EKS-ORC-00379
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00379
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR579.72.6E-174611944334
StatusUnreviewed
Ensembl ProteinENSOCUP00000004237
UniProt AccessionG1SMR5;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000004897ENSOCUP00000004237ENSOCUT00000004897
OrganismOryctolagus cuniculus
Functional Description
Protein Length994
Protein Sequence
(FASTA)
ILLFCYKINT RFLFKVVFSA VIFGAIANQE LPVIKCVLIN HKDNDSSVGK SSPYPTVSES 60
PEDLGCARRP ESAGAVYEAA AVEVDVAASI TLQVLLSTPG NISCLWVFKD SALNCQPHFD 120
LQNRGVVSMV ILKMTETQAG EYLLFIQSEA TNYTILFTVS IRNTLFYTLR RPYFRKMENQ 180
DALVCISESI PEPIVEWVLC DSQGESCKEE SAAVVKKEEK VLHELFGTDI KCCARNELGK 240
KCTKLFTIDL NQTPQTTLPQ LFLKVGEPLW IRCKAVHVNH GFGLTWELEH RALEEGSYFE 300
MSTYSTNRTM IRILLAFVSS VGRDNAGYYT CSSSQHASQS ALVTILEKGF INATNSSEDY 360
EIDQYEEFCF SVRFQAYPQI RCTWTFSQKS FPCEQRGLED GYSVSKFCNH KHQPGEYIFH 420
AENDDAQFTK MFTLHIRRKP QVLAEASASQ ASCSSDGYPL PSWTWRKCSD QSPNCTEEIT 480
EGVWNKKANR KVFGQWTSSS TLNMSESIKG FLVKCCAYNS VGTSCETILL NSPGPFPFIQ 540
DNISFYATIG LCLPFIAVLT MLLCHKYKKQ FRYESQLQMV QVTGSSDNEY FYIDFREYEY 600
DLKWEFPREN LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEREALM 660
SELKMMTHLG SHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK 720
EHNFSFYPTF QSHPNASMPG SREVQIHQEL DQSSGLNGNS FHSEDEIEYE NQKRLEEEED 780
LNVLTFEDLL CFAYQVAKGM EFLEFKSCVH RDLAARNVLV THGKLVKICD FGLARDIMSD 840
SNYVVRGNAR LPIKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPVDANFY 900
KLIQSGFKMD QPFYATEEIY FIMQSCWAFD SRKRPSFPNL TSFLGCQLAD AEEAMYQNMD 960
GHAPERSSGY QNRRSFGREM GSELPSPQAP AGDS 994
Nucleotide Sequence
(FASTA)
ATTTTGCTGT TTTGTTATAA GATAAATACA CGCTTTCTTT TCAAGGTTGT TTTCTCAGCT 60
GTGATATTTG GGGCTATTGC CAATCAAGAG CTGCCTGTGA TCAAGTGTGT TTTAATCAAT 120
CATAAGGACA ATGATTCATC AGTGGGGAAG TCATCACCAT ATCCCACGGT GTCGGAATCC 180
CCGGAAGACC TCGGGTGTGC GCGGAGACCG GAGAGCGCAG GCGCAGTGTA CGAAGCCGCC 240
GCGGTGGAAG TAGACGTGGC TGCGTCCATC ACGCTGCAAG TGCTGCTCAG CACGCCGGGG 300
AACATCTCCT GTCTCTGGGT CTTCAAAGAC AGCGCGCTGA ATTGCCAGCC GCACTTTGAT 360
TTACAGAACA GAGGAGTTGT TTCCATGGTC ATTTTGAAAA TGACAGAAAC CCAAGCTGGA 420
GAATACCTAC TTTTTATTCA GAGCGAAGCT ACCAATTACA CAATATTGTT TACAGTGAGT 480
ATAAGAAATA CATTGTTTTA CACATTAAGA AGACCTTACT TCAGAAAGAT GGAAAATCAG 540
GACGCCCTGG TGTGCATCTC TGAGAGCATT CCCGAGCCAA TTGTGGAGTG GGTGCTTTGT 600
GATTCGCAAG GTGAAAGCTG TAAAGAAGAA AGTGCAGCCG TTGTTAAAAA GGAGGAAAAG 660
GTACTGCACG AATTGTTTGG AACTGATATA AAGTGCTGTG CGAGAAACGA ACTGGGCAAG 720
AAATGCACCA AGCTGTTCAC CATAGATCTG AATCAGACTC CTCAGACCAC GCTGCCTCAG 780
CTGTTCCTGA AAGTAGGCGA GCCCCTGTGG ATACGGTGCA AAGCTGTTCA CGTGAACCAC 840
GGGTTCGGGC TCACGTGGGA ACTGGAACAC AGAGCCCTGG AGGAGGGCAG CTACTTCGAG 900
ATGAGCACGT ATTCCACAAA CAGAACTATG ATTCGGATTC TGCTGGCGTT TGTGTCGTCG 960
GTGGGAAGAG ACAATGCAGG CTACTACACC TGCTCCTCAT CCCAGCACGC CAGTCAGTCA 1020
GCACTGGTTA CCATTCTAGA AAAGGGGTTT ATAAACGCTA CCAATTCAAG TGAAGATTAT 1080
GAGATTGACC AATACGAAGA GTTCTGTTTT TCGGTGAGGT TTCAAGCATA CCCACAAATC 1140
AGATGCACCT GGACCTTCTC TCAAAAATCT TTTCCTTGTG AACAACGAGG TCTTGAGGAT 1200
GGATACAGCG TATCCAAGTT TTGCAACCAT AAACACCAGC CAGGAGAGTA TATATTCCAT 1260
GCAGAAAACG ACGATGCGCA ATTCACCAAA ATGTTCACGC TGCATATACG AAGGAAACCT 1320
CAAGTGCTGG CCGAAGCATC AGCAAGTCAG GCTTCTTGTT CGTCGGATGG CTACCCGTTA 1380
CCATCTTGGA CCTGGAGGAA GTGTTCAGAC CAGTCTCCCA ACTGCACAGA AGAAATCACA 1440
GAAGGCGTGT GGAATAAAAA GGCTAACAGG AAGGTGTTTG GGCAGTGGAC ATCGAGCAGT 1500
ACACTGAACA TGAGCGAGTC CATCAAAGGG TTCTTGGTCA AGTGCTGTGC GTACAACTCC 1560
GTGGGCACGT CGTGTGAAAC CATCCTCTTA AACTCACCAG GCCCCTTCCC GTTCATCCAA 1620
GACAATATCT CATTCTATGC GACAATTGGG CTTTGTCTTC CCTTCATTGC TGTTTTAACC 1680
ATGCTGCTTT GTCACAAGTA CAAAAAGCAA TTTCGGTATG AAAGCCAGCT GCAAATGGTC 1740
CAGGTGACCG GCTCCTCCGA TAACGAGTAC TTCTACATTG ATTTCAGAGA ATACGAGTAT 1800
GATCTCAAAT GGGAGTTCCC AAGAGAAAAT TTAGAGTTTG GGAAGGTCCT AGGATCAGGT 1860
GCTTTTGGAA AGGTGATGAA TGCAACAGCT TATGGAATTA GTAAGACAGG CGTCTCCATC 1920
CAGGTTGCAG TGAAAATGTT GAAAGAAAAA GCAGACAGTT CTGAAAGAGA GGCGCTCATG 1980
TCCGAACTCA AAATGATGAC TCACCTGGGG AGCCACGAGA ACATTGTGAA CCTGCTGGGG 2040
GCGTGCACGC TGTCAGGACC AATTTACTTG ATTTTTGAAT ATTGTTGCTA TGGTGATCTC 2100
CTCAACTATC TAAGAAGTAA AAGAGAAAAA TTTCACAGGA CGTGGACCGA GATTTTCAAG 2160
GAGCACAACT TCAGTTTCTA CCCCACTTTC CAGTCACATC CAAATGCCAG TATGCCTGGT 2220
TCAAGAGAAG TTCAGATACA CCAGGAGCTG GACCAGAGCT CGGGGTTGAA TGGGAATTCA 2280
TTTCACTCTG AAGATGAAAT TGAATACGAA AATCAAAAAA GGCTGGAGGA GGAGGAGGAC 2340
TTGAATGTGC TCACATTTGA AGATCTTCTT TGCTTTGCAT ATCAAGTTGC CAAAGGAATG 2400
GAATTTCTGG AATTTAAGTC GTGTGTGCAC AGGGACCTGG CGGCCCGGAA CGTGCTTGTC 2460
ACCCACGGCA AGCTGGTGAA GATCTGTGAT TTTGGATTGG CGCGCGACAT CATGAGCGAT 2520
TCCAACTATG TCGTGCGGGG CAACGCGCGT CTGCCCATCA AATGGATGGC TCCAGAGAGC 2580
TTGTTTGAAG GCATCTACAC CATTAAGAGT GACGTCTGGT CCTACGGAAT ACTGCTCTGG 2640
GAAATCTTTT CCCTTGGTGT GAATCCTTAC CCTGGAATTC CGGTGGACGC CAACTTCTAT 2700
AAACTCATTC AGAGTGGATT TAAGATGGAT CAGCCTTTTT ATGCCACAGA AGAAATATAC 2760
TTCATCATGC AGTCCTGCTG GGCTTTCGAC TCCAGGAAAC GGCCGTCCTT CCCGAACCTG 2820
ACTTCGTTTT TAGGATGTCA GCTGGCAGAC GCGGAGGAAG CGATGTACCA GAACATGGAT 2880
GGCCACGCTC CAGAACGTTC TTCCGGCTAC CAAAACAGGC GATCTTTTGG CAGAGAGATG 2940
GGTTCAGAGC TACCCTCGCC ACAGGCTCCC GCTGGAGACT CATAG 2985
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+sse+ealmselk+++hlG
Q: 611   LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTHLG  670
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 671   SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPT-  729
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++s+ + s+++s+e v++++++++ s  + ++++se++ +++++++   +eeed
Q: 730   ------FQSHPNASMPGSRE-VQIHQELDQSSGLNGNSFHSEDEIEYENQKRL--EEEED  780
         ......9*************.**************************999877..78999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++k+cvhrdlaarnvl+t+Gk+vkicdfGlardim+d
Q: 781   LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKLVKICDFGLARDIMSD  840
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvv+Gnarlp+kwmapes+f+++yt+ksdvwsyGillweifslG++pypg++vd++fy
Q: 841   SNYVVRGNARLPIKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY  900
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yateeiy imq+cw+++++krpsf +l+++l
Q: 901   KLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFPNLTSFL  944
         ****************************************9986
Domain Sequence
(FASTA)
LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEREALM SELKMMTHLG 60
SHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF 120
QSHPNASMPG SREVQIHQEL DQSSGLNGNS FHSEDEIEYE NQKRLEEEED LNVLTFEDLL 180
CFAYQVAKGM EFLEFKSCVH RDLAARNVLV THGKLVKICD FGLARDIMSD SNYVVRGNAR 240
LPIKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPVDANFY KLIQSGFKMD 300
QPFYATEEIY FIMQSCWAFD SRKRPSFPNL TSFL 334
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0002318; P:myeloid progenitor cell differentiation
GO:0045578; P:negative regulation of B cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0002328; P:pro-B cell differentiation
GO:0002572; P:pro-T cell differentiation
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013