EKS-ORC-00188

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00188

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	519.4	2.0E-156	4	287	284

Status

Unreviewed

Ensembl Protein

ENSOCUP00000002825

UniProt Accession

G1SJC0;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase-like 2;

Gene Name

CDKL2

Gene Synonyms/Alias

CDKL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000003254	ENSOCUP00000002825	ENSOCUT00000003254

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

569

Protein Sequence
(FASTA)

MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 60

ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDD QVVQKYLFQI INGIGFCHSH 120

NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 180

KAVDVWAIGC LVTEMLMGEP LFPGDSDIDQ LYLIMRCLGN LIPRHQELFY KNPVFAGVRL 240

PEIKESEPLE RRYPKLSEVV IDLAKKCLHV DPDKRPFCAE LLHHDFFQMD GFAERFSQEL 300

QMKVQKDARN ISLSKKSQNR KKEKEKDDSL GEERKTLVVQ DTNADSKFKD SKVFKIKGSK 360

IDGEKVDKGN RASNASCLHD SGTSHIKAVP STSLRDCSNV SVDHTRNPGM AIPRLTHNLS 420

AVAPGINSGM GTIPGVQSYR VDEKTKKYCI PFVKPNKHSP SGIYNMNVTT SVSSEKNLLQ 480

ANKKRGEYSK TDVRLPELNY NHLPELRALE GIARNSRLIR KENKILSESR IPSLAAIDLH 540

TPNIAVHQVS GSPLSDGSEA DSPWMEHQH 569

Nucleotide Sequence
(FASTA)

ATGGAAAAAT ATGAGAACCT TGGATTGGTT GGAGAAGGGA GTTATGGAAT GGTGATGAAG 60

TGTAGGAATA AAGATAGTGG AAGAATTGTG GCCATCAAGA AGTTCCTAGA AAGTGATGAT 120

GACAAAATGG TTAAAAAAAT TGCTATGCGA GAAATCAAGT TACTAAAGCA ACTGAGGCAT 180

GAAAATTTGG TGAATCTGTT GGAGGTGTGT AAGAAAAAAA AACGATGGTA CCTAGTCTTT 240

GAATTTGTTG ACCACACGAT TCTTGATGAC TTGGAACTCT TTCCAAATGG ACTAGATGAC 300

CAAGTAGTTC AAAAGTATTT GTTTCAGATT ATTAATGGAA TTGGATTTTG TCACAGTCAC 360

AATATCATAC ATAGAGATAT AAAGCCAGAG AATATATTGG TCTCCCAGTC TGGCGTTGTC 420

AAGTTATGTG ATTTTGGATT TGCACGGACA CTGGCAGCTC CCGGAGAGGT TTACACTGAT 480

TATGTGGCAA CTCGATGGTA CAGAGCTCCA GAACTACTGG TTGGTGATGT CAAGTATGGC 540

AAAGCTGTGG ATGTGTGGGC CATTGGTTGT CTGGTAACTG AAATGCTCAT GGGGGAACCC 600

CTGTTTCCTG GAGACTCTGA TATTGATCAG CTTTATCTTA TTATGAGGTG TTTAGGTAAT 660

CTAATTCCAA GACACCAGGA GCTTTTTTAT AAAAATCCTG TGTTTGCTGG AGTAAGGTTG 720

CCTGAAATCA AGGAATCAGA ACCTCTTGAA AGACGCTATC CCAAGCTCTC AGAAGTTGTG 780

ATAGATTTAG CAAAGAAATG CTTACATGTT GACCCAGACA AAAGGCCCTT CTGTGCTGAG 840

CTCCTACACC ATGATTTCTT TCAGATGGAT GGATTTGCTG AGCGGTTTTC TCAGGAACTA 900

CAGATGAAAG TACAGAAAGA TGCCAGAAAT ATATCTTTAT CTAAAAAATC CCAGAACAGA 960

AAGAAGGAAA AGGAAAAGGA TGATTCCTTA GGCGAAGAAA GAAAAACACT AGTGGTACAG 1020

GATACCAATG CTGACTCCAA ATTTAAGGAT TCTAAAGTAT TTAAAATAAA AGGATCAAAA 1080

ATTGATGGAG AAAAAGTTGA CAAAGGCAAT AGAGCCTCAA ATGCCAGCTG TCTCCATGAC 1140

AGTGGGACAA GCCACATCAA AGCAGTGCCT TCCACAAGCC TCAGAGACTG CAGCAATGTC 1200

AGTGTGGATC ACACAAGGAA TCCAGGCATG GCCATTCCCC GCCTTACGCA CAATCTTTCT 1260

GCAGTTGCTC CTGGAATTAA TTCTGGAATG GGGACTATCC CAGGAGTTCA GAGTTACAGA 1320

GTGGATGAGA AGACTAAGAA GTATTGTATT CCATTTGTTA AGCCAAATAA ACATTCTCCA 1380

TCAGGCATTT ATAATATGAA TGTGACCACA TCAGTCTCCA GTGAAAAGAA CCTCCTTCAG 1440

GCAAACAAGA AAAGAGGGGA GTACTCCAAG ACAGATGTCC GTTTGCCTGA ACTAAACTAT 1500

AATCATCTCC CTGAACTAAG AGCCTTGGAA GGCATTGCTC GAAATTCTAG GCTCATAAGA 1560

AAGGAGAACA AAATTCTTTC AGAATCTCGA ATTCCTTCTC TGGCTGCCAT TGACCTGCAC 1620

ACACCCAACA TTGCAGTACA TCAGGTGTCA GGATCTCCCC TGTCAGATGG TTCAGAGGCC 1680

GATTCGCCTT GGATGGAGCA CCAGCACTGA 1710

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lg vGeGsyG+v+kcrnkd+g+ivaikkfles+ddk+vkkia+reikllkql+henl

Q: 4     YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllev+++kk++ylvfe+vd+t+ld+le +pnG+++++v+k+l+qi+++i fch++nii

Q: 64    VNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDDQVVQKYLFQIINGIGFCHSHNII  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sgvvklcdfGfar+laapg+vytdyvatrwyrapellvgd+kyGk+v

Q: 124   HRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGcl++e+l+Geplfpg+sd+dqly+i+++lG+liprhq++f+kn+vfaGv+lpe+

Q: 184   DVWAIGCLVTEMLMGEPLFPGDSDIDQLYLIMRCLGNLIPRHQELFYKNPVFAGVRLPEI  243

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         ++ e+le++ypkl+ev++dl+kkcl++dp++r +c+ell+h++f

Q: 244   KESEPLERRYPKLSEVVIDLAKKCLHVDPDKRPFCAELLHHDFF  287

         ******************************************98

Domain Sequence
(FASTA)

YENLGLVGEG SYGMVMKCRN KDSGRIVAIK KFLESDDDKM VKKIAMREIK LLKQLRHENL 60

VNLLEVCKKK KRWYLVFEFV DHTILDDLEL FPNGLDDQVV QKYLFQIING IGFCHSHNII 120

HRDIKPENIL VSQSGVVKLC DFGFARTLAA PGEVYTDYVA TRWYRAPELL VGDVKYGKAV 180

DVWAIGCLVT EMLMGEPLFP GDSDIDQLYL IMRCLGNLIP RHQELFYKNP VFAGVRLPEI 240

KESEPLERRY PKLSEVVIDL AKKCLHVDPD KRPFCAELLH HDFF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013