EKS-ORC-00222

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00222

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	319.4	1.7E-95	3	237	235

Status

Unreviewed

Ensembl Protein

ENSOCUP00000004273

UniProt Accession

G1SMV0;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKAA2

Gene Synonyms/Alias

PRKAA2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000004942	ENSOCUP00000004273	ENSOCUT00000004940

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

521

Protein Sequence
(FASTA)

VGEHQLTGHK VAVKILNRQK IRSLDVVGKI KREIQNLKLF RHPHIIKLYQ VISTPTDFFM 60

VMEYVSGGEL FDYICKHGRV EEMEARRLFQ QILSAVDYCH RHMVVHRDLK PENVLLDAHM 120

NAKIADFGLS NMMSDGEFLR TSCGSPNYAA PEVISGRLYA GPEVDIWSCG VILYALLCGT 180

LPFDDEHVPT LFKKIRGGVF YIPEYLNRSV ATLLMHMLQV DPLKRATIKD IREHEWFKQD 240

LPTYLFPEDP SYDANVIDDE AVREVCEKFE CTESEVMNSL YSGDPQDQLA VAYHLIIDNR 300

RIMNQASEFY LASSPPAGSF MDDSAMHIPP GLKPHPERMP PLIADSPKAK CPLDALNTTK 360

PKSLAVKKAK WHLGIRSQSK PYDIMAEVYR AMKQLDFEWK VVNAYHLRVR RKNPVTGNYV 420

KMSLQLYLVD NRSYLLDFKS IDDEVVEQRS GSSTPQRSCS AAGLHRPRSS FDSTTAESHS 480

LSGSLTGSLT GSTLSSVSPR LGSHTMDFFE MCASLITTLA R 521

Nucleotide Sequence
(FASTA)

GTTGGAGAAC ATCAATTGAC AGGCCATAAA GTGGCAGTTA AAATCTTAAA TAGACAGAAG 60

ATTCGCAGTT TAGATGTTGT TGGAAAAATA AAACGAGAAA TTCAAAATCT AAAACTGTTT 120

CGCCATCCTC ATATTATCAA ACTCTATCAG GTGATCAGCA CTCCGACAGA CTTTTTTATG 180

GTAATGGAGT ATGTTTCTGG AGGTGAATTA TTTGATTACA TCTGTAAACA TGGACGGGTT 240

GAGGAGATGG AAGCCAGGCG CCTCTTTCAG CAGATTCTGT CTGCCGTAGA TTACTGTCAT 300

AGGCATATGG TTGTTCATCG AGACCTAAAA CCAGAAAATG TGCTTTTGGA TGCACACATG 360

AATGCCAAGA TAGCAGATTT TGGCTTATCA AACATGATGT CAGACGGTGA ATTTCTGCGG 420

ACCAGTTGTG GGTCCCCGAA TTATGCAGCG CCTGAAGTCA TCTCAGGCAG ATTGTATGCA 480

GGTCCTGAAG TTGATATCTG GAGCTGCGGT GTTATCTTGT ATGCGCTTCT CTGTGGCACT 540

CTCCCATTTG ATGATGAACA CGTTCCCACG TTGTTTAAGA AGATCCGAGG AGGTGTTTTT 600

TATATCCCGG AATATCTTAA TCGCTCTGTC GCCACCCTCC TGATGCATAT GCTGCAGGTT 660

GACCCCCTGA AACGAGCAAC CATCAAAGAC ATAAGAGAAC ATGAGTGGTT TAAACAAGAT 720

TTGCCCACTT ACTTATTTCC TGAAGACCCC TCCTATGATG CTAATGTCAT TGATGATGAG 780

GCTGTGAGAG AGGTGTGTGA AAAATTTGAG TGTACAGAAT CAGAAGTAAT GAACAGTTTA 840

TATAGTGGTG ACCCTCAAGA CCAGCTTGCG GTGGCTTATC ATCTTATCAT TGACAATCGG 900

AGAATAATGA ACCAAGCCAG TGAGTTCTAC CTCGCTTCCA GTCCTCCAGC AGGTTCTTTT 960

ATGGATGATA GTGCCATGCA TATTCCCCCA GGACTTAAAC CTCATCCAGA AAGGATGCCG 1020

CCTCTCATAG CAGACAGCCC CAAAGCAAAA TGTCCGTTGG ATGCACTAAA TACAACTAAG 1080

CCCAAATCTT TAGCTGTGAA AAAAGCCAAA TGGCATCTTG GAATCCGAAG TCAGAGCAAA 1140

CCATATGACA TCATGGCTGA AGTGTACCGA GCTATGAAGC AGCTGGACTT TGAATGGAAG 1200

GTAGTGAATG CATACCATCT TCGAGTAAGA AGAAAAAATC CAGTGACTGG CAATTATGTG 1260

AAAATGAGCT TGCAACTTTA CCTGGTTGAT AATAGAAGCT ATCTTTTGGA CTTTAAAAGC 1320

ATTGATGATG AGGTAGTGGA ACAGAGGTCT GGTTCCTCAA CACCTCAGCG CTCCTGCTCT 1380

GCGGCTGGCT TACACAGGCC AAGATCAAGT TTTGATTCTA CCACTGCAGA GAGTCATTCG 1440

CTTTCTGGCT CTCTCACTGG CTCTTTGACA GGAAGCACAT TGTCTTCAGT TTCACCTCGC 1500

CTGGGCAGTC ACACCATGGA TTTTTTTGAA ATGTGTGCCA GTCTGATCAC TACTTTAGCA 1560

CGT 1563

Domain Profile

S: 19    khketkekvavKiikkkkl.seeslekikrEieilkklkhpniikllevietkkklylvl  77

         +h++t++kvavKi++++k+ s + + kikrEi+ lk ++hp+iikl++vi+t +++++v+

Q: 3     EHQLTGHKVAVKILNRQKIrSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVM  62

         799***************96667788**********************************

S: 78    eyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkkeni  137

         ey+sggeLfdyi ++gr++e ear+lf+q++sav+Y+h++ +vHrDlKpeN+lld+++n

Q: 63    EYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNA  122

         ************************************************************

S: 138   kiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalvtgklP  197

         kiaDFGl+n++++g+ l+t+cGsp+YaaPe+++g+ Y gp+vD+Ws+Gv+Lyal++g+lP

Q: 123   KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLP  182

         ************************************************************

S: 198   fdeenlkellekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252

         fd+e++ +l++ki  g + ip++l++++++Ll ++L+vdp kRati++i++hew+

Q: 183   FDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF  237

         ******************************************************7

Domain Sequence
(FASTA)

EHQLTGHKVA VKILNRQKIR SLDVVGKIKR EIQNLKLFRH PHIIKLYQVI STPTDFFMVM 60

EYVSGGELFD YICKHGRVEE MEARRLFQQI LSAVDYCHRH MVVHRDLKPE NVLLDAHMNA 120

KIADFGLSNM MSDGEFLRTS CGSPNYAAPE VISGRLYAGP EVDIWSCGVI LYALLCGTLP 180

FDDEHVPTLF KKIRGGVFYI PEYLNRSVAT LLMHMLQVDP LKRATIKDIR EHEWF 235

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0004679	; F:AMP-activated protein kinase activity
GO:0005524	; F:ATP binding
GO:0003682	; F:chromatin binding
GO:0035174	; F:histone serine kinase activity
GO:0042149	; P:cellular response to glucose starvation
GO:0042593	; P:glucose homeostasis
GO:0008610	; P:lipid biosynthetic process
GO:0043066	; P:negative regulation of apoptotic process
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0010508	; P:positive regulation of autophagy
GO:0042752	; P:regulation of circadian rhythm

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013