EKS-ORC-00140
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00140
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR526.41.5E-158465741277
StatusUnreviewed
Ensembl ProteinENSOCUP00000002937
UniProt AccessionG1SJL4;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000003380ENSOCUP00000002937ENSOCUT00000003386
ENSOCUG00000003380ENSOCUP00000019548ENSOCUT00000021133
OrganismOryctolagus cuniculus
Functional Description
Protein Length799
Protein Sequence
(FASTA)
MWVLLALLGV LLGAPGAPAL SLEASEEVEL EPCPAPSLEQ PEQELTVALG QPVRLCCRRA 60
ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL CLARGSMTVL HNLTLAVDGK 120
RGWRGRLRSR GGGHSVRPPP PPPAPYWTHP QRMEKKLHAV PAGNTIKFRC PAAGNPMPTI 180
RWLKDGQAFH GENRIGGIRL RHQHWSLVME SVVPSDRGTY TCLVENPLGS IRYSYLLDVL 240
ERSPHRPILQ AGLPANTTAV AGSDVELLCK VYSDAQPHIQ WLKHIVINGS SFGADGFPYV 300
QVLKTADINS SEVEVLYLRN VSAEDAGEYT CLAGNSIGLS YQSAWLTVLP EEDPTWTAAS 360
PEARYTDIIL YASGSLALAV LLLLAGLYRG QVLHGRRARQ PATVQKLSRF PLARQFSLES 420
GSSGKSSSSL VRGVRLSSSG PPLLAGLVSL DLPLDPLWEF PRDRLVLGKP LGEGCFGQVV 480
RAEAFGMDPA RPDQASTVAV KMLKDNASDK DLADLVSEME VMKLIGQHKN IINLLGVCTQ 540
EGPLYVIVEC AAKGNLREFL RARRPPGPDL SPEGPRSSEG PLSFPALVSC AYQVARGMQY 600
LESQKCIHRD LAARNVLVTE DNVMKIADFG LARGVHHIDY YKKTSNGRLP VKWMAPEALF 660
DRVYTHQSDV WSFGILLWEI FTLGGSPYPG IPVEELFSLL REGHRMDRPP HCPPELYGLM 720
RECWHAAPSQ RPTFKQLVEA LDKVLLAVSE EYLDLRLTFG PYSPSGGDTS STCSSNDSVF 780
SHDPLPLGPS PFPFPGVQT 799
Nucleotide Sequence
(FASTA)
ATGTGGGTGC TACTGGCCCT GCTGGGGGTC CTGCTGGGGG CACCTGGGGC TCCAGCCTTG 60
TCCCTTGAGG CTTCTGAGGA AGTGGAGCTG GAACCCTGCC CAGCCCCCAG CCTGGAACAG 120
CCCGAGCAGG AACTGACCGT GGCCCTTGGG CAGCCCGTGC GGCTGTGCTG CAGGCGGGCT 180
GAGCGGGGCG GCCACTGGTA CAAGGAGGGC AGTCGCTTAG CACCTGCCGG CCGGGTGCGG 240
GGCTGGAGGG GCCGCCTGGA GATTGCCAGC TTCCTGCCCG AGGATGCCGG CCGCTACCTC 300
TGCCTGGCTC GAGGCTCCAT GACGGTCCTG CACAATCTCA CCTTGGCTGT GGATGGTAAG 360
AGGGGCTGGC GGGGGCGGCT GAGGTCCAGG GGTGGGGGGC ACTCAGTACG CCCACCTCCT 420
CCCCCCCCAG CTCCATACTG GACACACCCC CAGCGCATGG AGAAGAAACT GCATGCAGTG 480
CCTGCCGGGA ACACCATCAA GTTCCGCTGC CCAGCCGCAG GCAACCCCAT GCCCACCATC 540
CGCTGGCTCA AGGACGGACA GGCCTTCCAT GGGGAGAACC GCATTGGAGG GATTCGGCTG 600
CGCCACCAAC ACTGGAGCCT GGTGATGGAA AGCGTGGTGC CCTCGGACCG GGGCACGTAC 660
ACCTGCCTGG TGGAGAACCC TCTGGGCAGC ATCCGCTACA GCTACCTGCT GGATGTGCTG 720
GAGCGCTCCC CGCACCGGCC CATCCTGCAG GCGGGGCTGC CGGCCAACAC CACGGCTGTG 780
GCGGGCAGTG ACGTGGAGCT GCTGTGCAAG GTGTACAGTG ATGCCCAGCC CCACATCCAG 840
TGGCTGAAAC ACATCGTCAT CAACGGCAGC AGCTTTGGCG CCGACGGCTT CCCCTATGTG 900
CAAGTGCTGA AGACCGCAGA CATCAACAGC TCCGAAGTGG AAGTCCTGTA CCTGCGAAAC 960
GTTTCGGCCG AGGACGCGGG CGAGTACACC TGCCTGGCCG GCAACTCCAT CGGCCTCTCC 1020
TACCAGTCGG CCTGGCTCAC CGTGCTGCCA GAGGAGGACC CCACATGGAC AGCAGCCTCA 1080
CCCGAGGCCA GGTACACAGA CATCATCCTG TATGCCTCTG GCTCTCTGGC TCTGGCTGTG 1140
CTCCTGCTGC TGGCCGGGTT ATACCGAGGG CAGGTGCTCC ACGGCCGGCG TGCTCGGCAG 1200
CCCGCCACGG TGCAGAAGTT GTCCCGCTTC CCTCTGGCCC GACAGTTCTC TCTGGAGTCG 1260
GGCTCCTCAG GCAAGTCGAG TTCGTCCCTG GTGCGAGGCG TCCGGCTCTC CTCCAGCGGC 1320
CCCCCCTTGC TCGCTGGCCT CGTGAGTCTA GACCTCCCTC TGGACCCGCT GTGGGAGTTC 1380
CCCCGGGACA GGTTGGTGCT TGGGAAGCCG CTGGGAGAGG GCTGCTTCGG GCAGGTGGTG 1440
CGTGCAGAGG CCTTCGGCAT GGACCCTGCC CGCCCTGACC AAGCTAGCAC CGTGGCCGTC 1500
AAGATGCTCA AGGACAACGC CTCAGACAAG GACCTGGCCG ACCTGGTGTC TGAGATGGAG 1560
GTGATGAAGC TGATAGGCCA GCACAAGAAC ATCATCAACC TGCTAGGCGT CTGCACCCAG 1620
GAAGGGCCCC TGTACGTGAT TGTGGAATGT GCGGCCAAGG GAAACTTGCG GGAGTTCCTG 1680
CGGGCCCGGC GGCCCCCGGG CCCCGACCTC AGCCCCGAAG GACCGAGGAG CAGTGAGGGG 1740
CCACTGTCCT TCCCGGCCCT GGTCTCCTGT GCCTACCAGG TGGCGCGCGG CATGCAGTAC 1800
CTGGAGTCGC AGAAGTGCAT CCACCGGGAC CTGGCTGCCC GCAACGTGCT GGTGACCGAG 1860
GACAACGTGA TGAAAATCGC CGACTTCGGG CTGGCCCGAG GCGTCCACCA CATTGACTAC 1920
TACAAGAAAA CCAGCAATGG CCGCCTGCCT GTCAAGTGGA TGGCCCCCGA GGCCTTGTTT 1980
GACCGAGTGT ACACACACCA GAGTGATGTG TGGTCATTTG GGATCCTGCT CTGGGAGATC 2040
TTCACACTTG GGGGCTCCCC GTACCCCGGC ATCCCCGTGG AGGAACTGTT CTCACTGCTG 2100
CGGGAGGGCC ATCGGATGGA CCGGCCCCCA CACTGCCCCC CAGAGCTGTA CGGGCTGATG 2160
CGCGAGTGCT GGCACGCGGC GCCTTCCCAG AGACCCACCT TCAAGCAGCT GGTAGAAGCG 2220
CTGGACAAGG TGCTGCTGGC GGTCTCTGAG GAGTACCTCG ACCTCCGCCT GACCTTTGGA 2280
CCCTACTCCC CCTCCGGAGG AGACACCAGC AGCACCTGTT CCTCCAATGA CTCTGTCTTC 2340
AGTCACGACC CCTTACCATT GGGGCCCAGC CCCTTCCCCT TCCCTGGGGT ACAGACG 2397
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv+aea+g+d  ++++++tvavkmlk++a+dkdladlvsemev+kl
Q: 465   LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL  524
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s + +++se  l++
Q: 525   IGQHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPEGPRSSEGPLSF  584
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt
Q: 585   PALVSCAYQVARGMQYLESQKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKT  644
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh
Q: 645   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  704
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++p +c+ ely lmrecwha++s+rptfkqlve+l
Q: 705   RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL  741
         **********************************986
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVRAEA FGMDPARPDQ ASTVAVKMLK DNASDKDLAD LVSEMEVMKL 60
IGQHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPEG PRSSEGPLSF 120
PALVSCAYQV ARGMQYLESQ KCIHRDLAAR NVLVTEDNVM KIADFGLARG VHHIDYYKKT 180
SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240
RMDRPPHCPP ELYGLMRECW HAAPSQRPTF KQLVEAL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00141
EKS-ANC-00141
EKS-BOT-00149
EKS-CAF-00157
EKS-CAP-00150
EKS-EQC-00148
EKS-FEC-00139
EKS-ICT-00143
EKS-LOA-00148
EKS-MOD-00149
EKS-MUM-00154
EKS-MUP-00154
EKS-MYL-00158
EKS-PAT-00140
EKS-RAN-00148
EKS-SAH-00144
EKS-SUS-00130
EKS-TAG-00178
EKS-XET-00138
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005783; C:endoplasmic reticulum
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0061144; P:alveolar secondary septum development
GO:0016477; P:cell migration
GO:0042593; P:glucose homeostasis
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0055062; P:phosphate ion homeostasis
GO:0008284; P:positive regulation of cell proliferation
GO:2000573; P:positive regulation of DNA biosynthetic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048554; P:positive regulation of metalloenzyme activity
GO:0045862; P:positive regulation of proteolysis
GO:0046777; P:protein autophosphorylation
GO:0070857; P:regulation of bile acid biosynthetic process
GO:2000188; P:regulation of cholesterol homeostasis
GO:0010715; P:regulation of extracellular matrix disassembly
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013