EKS-ORC-00253
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00253
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK453.74.2E-136247575329
StatusUnreviewed
Ensembl ProteinENSOCUP00000003281
UniProt AccessionG1SKE4;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK1
Gene Synonyms/Alias HIPK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000003785ENSOCUP00000003281ENSOCUT00000003786
OrganismOryctolagus cuniculus
Functional Description
Protein Length1267
Protein Sequence
(FASTA)
NHRGACLPGG CVGSPFPELD PRWLPTEAHP LPLPPILCRR PISLTLVVSF FLFFNVGMAS 60
QLQVFSPPSV SSSAFCSAKK LKIEPSGWDV SGQSSNDKYY THSKTLPATQ GQANSSHQVA 120
NFNIPAYDQG LLLPAPAVEH IVVTAADSSA SAATSTFQSS QTLTHRGNVT LLEPYQKCGL 180
KRKSEEVDSN GSVQIIEEHP PLMLQNRTVV GAAATTTTVT TKSSSSSGEG DYQLVQHEIL 240
CSMTNSYEVL EFLGRGTFGQ VAKCWKRSTK EIVAIKILKN HPSYARQGQI EVSILSRLSS 300
ENADEYNFVR SYECFQHKNH TCLVFEMLEQ NLYDFLKQNK FSPLPLKYIR PILQQVATAL 360
MKLKSLGLIH ADLKPENIML VDPVRQPYRV KVIDFGSASH VSKAVCSTYL QSRYYRAPEI 420
ILGLPFCEAI DMWSLGCVIA ELFLGWPLYP GASEYDQIRY ISQTQGLPAE YLLSAGTKTT 480
RFFNRDPNLG YPLWRLKTPE EHELETGIKS KEARKYIFNC LDDMAQVNMS TDLEGTDMLA 540
EKADRREYID LLKKMLTIDA DKRITPLKTL NHQFVTMTHL LDFPHSNHVK SCFQNMEICK 600
RRVHMYDTVS QIKSPFTTHV APNTSTNLTM SFSNQLNTVH NQASVLASSS TAAAATLSLA 660
NSDVSLLNYQ SALYPSSAAP VPGVAQQGVS LQPGTTQICT QTDPFQQTFI VCPPAFQTGL 720
QATTKHSGFP VRMDNAVPIV PQAPAAQPLQ IQSGVLTQGS CTPLMVATLH PQVATITPQY 780
AVPFTLSCAA GRPALVEQTA AVLQAWPGGT QQILLPSTWQ QLPGVALHNS VQPTAVIPEA 840
LGSGQQLADW RNAHSHGNQY STIMQQPSLL TNHVTLATAQ PLNVGVAHVV RQQQSSSLPS 900
KKNKQTAPVS SKSSLEVLPS QVYSLVGSSP LRTTSSYNSL VPVQDQHQPI IIPDTPSPPV 960
SVITIRSDTD EEEDNKYKPN SSGLKPRSNV ISYVTVNDSP DSDSSLSSPY STDTLSALRG 1020
NSGSLLEGPG KVVADGTGTR TIIVPPLKTQ LGDCTVATQA SGLLSSKTKR VASVSGQSSG 1080
CCITPTGYRA QRGGTGAAQP LNLSQNQQSS SAPTSQERSS NPAPRRQQAF VAPLSQAPYA 1140
FQHGSPLHST GHPHLAPAPA HLPSQPHLYT YAAPTSAAAL GSTSSIAHLF SPQGSSRHAA 1200
AYTTHPSTLV HQVPVSVGPS LLTSASVAPA QYQHQFATQS YIGSSRGSTI YTGYPLSPTK 1260
ISQYSYL 1267
Nucleotide Sequence
(FASTA)
AATCACCGCG GAGCCTGCCT TCCGGGGGGG TGTGTGGGGA GTCCATTCCC CGAACTCGAT 60
CCACGCTGGC TCCCCACGGA GGCCCACCCA CTCCCACTGC CACCGATACT ATGCCGCCGT 120
CCTATATCTC TTACCCTTGT GGTTTCATTT TTCCTTTTTT TCAATGTAGG TATGGCATCA 180
CAGCTGCAGG TGTTTTCCCC CCCATCAGTG TCGTCGAGTG CCTTCTGCAG TGCGAAGAAA 240
TTGAAAATAG AGCCCTCTGG CTGGGATGTT TCAGGACAGA GCAGCAACGA CAAATATTAT 300
ACCCACAGCA AAACCCTCCC AGCCACACAA GGACAAGCCA ACTCCTCTCA CCAGGTAGCA 360
AATTTCAACA TCCCTGCTTA CGACCAAGGT CTCCTGCTCC CAGCCCCTGC AGTGGAGCAT 420
ATTGTTGTAA CAGCTGCTGA TAGCTCAGCT AGTGCTGCTA CGTCAACCTT CCAAAGCAGC 480
CAGACCCTGA CTCACAGAGG CAACGTTACT TTGCTTGAGC CATATCAAAA ATGTGGATTG 540
AAAAGAAAAA GTGAGGAAGT TGACAGCAAC GGTAGCGTGC AGATCATAGA AGAACATCCC 600
CCTCTCATGC TGCAAAACAG GACTGTGGTG GGTGCTGCTG CCACGACCAC CACTGTGACC 660
ACAAAGAGTA GCAGTTCCAG CGGAGAAGGG GATTACCAAC TGGTCCAGCA TGAGATCCTT 720
TGCTCTATGA CCAACAGCTA TGAAGTCTTG GAGTTCCTAG GCCGGGGGAC ATTTGGACAG 780
GTAGCTAAAT GCTGGAAGCG GAGCACGAAG GAAATTGTGG CTATTAAAAT CTTGAAGAAT 840
CATCCCTCCT ATGCCAGACA AGGACAGATT GAAGTGAGCA TTCTTTCCCG CCTAAGCAGT 900
GAAAATGCTG ATGAGTATAA TTTTGTCCGT TCTTATGAGT GCTTTCAACA TAAGAATCAC 960
ACCTGCCTTG TTTTTGAGAT GTTGGAGCAG AACTTATATG ATTTTCTAAA GCAGAACAAG 1020
TTTAGCCCAC TGCCACTCAA GTACATCAGA CCAATCTTGC AGCAGGTGGC CACAGCCTTG 1080
ATGAAGCTCA AGAGCCTTGG TTTGATTCAC GCTGACCTTA AGCCTGAAAA CATAATGCTG 1140
GTTGATCCAG TTCGCCAACC CTACCGAGTG AAGGTCATTG ACTTTGGTTC TGCCAGTCAC 1200
GTTTCCAAAG CTGTGTGCTC AACCTACTTA CAGTCACGTT ACTACAGGGC CCCTGAAATT 1260
ATTCTCGGAT TACCATTTTG TGAAGCTATT GACATGTGGT CACTGGGCTG TGTGATAGCT 1320
GAGCTATTCC TGGGATGGCC ACTGTATCCT GGTGCTTCAG AATATGATCA GATTCGTTAC 1380
ATTTCACAAA CACAAGGCCT ACCAGCTGAA TATCTTCTCA GCGCTGGGAC AAAAACAACT 1440
AGGTTCTTCA ACAGGGATCC TAATTTGGGC TACCCACTGT GGAGACTTAA GACACCTGAA 1500
GAACATGAGT TGGAGACTGG AATAAAATCA AAAGAAGCTC GGAAGTACAT TTTCAACTGT 1560
TTAGATGACA TGGCTCAGGT GAATATGTCT ACAGACTTAG AGGGAACAGA CATGTTGGCA 1620
GAGAAGGCGG ATCGAAGAGA ATACATTGAT CTTTTAAAAA AAATGTTAAC AATTGATGCA 1680
GATAAGAGAA TTACTCCTCT GAAAACTCTG AACCATCAGT TTGTAACAAT GACCCACCTT 1740
CTGGATTTTC CGCATAGCAA TCATGTTAAA TCTTGTTTTC AGAACATGGA GATCTGCAAG 1800
CGGAGGGTTC ACATGTATGA TACAGTGAGT CAGATCAAGA GTCCTTTCAC TACACATGTT 1860
GCCCCAAATA CAAGCACAAA TCTAACAATG AGCTTCAGCA ACCAGCTCAA TACAGTGCAT 1920
AATCAGGCCA GTGTTCTAGC TTCCAGTTCT ACTGCAGCAG CTGCCACTCT TTCTCTGGCT 1980
AATTCAGATG TGTCTCTGCT AAACTACCAG TCAGCTTTGT ACCCTTCGTC TGCAGCACCA 2040
GTTCCTGGAG TTGCCCAGCA GGGTGTTTCC TTGCAACCTG GAACCACCCA GATTTGCACT 2100
CAGACAGATC CATTCCAACA GACGTTTATC GTATGTCCAC CTGCTTTCCA AACTGGACTG 2160
CAAGCAACAA CAAAGCATTC TGGATTCCCT GTGAGGATGG ATAATGCCGT GCCAATTGTA 2220
CCCCAGGCCC CAGCTGCTCA GCCACTACAG ATTCAGTCAG GAGTTCTTAC ACAGGGAAGC 2280
TGTACACCAC TAATGGTAGC AACTCTCCAC CCTCAAGTAG CCACCATCAC ACCGCAGTAT 2340
GCGGTGCCCT TTACTCTGAG CTGCGCAGCC GGCCGGCCGG CGCTGGTTGA ACAGACTGCC 2400
GCTGTACTGC AGGCTTGGCC TGGAGGAACT CAACAAATTC TCCTGCCTTC AACGTGGCAA 2460
CAGTTGCCTG GGGTAGCTCT ACACAACTCT GTCCAACCCA CAGCAGTGAT TCCAGAGGCC 2520
TTGGGGAGTG GCCAGCAGCT GGCAGACTGG AGGAATGCCC ACTCTCATGG CAACCAGTAT 2580
AGCACCATCA TGCAGCAGCC ATCCTTGCTG ACTAACCATG TGACACTGGC CACTGCTCAG 2640
CCCCTAAATG TTGGTGTTGC CCATGTTGTC AGACAGCAGC AGTCTAGTTC TCTCCCTTCA 2700
AAGAAGAATA AGCAGACTGC TCCAGTCTCT TCCAAATCCT CTCTGGAAGT CCTGCCTTCC 2760
CAAGTCTATT CTCTGGTTGG GAGCAGTCCT CTCCGCACCA CTTCTTCTTA TAATTCCCTA 2820
GTCCCTGTCC AAGATCAGCA TCAGCCAATC ATCATTCCAG ATACTCCCAG CCCTCCTGTG 2880
AGTGTCATCA CCATCCGAAG TGACACTGAT GAGGAAGAGG ACAACAAATA CAAGCCCAAT 2940
AGCTCTGGCC TGAAGCCAAG GTCTAATGTC ATCAGTTATG TTACTGTCAA TGATTCTCCA 3000
GACTCCGACT CTTCCTTGAG CAGCCCATAT TCCACTGACA CCTTGAGTGC TCTCCGGGGC 3060
AACAGTGGAT CTCTTCTGGA GGGGCCAGGC AAAGTTGTGG CAGATGGCAC AGGCACCCGC 3120
ACCATAATTG TGCCTCCGCT GAAAACTCAG CTTGGTGACT GCACAGTAGC AACCCAAGCC 3180
TCAGGTCTCC TGAGCAGTAA GACCAAGCGT GTGGCCTCAG TGAGTGGGCA GTCATCTGGA 3240
TGCTGTATTA CCCCTACAGG GTACCGAGCT CAACGTGGGG GTACTGGCGC AGCCCAGCCA 3300
CTCAACCTTA GCCAGAACCA GCAGTCATCT TCAGCTCCAA CCTCTCAGGA GAGAAGCAGC 3360
AACCCTGCCC CCCGCAGGCA GCAGGCGTTT GTGGCCCCGC TCTCCCAAGC CCCCTACGCC 3420
TTTCAGCATG GCAGTCCACT ACACTCGACG GGGCACCCAC ACCTGGCCCC AGCCCCTGCT 3480
CACCTGCCAA GCCAGCCTCA CCTGTACACG TATGCTGCCC CCACCTCTGC TGCTGCATTG 3540
GGCTCCACCA GCTCCATTGC TCATCTGTTC TCTCCCCAGG GTTCCTCAAG GCATGCTGCA 3600
GCCTATACCA CCCACCCAAG CACTCTTGTG CACCAAGTCC CTGTCAGTGT TGGTCCCAGC 3660
CTCCTCACTT CTGCCAGTGT GGCCCCTGCA CAGTACCAAC ACCAGTTTGC TACCCAGTCC 3720
TATATTGGGT CCTCTCGAGG CTCAACAATT TACACTGGAT ACCCGCTGAG TCCTACCAAG 3780
ATCAGCCAGT ATTCATACTT G 3801
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevle++g+G+fgqV+k+++++tkeivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 247   YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENADE  305
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr +e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+
Q: 306   YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS  365
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 366   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  425
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff  
Q: 426   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFnr  485
         **********************************************************66
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
           + ++p ++lkt          ks++++k+++n+ +++++++++++ e +++l+ek+d+
Q: 486   dPNLGYPLWRLKTPeeheletgiKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADR  545
         556778889998889********************************************9
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + ++dllk+ml++d++kRitp ++l+h+fv
Q: 546   ReYIDLLKKMLTIDADKRITPLKTLNHQFV  575
         99***************************7
Domain Sequence
(FASTA)
YEVLEFLGRG TFGQVAKCWK RSTKEIVAIK ILKNHPSYAR QGQIEVSILS RLSSENADEY 60
NFVRSYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPILQQV ATALMKLKSL 120
GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTTRFFNRD 240
PNLGYPLWRL KTPEEHELET GIKSKEARKY IFNCLDDMAQ VNMSTDLEGT DMLAEKADRR 300
EYIDLLKKML TIDADKRITP LKTLNHQFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00250
EKS-ANC-00257
EKS-BOT-00268
EKS-CAE-00238
EKS-CAJ-00274
EKS-CAF-00275
EKS-CAP-00303
EKS-ECT-00028
EKS-EQC-00260
EKS-FEC-00254
EKS-GAG-00225
EKS-GOG-00268
EKS-HOS-00274
EKS-LAC-00279
EKS-LOA-00278
EKS-MAM-00270
EKS-MEG-00213
EKS-MOD-00265
EKS-MUP-00265
EKS-MYL-00270
EKS-NOL-00245
EKS-ORL-00328
EKS-OTG-00274
EKS-PAT-00253
EKS-PES-00238
EKS-POA-00259
EKS-PTV-00035
EKS-RAN-00283
EKS-SAH-00252
EKS-SUS-00239
EKS-TAG-00284
EKS-TUT-00033
EKS-VIP-00011
EKS-XET-00343
EKS-XIM-00339
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016607; C:nuclear speck
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0009952; P:anterior/posterior pattern specification
GO:0048596; P:embryonic camera-type eye morphogenesis
GO:0060059; P:embryonic retina morphogenesis in camera-type eye
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0061072; P:iris morphogenesis
GO:0060235; P:lens induction in camera-type eye
GO:0030182; P:neuron differentiation
GO:0008284; P:positive regulation of cell proliferation
GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0010842; P:retina layer formation
GO:0007224; P:smoothened signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013