EKS-ORC-00346
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00346
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src442.93.5E-133247497251
StatusUnreviewed
Ensembl ProteinENSOCUP00000002661
UniProt AccessionG1SIY6;
Protein Name
Protein Synonyms/Alias
Gene NameLYN
Gene Synonyms/Alias LYN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000003056ENSOCUP00000002661ENSOCUT00000003059
OrganismOryctolagus cuniculus
Functional Description
Protein Length512
Protein Sequence
(FASTA)
MGCIKSKRKD NLNDDGVDLK TQPVRNTDRT IYVRDPTSNK QPRPVPESQL LPGQRFQTKD 60
PEEQGDIVVA LYPYDGIHQD DLSFKKGEKM KVLEEHGEWW KAKSLSTKRE GFIPSNYVAK 120
VNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DYDPVHGDVI 180
KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQSDGLCR RLEKACISPK PQKPWDKDAW 240
EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 300
KLVRLYAVVT KEEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER 360
KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF 420
TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRMENCPD ELYDIMKMCW 480
KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP 512
Nucleotide Sequence
(FASTA)
ATGGGATGTA TAAAATCAAA AAGGAAAGAC AATCTGAATG ACGATGGAGT AGATTTGAAG 60
ACTCAACCAG TACGTAATAC TGACCGAACT ATTTATGTGA GAGATCCAAC GTCCAATAAA 120
CAGCCGAGGC CAGTTCCAGA ATCTCAGCTT TTACCAGGAC AGAGGTTTCA AACTAAAGAT 180
CCAGAGGAAC AAGGGGACAT TGTGGTGGCC TTGTACCCCT ATGATGGCAT CCACCAGGAC 240
GACTTGTCTT TCAAGAAAGG AGAGAAGATG AAAGTGCTGG AGGAGCATGG AGAGTGGTGG 300
AAAGCTAAAT CTCTTTCAAC AAAGAGGGAA GGCTTCATTC CCAGCAACTA CGTGGCCAAA 360
GTCAACACCT TGGAGACAGA AGAGTGGTTT TTCAAGGATA TAACCAGGAA GGATGCAGAA 420
CGGCAGCTCC TGGCACCAGG GAATAGCGCA GGAGCCTTTC TTATTAGAGA AAGTGAAACG 480
CTGAAAGGAA GCTTCTCCTT GTCTGTCAGA GACTATGACC CTGTGCATGG TGATGTGATC 540
AAGCACTACA AGATTAGAAG TCTGGACAAC GGGGGCTACT ACATTTCCCC ACGGATCACT 600
TTCCCCTGTA TTAGTGACAT GATCAAGCAT TACCAGAAGC AGTCAGATGG CTTGTGCAGA 660
AGATTGGAGA AGGCGTGCAT TAGTCCCAAA CCACAGAAGC CTTGGGATAA AGACGCCTGG 720
GAGATTCCCC GGGAATCAAT CAAGTTGGTG AAAAGGCTCG GCGCTGGACA GTTCGGGGAG 780
GTCTGGATGG GTTACTATAA CAATAGCACC AAGGTGGCTG TGAAGACCCT GAAACCAGGC 840
ACCATGTCTG TGCAAGCATT CCTTGAAGAA GCAAACCTCA TGAAGACCCT GCAGCATGAC 900
AAGCTTGTGA GACTCTATGC CGTGGTCACC AAGGAGGAGC CCATCTACAT CATCACTGAG 960
TACATGGCCA AGGGCAGTTT GCTGGATTTC CTGAAGAGCG ACGAGGGTGG CAAGGTGCTG 1020
CTTCCGAAGC TCATTGACTT CTCCGCCCAG ATTGCGGAGG GAATGGCGTA CATCGAGCGC 1080
AAGAACTACA TCCACCGGGA CCTACGAGCA GCCAACGTCC TGGTCTCTGA GTCTCTCATG 1140
TGCAAGATCG CAGACTTCGG CCTTGCTAGA GTCATTGAAG ATAACGAGTA TACGGCAAGG 1200
GAAGGTGCTA AGTTCCCTAT TAAATGGACA GCTCCGGAAG CAATCAACTT CGGATGCTTC 1260
ACAATTAAGT CTGATGTCTG GTCCTTCGGA ATTCTGCTGT ATGAAATCGT TACCTATGGG 1320
AAAATTCCCT ACCCAGGAAG AACTAACGCC GACGTGATGA CCGCCTTATC CCAGGGCTAC 1380
CGGATGCCCC GCATGGAGAA CTGCCCAGAT GAACTCTATG ACATCATGAA AATGTGCTGG 1440
AAAGAAAAGG CGGAGGAGAG GCCCACGTTT GACTACTTGC AGAGTGTGCT GGATGACTTC 1500
TACACCGCCA CAGAAGGGCA GTACCAGCAG CAGCCGTAG 1539
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         +klvk+lG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly
Q: 247   IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  306
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++eePiyi+te+makGslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+ihr
Q: 307   AVVTKEEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR  366
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+nvlv+esl++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 367   DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV  426
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+Gk+PypG tn++v++++++gyr+pr+e+cp+ely+++++cwk+++ee
Q: 427   WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRMENCPDELYDIMKMCWKEKAEE  486
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++lq+vl
Q: 487   RPTFDYLQSVL  497
         ********986
Domain Sequence
(FASTA)
IKLVKRLGAG QFGEVWMGYY NNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60
AVVTKEEPIY IITEYMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA YIERKNYIHR 120
DLRAANVLVS ESLMCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGCFTIKSDV 180
WSFGILLYEI VTYGKIPYPG RTNADVMTAL SQGYRMPRME NCPDELYDIM KMCWKEKAEE 240
RPTFDYLQSV L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00342
EKS-ANC-00358
EKS-BOT-00368
EKS-CAJ-00372
EKS-CAF-00369
EKS-CAP-00401
EKS-DAR-00748
EKS-EQC-00359
EKS-GAG-00312
EKS-GAA-00452
EKS-GOG-00359
EKS-HOS-00374
EKS-ICT-00348
EKS-LAC-00384
EKS-LOA-00377
EKS-MAM-00368
EKS-MOD-00359
EKS-MUM-00400
EKS-MUP-00362
EKS-MYL-00366
EKS-NOL-00336
EKS-ORN-00477
EKS-ORA-00322
EKS-ORL-00439
EKS-OTG-00372
EKS-PAT-00348
EKS-PES-00327
EKS-POA-00358
EKS-RAN-00382
EKS-SAH-00338
EKS-SUS-00327
EKS-TAG-00441
EKS-TAS-00040
EKS-TEN-00466
EKS-XET-00488
EKS-XIM-00465
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001782; P:B cell homeostasis
GO:0050853; P:B cell receptor signaling pathway
GO:0071300; P:cellular response to retinoic acid
GO:0097028; P:dendritic cell differentiation
GO:0030218; P:erythrocyte differentiation
GO:0002774; P:Fc receptor mediated inhibitory signaling pathway
GO:0002431; P:Fc receptor mediated stimulatory signaling pathway
GO:0035556; P:intracellular signal transduction
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0030889; P:negative regulation of B cell proliferation
GO:0070373; P:negative regulation of ERK1 and ERK2 cascade
GO:0043407; P:negative regulation of MAP kinase activity
GO:0070667; P:negative regulation of mast cell proliferation
GO:0002762; P:negative regulation of myeloid leukocyte differentiation
GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway
GO:0031175; P:neuron projection development
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0002576; P:platelet degranulation
GO:0030335; P:positive regulation of cell migration
GO:2000670; P:positive regulation of dendritic cell apoptotic process
GO:0070668; P:positive regulation of mast cell proliferation
GO:0010976; P:positive regulation of neuron projection development
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304; P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0002902; P:regulation of B cell apoptotic process
GO:0050855; P:regulation of B cell receptor signaling pathway
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0050707; P:regulation of cytokine secretion
GO:0045646; P:regulation of erythrocyte differentiation
GO:0050727; P:regulation of inflammatory response
GO:0043304; P:regulation of mast cell degranulation
GO:0090025; P:regulation of monocyte chemotaxis
GO:0090330; P:regulation of platelet aggregation
GO:0006974; P:response to DNA damage stimulus
GO:0009725; P:response to hormone stimulus
GO:0002513; P:tolerance induction to self antigen
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013