAGCAT CAAAAACATG AAAATCAAAT GCGAGATCTT 3420

CAGCTGCAGT GTGAAGCCAA CGTGAGAGAA CTGCATCAGC TGCAGAATGA AAAATGCCAC 3480

CTGTTGGTTG AGCATGAGAC TCAGAAACTA AAAGAGCTAG ATGAAGAACA CAGCCAAGAA 3540

TTAAAGGAGT GGAGAGAGAA GTTGAGACCT AGGAAAAAGA CATTGGAAGA AGAGTTTGCC 3600

AGGAAACTCC AGGAACAGGA AGTGTTCTTT AAAATGACTG GAGAGTCTGA ATGCCTTAAC 3660

CCGTCAACAC AGAGCCGAAT TTCTAAATTC TATCCCATTC CTAGCTTGCA TTCCACTGGA 3720

TCGTAA 3726

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e++ e+g+Ga+gkvy+a++k+t+ l+a k+i+++++e+le+++ ei +l +++hpniv+

Q: 34    WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVK  93

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f++e++lw+++e++agG+++ ++  el+++l+E+qi+++++++l+aL+ylH++k+i

Q: 94    LLDAFYYENNLWILIEFCAGGAVDAVML-ELERPLTESQIQVVCKQTLEALNYLHDNKII  152

         **************************99.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+niL+t +g++kL+dfgv+a+ ++t ++r++++gtpywmAPEv+ +e   ++ Y

Q: 153   HRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCEtskDRPY  212

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaD+wslGIt+ie+ae epP+++l+p+++llki+k+epp+l +++++s+ fk+f++kc

Q: 213   DYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSDFKDFLKKC  272

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+kn+++R+++s+ll+h+F+

Q: 273   LEKNVDARWNTSQLLQHPFV  292

         *******************7

Domain Sequence
(FASTA)

WEIIGELGDG AFGKVYKAQN KETNVLAAAK VIDTKSEEEL EDYMVEIDIL ASCDHPNIVK 60

LLDAFYYENN LWILIEFCAG GAVDAVMLEL ERPLTESQIQ VVCKQTLEAL NYLHDNKIIH 120

RDLKAGNILF TLDGDIKLAD FGVSAKNTRT IQRRDSFIGT PYWMAPEVVM CETSKDRPYD 180

YKADVWSLGI TLIEMAEIEP PHHELNPMRV LLKIAKSEPP TLAQPSRWSS DFKDFLKKCL 240

EKNVDARWNT SQLLQHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001943	; UVR_dom.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50151	; UVR; 1.

Prints

Created Date

20-Feb-2013