EKS-ORC-00139

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00139

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	555.1	2.6E-167	489	765	277

Status

Unreviewed

Ensembl Protein

ENSOCUP00000003590

UniProt Accession

G1SL66;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000004150	ENSOCUP00000003590	ENSOCUT00000004150

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

833

Protein Sequence
(FASTA)

MWSWKCLLFW AVLVTATLCT ARPAAPTLPE QGKAQAPVPG VAAAQPWGAP VEVESLLVHP 60

GDLLQLRCRL RDDVQSINWL RDGVQLAESN RTRITGEEVE VRDSVPADSG LYACVTSSPS 120

GSDTTYFSVN VSDALPSSED DDDDDDSSSE EKETDNTKPN PVAPYWTSPE KMEKKLHAVP 180

AAKTVKFKCP SSGTPNPTLR WLKNGKEFKP DHRIGGYKVR YATWSIIMDS VVPSDKGNYT 240

CIVENEYGSI NHTYQLDVVE RSPHRPILQA GLPANKTVAL GSNVEFMCKV YSDPQPHIQW 300

LKHIEVNGSK IGPDNLPYVQ ILKTAGVNTT DKEMEVLHLR NVSFEDAGEY TCLAGNSIGL 360

SHHSAWLTVL EALEERPAVM TSPLYLEIII YCTGAFLISC MVGSVIIYKM KSGTKKSDFH 420

SQMAVHKLAK SIPLRRQVTV SADSSASMNS GVLLVRPSRL SSSGTPMLAG VSEYELPEDP 480

RWELPRDRLV LGKPLGEGCF GQVVLAEAIG LDKDKPNRVT KVAVKMLKSD ATEKDLSDLI 540

SEMEMMKMIG KHKNIINLLG ACTQDGPLYV IVEYASKGNL REYLQARRPP GLEYCYNPSH 600

NPEEQLSSKD LVSCAYQVAR GMEYLASKKC IHRDLAARNV LVTEDNVMKI ADFGLARDIH 660

HIDYYKKTTN GRLPVKWMAP EALFDRIYTH QSDVWSFGVL LWEIFTLGGS PYPGVPVEEL 720

FKLLKEGHRM DKPSNCTNEL YMMMRDCWHA VPSQRPTFKQ LVEDLDRIVA LTSNQEYLDL 780

SMPLDQYSPS FPDTRSSTCS SGEDSVFSHE PLPEEPCLPR RSAQLANGGL KRR 833

Nucleotide Sequence
(FASTA)

ATGTGGAGCT GGAAGTGTCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC GCTCTGTACT 60

GCCAGGCCAG CAGCGCCCAC CTTGCCTGAA CAAGGTAAGG CACAGGCGCC CGTCCCTGGG 120

GTGGCTGCAG CCCAGCCCTG GGGAGCCCCT GTGGAAGTGG AGTCCTTGCT GGTCCACCCG 180

GGTGACCTGC TGCAGCTTCG CTGTCGGCTG CGGGACGATG TGCAGAGCAT CAACTGGCTG 240

CGGGACGGGG TGCAGCTGGC AGAAAGCAAC CGCACGCGCA TCACGGGCGA GGAGGTGGAG 300

GTGCGGGACT CCGTGCCCGC CGACTCCGGC CTCTACGCAT GCGTGACCAG CAGCCCCTCG 360

GGCAGCGACA CCACCTACTT CTCCGTCAAC GTCTCAGATG CGCTCCCCTC ATCGGAGGAC 420

GACGACGACG ATGATGACTC CTCTTCGGAG GAGAAAGAGA CAGATAACAC CAAACCAAAC 480

CCCGTAGCGC CGTACTGGAC ATCCCCTGAA AAGATGGAAA AGAAACTGCA CGCCGTACCG 540

GCTGCCAAGA CCGTGAAGTT CAAGTGCCCT TCCAGCGGGA CACCGAACCC CACGCTGCGC 600

TGGCTGAAAA ATGGCAAAGA GTTCAAACCT GACCACAGGA TTGGAGGCTA CAAGGTCCGC 660

TATGCCACCT GGAGCATCAT CATGGACTCC GTGGTTCCCT CCGATAAGGG CAACTACACT 720

TGCATTGTGG AGAACGAGTA CGGCAGCATC AACCACACCT ACCAACTGGA CGTCGTGGAG 780

CGGTCGCCTC ACCGGCCCAT CCTGCAGGCA GGGCTGCCTG CCAACAAGAC GGTGGCCCTG 840

GGCAGCAATG TGGAGTTCAT GTGTAAGGTG TACAGTGACC CTCAGCCTCA CATCCAGTGG 900

CTAAAGCACA TCGAGGTCAA CGGGAGTAAG ATCGGCCCAG ACAATCTGCC CTACGTCCAG 960

ATCTTGAAGA CTGCCGGAGT TAACACCACT GACAAAGAGA TGGAGGTGCT TCACTTGCGG 1020

AACGTCTCCT TCGAGGACGC GGGCGAGTAT ACGTGCTTGG CGGGTAACTC TATCGGACTC 1080

TCCCATCACT CTGCATGGCT GACCGTTCTG GAAGCCCTGG AAGAGAGACC AGCCGTGATG 1140

ACATCGCCCC TGTACCTGGA GATCATCATC TATTGCACGG GGGCCTTCCT CATCTCCTGC 1200

ATGGTGGGCT CCGTCATCAT CTACAAGATG AAGAGTGGCA CCAAGAAGAG CGACTTCCAC 1260

AGCCAGATGG CCGTGCACAA GCTGGCCAAG AGCATCCCCC TGCGCAGACA GGTAACAGTG 1320

TCGGCTGACT CCAGTGCATC CATGAATTCA GGGGTTCTTC TGGTTCGGCC CTCACGGCTC 1380

TCCTCCAGCG GGACCCCCAT GTTAGCTGGG GTCTCTGAAT ATGAGCTGCC CGAAGACCCT 1440

CGCTGGGAGC TGCCTCGAGA CAGACTGGTC TTGGGCAAAC CCCTGGGAGA GGGCTGCTTC 1500

GGGCAGGTGG TGTTGGCGGA GGCCATTGGG CTGGACAAGG ACAAACCCAA CCGTGTGACC 1560

AAAGTGGCCG TGAAGATGTT GAAGTCGGAT GCAACAGAGA AAGATCTTTC CGATCTGATC 1620

TCAGAAATGG AGATGATGAA GATGATTGGG AAGCACAAGA ACATCATCAA CCTGCTGGGG 1680

GCCTGCACGC AGGACGGTCC CTTGTACGTC ATCGTGGAGT ACGCCTCCAA GGGCAACCTG 1740

CGGGAGTACC TGCAGGCCCG GCGGCCCCCG GGGCTGGAAT ACTGTTACAA CCCCAGCCAC 1800

AACCCCGAGG AGCAGCTCTC CTCCAAGGAC CTGGTGTCCT GCGCCTACCA GGTGGCCCGA 1860

GGCATGGAAT ACCTCGCCTC CAAGAAGTGC ATACACAGAG ACCTGGCCGC CAGGAACGTC 1920

CTGGTGACGG AGGACAACGT GATGAAGATC GCCGACTTCG GCCTAGCACG AGACATTCAC 1980

CACATCGACT ACTACAAAAA GACGACCAAC GGCCGGCTGC CCGTGAAGTG GATGGCGCCC 2040

GAGGCGTTGT TCGATCGGAT CTACACCCAT CAGAGTGATG TGTGGTCTTT TGGGGTGCTC 2100

CTGTGGGAAA TCTTCACCCT GGGCGGCTCC CCGTACCCCG GCGTGCCTGT GGAGGAGCTT 2160

TTCAAGCTGC TGAAGGAAGG CCACCGCATG GACAAGCCCA GCAACTGCAC CAATGAGCTG 2220

TACATGATGA TGCGGGACTG CTGGCACGCA GTGCCCTCCC AGAGGCCCAC CTTCAAGCAG 2280

CTGGTAGAAG ACCTGGACCG CATTGTGGCC TTGACCTCCA ACCAGGAGTA CCTGGACCTG 2340

TCCATGCCCC TGGACCAGTA CTCGCCCAGC TTTCCCGACA CCCGAAGCTC CACCTGCTCC 2400

TCGGGCGAGG ACTCCGTCTT TTCTCACGAG CCGTTGCCCG AGGAGCCGTG TCTGCCCCGA 2460

CGCTCGGCCC AACTTGCCAA TGGCGGACTC AAACGACGC 2499

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 489   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  548

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 549   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  608

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 609   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  668

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 669   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  728

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 729   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  765

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008201	; F:heparin binding
GO:0001525	; P:angiogenesis
GO:0060117	; P:auditory receptor cell development
GO:0060445	; P:branching involved in salivary gland morphogenesis
GO:0048469	; P:cell maturation
GO:0002062	; P:chondrocyte differentiation
GO:0030326	; P:embryonic limb morphogenesis
GO:0035607	; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0001701	; P:in utero embryonic development
GO:0042472	; P:inner ear morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0048762	; P:mesenchymal cell differentiation
GO:0030901	; P:midbrain development
GO:0042474	; P:middle ear morphogenesis
GO:0043066	; P:negative regulation of apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759	; P:organ induction
GO:0042473	; P:outer ear morphogenesis
GO:0048339	; P:paraxial mesoderm development
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0045787	; P:positive regulation of cell cycle
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045666	; P:positive regulation of neuron differentiation
GO:0010976	; P:positive regulation of neuron projection development
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0007605	; P:sensory perception of sound
GO:0001657	; P:ureteric bud development
GO:0021847	; P:ventricular zone neuroblast division

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013