EKS-ORC-00285

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00285

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/Alpha	314.0	5.6E-94	1549	1769	221

Status

Unreviewed

Ensembl Protein

ENSOCUP00000002725

UniProt Accession

G1SJ36;

Protein Name

Protein Synonyms/Alias

Gene Name

TRPM7

Gene Synonyms/Alias

TRPM7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000003125	ENSOCUP00000002725	ENSOCUT00000003137

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1818

Protein Sequence
(FASTA)

RCFCGRLVKQ HACFTASLAM KYSDVKLVDH FNQATEEWSV EKHTEQSPTD AYGVINFQGG 60

SHSYRAKYVR LSYDTKPEII LQLLLKEWQM ELPKLVISVH GGMQKFELHP RIKQLLGKGL 120

IKAAVTTGAW ILTGGVNTGV AKHVGDALKE HASRSSRKIC TIGIAPWGVI ENRNDLVGRD 180

VVAPYQTLLN PLSKLNVLNN LHSHFILVDD GTVGKYGAEV KLRRELEKTI NQQRIHARIG 240

QGVPVVALVF EGGPNVILTV LEYLQESPPV PVVVCEGTGR AADLLAYIHK QTEEGGNLPD 300

AAEPDIISTI KKTFNFGQSE AVHLFQTLME CMKKKELITV FHIGSEEHQD IDVAILTALL 360

KGTNASAFDQ LILTLAWDRV DIAKNHVFVY GQQWLVGSLE QAMLDALVMD RVAFVKLLIE 420

NGVSMHKFLT IPRLEELYNT KQGPTNPMLF HLIRDVKQGN LPPGYKITLI DIGLVIEYLM 480

GGTYRCTYTR KRFRLIYNSL GGNNRRSGRN TSSSTPQLRK SHESFGNRAD KKEKMRHNHF 540

IKTAQPYRPK LETCKNPGQM PFTPDEMIHL LDAERRKYPT HDILIRGLTH EEPGPSRVLL 600

WQHGEESMAK ALVACKIYRS MAYEAKQSDL VDDTSEELKQ YSNDFGQLAV ELLEQSFRQD 660

ETMAMKLLTY ELKNWSNSTC LKLAVSSRLR PFVAHTCTQM LLSDMWMGRL NMRKNSWYKV 720

ILSILVPPAI LMLEYKTKAE MSHIPQSQDA HQMTMEDSEN NFQNITEEIP MEVFKEVKIL 780

GTNEGKNEMD IQIKSKKLPI TRKFYAFYHA PIVKFWFNTL AYLGFLMLYT FVVLVQMERL 840

PSVQEWIVIA YIFTYAIEKV REIFMSEAGK ISQKIKVWFS DYFNITDSIA IISFFIGFGL 900

RFGAKWNFEN AYDNHVFVAG RLIYCLNIIF WYVRLLDFLA VNQQAGPYVM MIGKMVANMF 960

YIVVIMALVL LSFGVPRKAI LYPYEAPSWT LAKDIVFHPY WMIFGEVYAY EIDEVCANDS 1020

VVKEICGPGT WLTPFLQAVY LFVQYIIMVN LLIAFFNNVY LQVKAISNIV WKYQRYHFIM 1080

AYHEKPVLPP PLIILSHIVS LFCCICKRRK KDKTSDGPKL FLTEEDQKKL HDFEEQCVEM 1140

YFNEKDDKFH SGSEERIRVT FERVEQMCIQ IKEVGDRVNY IKRSLQSLDS QIGHLQDLSA 1200

LTVDTLKTLT AQKASEASKV HNEITRELSI SKHLTQNLMD DGPVRPSLWK KHSVANTLSS 1260

SLPQGDIENN NPFLCNIFMK DEKDPQYNIF GQDLPIIPQK KEFNFPEAGS SCGALFPSAL 1320

SPPELRQRRH GIESSSSNST PHLSSPPTKF SISTPSQPSC KRHLESVTKD QETICSKAAE 1380

GDNTEFGAFV GHRDSMDLQR FKETSNKIKE LLSNDNPSEN TLKHVSSFAG FTECQKTFSS 1440

LHLEQVEINS RRPSAEDTHE VDSKAALLPD WLQDRPSKRE ILPSEEGTLN GLASPFKPVM 1500

DTNYYYSAVE RNNLMRLSQS IPFTPVPPRG EPVTVYRLEE SSPSILNNSM SSWSQLGLCA 1560

KIEFLSKEEM GGGLRRAVKV QCTWSEHDIL KSGHLYIIKS FLPEVVNTWS SIYKEDTVLH 1620

LCLREIQQQR AAQKLTFAFN QMKPKSIPYS PRFLEVFLLY CHSAGQWFAV EECMTGEFRK 1680

YNNNNGDEII PTNTLEEIML AFSHWTYEYT RGELLVLDLQ EKGVGENLTD PSVIKAEEKR 1740

SCDMVFGPAN LGEDAIKNFR AKHHCNSCCR KLKLPDLKRN DYTPDKIIFP QDEPSDFNLQ 1800

PENSTKESES TNSVRLML 1818

Nucleotide Sequence
(FASTA)

AGATGTTTTT GTGGTCGCCT GGTCAAGCAA CATGCTTGTT TTACTGCAAG TCTTGCCATG 60

AAATACTCAG ATGTGAAATT GGTTGACCAT TTTAATCAGG CAACAGAAGA ATGGTCTGTG 120

GAAAAGCATA CAGAACAGAG CCCAACGGAT GCTTATGGAG TCATAAATTT TCAAGGGGGT 180

TCTCATTCCT ACAGAGCTAA GTATGTGAGG CTATCATACG ACACAAAACC TGAAATCATT 240

CTACAACTTC TGCTTAAAGA ATGGCAAATG GAATTACCAA AACTGGTTAT CTCTGTACAT 300

GGAGGCATGC AGAAATTTGA GCTACATCCT CGAATCAAGC AGTTGCTTGG AAAAGGCCTT 360

ATTAAAGCTG CAGTTACAAC GGGAGCCTGG ATTTTAACTG GAGGAGTCAA CACAGGTGTG 420

GCAAAACATG TTGGTGATGC ACTTAAAGAA CATGCTTCCA GATCATCTCG AAAGATTTGC 480

ACTATTGGAA TAGCTCCATG GGGAGTGATT GAAAACAGAA ATGATCTTGT TGGGAGAGAT 540

GTCGTTGCTC CTTATCAAAC CTTACTGAAC CCCCTGAGCA AACTGAATGT TCTGAATAAT 600

CTCCATTCCC ATTTTATATT GGTGGATGAT GGCACTGTTG GAAAGTATGG GGCAGAAGTG 660

AAACTGAGAA GAGAACTTGA AAAAACTATT AATCAGCAAA GAATCCATGC TAGAATTGGC 720

CAAGGTGTCC CTGTAGTGGC ACTTGTATTT GAAGGTGGGC CTAATGTTAT CCTCACAGTT 780

CTAGAATACC TTCAAGAGAG TCCCCCTGTT CCAGTAGTTG TATGTGAAGG AACAGGCAGA 840

GCTGCAGATC TGCTAGCATA CATTCATAAG CAAACAGAAG AAGGAGGAAA TCTTCCTGAT 900

GCTGCAGAGC CTGATATTAT TTCAACCATC AAAAAAACAT TCAACTTTGG TCAGAGTGAA 960

GCAGTTCATT TATTTCAAAC ACTGATGGAG TGCATGAAAA AAAAGGAGCT TATCACTGTT 1020

TTCCACATTG GATCAGAGGA ACATCAAGAT ATAGATGTAG CAATACTTAC TGCATTGCTA 1080

AAAGGTACTA ATGCATCTGC ATTTGACCAG CTTATCCTTA CATTGGCATG GGATAGAGTT 1140

GACATTGCCA AAAATCATGT ATTTGTTTAT GGACAACAGT GGCTGGTTGG ATCCTTAGAA 1200

CAAGCTATGC TTGATGCTCT TGTAATGGAT AGAGTTGCAT TTGTAAAACT TCTTATAGAA 1260

AATGGAGTAA GCATGCATAA ATTCCTTACC ATTCCAAGAC TGGAAGAACT TTACAACACT 1320

AAACAAGGCC CAACTAATCC AATGCTGTTT CATCTTATTC GAGATGTGAA ACAGGGAAAT 1380

CTTCCTCCTG GATATAAAAT CACTCTAATT GATATAGGAC TCGTTATTGA ATATCTCATG 1440

GGGGGAACCT ACAGATGTAC CTATACTCGG AAACGTTTTC GATTAATATA CAATAGTCTT 1500

GGTGGAAATA ATCGGAGGTC TGGCCGAAAT ACTTCCAGTA GCACTCCTCA GTTGCGAAAG 1560

AGTCATGAAT CTTTTGGTAA TAGAGCTGAT AAAAAGGAAA AAATGAGACA TAATCATTTC 1620

ATTAAAACAG CACAGCCCTA CAGACCAAAA TTAGAAACTT GTAAAAATCC CGGGCAAATG 1680

CCATTTACTC CCGATGAAAT GATACATCTG TTGGATGCAG AAAGAAGAAA ATATCCAACT 1740

CATGATATAT TAATTAGAGG CTTGACTCAT GAAGAGCCTG GTCCAAGTCG CGTGCTCTTA 1800

TGGCAGCATG GTGAAGAATC AATGGCTAAA GCATTAGTTG CCTGTAAGAT CTATCGTTCA 1860

ATGGCATATG AAGCAAAGCA GAGCGACTTG GTAGATGATA CTTCAGAAGA ACTGAAACAG 1920

TATTCCAATG ATTTTGGTCA ACTGGCTGTT GAATTACTAG AACAGTCATT CAGACAAGAT 1980

GAAACAATGG CTATGAAATT GCTCACATAT GAACTGAAAA ACTGGAGTAA TTCAACCTGC 2040

CTTAAATTAG CAGTTTCATC AAGACTTAGA CCTTTTGTAG CCCACACCTG TACACAAATG 2100

TTATTATCCG ATATGTGGAT GGGAAGGCTT AATATGAGGA AAAATTCGTG GTACAAGGTC 2160

ATATTAAGTA TTTTAGTTCC ACCTGCGATA TTAATGCTAG AATATAAAAC TAAAGCTGAA 2220

ATGTCCCATA TCCCACAATC TCAAGATGCT CATCAGATGA CAATGGAAGA CAGTGAAAAC 2280

AACTTTCAAA ACATAACAGA AGAGATCCCC ATGGAAGTAT TTAAAGAAGT AAAGATTTTG 2340

GGTACTAATG AAGGAAAGAA TGAAATGGAT ATACAGATAA AATCCAAAAA GCTTCCAATC 2400

ACACGAAAGT TCTATGCCTT TTATCATGCA CCAATTGTAA AGTTCTGGTT TAACACGTTG 2460

GCATATTTAG GATTTCTGAT GCTGTATACA TTTGTAGTTC TTGTACAAAT GGAACGGTTA 2520

CCTTCAGTTC AAGAATGGAT TGTTATTGCC TATATTTTTA CCTATGCTAT TGAGAAAGTC 2580

CGTGAGATCT TCATGTCTGA AGCTGGAAAA ATAAGCCAGA AGATTAAAGT GTGGTTTAGT 2640

GATTATTTCA ATATCACTGA TTCAATTGCC ATAATTTCAT TCTTCATTGG ATTTGGACTA 2700

AGATTTGGAG CAAAATGGAA TTTTGAGAAT GCATATGATA ATCATGTTTT TGTGGCTGGA 2760

AGATTAATTT ACTGTCTTAA CATAATATTT TGGTATGTGC GTTTGCTAGA TTTTCTAGCT 2820

GTAAATCAAC AGGCAGGACC TTATGTAATG ATGATTGGAA AAATGGTGGC CAATATGTTC 2880

TACATTGTAG TGATTATGGC TCTTGTGTTA CTTAGTTTTG GTGTTCCCAG AAAGGCAATA 2940

CTTTATCCTT ATGAAGCACC ATCTTGGACT CTTGCTAAAG ATATAGTGTT TCATCCATAC 3000

TGGATGATTT TTGGTGAAGT TTATGCATAT GAAATTGATG AAGTGTGTGC AAATGATTCC 3060

GTTGTCAAGG AAATCTGTGG TCCTGGGACA TGGTTGACTC CATTTCTTCA AGCAGTCTAC 3120

CTCTTTGTAC AGTATATCAT TATGGTTAAT CTTCTTATTG CATTTTTCAA CAATGTGTAT 3180

TTACAAGTTA AAGCAATTTC CAATATTGTA TGGAAGTACC AGCGTTACCA TTTTATTATG 3240

GCTTATCATG AGAAACCAGT TCTGCCTCCT CCACTTATCA TTCTTAGCCA TATAGTTTCT 3300

CTGTTTTGCT GTATATGTAA AAGAAGAAAA AAAGATAAGA CTTCTGATGG ACCAAAACTT 3360

TTCCTAACAG AAGAAGATCA AAAGAAACTT CATGATTTTG AAGAACAGTG TGTTGAGATG 3420

TATTTTAATG AAAAAGATGA CAAATTCCAT TCTGGAAGTG AAGAGAGAAT TCGTGTCACT 3480

TTTGAAAGAG TGGAACAGAT GTGTATTCAG ATTAAAGAAG TTGGAGATCG AGTCAACTAC 3540

ATAAAAAGAT CTTTACAGTC ATTAGATTCT CAAATTGGAC ATTTACAAGA TCTTTCAGCC 3600

CTAACAGTAG ATACATTAAA GACACTCACT GCCCAGAAAG CTTCAGAAGC TAGCAAAGTT 3660

CATAATGAAA TAACACGAGA ATTGAGCATT TCCAAACATT TGACTCAAAA CCTTATGGAT 3720

GATGGTCCTG TAAGACCTTC TTTATGGAAA AAGCACAGTG TTGCTAATAC ACTTAGCTCC 3780

TCTCTTCCCC AAGGTGATAT TGAAAATAAT AATCCTTTTC TTTGTAATAT TTTTATGAAA 3840

GATGAAAAAG ATCCTCAGTA TAACATATTT GGTCAAGATT TACCTATAAT ACCCCAGAAA 3900

AAAGAATTCA ATTTTCCAGA GGCTGGTTCC TCTTGTGGTG CCTTATTCCC AAGTGCTCTT 3960

TCTCCTCCAG AACTACGACA GAGACGACAT GGCATAGAAA GCAGTTCATC TAATAGTACA 4020

CCACATCTAT CATCCCCACC AACCAAATTT TCTATTAGTA CACCATCCCA GCCAAGTTGC 4080

AAACGCCACT TGGAAAGTGT AACCAAAGAT CAAGAAACTA TTTGCTCTAA AGCTGCAGAA 4140

GGAGATAATA CAGAATTTGG TGCATTTGTA GGACACAGAG ATAGTATGGA TTTGCAGAGG 4200

TTTAAAGAAA CATCAAACAA GATAAAAGAA TTACTATCTA ATGATAATCC TTCTGAAAAT 4260

ACTTTGAAAC ATGTGAGTTC TTTTGCTGGA TTTACTGAGT GTCAGAAAAC TTTCAGTTCT 4320

CTTCATTTGG AACAAGTGGA AATCAATAGC CGAAGGCCAT CTGCAGAAGA TACTCATGAA 4380

GTAGATTCCA AAGCAGCTTT ACTACCGGAT TGGTTACAAG ATAGACCATC AAAAAGAGAA 4440

ATATTACCAT CTGAAGAAGG AACATTAAAT GGTCTTGCTT CTCCTTTTAA GCCAGTTATG 4500

GATACAAATT ATTATTACTC AGCTGTGGAA AGAAATAACT TGATGAGGTT ATCACAGAGC 4560

ATTCCATTCA CACCTGTACC TCCAAGAGGT GAACCTGTCA CAGTGTATCG TTTGGAAGAG 4620

AGTTCTCCCA GCATACTGAA TAACAGTATG TCTTCTTGGT CACAGCTAGG CCTTTGTGCC 4680

AAAATAGAGT TTTTAAGTAA AGAGGAAATG GGAGGAGGTT TACGAAGAGC TGTCAAAGTA 4740

CAGTGTACCT GGTCAGAACA TGATATCCTC AAATCAGGAC ATCTTTATAT TATCAAGTCT 4800

TTTCTTCCTG AGGTGGTTAA CACATGGTCA AGTATTTATA AAGAAGATAC GGTTCTTCAT 4860

CTCTGCCTCA GAGAAATTCA ACAACAGAGA GCTGCACAAA AGCTCACATT TGCCTTCAAT 4920

CAAATGAAAC CCAAATCTAT ACCATATTCT CCCAGATTTC TGGAAGTTTT CCTGCTGTAT 4980

TGCCATTCAG CTGGACAGTG GTTTGCTGTG GAAGAGTGTA TGACTGGAGA ATTTAGAAAA 5040

TACAACAACA ATAATGGTGA TGAGATTATT CCAACTAATA CACTGGAAGA GATCATGCTA 5100

GCCTTTAGCC ATTGGACTTA TGAATATACC AGAGGGGAGT TACTGGTACT TGATTTACAA 5160

GAAAAAGGTG TGGGTGAAAA TTTGACTGAC CCATCCGTGA TAAAAGCAGA AGAAAAAAGA 5220

TCCTGTGATA TGGTTTTTGG CCCAGCAAAT CTAGGAGAAG ATGCAATAAA AAACTTCAGA 5280

GCAAAACATC ACTGTAATTC TTGCTGTAGA AAGCTTAAAC TTCCAGATCT GAAGAGGAAT 5340

GACTATACAC CTGATAAAAT TATATTTCCT CAAGATGAGC CTTCAGATTT CAATCTTCAG 5400

CCTGAAAATT CCACCAAAGA ATCAGAATCA ACTAATTCTG TTCGTCTGAT GTTATAA 5457

Domain Profile

S: 1     ssesWsqqetivlikvlskeekkGalRkalrv..........kkgslflvkeelkevvry  50

         s++sWsq +++++i++lskee+ G+lR+a++v          k+g+l+++k++l+evv++

Q: 1549  SMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVqctwsehdilKSGHLYIIKSFLPEVVNT  1608

         699*********************************************************

S: 51    vakiykeqkvlhlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqll  110

         +++iyke++vlhl+lr++++qraaqkl+++fnq+kPk+i+y+pr++evfL +++s++q++

Q: 1609  WSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWF  1668

         ************************************************************

S: 111   tvEeyllGefvKynnnngdeikrenkleelmlafsHftyeytngellVvDlq..Gvgekl  168

         +vEe+++Gef+Kynnnngdei+++n+lee+mlafsH+tyeyt+gellV+Dlq  Gvge+l

Q: 1669  AVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQekGVGENL  1728

         ***************************************************9778*****

S: 169   TDpqiat....ksrgtkfgkanlgeraiknFfakhhCNeiC  205

         TDp++++    +s++++fg+anlge+aiknF+akhhCN++C

Q: 1729  TDPSVIKaeekRSCDMVFGPANLGEDAIKNFRAKHHCNSCC  1769

         *******99999*****************************

Domain Sequence
(FASTA)

SMSSWSQLGL CAKIEFLSKE EMGGGLRRAV KVQCTWSEHD ILKSGHLYII KSFLPEVVNT 60

WSSIYKEDTV LHLCLREIQQ QRAAQKLTFA FNQMKPKSIP YSPRFLEVFL LYCHSAGQWF 120

AVEECMTGEF RKYNNNNGDE IIPTNTLEEI MLAFSHWTYE YTRGELLVLD LQEKGVGENL 180

TDPSVIKAEE KRSCDMVFGP ANLGEDAIKN FRAKHHCNSC C 221

Keyword

Complete proteome; Ion transport; Ionic channel; Membrane; Reference proteome; Transmembrane; Transport.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0001726	; C:ruffle
GO:0005524	; F:ATP binding
GO:0005262	; F:calcium channel activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0031032	; P:actomyosin structure organization
GO:0016340	; P:calcium-dependent cell-matrix adhesion
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR005821	; Ion_trans_dom.
IPR011009	; Kinase-like_dom.
IPR004166	; MHCK_EF2_kinase.

Pfam

PF02816	; Alpha_kinase; 1.
PF00520	; Ion_trans; 1.

SMARTs

SM00811

; Alpha_kinase; 1.

Prosites

PS51158

; ALPHA_KINASE; 1.

Prints

Created Date

20-Feb-2013