EKS-ORC-00291

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00291

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	364.8	2.8E-109	25	289	265

Status

Unreviewed

Ensembl Protein

ENSOCUP00000003971

UniProt Accession

G1SM46;

Protein Name

Protein Synonyms/Alias

Gene Name

TNIK

Gene Synonyms/Alias

TNIK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000004598	ENSOCUP00000025979	ENSOCUT00000027370
ENSOCUG00000004598	ENSOCUP00000003971	ENSOCUT00000004603
ENSOCUG00000004598	ENSOCUP00000022137	ENSOCUT00000022651

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1360

Protein Sequence
(FASTA)

MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 60

DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 120

KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180

TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 240

ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR EQPNERQVRI 300

QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 360

NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 420

REQRRHYEEQ MRREEERRRA EHEQEYIRRQ LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL 480

EEQRQAERLQ RQLKQERDYL VSLQHQRQEQ RPVEKKPLYH YKEGMSPSEK PAWAKEVEER 540

SRLNRQSSPA MPHKVANRIS DPNLPPRSES FSISGVQPAR TPPMLRPVDP QIPHLVAVKS 600

QGPALTASQS VHEQPTKGLS GFQEALSVTS HRVEMPRQNS DPTSENPPLP TRIEKFDRSS 660

WLRQEEDIPP KVPQRTTSIS PALARKNSPG NGSALGPRLG SQPIRASNPD LRRTEPVLES 720

PLHRTSSGSS SSSSTPSSQP SSQGGSQPGS QAGSSERTRV RANSKSEGSP VLPHEPAKVK 780

PEESRDITRP GRPASYKKAI DEDLTALAKE LRELRIEETN RPLKKVTDYS SSSEESESSE 840

EEEEDGESET HDGTVAVSDI PRLIPTGTPG SNEQYNVGMA GTHGLETSHA DTFSGSISRE 900

GTLMIRETSG EKKRSGHSDS NGFAGHINLP DLVQQSHSPA GTPTEGLGRV STHSQEMDSG 960

TEYGMGSSTK ASFTPFVDPR VYQTSPTDED EEDEESSAAA LFTSELLRQE QAKLNEARKI 1020

SVVNVNPTNI RPHSDTPEIR KYKKRFNSEI LCAALWGVNL LVGTENGLML LDRSGQGKVY 1080

NLINRRRFQQ MDVLEGLNVL VTISGKKNKL RVYYLSWLRN RILHNDPEVE KKQGWITVGD 1140

LEGCIHYKVV KYERIKFLVI ALKNAVEIYA WAPKPYHKFM AFKSFADLQH KPLLVDLTVE 1200

EGQRLKVIFG SHTGFHVIDV DSGNSYDIYI PSHIQGNITP HAIVILPKTD GMEMLVCYED 1260

EGVYVNTYGR ITKDVVLQWG EMPTSVAYIH SNQIMGWGEK AIEIRSVETG HLDGVFMHKR 1320

AQRLKFLCER NDKVFFASVR SGGSSQVFFM TLNRNSMMNW 1360

Nucleotide Sequence
(FASTA)

ATGGCGAGCG ACTCCCCGGC TCGCAGCCTG GATGAAATCG ATCTCTCGGC TCTGAGGGAC 60

CCAGCAGGGA TCTTTGAATT GGTGGAACTT GTTGGAAACG GGACATATGG GCAAGTTTAT 120

AAGGGTCGTC ATGTCAAAAC CGGCCAGCTT GCAGCCATTA AGGTTATGGA CGTCACAGGG 180

GATGAAGAGG AAGAAATCAA ACAAGAAATT AACATGTTGA AGAAATATTC TCATCACCGG 240

AATATTGCTA CGTACTATGG TGCTTTTATC AAGAAGAACC CGCCCGGCAT GGATGACCAG 300

CTTTGGCTGG TGATGGAGTT TTGCGGAGCT GGCTCTGTCA CTGACCTGAT TAAGAACACG 360

AAAGGGAACA CGCTGAAAGA AGAGTGGATC GCATACATCT GCAGAGAGAT CTTACGGGGG 420

CTGAGTCACC TGCACCAGCA TAAAGTGATT CATCGAGATA TTAAAGGTCA AAATGTCTTG 480

CTGACGGAAA ATGCGGAAGT TAAACTAGTG GATTTTGGGG TGAGTGCCCA GCTTGATAGA 540

ACAGTGGGCA GGAGGAATAC TTTCATTGGC ACTCCCTACT GGATGGCACC TGAAGTTATT 600

GCCTGTGATG AAAACCCAGA TGCCACCTAT GACTTCAAGA GTGACCTGTG GTCTCTGGGA 660

ATTACCGCCA TCGAGATGGC AGAAGGCGCT CCCCCTCTCT GTGACATGCA CCCCATGAGA 720

GCCCTCTTCC TCATCCCCCG GAACCCAGCA CCTCGGCTGA AGTCCAAGAA GTGGTCCAAA 780

AAATTCCAGT CCTTCATCGA GAGCTGCTTG GTGAAGAATC ACAGCCAGCG GCCGGCCACC 840

GAGCAGCTGA TGAAGCACCC GTTTATCCGC GAGCAGCCCA ACGAGCGCCA GGTCCGCATC 900

CAGCTCAAGG ACCACATCGA CAGGACAAAG AAGAAGCGCG GGGAGAAAGA TGAGACTGAG 960

TACGAGTACA GCGGAAGTGA GGAAGAGGAG GAGGAGAACG ACTCGGGAGA GCCCAGCTCC 1020

ATCCTGAACC TGCCAGGGGA GTCGACACTG CGGCGGGACT TCCTGAGGCT CCAGCTGGCC 1080

AACAAGGAGC GGTCGGAGGC CCTGCGGCGG CAGCAGCTGG AGCAGCAGCA GCGGGAGAAC 1140

GAGGAGCACA AGCGGCAGCT GCTGGCTGAG CGCCAGAAGC GCATCGAGGA GCAGAAGGAG 1200

CAGCGCCGGC GGCTGGAGGA GCAACAAAGG CGGGAGAAGG AGCTGCGCAA GCAGCAGGAG 1260

AGGGAGCAGC GCCGCCACTA CGAGGAGCAG ATGCGGCGGG AGGAGGAGCG GAGGCGCGCT 1320

GAGCACGAGC AGGAATACAT CAGGCGACAG TTAGAGGAGG AACAGAGACA GTTAGAGATC 1380

TTGCAGCAGC AGCTACTGCA TGAACAAGCT CTCCTTCTGG AGTATAAGCG CAAACAGCTG 1440

GAAGAGCAGA GACAAGCAGA AAGGCTGCAG AGACAGCTAA AGCAGGAGAG GGACTACTTG 1500

GTTTCCCTTC AGCATCAGCG GCAGGAGCAG AGACCCGTGG AGAAGAAGCC ACTGTACCAT 1560

TACAAAGAAG GCATGAGTCC CAGTGAGAAG CCAGCATGGG CCAAGGAGGT AGAAGAACGG 1620

TCAAGGCTTA ACCGGCAGAG TTCACCTGCC ATGCCTCACA AGGTTGCCAA CAGAATATCT 1680

GACCCCAACC TGCCCCCAAG GTCGGAATCC TTCAGCATTA GTGGGGTTCA GCCTGCTCGG 1740

ACACCCCCCA TGCTTAGACC AGTGGATCCC CAGATCCCTC ATCTGGTAGC TGTGAAATCC 1800

CAGGGACCTG CTTTGACCGC CTCCCAGTCA GTGCATGAGC AGCCCACCAA GGGCCTGTCT 1860

GGGTTTCAGG AGGCTCTGAG CGTGACCTCT CACCGCGTGG AGATGCCGCG CCAGAACTCA 1920

GATCCCACCT CTGAAAACCC GCCTCTCCCG ACGCGAATCG AAAAGTTTGA CCGAAGTTCT 1980

TGGTTACGAC AGGAGGAAGA CATTCCACCA AAGGTGCCTC AAAGAACTAC TTCTATATCC 2040

CCAGCGTTAG CCAGAAAGAA TTCTCCTGGG AATGGTAGTG CTCTGGGACC CAGACTAGGA 2100

TCTCAGCCCA TCAGAGCAAG CAACCCGGAT CTCCGGAGAA CTGAGCCTGT CCTGGAGAGT 2160

CCCCTGCACA GGACCAGCAG TGGTAGCTCC TCCAGCTCCA GCACCCCCAG CTCCCAGCCC 2220

AGCTCGCAAG GAGGCTCCCA GCCAGGGTCA CAAGCTGGGT CCAGTGAACG TACCAGAGTT 2280

CGAGCCAACA GCAAGTCAGA AGGATCACCT GTGCTCCCCC ATGAGCCTGC CAAGGTGAAA 2340

CCAGAAGAAT CCAGGGACAT TACCCGGCCT GGTCGACCAG CTAGCTATAA GAAAGCTATA 2400

GATGAGGATC TGACGGCATT AGCCAAAGAA TTAAGAGAAC TTCGGATTGA AGAAACAAAC 2460

CGCCCACTGA AGAAGGTGAC CGATTACTCC TCCTCCAGTG AGGAGTCGGA GAGTAGTGAA 2520

GAGGAGGAGG AAGATGGAGA GAGCGAGACC CATGATGGGA CAGTGGCTGT CAGTGACATA 2580

CCCAGACTGA TACCAACAGG CACTCCAGGG AGCAACGAGC AGTACAATGT GGGAATGGCT 2640

GGGACGCACG GGCTGGAGAC CTCTCATGCG GACACCTTCA GCGGCAGCAT TTCAAGAGAG 2700

GGAACCTTGA TGATCAGAGA GACATCTGGA GAGAAGAAGC GATCCGGCCA TAGTGACAGC 2760

AATGGCTTCG CGGGTCACAT CAATCTCCCA GACCTGGTGC AGCAGAGCCA TTCTCCGGCT 2820

GGGACCCCGA CTGAGGGCCT GGGGCGTGTG TCTACCCATT CCCAGGAGAT GGACTCGGGG 2880

ACTGAATATG GCATGGGGAG CAGCACCAAA GCCTCCTTCA CCCCCTTCGT GGACCCCCGA 2940

GTATACCAGA CCTCTCCCAC CGATGAAGAC GAAGAGGATG AGGAATCGTC AGCTGCAGCT 3000

CTGTTTACTA GTGAACTTCT TAGGCAAGAA CAGGCCAAAC TCAATGAAGC AAGAAAGATC 3060

TCAGTGGTAA ATGTGAACCC AACCAACATC CGGCCTCATA GCGACACACC AGAAATCAGA 3120

AAATACAAGA AGCGATTCAA CTCAGAAATA CTCTGTGCGG CTCTGTGGGG TGTAAACCTT 3180

CTGGTGGGGA CTGAAAATGG CCTGATGCTC TTGGACCGAA GTGGGCAAGG CAAAGTCTAC 3240

AATCTGATCA ACCGGAGGCG ATTTCAGCAG ATGGATGTGC TAGAGGGATT GAATGTCCTT 3300

GTGACAATAT CAGGAAAGAA GAATAAGCTA CGAGTTTACT ATCTGTCATG GTTAAGAAAC 3360

AGAATACTAC ACAATGACCC AGAAGTAGAA AAGAAACAAG GCTGGATCAC TGTTGGGGAC 3420

TTGGAAGGCT GCATACATTA CAAAGTTGTT AAATATGAAA GGATTAAATT CTTGGTGATT 3480

GCCTTAAAGA ATGCTGTGGA GATATATGCT TGGGCTCCTA AACCATATCA TAAGTTCATG 3540

GCATTTAAGT CTTTTGCAGA TCTCCAGCAC AAGCCTCTGC TAGTTGATCT CACCGTAGAG 3600

GAAGGTCAAA GATTAAAGGT TATTTTTGGC TCACACACTG GTTTCCATGT AATTGATGTT 3660

GATTCAGGAA ACTCTTATGA TATCTACATA CCATCTCATA TTCAGGGCAA TATCACTCCT 3720

CATGCTATTG TCATCTTGCC TAAAACAGAT GGAATGGAAA TGCTTGTTTG CTATGAGGAT 3780

GAGGGGGTGT ACGTAAACAC CTATGGCCGG ATAACTAAGG ATGTGGTGCT GCAATGGGGA 3840

GAAATGCCCA CGTCTGTGGC CTACATTCAT TCCAATCAGA TAATGGGCTG GGGCGAGAAA 3900

GCTATTGAGA TCCGGTCAGT GGAAACAGGA CATTTGGATG GAGTATTTAT GCATAAGCGA 3960

GCTCAAAGGT TAAAGTTTCT ATGTGAAAGA AATGATAAGG TATTTTTTGC ATCCGTGCGA 4020

TCTGGAGGAA GTAGCCAAGT GTTTTTCATG ACCCTCAACA GAAATTCCAT GATGAACTGG 4080

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e +g+G++g+vy++r++ktg+l+aik+++++  +++ee+++ei++lkk++h +ni

Q: 25    FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG-DEEEEIKQEINMLKKYSHhRNIA  83

         899********************************8.999*************998****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+k      +++lwlvme++ +Gs++dl+k+++ ++lkEe+iayi+re+l++L++

Q: 84    TYYGAFIKknppgmDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSH  143

         ************************************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++

Q: 144   LHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  203

         ************************************************************

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

            + +Yd k+D+wslGItaie+aeg+pP++d++p++al++i++n++p+lksk k+sk+f

Q: 204   enpDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSK-KWSKKF  262

         999999********************************************888.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

         ++f+e+cl kn ++Rp++++l+kh+F+

Q: 263   QSFIESCLVKNHSQRPATEQLMKHPFI  289

         **************************7

Domain Sequence
(FASTA)

FELVELVGNG TYGQVYKGRH VKTGQLAAIK VMDVTGDEEE EIKQEINMLK KYSHHRNIAT 60

YYGAFIKKNP PGMDDQLWLV MEFCGAGSVT DLIKNTKGNT LKEEWIAYIC REILRGLSHL 120

HQHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180

NPDATYDFKS DLWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPAPRLK SKKWSKKFQS 240

FIESCLVKNH SQRPATEQLM KHPFI 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0007256	; P:activation of JNKK activity
GO:0046777	; P:protein autophosphorylation
GO:0048814	; P:regulation of dendrite morphogenesis

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013