EKS-ORC-00414
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00414
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/DMPK472.63.9E-14245307263
StatusUnreviewed
Ensembl ProteinENSOCUP00000022132
UniProt AccessionG1SMN4;
Protein Name
Protein Synonyms/Alias Rho-associated protein kinase 1;
Gene NameROCK1
Gene Synonyms/Alias ROCK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000004848ENSOCUP00000022132ENSOCUT00000031946
ENSOCUG00000004848ENSOCUP00000004197ENSOCUT00000004853
OrganismOryctolagus cuniculus
Functional Description
Protein Length599
Protein Sequence
(FASTA)
DGLDALVYDL DFPALRKNKN IDNFLSRYKD TINKIRDLRM KAEDYEVVKV IGRGAFGEVQ 60
LVRHKSTRKV YAMKLLSKFE MIKRSDSAFF WEERDIMAFA NSPWVVQLFY AFQDDRYLYM 120
VMEYMPGGDL VNLMSNYDVP EKWARFYTAE VVLALDAIHS MGFIHRDVKP DNMLLDKSGH 180
LKLADFGTCM KMNKEGMVRC DTAVGTPDYI SPEVLKSQGG DGYYGRECDW WSVGVFLYEM 240
LVGDTPFYAD SLVGTYSKIM NHKNSLTFPD DNDISKEAKN LICAFLTDRE VRLGRNGVEE 300
IKRHLFFKND QWAWETLRDT VAPVVPDLSS DIDTSNFDDL EEDKGDEETF PIPKAFVGNQ 360
LPFVGFTYYS NPLVLMSDSG ICQNKKAEQQ RKRLKQENLQ KTIYKLEEQL HNEMQLKDEM 420
EQKCRTSNIK LDKIMKELDE EGNQRRNLES TVSQIEKEKM LLQHRINEYQ RKAEQENEKR 480
RNVENEVSTL KDQLEDLKKV SQNSQLANEK LAQLQKQLEE ANDLLRTESD TAVRLRKSHT 540
EMSKSISQLE SLNRELQERN RILENSKSQT DKDYYQLQAV LEAERRDRGH DSEMIGDLQ 599
Nucleotide Sequence
(FASTA)
GATGGATTGG ATGCTTTGGT GTATGATTTG GATTTTCCTG CCTTAAGAAA AAACAAAAAT 60
ATTGACAACT TTTTAAGCAG ATATAAAGAT ACAATAAATA AAATTAGAGA TTTACGAATG 120
AAAGCTGAAG ATTATGAAGT AGTGAAAGTG ATTGGTAGAG GTGCATTTGG AGAAGTTCAA 180
TTGGTAAGGC ATAAATCCAC CAGAAAGGTA TATGCTATGA AGCTTCTCAG CAAGTTTGAA 240
ATGATTAAGA GATCTGATTC TGCATTTTTC TGGGAAGAAA GAGACATCAT GGCTTTTGCT 300
AACAGTCCTT GGGTTGTTCA GCTTTTTTAT GCATTCCAAG ACGATCGTTA TCTGTACATG 360
GTGATGGAAT ACATGCCTGG TGGAGATCTT GTAAACTTAA TGAGCAACTA TGATGTGCCT 420
GAAAAATGGG CACGCTTCTA TACTGCAGAA GTAGTTCTTG CATTGGATGC AATCCATTCC 480
ATGGGTTTTA TTCATAGAGA TGTGAAGCCT GACAACATGC TGCTGGATAA ATCTGGACAT 540
TTGAAGTTAG CAGATTTTGG TACTTGTATG AAGATGAATA AGGAAGGTAT GGTACGATGT 600
GATACAGCAG TTGGAACACC TGATTATATT TCCCCTGAAG TATTAAAATC CCAAGGTGGT 660
GATGGTTATT ATGGACGAGA ATGTGACTGG TGGTCAGTTG GAGTATTTTT ATATGAAATG 720
CTTGTAGGTG ATACACCTTT TTATGCAGAT TCTCTGGTTG GGACTTACAG TAAAATTATG 780
AATCATAAAA ATTCACTTAC CTTCCCTGAT GATAATGACA TATCAAAAGA AGCAAAAAAT 840
CTTATTTGTG CCTTCCTTAC TGACAGAGAA GTGCGATTAG GGCGAAATGG TGTAGAAGAA 900
ATCAAACGAC ATCTTTTCTT CAAAAATGAC CAGTGGGCTT GGGAAACACT CCGAGACACT 960
GTAGCACCAG TTGTACCTGA TTTAAGTAGT GACATTGATA CTAGTAATTT TGATGACTTG 1020
GAAGAAGATA AAGGAGATGA AGAAACATTC CCTATTCCTA AAGCTTTTGT TGGCAATCAG 1080
CTACCTTTTG TAGGATTTAC ATACTATAGT AATCCATTAG TCTTAATGAG TGATTCAGGT 1140
ATATGTCAAA ACAAAAAGGC AGAACAGCAG AGAAAGAGAC TGAAGCAGGA AAATTTGCAA 1200
AAAACTATCT ACAAGCTGGA AGAACAGCTG CATAATGAAA TGCAATTAAA AGATGAAATG 1260
GAACAGAAGT GCAGAACTTC AAACATAAAA CTAGACAAGA TAATGAAAGA ATTGGATGAA 1320
GAGGGGAATC AAAGAAGAAA TCTAGAATCT ACAGTGTCTC AAATTGAGAA GGAGAAAATG 1380
TTACTACAGC ATAGAATTAA TGAGTACCAA AGAAAGGCTG AACAGGAAAA TGAGAAGAGG 1440
AGAAATGTAG AAAATGAAGT TTCTACTTTA AAGGACCAAT TAGAAGACTT AAAGAAAGTA 1500
AGTCAGAATT CACAGCTTGC TAATGAGAAG CTAGCACAAT TACAAAAGCA GCTAGAAGAA 1560
GCCAATGACT TACTTAGGAC AGAATCGGAC ACAGCTGTAA GATTAAGGAA GAGTCATACG 1620
GAGATGAGCA AATCAATTAG TCAGCTAGAG TCCCTCAACA GAGAATTGCA AGAGAGAAAC 1680
AGAATTTTAG AGAATTCCAA GTCACAAACA GATAAGGATT ATTACCAGCT GCAAGCTGTA 1740
TTAGAAGCTG AACGAAGAGA CAGAGGTCAT GATTCTGAGA TGATTGGAGA CCTTCAA 1797
Domain Profile
S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60
         +e++kviGrGafgev++vr+k+t+kvyamk+l+k+e++kr++saff+eerd++++a+s+w
Q: 45    YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  104
         89**********************************************************
S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120
         +vql+yafqd++yly+vmey++GGdl++l+s+y+  +pe++arfy+ae+vlald++h++g
Q: 105   VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMG  162
         **********************************..9***********************
S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180
         ++hrd+kpdn+lldksGh+kladfG+c+k+n++g+v++++avGtpdyispevlk+++ g+
Q: 163   FIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GD  221
         ********************************************************9.**
S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240
         g+yg+ecdwws+Gv+lye+lvg+tpfya+slv tyski+nhk+sl+fp+d+++s+eak+l
Q: 222   GYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNL  281
         ************************************************************
S: 241   ikklltsreerlgregiedlkkhpff  266
         i+++lt+re rlgr+g+e++k+h ff
Q: 282   ICAFLTDREVRLGRNGVEEIKRHLFF  307
         *************************9
Domain Sequence
(FASTA)
YEVVKVIGRG AFGEVQLVRH KSTRKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60
VVQLFYAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA RFYTAEVVLA LDAIHSMGFI 120
HRDVKPDNML LDKSGHLKLA DFGTCMKMNK EGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180
GRECDWWSVG VFLYEMLVGD TPFYADSLVG TYSKIMNHKN SLTFPDDNDI SKEAKNLICA 240
FLTDREVRLG RNGVEEIKRH LFF 263
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Saccharomyces cerevisiae"; ?>
EKS-CAE-00377
EKS-SAC-00062
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0030036; P:actin cytoskeleton organization
GO:0003383; P:apical constriction
GO:0032060; P:bleb assembly
GO:0000910; P:cytokinesis
GO:0035556; P:intracellular signal transduction
GO:0050901; P:leukocyte tethering or rolling
GO:0022614; P:membrane to membrane docking
GO:0016525; P:negative regulation of angiogenesis
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0032970; P:regulation of actin filament-based process
GO:0045616; P:regulation of keratinocyte differentiation
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011072; HR1_rho-bd.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR020684; Rho-assoc_coiled-coil_kin.
IPR015008; Rho-bd.
Pfam
PF02185; HR1; 1.
PF00169; PH; 1.
PF00433; Pkinase_C; 1.
PF08912; Rho_Binding; 1.
SMARTs
SM00109; C1; 1.
SM00233; PH; 1.
SM00133; S_TK_X; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
Created Date20-Feb-2013