EPS-ORC-00022

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORC-00022

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	237.5	2.4E-70	94	344	251

Status

Unreviewed

Ensembl Protein

ENSOCUP00000002993

UniProt Accession

G1SJR3;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1K

Gene Synonyms/Alias

PPM1K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000003452	ENSOCUP00000002993	ENSOCUT00000003450

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

372

Protein Sequence
(FASTA)

MSTAALITLV RSGGNQVRRR ALLTSRLLQD ERRLPATCHS STSEPRCSRF DPDGSGRPAT 60

WDSFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCASH IGKRKENEDR FDFAQLTDEV 120

LYFAVYDGHG GPAAANFCHT RMEKCILDLL PKEKNLETVL TLAFLEIDKA FASHAHLSAD 180

ASILTSGTTA TVALLRDGIE LVVASVGDSR AILCRKGKPM KLTIDHTPER KDEKERIKKC 240

GGFVAWNSLG QPHVNGRLAM TRSIGDLDLK ASGVIAEPET KRIKLHHADD SFLVLTTDGI 300

NFMVNSQEIC DFVNQCHDPN EAAHAVTEQA IQYGTEDNST AVVVPFGAWG KYKNSEINFS 360

FSRSFASSGR WA 372

Nucleotide Sequence
(FASTA)

ATGTCAACAG CTGCCTTAAT CACTTTGGTT AGAAGTGGCG GGAACCAGGT GAGAAGGAGA 60

GCGCTGCTGA CCTCCCGCCT GCTGCAGGAC GAGCGCCGCC TGCCGGCCAC CTGCCACAGC 120

TCCACCTCAG AGCCCAGGTG TTCTCGATTC GACCCCGACG GCAGTGGGCG TCCGGCCACC 180

TGGGACAGTT TCGGGATCTG GGACAACCGC ATTGACGAGC CAATTCTACT GCCCCCCAGC 240

ATTAAGTATG GCAAGCCGAT CCCCAAAATC AGCCTGGAAA ACGTGGGCTG CGCCTCGCAC 300

ATTGGCAAAC GGAAAGAGAA TGAAGATCGA TTCGACTTCG CCCAGCTGAC AGATGAGGTC 360

CTGTACTTCG CTGTGTATGA TGGGCACGGC GGACCCGCAG CCGCTAATTT CTGCCACACC 420

CGCATGGAGA AATGTATTCT GGATTTGCTT CCTAAGGAGA AGAACTTGGA AACTGTGTTG 480

ACCTTGGCTT TTCTAGAAAT AGATAAAGCC TTTGCGAGTC ATGCCCACCT GTCTGCTGAT 540

GCAAGCATTC TGACCTCTGG GACTACTGCA ACAGTAGCCC TACTGCGAGA TGGTATTGAA 600

CTGGTGGTAG CCAGTGTTGG GGACAGCCGA GCTATTTTGT GTAGAAAAGG AAAACCCATG 660

AAGCTGACCA TTGATCATAC TCCAGAAAGA AAAGATGAAA AAGAAAGGAT CAAGAAATGT 720

GGTGGTTTTG TAGCTTGGAA CAGCTTGGGA CAGCCTCACG TAAACGGCCG ACTGGCCATG 780

ACGAGGAGCA TTGGAGATTT AGATCTCAAA GCCAGCGGAG TGATAGCCGA GCCAGAAACA 840

AAGAGGATCA AGCTGCACCA TGCTGATGAC AGCTTCCTGG TCCTCACCAC AGACGGAATC 900

AACTTCATGG TGAATAGTCA AGAGATCTGT GACTTTGTCA ATCAGTGCCA TGATCCCAAC 960

GAAGCTGCCC ATGCAGTGAC TGAACAGGCG ATCCAGTATG GCACTGAGGA TAACAGTACG 1020

GCCGTCGTAG TGCCTTTTGG CGCCTGGGGA AAATATAAGA ACTCTGAAAT CAACTTCTCC 1080

TTCAGCAGAA GCTTTGCCTC CAGCGGGCGA TGGGCCTGA 1119

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         +vg++s  g+r+e ed++    +f++ +++   + +f+vyDGhgg  +a+fc++++++++

Q: 94    NVGCASHIGKRKENEDRF----DFAQLTDE---VLYFAVYDGHGGPAAANFCHTRMEKCI  146

         58999*************....57887665...78*************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidk....sGstavvalikds.k  116

            l     +e++++++l+ aFl++d+++   ++++l+ d+    sG+ta+val++d  +

Q: 147   LDLLP----KEKNLETVLTLAFLEIDKAF--ASHAHLSADAsiltSGTTATVALLRDGiE  200

         ***77....********************..55555555555677*************9*

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLav  174

         l+va vGdSra+Lcr+gk+++l+ dH+p+r+dE+eRi++ gg v+ ++ g+ +v+G La+

Q: 201   LVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSlGQpHVNGRLAM  260

         ********************************************98889999********

S: 175   sRalGdlylk.pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekk  232

         +R++Gdl+lk + v++ePe+  ++l++ d+ fl+L +DG+  +v+++e++++v+++++

Q: 261   TRSIGDLDLKaSGVIAEPETKRIKLHHADDsFLVLTTDGINFMVNSQEICDFVNQCHD--  318

         **********556************999999***************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           ++eaa+ ++++a+++g++dn +a+vv

Q: 319   --PNEAAHAVTEQAIQYGTEDNSTAVVV  344

         ..***********************997

Domain Sequence
(FASTA)

NVGCASHIGK RKENEDRFDF AQLTDEVLYF AVYDGHGGPA AANFCHTRME KCILDLLPKE 60

KNLETVLTLA FLEIDKAFAS HAHLSADASI LTSGTTATVA LLRDGIELVV ASVGDSRAIL 120

CRKGKPMKLT IDHTPERKDE KERIKKCGGF VAWNSLGQPH VNGRLAMTRS IGDLDLKASG 180

VIAEPETKRI KLHHADDSFL VLTTDGINFM VNSQEICDFV NQCHDPNEAA HAVTEQAIQY 240

GTEDNSTAVV V 251

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013