EKS-ORC-00349
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00349
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src435.27.8E-131246495250
StatusUnreviewed
Ensembl ProteinENSOCUP00000003181
UniProt AccessionG1SK64;
Protein Name
Protein Synonyms/Alias
Gene NameLCK
Gene Synonyms/Alias LCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000003668ENSOCUP00000003181ENSOCUT00000003670
OrganismOryctolagus cuniculus
Functional Description
Protein Length510
Protein Sequence
(FASTA)
MGCSCSSNPE DDWMENIDVC ENCHYPIVPL EGKATLPIRN GSEVRDPLVT YEGSNPPASP 60
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQNGEWWKA QSLTTGQEGF IPFNFVAKAN 120
SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLDSGKSEST AGSFSLSVRD FDQNQGEVVK 180
HYKIRNLDNG GFYISPRITF PGLHELVRHY TSAPDGLCTR LSRPCQTQKP QKPWWEDEWE 240
VPRETLKLVE RLGAGQFGEV WMGYYNGHTK VAVKSLKQGS MSPDAFLAEA NLMKQLQHQR 300
LVRLYAVVTQ EPIYIITEYM ENGSLVDFLK TPTGIKLTIN KLLDMAAQIA EGMAFIEERN 360
YIHRDLRAAN ILVSDTLSCK IADFGLARLI EDNEYTAREG AKFPIKWTAP EAINYGTFTI 420
KSDVWSFGIL LTEIVTHGRI PYPGMTNPEV IQNLERGYRM VRPENCPEEL YHLMKLCWKE 480
RPEDRPTFDY LRSVLEDFFT ATEGQYQPQP 510
Nucleotide Sequence
(FASTA)
ATGGGCTGTA GCTGCAGCTC AAACCCTGAA GATGACTGGA TGGAAAACAT CGACGTGTGT 60
GAGAACTGCC ACTACCCCAT AGTCCCACTG GAAGGCAAGG CCACGCTGCC CATCCGGAAC 120
GGCTCTGAGG TTCGGGACCC ACTGGTCACC TATGAAGGCT CAAACCCTCC GGCATCCCCA 180
CTGCAAGACA ACCTGGTTAT CGCCCTGCAC AGCTATGAGC CCTCTCACGA CGGAGACCTG 240
GGCTTCGAGA AGGGAGAACA GCTCCGTATC CTGGAGCAGA ACGGGGAGTG GTGGAAGGCG 300
CAGTCCCTGA CCACAGGCCA GGAAGGCTTC ATCCCCTTCA ACTTCGTGGC CAAAGCGAAC 360
AGCCTGGAGC CCGAACCCTG GTTCTTCAAG AACCTAAGCC GCAAGGACGC AGAGCGGCAG 420
CTCCTGGCGC CCGGGAACAC GCACGGCTCC TTTCTTGATT CCGGGAAGAG CGAGAGCACC 480
GCGGGATCAT TTTCACTGTC GGTGCGGGAT TTCGACCAGA ACCAGGGAGA GGTGGTGAAA 540
CATTACAAGA TCCGTAACCT GGACAACGGC GGCTTCTACA TCTCCCCTCG CATCACTTTT 600
CCAGGCCTGC ACGAGCTGGT CCGCCATTAC ACCAGTGCTC CGGACGGGCT GTGCACGCGG 660
CTGAGCCGCC CCTGCCAGAC CCAGAAGCCC CAGAAGCCTT GGTGGGAGGA CGAATGGGAG 720
GTTCCCAGGG AGACGCTGAA GCTGGTGGAG CGGCTCGGGG CCGGACAGTT CGGGGAGGTG 780
TGGATGGGCT ATTACAACGG GCACACAAAG GTGGCGGTGA AGAGCCTGAA GCAGGGCAGC 840
ATGTCCCCCG ACGCCTTCCT GGCCGAGGCC AACCTCATGA AGCAGCTGCA GCACCAGCGG 900
CTGGTCCGGC TCTACGCGGT GGTCACCCAG GAGCCCATCT ACATCATCAC GGAATACATG 960
GAAAACGGGA GCTTAGTGGA TTTTCTCAAG ACCCCTACAG GCATCAAATT GACCATCAAC 1020
AAACTCTTGG ACATGGCAGC CCAAATTGCA GAGGGCATGG CATTCATTGA AGAGCGGAAT 1080
TATATCCACC GGGACCTGCG GGCTGCCAAC ATCCTGGTTT CTGACACCCT GAGCTGCAAG 1140
ATTGCAGACT TTGGCCTAGC GCGCCTCATT GAGGACAATG AATACACAGC CAGGGAAGGA 1200
GCCAAGTTTC CTATTAAGTG GACAGCACCA GAAGCCATTA ACTATGGGAC ATTCACCATC 1260
AAGTCAGATG TGTGGTCCTT TGGGATCCTG CTGACGGAGA TCGTCACTCA TGGCCGCATC 1320
CCTTACCCAG GGATGACTAA TCCTGAAGTG ATCCAGAACC TGGAGCGGGG CTACCGCATG 1380
GTGCGCCCTG AGAACTGCCC AGAGGAGCTG TACCACCTCA TGAAGCTGTG CTGGAAAGAG 1440
CGCCCAGAGG ACCGGCCCAC CTTTGACTAC CTGCGCAGCG TGCTGGAGGA CTTCTTCACG 1500
GCCACAGAGG GCCAGTACCA GCCCCAGCCT TGA 1533
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv++lG+GqfGevw+g+++g++kvavk+lk+g++sp+afl+ea+++k+l+h++lv+ly
Q: 246   LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY  305
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+m++Gsl+dflk+ +g kl+++kl+d+aaq+aeGma++ee+n+ihr
Q: 306   AVVTQ-EPIYIITEYMENGSLVDFLKTPTGIKLTINKLLDMAAQIAEGMAFIEERNYIHR  364
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+++l +k+adfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 365   DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  424
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillteivt+G++PypGmtn ev++++ergyr+ rpe+cpeely+l++ cwk++pe+
Q: 425   WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPENCPEELYHLMKLCWKERPED  484
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++l++vl
Q: 485   RPTFDYLRSVL  495
         *******9876
Domain Sequence
(FASTA)
LKLVERLGAG QFGEVWMGYY NGHTKVAVKS LKQGSMSPDA FLAEANLMKQ LQHQRLVRLY 60
AVVTQEPIYI ITEYMENGSL VDFLKTPTGI KLTINKLLDM AAQIAEGMAF IEERNYIHRD 120
LRAANILVSD TLSCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180
SFGILLTEIV THGRIPYPGM TNPEVIQNLE RGYRMVRPEN CPEELYHLMK LCWKERPEDR 240
PTFDYLRSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00347
EKS-BOT-00370
EKS-CAJ-00376
EKS-CAF-00371
EKS-CAP-00402
EKS-DAR-00750
EKS-DIO-00065
EKS-EQC-00361
EKS-ERE-00004
EKS-FEC-00358
EKS-GAA-00453
EKS-GOG-00391
EKS-HOS-00376
EKS-ICT-00351
EKS-LAC-00385
EKS-LOA-00383
EKS-MEG-00303
EKS-MIM-00060
EKS-MOD-00357
EKS-MUM-00403
EKS-MUP-00365
EKS-MYL-00368
EKS-OCP-00080
EKS-ORN-00480
EKS-ORL-00441
EKS-OTG-00374
EKS-PAT-00349
EKS-PES-00333
EKS-POA-00359
EKS-RAN-00384
EKS-SAH-00340
EKS-SOA-00006
EKS-SUS-00324
EKS-TAR-00475
EKS-TUT-00115
EKS-XET-00485
EKS-XIM-00468
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045588; P:positive regulation of gamma-delta T cell differentiation
GO:0010628; P:positive regulation of gene expression
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0050856; P:regulation of T cell receptor signaling pathway
GO:0051209; P:release of sequestered calcium ion into cytosol
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013