EKS-ORC-00299
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00299
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20348.62.6E-10427278252
StatusUnreviewed
Ensembl ProteinENSOCUP00000016339
UniProt AccessionG1SM04;
Protein Name
Protein Synonyms/Alias
Gene NameSTK3
Gene Synonyms/Alias STK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000004545ENSOCUP00000016339ENSOCUT00000023961
ENSOCUG00000004545ENSOCUP00000003920ENSOCUT00000004542
OrganismOryctolagus cuniculus
Functional Description
Protein Length448
Protein Sequence
(FASTA)
MERMGIRKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG QVVAIKQVPV 60
ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME YCGAGSVSDI IRLRNKTLTE 120
DEIATILKST LKGLEYLHFM RKIHRDIKAG NILLNTEGHA KLADFGVAGQ LTDTMAKRNT 180
VIGTPFWMAP EVIQEIGYNC VADIWSLGIT SIEMAEGKPP YADIHPMRAI FMIPTNPPPT 240
FRKPELWSDD FTDFVKKCLV KNPEQRATAT QLLQHPFIKN AKPVSILRDL ITEAMEIKAK 300
RHEEQQRELE EEEENSDEDE LDSHTMVKTS SESVGTMRAT STMSEGAQTM IEHNSTMLES 360
DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ DFKNKSHENC NQNMHEPFPM 420
SKNVFPDNWK VPQDGDFDFV STLPFSQL 448
Nucleotide Sequence
(FASTA)
ATGGAAAGGA TGGGGATTAG GAAGAGTAAG CTAAAAAAGC TGAGTGAAGA CAGTTTGACT 60
AAGCAACCTG AAGAAGTTTT TGATGTACTA GAGAAGCTTG GAGAAGGGTC TTATGGAAGT 120
GTATTTAAAG CAATACATAA GGAATCTGGA CAAGTTGTTG CAATTAAACA AGTACCTGTG 180
GAGTCAGATC TTCAGGAAAT AATTAAAGAA ATTTCCATAA TGCAGCAATG TGACAGCCCG 240
TATGTTGTGA AGTACTATGG CAGTTACTTT AAGAACACAG ATCTCTGGAT TGTTATGGAG 300
TACTGCGGCG CTGGCTCTGT CTCAGACATA ATTAGATTAC GAAACAAGAC ATTAACAGAA 360
GATGAAATTG CAACCATTCT TAAATCTACA TTGAAAGGAC TAGAATATTT GCACTTTATG 420
AGGAAAATTC ACAGAGATAT AAAAGCTGGA AATATTCTCC TCAATACAGA AGGACACGCA 480
AAATTGGCAG ACTTTGGTGT GGCTGGTCAG TTAACAGATA CAATGGCAAA ACGTAATACT 540
GTGATAGGAA CTCCATTTTG GATGGCTCCT GAAGTAATTC AAGAAATAGG CTATAACTGT 600
GTGGCTGACA TCTGGTCCCT TGGCATTACT TCTATAGAAA TGGCTGAAGG AAAACCACCT 660
TATGCGGATA TACATCCAAT GAGGGCTATT TTTATGATTC CAACAAACCC ACCACCGACA 720
TTCAGGAAGC CAGAACTTTG GTCTGATGAT TTCACTGATT TTGTTAAAAA ATGCTTAGTG 780
AAGAATCCTG AACAGAGAGC TACTGCAACG CAACTTTTAC AGCATCCTTT TATTAAGAAT 840
GCAAAGCCAG TATCAATATT AAGAGACCTG ATCACAGAAG CTATGGAGAT CAAGGCGAAA 900
AGACATGAGG AGCAACAGCG AGAATTGGAA GAGGAAGAAG AGAATTCGGA TGAAGATGAG 960
CTGGATTCCC ACACAATGGT GAAGACCAGC TCGGAGAGTG TGGGCACGAT GCGGGCCACG 1020
AGCACAATGA GTGAGGGGGC CCAGACCATG ATTGAACATA ACAGCACCAT GCTAGAATCT 1080
GACCTGGGGA CCATGGTTAT AAACAGTGAG GATGAGGAAG AAGAAGATGG AACTATGAAA 1140
AGAAATGCAA CTTCACCACA AGTACAAAGA CCATCATTCA TGGACTACTT TGATAAGCAG 1200
GACTTCAAGA ATAAGAGTCA TGAAAACTGT AATCAGAACA TGCATGAACC TTTCCCTATG 1260
TCCAAAAATG TTTTTCCTGA TAACTGGAAA GTTCCTCAAG ATGGAGACTT CGACTTTGTA 1320
AGTACACTTC CATTCTCCCA GTTA 1344
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         +++le++g+G++g+v++a +k++g++vaik++ +e+  +l+e++keis+++++++p++v+
Q: 27    FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES--DLQEIIKEISIMQQCDSPYVVK  84
         7899*******************************7..9*********************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s++k+++lw+vmey+ +Gs+sd+++  ++++l+E++ia+il+++lk+LeylH +++i
Q: 85    YYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLTEDEIATILKSTLKGLEYLHFMRKI  143
         ****************************.99*****************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180
         Hrdika+niLl++eg+ kL+dfgva ql++t++kr+tv+gtp+wmAPEvi+  e gY++ 
Q: 144   HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ--EIGYNCV  201
         ***************************************************..9******
S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240
         aDiwslGIt+ie+aeg+pP++d++p++a+++i++n+pp++++++ +s+ f++fv+kcl k
Q: 202   ADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVK  261
         ************************************************************
S: 241   npekRpsasellkhkFl  257
         npe+R++a++ll+h+F+
Q: 262   NPEQRATATQLLQHPFI  278
         ****************7
Domain Sequence
(FASTA)
FDVLEKLGEG SYGSVFKAIH KESGQVVAIK QVPVESDLQE IIKEISIMQQ CDSPYVVKYY 60
GSYFKNTDLW IVMEYCGAGS VSDIIRLRNK TLTEDEIATI LKSTLKGLEY LHFMRKIHRD 120
IKAGNILLNT EGHAKLADFG VAGQLTDTMA KRNTVIGTPF WMAPEVIQEI GYNCVADIWS 180
LGITSIEMAE GKPPYADIHP MRAIFMIPTN PPPTFRKPEL WSDDFTDFVK KCLVKNPEQR 240
ATATQLLQHP FI 252
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00292
EKS-ANC-00302
EKS-BOT-00315
EKS-CAJ-00324
EKS-CAF-00320
EKS-CAP-00351
EKS-DAR-00665
EKS-DRM-00159
EKS-EQC-00323
EKS-FEC-00303
EKS-GAG-00266
EKS-GAA-00391
EKS-GOG-00312
EKS-HOS-00325
EKS-ICT-00297
EKS-LOA-00326
EKS-MAM-00319
EKS-MOD-00318
EKS-MUM-00350
EKS-MUP-00329
EKS-MYL-00312
EKS-NOL-00291
EKS-ORN-00409
EKS-OTG-00322
EKS-PAT-00300
EKS-POA-00306
EKS-PRC-00047
EKS-RAN-00332
EKS-SUS-00276
EKS-TAG-00380
EKS-TAR-00411
EKS-TEN-00410
EKS-TUT-00073
EKS-XET-00384
EKS-XIM-00399
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0043539; F:protein serine/threonine kinase activator activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0060706; P:cell differentiation involved in embryonic placenta development
GO:0007417; P:central nervous system development
GO:0003157; P:endocardium development
GO:0035329; P:hippo signaling cascade
GO:0007243; P:intracellular protein kinase cascade
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0008285; P:negative regulation of cell proliferation
GO:0046621; P:negative regulation of organ growth
GO:0001841; P:neural tube formation
GO:0046330; P:positive regulation of JNK cascade
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0060215; P:primitive hemopoiesis
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR011524; SARAH.
IPR024205; SARAH_domain.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF11629; Mst1_SARAH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50951; SARAH; 1.
Prints
Created Date20-Feb-2013