EKS-ORC-00006
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00006
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph513.58.8E-155619878260
StatusUnreviewed
Ensembl ProteinENSOCUP00000003307
UniProt AccessionG1SKG7;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB1
Gene Synonyms/Alias EPHB1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000003812ENSOCUP00000021953ENSOCUT00000029271
ENSOCUG00000003812ENSOCUP00000020000ENSOCUT00000022854
ENSOCUG00000003812ENSOCUP00000003307ENSOCUT00000003814
OrganismOryctolagus cuniculus
Functional Description
Protein Length984
Protein Sequence
(FASTA)
MALDCLLLFL LASAVAAMEE TLMDTRTATA ELGWTANPAS GWEEVSGYDE NLNTIRTYQV 60
CNVFEPNQNN WLLTTFIDRR GAHRIYAEMR FTVRDCSSLP NVPGSCKETF NLYYYETDSV 120
IATKKSAFWS EAPYLKVDTI AADESFSQVD FGGRLMKVNT EVRSFGPLTR NGFYLAFQDY 180
GACMSLLSVR VFFKKCPSIV QNFAVFPETM TGAESTSLVI ARGTCIPNAE EVDVPIKLYC 240
NGDGEWMVPI GRCTCKAGYE PENSVACKAC PAGTFKANQE AEGCSHCPSN SRSPSEASPI 300
CTCRTGYYRA DFDPPEVACT SVPSGPRNVI SIVNETSIIL EWHPPRETGG RDDVTYNIIC 360
KKCRADRRSC SRCDDNVEFV PRQLGLTECR VSISSLWAHT PYTFDIQAIN GVSSKSPFPP 420
QHVSVNITTN QAAPSTVPIM HQVSATMRSI TLSWPQPEQP NGIILDYEIR YYEKEHNEFN 480
SSMARSQTNT ARIDGLRPGM VYVVQVRART VAGYGKFSGK MCFQTLTDED YKSELREQLP 540
LIAGSAAAGV VFVVSLVAIS IVCSRKRAYS KEAVYSDKLQ HYSTGRGSPG MKIYIDPFTY 600
EDPNEAVREF AKEIDVSFVK IEEVIGAGEF GEVYKGRLKL PGKREIYVAI KTLKAGYSEK 660
QRRDFLSEAS IMGQFDHPNI IRLEGVVTKS RPVMIITEFM ENGALDSFLR QNDGQFTVIQ 720
LVGMLRGIAA GMKYLAEMNY VHRDLAARNI LVNSNLVCKV SDFGLSRYLQ DDTSDPTYTS 780
SLGGKIPVRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSF GERPYWDMSN QDVINAIEQD 840
YRLPPPMDCP AALHQLMLDC WQKDRNSRPR FAEIVNTLDK MIRNPASLKT LATITAVPSQ 900
PLLDRSIPDF TAFTTVDDWL SAIKMVQYRD SFLTAGFTSL QLVTQMTSED LLRIGVTLAG 960
HQKKILNSIH SMRVQMSQSP TAMA 984
Nucleotide Sequence
(FASTA)
ATGGCCTTGG ATTGCCTGCT GCTGTTCCTC CTGGCATCCG CAGTGGCCGC GATGGAAGAG 60
ACACTCATGG ACACCAGGAC AGCTACTGCA GAGCTGGGCT GGACAGCCAA TCCCGCCTCG 120
GGGTGGGAAG AAGTCAGTGG CTACGATGAG AACCTGAACA CCATCCGCAC GTACCAGGTG 180
TGCAACGTCT TCGAGCCCAA CCAGAACAAC TGGCTGCTCA CCACGTTCAT CGACCGGCGC 240
GGGGCCCACC GCATCTACGC CGAGATGCGC TTCACCGTGA GAGACTGCAG CAGCCTCCCC 300
AACGTCCCCG GCTCCTGCAA GGAGACCTTC AACTTGTACT ACTACGAGAC CGACTCGGTC 360
ATCGCCACCA AGAAGTCGGC CTTCTGGTCC GAAGCCCCCT ACCTCAAGGT GGACACCATC 420
GCTGCGGACG AGAGCTTCTC CCAGGTAGAC TTCGGGGGAA GGCTGATGAA AGTCAACACA 480
GAAGTCAGGA GCTTCGGGCC GCTCACGCGG AACGGCTTTT ACCTCGCCTT CCAGGATTAC 540
GGGGCCTGCA TGTCTCTCCT TTCGGTCCGG GTCTTCTTCA AAAAGTGCCC CAGCATCGTG 600
CAAAATTTCG CAGTGTTCCC AGAGACCATG ACGGGGGCGG AGAGCACATC CCTGGTGATT 660
GCCCGGGGCA CGTGCATCCC CAATGCAGAG GAAGTGGACG TGCCCATCAA ACTCTACTGC 720
AACGGCGACG GGGAGTGGAT GGTGCCCATC GGGCGCTGCA CCTGCAAGGC TGGCTATGAG 780
CCGGAGAACA GCGTGGCCTG CAAGGCCTGC CCTGCAGGGA CGTTCAAGGC CAACCAGGAA 840
GCTGAGGGCT GCTCCCACTG CCCCTCCAAC AGCCGCTCCC CTTCGGAGGC GTCTCCCATC 900
TGCACCTGCC GGACTGGCTA TTACAGAGCA GATTTTGACC CCCCGGAAGT GGCGTGCACT 960
AGCGTCCCAT CGGGGCCCCG CAATGTCATC TCCATTGTCA ACGAGACGTC CATCATTCTG 1020
GAGTGGCACC CTCCGAGGGA GACAGGGGGA CGGGACGACG TGACCTACAA CATCATCTGT 1080
AAAAAATGCC GGGCAGACCG CCGGAGCTGC TCACGCTGCG ACGACAACGT GGAGTTTGTC 1140
CCCAGGCAGC TGGGCCTGAC CGAGTGCCGA GTCTCCATCA GCAGCCTGTG GGCCCACACC 1200
CCCTACACCT TTGATATCCA GGCCATCAAT GGGGTCTCCA GCAAGAGTCC CTTCCCCCCG 1260
CAACACGTCT CTGTCAATAT CACGACAAAC CAAGCTGCCC CCTCCACTGT TCCCATCATG 1320
CACCAGGTCA GTGCCACCAT GAGAAGCATC ACCCTGTCGT GGCCACAGCC GGAACAGCCC 1380
AATGGCATCA TCCTGGACTA TGAGATCCGG TACTATGAGA AGGAACACAA CGAGTTCAAC 1440
TCCTCCATGG CGAGGAGCCA GACAAACACG GCGCGGATCG ACGGGCTGCG GCCGGGCATG 1500
GTGTACGTGG TACAGGTGCG CGCCCGCACC GTGGCTGGCT ATGGGAAGTT CAGTGGCAAG 1560
ATGTGCTTCC AGACTCTGAC AGACGAGGAC TACAAGTCGG AGCTGAGGGA GCAGCTGCCC 1620
CTCATTGCAG GCTCGGCAGC GGCCGGGGTC GTGTTCGTCG TGTCCTTGGT GGCCATCTCC 1680
ATAGTCTGCA GCCGGAAACG GGCGTACAGC AAAGAGGCGG TTTACAGCGA TAAACTCCAG 1740
CATTACAGCA CAGGCCGAGG CTCCCCAGGG ATGAAGATCT ACATTGATCC CTTCACTTAT 1800
GAGGACCCCA ATGAAGCCGT CCGGGAGTTT GCCAAGGAGA TTGATGTGTC TTTTGTGAAA 1860
ATCGAAGAGG TCATCGGAGC AGGTGAGTTT GGAGAGGTGT ACAAGGGACG TTTGAAACTG 1920
CCCGGCAAGA GGGAAATCTA CGTGGCCATC AAAACCCTGA AGGCCGGGTA CTCGGAGAAG 1980
CAGCGGCGGG ACTTTCTGAG CGAGGCCAGC ATCATGGGCC AGTTCGACCA CCCCAACATC 2040
ATCCGCCTGG AGGGCGTGGT CACCAAGAGC CGGCCGGTCA TGATCATCAC GGAGTTCATG 2100
GAGAACGGTG CTCTAGATTC CTTCCTCAGG CAGAATGACG GGCAGTTCAC GGTGATCCAG 2160
CTGGTGGGGA TGCTCAGAGG CATTGCTGCG GGCATGAAGT ACCTGGCCGA GATGAACTAC 2220
GTGCACCGGG ACCTGGCTGC GAGGAACATC TTGGTCAACA GCAACCTGGT GTGCAAGGTG 2280
TCTGACTTTG GCCTGTCCCG CTACCTCCAG GATGACACCT CAGACCCCAC CTACACCAGC 2340
TCCCTGGGAG GGAAGATTCC TGTGAGATGG ACGGCTCCTG AGGCCATTGC CTACCGCAAG 2400
TTCACTTCGG CCAGCGACGT CTGGAGCTAC GGGATTGTCA TGTGGGAAGT CATGTCCTTT 2460
GGAGAGAGAC CCTACTGGGA TATGTCCAAC CAAGATGTCA TCAATGCTAT CGAACAGGAC 2520
TACCGGCTGC CCCCTCCCAT GGACTGCCCC GCAGCCCTAC ACCAGCTCAT GCTGGACTGT 2580
TGGCAGAAGG ACCGGAACAG TCGGCCCCGC TTTGCGGAGA TTGTCAACAC CCTAGACAAG 2640
ATGATCCGGA ACCCGGCAAG TCTCAAGACT CTGGCAACCA TCACCGCCGT GCCTTCCCAG 2700
CCCCTACTCG ACCGCTCCAT CCCAGACTTC ACGGCCTTCA CCACCGTGGA CGACTGGCTC 2760
AGTGCCATCA AAATGGTCCA GTACAGGGAC AGCTTCCTCA CCGCCGGCTT CACTTCCCTC 2820
CAGCTGGTTA CCCAGATGAC GTCAGAAGAC CTTCTGAGAA TAGGGGTCAC CCTGGCAGGC 2880
CACCAGAAGA AGATCCTGAA CAGCATTCAT TCGATGCGGG TCCAGATGAG TCAGTCACCG 2940
ACGGCGATGG CC 2952
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGev++Grlklpgkrei+vaiktlkag++ekqrrdflseasi+Gqfdhp
Q: 619   VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHP  678
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtks+pvmi+te+mengaldsflr++dgqftviqlvgmlrGia+gmkyl++m
Q: 679   NIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEM  738
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr l+dd+ +++yt+s ggkip+rwtapeaiay
Q: 739   NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTsDPTYTSSlGGKIPVRWTAPEAIAY  798
         *******************************99999*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlpppmdcpaal+qlml
Q: 799   RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLML  858
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f++iv++l
Q: 859   DCWQKDRNSRPRFAEIVNTL  878
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVYKGRL KLPGKREIYV AIKTLKAGYS EKQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT KSRPVMIITE FMENGALDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLAEM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRY LQDDTSDPTY TSSLGGKIPV RWTAPEAIAY 180
RKFTSASDVW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPMD CPAALHQLML 240
DCWQKDRNSR PRFAEIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00006
EKS-BOT-00012
EKS-CAJ-00006
EKS-CAF-00006
EKS-CAP-00013
EKS-DRM-00001
EKS-EQC-00006
EKS-FEC-00003
EKS-GAG-00006
EKS-GAA-00007
EKS-GOG-00005
EKS-ICT-00005
EKS-MAM-00005
EKS-MEG-00005
EKS-MIM-00001
EKS-MOD-00007
EKS-MUM-00006
EKS-MUP-00006
EKS-MYL-00006
EKS-NOL-00005
EKS-ORN-00008
EKS-ORL-00006
EKS-OTG-00004
EKS-PAT-00006
EKS-PES-00006
EKS-POA-00004
EKS-RAN-00006
EKS-TAG-00013
EKS-TAR-00007
EKS-XET-00003
EKS-XIM-00006
Gene Ontology
GO:0030424; C:axon
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0045121; C:membrane raft
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0001525; P:angiogenesis
GO:0048593; P:camera-type eye morphogenesis
GO:0031589; P:cell-substrate adhesion
GO:0021952; P:central nervous system projection neuron axonogenesis
GO:0060997; P:dendritic spine morphogenesis
GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain
GO:0030010; P:establishment of cell polarity
GO:0061351; P:neural precursor cell proliferation
GO:0021631; P:optic nerve morphogenesis
GO:0051965; P:positive regulation of synapse assembly
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0046328; P:regulation of JNK cascade
GO:0031290; P:retinal ganglion cell axon guidance
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013